Syngnathus scovelli (Gulf pipefish): 125978735 Help Entry 125978735         CDS       T08785                                  Symbol ryr2b Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism sscv  Syngnathus scovelli (Gulf pipefish) Pathway sscv04020   Calcium signaling pathway sscv04260   Cardiac muscle contraction sscv04261   Adrenergic signaling in cardiomyocytes sscv04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:sscv00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     125978735 (ryr2b)    04020 Calcium signaling pathway     125978735 (ryr2b)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     125978735 (ryr2b)    04261 Adrenergic signaling in cardiomyocytes     125978735 (ryr2b)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:sscv04040]     125978735 (ryr2b)    04990 Domain-containing proteins not elsewhere classified [BR:sscv04990]     125978735 (ryr2b) Ion channels [BR:sscv04040]  Voltage-gated cation channels   Ryanodine receptor    125978735 (ryr2b) Domain-containing proteins not elsewhere classified [BR:sscv04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    125978735 (ryr2b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_6 EF-hand_1 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  125978735 NCBI-ProteinID:  XP_068508733 LinkDB All DBs Position 12:10890801..10928938 Genome browser AA seq 4865 aa AA seqDB search MSDSGEGDDEFQFLRTGDEVVLQSVFTSQEEHVKVCLAAEGFGSRLCRLEATSNCKNVPP DLSVCGFILVQCLSVRALQEMLAHSESLVGAGGNHRTLLYGQAVLFQHSYSDMYLSCLSA SQSSADKLAFDVGLQEDEAGETCWWTVHPASRQRSEGEKVRVGDDLILVNVSSERYLHVS FGATCDNRGLADTLIVDAAFRRSLWSVAPICSASGLAPGYLRGGETLRLLHSHTDACLTI PTAERDEELQRIMQYEIGAVCRHARSLWRLENLHVVWSGKHVCWGQPFRLCHVTTGRYLG LSDQRGLRLLDREKADVSATAFCFRSAKEKLDCGRKSHVDGMGSPEIKYGDSVCYLQHVD SGLWLTYRAMDSKSACVGGAQRKAILHSEGHMDDGLTLSRSQREESHTASLIHGATLLFT TFIRKLDSCHGQGNVEPIVLPATNVTRGLQDLISFFQPPPEEQSQESRQNSQTVLKSRQN MFQEEGVIELVLEFIERLHRSNQAANQNWENVLGHFYQLLASLIRRNRANCAHFSSSLDW LISRLDQLEASSGVLEVLHCVLVESPEALNGIKEGHIRSIIAFLDKHGCNHKVLEVLCSL CVCHGVAVRANQNLICENLLPERDLLLQTRLVNWVTSVRPNIFLCLGEDSAQPRRWYYEL VVDHVEPFLTAEPTHLRVGWARSDGYRPRPTGGEGWGGNGVGDDLCSFGFDGLHLWAGCV GRRVRSPFPHLLTDDDVVSCCVDLSAPCISFRVNGLPVQGMLENFCVDGLLHPVVSFSPG VKVRFLFGGEHGEFRFLPPHGFVPCSEALLPNVKLTVEACHKYLLTHEDGKRELIGPFEP ISPVTFTPSPVDISKVELPLQFEDIRDKMAENIHELWVMERVDLGWSQGNERDEGKRLEP CLVEFSMMPDQERHQNLQTAQDTLRTLLALGFHIGFRDEYTVEGIHFMRLSNRYEQPGGY RPAPLDVSRVVLSTVHEEAIQLLAENEHNLWASERIKQGWTYGAQQDGKSKRSPDLVPYS LLDEKSRKMGQKAGREAVCTLLAYGYSLETLHQEKIILSNSCFFSSEKRRVFRADKSFAV TRGKWYFECELVTVGNVRVGWARPGCSPDKELGSDDQAFVFDGFEARWYHQGGEPLGRAC KQADVVGCLLDTSESTMMLTLNGELLFNDRGSELAAKDFDVRDGLLPVVSVGVNQVVRLN LGRQEGSLRYFSVCGLQEGYEPFAFNMARDPSLWMSWKRAQFKSILPDHPALQVSRVTGS KDSSPSLRVSQRLPAHHGVDSEMGFYRLSMSIQCAAVLTSPVEGVLPVASGCFSPGRREE EEVDSDFEVLMKSAHSFATSRDEPEYKDHAQDKTSRLKQRFMLKRNKPGLVSSNSSARLL EDVLVDKDNADHLIQTTRYYYSVRVLPNQEPFNVWVGWVTPDFHPNDMTFDIDDDLTVTV TLGDDTGKVQESVKRSNCYMVCAGEATGLSRSRRSAGLEIGCLIDTAAGLLTFTSSGVEM STFYQVEADTKLYPAVFIRPTTTNMFQFELGCIKNVMPLSAGLLRSLRTTSAPQCPPRFQ VQHLSPISWTRVPDRSPTVMVERSDERHGWRVHCLEPLQVMTVQIPNESRCVDILELSEL DDILTFHYHTLLLYCALCALGNARVCHAICSHVDQSQFLHAIQSPYLPGPLRSAFYQLLV QVHLSSNANARLMMNHEYIVPLSDQTRDVSLYQINGDDGRKCPLPLCIPSMRGSASLKPP MRFSRPCFVSIDVMGREVTCSDSPEIPLEILKSLTVDMLTAAVRAVHRGVRDPVGGSMEL LLVPLIKLFHTLLVMGVLTDDDLAKVLQLMEPGVFSTEKEDERKLGDHLSCAQHGLLQMK LPETVKLELCNVLSYLCDLQVRHRVEAVVAFSENFVGQLQENQRFRYKQVMQALNMSAAL TARKTKEFRSPPQEQINMLLSFKDDDQQEKSPCPVETQRLLRDFHQLLKSHCGIELDAAS EEDEPVETSVRDQLLSLGARVLGLKKTATRVEENEPLSHKSLKILISETMLRWAQEMEME DPRLVRAVFSLLHRQYQGLGGQMASALSKAYTISQASVEDTMTLLFSLGQIRLLLSVRMG NVEEKLMIRRLGDIMNNKVFYQHPDLMRALGMHETVMEVMVNVLGEKESKEISFPKMVAS CCRFLCYFCRISRLNQGALFDHLSYLLENSSVGLASPSMRGATPLDVAAASVMDNNELAL ALREPELEKVVHCLARCGLQSCSLLVAKGYPDIGWNPVEGERYLNFLRFVVFCNGESVEE NAYLVLRLLIRRPECFGPALRGDCGHGLLAAMKEAISISEESSLNGPCMAHQFNVTIDTV QDGEEDPIHMGHAIMTFYSALIDLLGRCAPEMQLIQRGQLEAVRMRAILRSLIPIQDLEG VISISFQAPSLSKDGSMLEPDLSSVFCPDHKAAMVLFVDRVYGVDTQSFLLRLLQDGFLS DLQMAVSLDTDDFGSTDMALAINRYLCSAVLPLLTKCSALLHGLEDHAALMDSLIQAIYS LSRASSLTKAQRDTTEDCLLAVCSKLHPTLMQPLLRRLVFDVPTLTDQSKIPIKLLSRHY EQRWKYYSLSGGQGKQSLASDEELHLSLKLFWGIFKALAKKQYEPELSKLCVHCLGAMAE ALPPDHLDPHTTSQMDQNTDGNFDPQPVETSTMSVPEGLEFVVNKYAEHTHEKWSLDKFA NGWVHGEQLCENTKVHPLLKPYRALAEKDKEAYRWAIKETIKSMLAFGWTIERTGEGEPF GLHTCMRRISQSGQLSFEGASTFTPKPFDTSSITLSWDQCAMAEKLAENYHNSWAKRKKL EQESKGGRGHATAVPFDNLTVKEKSKFRQRAQDVLKFLLLNGYTVWRDGKQADLDFPVTA NCFGHTLLQRLLFYAEDAQEHMLEREVMQARRQTSKGDRASHQHPVQFFLKVVIPLLEEY VKGHQLYFLSVSRSSDTNRSHASTKEKEMIARLFCKIAALVRHRPFLFGNETSTVTSCLH ALARALDARTLMKSAPESVQQSLHSFFQAAASDLEATMENLSATSLSLPQCRSQQAKGVA EVLGYTTSMLLPVLTSLFRHLASHNYGIDLLVGSVQGSCYRIINSLYWLGTGGGAVYMEG QRSAAGACLAALTAAFPVCFLGPPINQNHHSTMWKPERDDVGLPLDVEATCPLLPSLEEA MGEAQELTDAGAAAGQAQYGHVTDVTLPMLCAYLSRRRSDGPLLTSLTPQRASDLLGYIL RIIHNHVGASQGDWMKQLAVHSQPIICKARAELLKSHFLPLMDKLRKRAESVLLEEERMK AEGDAASEAELHIQERFSVLVRDLYAFYPLLIPFVDSNRARWQQESNPDAERLFSMVAEV FIFWAKSHNFKWEEQNYVVQNEINNLAFLLNDKTSKLDYQKRTIKRKGDRYSVHTSLIVA SVKRLLPVGLRVCFPTDESLITMAKSAFAQKNTEDEIRDCVYKYLLHSRDQSSTNSLRSN LNSETQNTLYATADLETTADKVVGLARVLHYLDQVEHPHKYKKGTRHKVLSKQRKQAVVA CLRMAPLYNLARHRAVNLFLQGYNKSWILDEEHTLEEKLVEDLAKLSETELTGGRREQKR DGAKLVDPLLQLITLFSCSALMERSDLGIDWLYVSYVEIMAKSCHNEDDDEEQQELQSFE EKEMEKQKLLYQQARLHLRGASEMVLQSISASRGTMGSTIAPTLKLGIAVLHGGNATVQQ KMLNYLRARRDVGFFQSMAGLMQSCSVLDLNAFERQNKAEGLGMATDERSEKVMPDEELT CDLFRFLQLLCEGHNSEFQNYLRTQTGNNTTVNMIISTVDYLLRIQESISDFYWHYSGKT AIDTQGQRNFSKAIKVAKQVFNTLTEYIQGPCNGNQQSLAHSRLWDAVVGFLHAFAHMQM KLSQDSRQIELLKELMDLQKDMVVFLLSMLEGNIVNGTIGKQMVDMLVESSSNVEMILQF FDMFLKLKDLTASDAFHQFDPDGKGRISRKDFQKAMELSKQFSQAETHFLLSCADTDDGE IPDYRAFVDRFHEPAKDIGFSIAVLLTNLSEHMPNDSRLRAFLELAECVLTYFQPYLGRI EILGGGKRIERVYFEISQSSRMQWEKPQVKESKRQFIFDVVNQGGEKEKMEMFVNFCEDT IFEMQLAAQISGSDNGERHGGEDEEESEEQDLDKKGMFFISFKKFHALTKMSLKDVLLSS VAFLRFLFMTLLGCLCFIVSGASRSLYVAFVNGGIVEGAKMMTVYDLFGGILEPTLDEVT EVTSGAERPRRPSTTLSPRRQSGQTAAVTSARGTDVLSDIFGLKVKRDGGQYRLATQDVT SSRLDLRNPNDVTFSDRRQGLQHEAGEEKAEDEMMSESDKWETCEETTAKEDGRKAKRLS NKSEEAGCQRSAFGEMISAHHKSLLNYFARTFYNMRLLSLFVTFAINFILLFYKVVSLRS SSESEVPEGDEGGVDYVLEESSGYMEPSLHLLAVAHTLISFSCIIGYYCLKVPLVIFKRE KEVARRLEFDGLYVTQQPPEEDIKGQWDRLVINTVSFPSNYWDKFVKRKVMDKYGDFYGR ETISELLGLDQASSDFSSDGTERNKFRKEAAWVTLFSSIDVKYQMWKLGVVLTDNSFLYL ACYMAMSVLGHYNNFFFAAHLLDIAMGIKTLRTILSSVTHNGKQLVLTLGLLAVVVYLYT VVAFNFFRKFYDKSDDKDGPNMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDDSEVE RIVFDITFFFFVVVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSEYFDKVP HGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPVGDCFRKQY EDQLG NT seq 14598 nt NT seq  +upstreamnt  +downstreamnt atgtctgactcgggtgagggtgatgacgaattccagtttctacgaacgggtgatgaagtg gtcctgcagagcgttttcacttctcaggaggaacatgtgaaggtttgcctggctgctgag ggatttggcagcaggctgtgcaggctggaggccacctccaactgtaagaatgttccacca gacttgtccgtgtgcggcttcattctggtccagtgtctgtctgtgcgagctctgcaggag atgctggcacacagcgaaagcctggttggagctgggggcaaccaccgcacccttctatac ggccaggctgtgcttttccagcattcgtacagcgacatgtatctcagctgcttgtctgca tcgcagtcctccgctgacaagctggcttttgatgtgggcctgcaggaagatgaagcgggt gagacctgttggtggacagtgcatccggcttccagacagaggtcagagggggagaaagtg cgtgttggggatgacctcattctggttaacgtgtcctcggagagatatctgcacgtgtcc tttggtgcgacctgcgacaacagaggcttggccgacactctgattgtggatgcggccttc cgccgctctctgtggagcgtcgctcccatctgctccgcaagtggacttgctccaggatac ctgagaggtggcgaaacgctcaggcttctccacagccacaccgacgcatgtctgacgatt cccacggcagagcgagatgaagagctgcaaaggataatgcagtatgagataggagccgtg tgcagacacgcccgctctctgtggaggctggagaacctgcatgtggtgtggagcggcaaa cacgtgtgctgggggcagccctttcgactctgtcatgtgaccaccggacgctatctaggc ctgagcgaccaacgaggcctccgtctgctcgatcgggagaaagcagacgttagcgcgact gccttctgcttccgctctgccaaggaaaagctggactgtgggagaaaaagtcacgtggac ggcatgggctccccagaaatcaaatacggagactccgtgtgttatcttcagcatgtcgac tctggtctgtggctcacctaccgagccatggatagcaagtctgcgtgtgtgggaggagct cagcggaaggcgatcttgcacagtgagggtcacatggacgacgggttgacgctgtctcgg tctcagagggaagaatctcacactgccagcctcatacatggcgcaacgctcctcttcact acttttatcaggaaacttgattcttgtcatgggcaaggaaacgtggagcccatcgtttta ccagcgacgaatgtgactcgcggccttcaagacctcataagctttttccaaccgccacca gaggagcagagccaggagtctcgacaaaacagccaaaccgtgttaaagagtcggcagaac atgtttcaagaagagggagtgatcgagttggtattggagttcattgagcgtctccatcgc tctaatcaggctgccaaccaaaattgggagaatgtccttgggcatttttatcagcttctg gcctcgcttattaggagaaaccgcgcaaactgtgcacatttctcgagttcgctcgactgg ctcattagcaggctggaccaactggaggcctcttctggagttttggaggttctgcactgc gttttggtggaaagtcccgaagcactaaatggcatcaaagagggacacatccgctctatc attgcttttctagacaagcatggatgcaaccacaaggtgttggaagtgctttgttctttg tgcgtgtgccatggcgttgccgtgcgcgccaatcagaacctcatctgtgaaaatctactg cccgagagagacttgctgctgcaaactcggctggttaattgggtcaccagcgtaaggccc aacatcttcctgtgtctgggggaagattcagcgcagccccgccggtggtactatgagctc gtggtggatcacgtagagcctttcctcacagcggagcccacgcacctacgcgtcggctgg gctcgaagcgacggctaccggcccagacccactggaggagagggctgggggggcaatggc gtgggagatgacctctgctcctttggctttgatggccttcacttatgggcaggttgcgtg gggcgcagagtgcgttcgcccttccctcacctgctgacggacgacgacgtggttagctgc tgcgtggacctcagcgccccctgcatttcatttcgggtcaacggtctccctgtgcagggc atgctggagaacttctgcgtggatggacttcttcatcccgtagtcagcttctcacctgga gtcaaggttcggtttctctttggaggggaacacggcgagttccgatttcttcccccgcac ggttttgtgccatgttctgaggctctcctcccgaacgtcaagctgacggtagaagcgtgc cataagtacctcttgactcacgaagacgggaaacgagagctcattggcccgtttgaacca atcagtccggttactttcactccctcaccggtagacatcagcaaggtggaactgccgctg caattcgaggatatccgtgataaaatggccgagaacatccatgaactgtgggtcatggaa agggttgatctcggctggtctcaaggaaatgagcgagacgaagggaagcgactcgagccc tgtctggtggagttctctatgatgcccgatcaggagagacaccagaacctccagactgcc caggacaccctaaggactcttcttgctcttggtttccatattggcttcagagatgaatat acagtggagggaatccatttcatgagactctccaacaggtacgagcagccaggtggctac agaccggccccgctagatgtgagccgtgttgttctcagcaccgtccacgaggaagcgatc cagttgttggcagagaatgagcacaacctctgggccagtgagcgtatcaagcaaggatgg acttacggtgctcaacaggatggtaaatcaaagcggagcccagatcttgtgccctacagc ctgcttgatgagaagagtagaaaaatgggacaaaaggctggaagggaggcagtttgcacc ctgctggcctatggttatagcttggagaccctccaccaggaaaagatcattttatcaaac agctgcttcttctccagcgaaaagcgccgagtgttccgagcagataaatcttttgctgtg actcgggggaagtggtactttgaatgcgaactggtcactgtggggaatgtgagagtcggc tgggcccggcctggctgctcccccgataaagagctgggctcagatgaccaggcgtttgtg tttgatggatttgaggctcggtggtaccatcagggtggagagcctctgggacgtgcctgc aagcaggcggacgtggttggttgcttgctggacacgagcgaaagcaccatgatgctcact ctcaacggagagttgctgtttaatgaccgaggatcagagctggctgccaaggactttgac gtcagagatggcctgctccccgtggtcagtgtgggtgtgaaccaggtggtgaggctgaac ctcggccgccaagagggctcgctgcggtactttagtgtgtgcggtctacaggagggttat gagccttttgctttcaatatggctcgagatccatccctgtggatgagttggaaacgtgct cagtttaaatccatactgccagaccatcccgccttgcaggtcagtagagtcactggctca aaggattcctcgccgagccttagggtctcacaacggttgccggcacaccacggcgtagac agcgaaatgggcttttaccggctcagcatgtccatccagtgcgccgctgtcctcaccagc ccagttgagggcgtgctgccggtggcatccggttgtttttcaccaggtaggagagaggag gaggaggtggactctgactttgaagtgttgatgaagtcggcccacagttttgcaacttca agagacgagcccgagtacaaggatcacgctcaggacaaaacgtcacgactcaagcaacgg ttcatgctgaagcgaaacaaaccaggcctggtcagcagcaactcctccgctcggctcctg gaggatgtcctcgttgacaaagataacgctgatcacctcattcagaccaccagatactac tattcggtgagagtcttgccaaaccaggagcctttcaatgtgtgggtgggctgggtgaca cctgattttcacccgaacgacatgacgtttgacattgacgatgacctcacagtgactgtc accctcggagacgacactggcaaagtccaagagagtgtgaagaggagtaactgttacatg gtctgcgccggagaggctacaggtttgtcacgcagccggaggagtgccggcttagaaatt ggttgcttgattgacacggccgccgggctgctgacgtttacctccagtggcgtggagatg tccaccttctaccaagtcgaggccgatacaaagctgtatcctgccgttttcatccgacct accactaccaatatgtttcaatttgaactgggatgcattaagaatgtgatgccgctgtca gccggcttgcttcgcagccttcgaacgacgagcgcgcctcagtgcccgcccaggtttcag gtgcagcatctgagtccgatctcatggacgcgagtgcctgacagatcaccgacggtgatg gtggagcgttccgatgaacgccacggctggagagtccattgccttgagccacttcaagtc atgaccgtccaaatccccaatgaaagcaggtgcgtggacattttggagctgtctgagctg gatgacatcttgacctttcattaccacactctcctcctctactgcgctttatgcgccctg ggcaacgcaagagtgtgccatgccatctgtagccacgtggatcagtcgcagttccttcac gccattcagagtccatacctgcctggcccgctgcgctctgctttttatcagcttcttgtg caggttcacctcagcagcaatgccaatgcacgtctcatgatgaaccatgaatacatcgtc cctctgtcggaccaaaccagagacgtcagcctttatcaaatcaatggcgacgacgggaga aaatgtccacttcctctctgcatcccgagcatgaggggaagtgcttccctgaaaccaccg atgcgcttctccaggccttgttttgtcagcattgatgtgatgggacgggaagtcacctgc agtgacagtcctgaaatccctctggagattctgaagagcctgacagtggacatgctgact gcagccgtgcgggctgtgcatcgtggtgtcagagaccctgtaggtggcagtatggagctt ctgctagttcccctcattaagttgtttcacactcttctggtgatgggggtattgactgat gatgacctggctaaagttctccaactaatggaacctggagtcttctctacagagaaagaa gatgaaagaaagctgggagatcacttgagttgtgctcaacacggactgctgcaaatgaaa cttccagaaacagtcaaacttgagctatgcaacgtgctgagctacctgtgcgatcttcag gtgcgccacagggtcgaagccgtggtagccttctcagaaaactttgttgggcaactgcag gagaaccagcgcttccgttacaaacaagtcatgcaggcactcaacatgtccgctgctctc accgcccgcaagaccaaagagttccgctcacctccgcaagagcagatcaacatgcttctg agcttcaaagatgacgaccagcaggagaaaagtccgtgtccggtggaaacccaacggctc ctgcgagacttccaccagcttctcaaatcccactgtggtatcgaattagatgctgcctcg gaagaagacgagcctgtcgagacgtcggtacgggatcaacttttaagcctgggggccaga gttcttggactgaagaagacggccacacgagtggaggaaaatgaaccgctgagtcacaag tccctgaaaattttgatctcagaaacaatgctgcgctgggctcaagagatggaaatggaa gatccccgcctggtcagggctgtcttctcattgctgcaccgccaatatcagggtcttggc gggcaaatggcgtccgctctttccaaagcttacacaattagccaagcctccgtggaggac accatgaccttgctgttctctttgggccaaatccgcttgttactcagcgtccgaatggga aatgtagaggaaaagctgatgatcagaagactaggagatatcatgaacaataaggttttc taccagcaccccgatctaatgagggcattgggcatgcacgagacagtcatggaagtgatg gtcaatgttcttggggagaaggaatccaaggaaatttcctttccaaagatggtggccagc tgctgtagattcctttgttatttttgccgcatcagccgactcaatcagggagcacttttt gaccacctcagctacctgttagaaaacagcagcgttggactcgcttcaccatcaatgcgc ggggccacccctctggatgtggcagcagcctcagtcatggacaataatgagctggccctc gctttgagggagcctgaactagaaaaggtggtgcattgccttgcacgctgtggtctgcaa agctgctcactgcttgtggccaaaggctaccctgatatcggatggaaccctgtggaggga gagcgttacctgaattttctacgttttgtcgttttctgcaatggcgaaagtgtagaggag aacgcgtacttggtgttgaggttgctgattcgtcgccccgaatgtttcggtccggccctg cgaggtgactgcggacacggcctcctagcggccatgaaagaggccatcagcatatcggag gagtcgtctctaaatggaccctgcatggctcaccagttcaacgtaaccatcgatactgtc caggatggtgaggaagaccccattcatatgggccacgccatcatgaccttctactctgcc cttatcgacttgctaggacgctgcgctccagagatgcaattgattcaaagaggccaactg gaagccgtccgcatgcgggccatcctgaggtcactcatccccatccaggatcttgaggga gtcatcagcatctcctttcaagccccatcgctgtcaaaagatggttcgatgctggagccc gacttatcgagtgtcttctgcccggaccacaaagcagctatggttctgtttgtggaccga gtgtacggcgtagacacgcagagttttctcctccgcctccttcaagatggcttcctgtct gaccttcagatggccgtctctctcgacaccgatgactttgggtccactgacatggccttg gccatcaatagatacttatgctcagctgtgcttccgctgctcaccaagtgttctgccctc ctccacggtttggaggaccacgccgcccttatggattctctcatccaggccatctacagt ctctccagggcctcaagcctaaccaaagcccagagggacacaactgaggattgtttgtta gctgtgtgcagcaaactccatccgactttgatgcagcctcttcttcgccgtcttgtcttt gacgttcccactctcacagaccaaagcaagataccaataaagcttttgagcagacattat gagcagagatggaaatactactctttaagtggcgggcaagggaagcagagcctggcctct gatgaggagctgcacttatcgctgaagctcttctggggcatctttaaggcgttagcgaag aagcaatatgagccagagttatccaaattgtgtgtccactgcttgggtgcaatggctgag gcccttcctcctgaccatttggacccacacactacgtcccaaatggaccaaaacacagat ggaaactttgatccgcaacctgtagaaacctcaaccatgtctgtgccagagggactggag tttgtggtcaacaaatacgctgagcacactcatgagaagtggtcgctagataagtttgcc aacggctgggttcatggggagcagctatgcgagaacaccaaagttcatcccctcctcaag ccctacagggccttggctgaaaaggacaaagaagcataccgctgggccattaaggagacg ataaaaagtatgctggccttcgggtggactatcgagcgcaccggggaaggagaacccttt ggcttgcacacatgcatgagaagaatttcgcagtccggtcagttgtcttttgaaggggcg tccaccttcacccctaaaccctttgacaccagtagcattaccttatcatgggatcagtgt gctatggctgaaaagttagctgaaaactaccacaattcttgggctaagaggaagaaactt gaacaagagagtaaagggggacgtgggcatgcgaccgccgtgccctttgacaacctgact gtgaaggaaaagagcaaattccggcagagagcccaggatgtgctcaaattccttctgctc aatggctacacggtgtggagggatggcaagcaagctgatctggattttccagtcacagcc aactgttttggccacactctactccagcgcttgctgttttatgcagaggatgctcaggaa cacatgttggagcgagaggtgatgcaagccagacgacagacctcaaaaggcgatagagcg tcacaccagcaccccgttcaattcttcctcaaggttgtcattccacttttggaagaatat gtgaaaggccaccagctgtacttcctgtctgtgtcgcgctcttcggacaccaacagaagc catgcgtccaccaaggaaaaagaaatgattgccagactcttttgtaaaattgcagctcta gtaagacacaggccctttctttttggaaatgaaacttcaactgtcacaagctgcctccat gctttggcccgggcgttggatgccaggactttaatgaagtcagccccggagtccgtccag cagtctctgcattccttcttccaagcagcagcgtctgatctcgaggcaaccatggaaaac ctctcggccacttcgctctcgttgcctcagtgtcgcagtcaacaggcgaaaggcgtggct gaggttctcggctacacaacctccatgctccttcccgtgctcacgtcactcttccgacat cttgccagccacaattatggcattgaccttctggtgggaagcgtgcaggggtcctgttac aggatcattaacagcctctactggctcggcaccggcggcggcgccgtatacatggaaggg cagaggtcagcagcaggtgcttgtctcgcagcgctgactgctgcctttcctgtctgcttc cttggaccacccatcaatcaaaaccaccacagcacaatgtggaaacctgaaagagatgac gtggggttaccacttgacgtggaagcaacatgcccccttctgccctctttggaggaagcg atgggggaagcgcaggagttgacggatgccggcgctgctgccgggcaggcccaatatggc cacgtcacggacgtcacattgccgatgctttgcgcttatttgtcccgccggcggtcagac ggcccgctcctcacctcgctaactcctcagcgtgccagcgacctgctaggctacattctc cgaatcatccacaaccacgtgggggcaagccagggtgactggatgaagcagctggcagtc cattcccagccaatcatctgcaaagcccgcgctgagctgctgaagagccacttccttcct ctcatggacaagctgaggaagagggcggaaagtgtgctgcttgaggaggagcggatgaaa gcagaaggtgatgctgcgtcggaagcagaactgcacatacaagaaaggttcagcgtactc gtgcgagacctctacgccttctatcccctcctcatccccttcgtggactccaatcgggcc cgttggcagcaagagtcaaacccggatgccgagcggctgttcagcatggtggcggaggtc ttcattttctgggccaaatctcataacttcaagtgggaggaacagaactatgtggtccaa aacgaaatcaacaatttggcattcttactcaacgacaagacgtcaaagcttgactaccag aaaaggacgataaagaggaagggcgatcgttattccgtacacacctccctcattgtggct tccgtgaagcgacttctcccggtgggactcagggtttgttttcccactgacgagagtctc atcacgatggcgaagagcgctttcgctcagaagaacactgaagatgagattcgtgactgt gtgtataaataccttttacattctcgtgatcagtcatcaacaaactcgctgagaagcaac ctgaattcagaaacccagaatactctttacgccactgctgacttggagacaaccgcagac aaggtggtgggactcgcccgtgtccttcattacctcgaccaggtggaacatccacacaag tataaaaaaggaactcggcacaaagtcttgtccaagcagagaaagcaagcagtagtggct tgtctgaggatggctcctctttacaacctggccaggcaccgagctgtcaacctgttcctc caaggctacaacaaatcctggatattagatgaggagcacactttggaggagaagcttgtg gaggatttggctaaactcagcgagacagaactaacgggaggaagacgagaacagaaaaga gacggtgccaaattggtggatcccctcctacagctcatcacgctcttcagttgcagtgcc ttgatggaacggagtgatcttggaattgactggctttatgtttcttacgtggagataatg gccaagagctgccataacgaagatgacgacgaggagcagcaagagctgcaaagttttgaa gagaaagagatggagaagcagaagctgctgtaccagcaggccaggttgcaccttcgcggc gcttccgagatggtcttgcaaagtatcagtgccagcagaggaactatgggctccacgatt gcgccaacactcaagttgggcattgctgttctacatggaggaaacgccaccgttcagcag aaaatgctgaattatttgagggcaagacgagatgtgggcttctttcagagcatggccgga ctcatgcagtcatgtagtgtactggatctgaacgcatttgagcgacagaacaaagctgaa ggattaggcatggccacggatgagcgctcagagaaggtgatgcctgatgaagaactcacc tgcgacctgttccgttttctacaattgctttgtgaaggacacaactcagagttccagaat tacttgcgaacgcagacaggaaacaatacgaccgtcaacatgatcatctccactgtggat tatctactaagaatacaggagtctatcagtgacttctactggcactactctggaaagact gccattgacacgcaaggccaacgcaatttttctaaggctatcaaagtggctaagcaggtc ttcaacacactcaccgaatacatacagggcccgtgtaatggaaaccagcagagtctggct cacagtcgtctgtgggatgccgtggtgggattcctccacgcctttgctcatatgcagatg aagctctcccaggattcacggcaaatagagctcctaaaagagctcatggacttacaaaag gatatggttgtcttcttgctgtccatgttggaagggaatatcgtaaacggaaccatcgga aagcagatggtggatatgttggtggaatcgtcgagcaacgtggagatgatcctccaattt ttcgacatgttcctcaaacttaaagacctcacggcttcggacgcctttcaccagtttgac cccgatggcaaaggccgcatctccagaaaggacttccagaaagccatggagctctccaag cagttctcacaagccgagactcatttcctcctctcctgtgcggacacggacgacggggaa atcccggattaccgagcttttgtggatcgcttccacgagccggccaaagacatcggcttc agcattgccgtgctgctcaccaatttgtccgagcacatgcccaatgactcgaggctgcga gccttcttggagctggccgagtgcgtcttgacttacttccaaccctacttaggccgcatc gagatcctcggtggcggcaagcgcatagagcgcgtctactttgagatcagccaatccagc cgcatgcagtgggagaagccgcaggtgaaggagtccaagcggcagttcattttcgacgtg gtcaaccaaggcggcgagaaagagaaaatggagatgtttgtcaacttctgcgaagacaca attttcgagatgcagctggcggctcagatctctggctctgacaacggagagcgacacggg ggagaagacgaggaggaaagcgaagaacaagacctggacaagaagggaatgtttttcatt tctttcaaaaagtttcacgctctgaccaaaatgagcctgaaggatgtcctcctgtcatct gtcgcattcctcagattccttttcatgactttgctcgggtgcctttgcttcattgtgagc ggcgctagccgcagcctatacgtagcttttgtcaatggcggcattgtggagggagccaaa atgatgaccgtgtacgacctctttggtggtatactcgaaccgacgcttgatgaggtcaca gaggtaacgagcggcgccgagcgtccgaggcggccctccaccactctctcccctcggcga cagagcggccagacggcggctgtgacctccgctagggggactgatgtactgtctgacata tttggcctcaaagtgaaaagagacggaggacaatacaggctcgccacacaagacgtgacg agcagtcgcttggatctgcgcaatcccaatgacgtgacgttttctgaccgacgtcagggg ctgcagcatgaggctggagaggaaaaagctgaggatgagatgatgtctgaatcagataaa tgggagacatgcgaggagacgacagcgaaggaggatggacggaaagccaagagactctcg aataaatcagaggaagcaggatgccagcgttccgctttcggcgagatgataagtgctcat cacaagagcctgctgaattactttgccaggacgttttataacatgcgtttgttgtccctc tttgtcacctttgccatcaacttcattctcctcttttataaggtggtatctttgcgttcg tcatctgaatcggaagtgccagagggagatgagggcggagttgattatgttttggaagaa agcagcggttacatggagccgtcgcttcacctcctggcggtggcgcacacgctcatctcc ttctcttgcattatcggttactactgcctcaaggtcccgctggtgatcttcaaacgggag aaggaagtggcccgaagacttgagtttgatggcctgtatgtgacccagcagcccccggag gaagacattaaaggccagtgggatcgactggtcatcaacactgtgtcgtttccaagtaat tactgggacaagtttgttaaaagaaaggtgatggacaaatatggtgacttttatggccgg gagacgatcagtgaacttcttggtttggaccaggcgtcctcagacttcagctctgacgga acggagaggaacaagttcagaaaagaagctgcctgggtcacactcttcagctccattgac gtcaagtaccagatgtggaaacttggggttgttctcactgacaattctttcctctatttg gcctgctacatggccatgtccgttctgggacattataacaattttttcttcgcggcccat cttctggacatcgcgatgggaatcaagactcttcgcaccatcctctcctctgtcacacac aatggaaagcagttggtgctgacattgggcctcctggctgtggtggtctacctctacacg gtggtggccttcaacttcttccgtaaattttacgacaagagtgacgacaaggacggcccg aacatgaagtgcgacgacatgcttacttgctacatgttccacatgtacgtgggagtacga gcgggagggggcatcggcgatgagatcgaggaccccgccggcgatgactctgaggtggaa cgtatcgtctttgacatcacctttttcttttttgtggtcgtcattttgctggctatcatt caaggtttgataattgatgcctttggggagctgcgtgaccagcaagagcaggtgaaagag gatatggagaccaagtgttttatttgtggaataggaagcgagtactttgataaagttcct catggttttgagactcatactctgcaggagcacaacttggccaactatctattcttcttg atgtacctcattaacaaagacgaaacggaacacacaggacaggaatcctatgtgtggaaa atgtaccaggaacgttgctgggaattttttcctgtgggagactgtttccgtaagcaatat gaagatcagctgggatga

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