Syngnathus scovelli (Gulf pipefish): 125991033 Help Entry 125991033         CDS       T08785                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism sscv  Syngnathus scovelli (Gulf pipefish) Pathway sscv04020   Calcium signaling pathway sscv04260   Cardiac muscle contraction sscv04261   Adrenergic signaling in cardiomyocytes sscv04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:sscv00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     125991033 (ryr2a)    04020 Calcium signaling pathway     125991033 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     125991033 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     125991033 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:sscv04040]     125991033 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:sscv04990]     125991033 (ryr2a) Ion channels [BR:sscv04040]  Voltage-gated cation channels   Ryanodine receptor    125991033 (ryr2a) Domain-containing proteins not elsewhere classified [BR:sscv04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    125991033 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 baeRF_family6 Motif Other DBs NCBI-GeneID:  125991033 NCBI-ProteinID:  XP_049614487 LinkDB All DBs Position 21:complement(8739088..8768261) Genome browser AA seq 4938 aa AA seqDB search MADGEGEDEIQFLRTNDEVVLQCSATIHKEQQKLCLAAEGFGNRLCFLESISNSKNVPPD LSICTFVLEQSLSVRALQEMLASNEEKTGGIIQGGGHRTSLYGHAILLRHSYSGMYLCCL STSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSISSERYLH LSYGNQCQNVDAAFQQTLWSITPICSGSEVAQGFLIGGDVLRLLHGHMDECLTVPSEDHG EEQKRTVHYEGGAVSSHARSLWRLETLRVLWSGSHIRWGQPFRLRHVTSGRYLSLTEKSL LLMEKDKADAKSTAFCFRSSKEKVDLGVKKEVDGMGTPDIKYGDSVCYIQHVDTGLWLTY QTADAKSARIGDIQRKALMHHEGHMDDGLTLSRSQHEESHTARVIRSTVFLFNLFIRSLD TLRAKGKSASFDIPIDSISLSLQDLIGYFQPPDDHLDHEDKQNLLRALKNRQNLFQEEGM ISLVLECIDRLHAYSSAAHFTEAAGKEAGEAWSSSLNSLYQLLAALIRGNRKNCAQFSGS LDWLVSRLERLEASSGILEVLHCVLVESPEALNLIKEGHIKSIISLLDKHGRNHKVLDVL CSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLINYVSSMCPNIFLGVSEGSAQYKKWY YELIVDQALPFVTAEASHLRVGWANTNGYMPCPSGGEVWGGNGVGDDLYSFGFDGLHLWT GCIAKSVNSPNQHLLKADDVVSCCLDLSVPSISFRINGQPVQGMFENFNSDGLFFPVASF SAGVKLRFLLGGRHGEFKFLPPPGYAPCFEAVLPREKLKLEPSQHQTAARDLLGPTITMS QAAFTPMPVNTSQIVLPFHLEKIKEKLAENIHELWVMNKIEIGWTYGVVRDDTKRQHPCL VEFSKLPEQERSYNLQMSVETLKTLLALGCHVGLADEHAVEKVKSLKLSSSYELSSGYKP APLDLCHIKLTSTQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKSRRNPRLVPYSLL DERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHTLFDHSNMSAERFRIFRAERSYCVNAG KWYFELEVLTAGEMRVGWARPGCLPDLELGSDEQAFVFDGFKVQRWHQGNEHFGRAWQAG DVVGCMVDLNEHTMMFTLNGEILLDDSGSELAFKDFDVGEGFIPVCSLGVCQAGRIDFGK HVSTLKYFTICGLQEGYEPFAVNMNRDVTIWLSKRLPQFVPIPPDHQHIEVTRIDGTVDS CPCLKVTQKSFSSQNSNTDITFYRLSMPIECAESFSKPPSTSDLLSLKTDLEDFESDFEV LVKTPHGHNGPSGPDRGEFNNHKDYHQEKTSKLKPSRFLLKKNKAENLYRSPPCLSEDVM VDDRNEYEVLMQASTHSYSVRIFPGQEPSNVWVGWVTSDFHQYEPGFGLDKVQTVTVTLG DEKGKVHESIKRSNCYMVWAGESSSPEGRNNNGLEIGCLLDTANGLLSFTANGKELSTYY QLEPSTKLFPAVFAKATSPNVFQFELGQMKNVMPLSAGLFKSERKNSIPQCPPRLHVQFL TPVLWSRVPNDYPKVSVSRSNDRHGWLVQCHEPLQFLSLHIPEENRSLDVLELTERRDLL KFHYHTLRLYSAICALGNNRVAHALCSHVDEAQLLHAIESKYMPGWLRAGYYDLLIDIHL SNYATARLMMNNEYIVPMTGETKSITLFPNEEKKHGVPGIGLSTSLRPRMQFASPNFVSG SGSSQFTTNLNNGAIDSCQYSPEFPLDVLKTKTVEMLTEAVCEGNMHVRDPIGGSTEFLF VPLIKLFYTMLIMGVFQNGDLKKILRLIEPSVFSEKFEEEMQKKLGSEEGKDDEGQSVPK EGLLQMKLPEPVKLQMCHVLQYLCDCQVRHRIEAVVAFSDDFVACLQENQRFRYNEVMLA LNMSAALTAKKTKEFRSPPQEQINMLLNFKKEMQECPCPQYIREQLLDFHEDLMKHCGIE IIEDSSLDGDSNFNFRGRLMSLVEKVSYLKNKIVNPPKENTDRKPSTLQQLVSETMVRWA QESVIEDPELVRAMFVLLHRQYDGIGGQVRALPKTYTINSVSIEDTINLLAALGQIRSLL SVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLSGGVSKEITFP KMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGATPLDVAAASVMDN NELALALREPDLEKVVQYLAGCGLQSCTMLVCKGYPDIGWNPVEGERYLDFLRFAVFCNG ESVEENANVVVRLLIRRPECFGPALRGEGGDGLLATMEEAIKISLDPLRDGPSLASESSN IPNDGRQEEDDTIHLGNAIMTFYAALIDLLGRCGPEMHLIHAGKGEAIRIRAILRSLIPI EDLVGVICIPFSMPSLGKDGLVLEPDMSAGFCPDHKAAMVLFLDRVYGVQDQNFLLHLLE VGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTKCAPLFAGTEPFASLIDSLL HTVYRLSKGCCLTKAQRDSIEECLLAVCGKLRPSMMQHLLRRLVFDIPLLNEHTKMPLKL LTNHYERCWKYYCLTAGWGSFGVASDEELHLSRKLFWGIFDALSHKPYDQELFKIALSCL SAVGGALPPDYMESNYMAMMDKQSSLDSEGNFTPQPADTANVTVPENLDIFIARYAEHNH EKWCFEKLSNGWSYGENACEISRSHNLLKSFKALSDKDKEFYCLPIRECLKTMLSWGWSI NRIRESDTANLHNKSRRISLASQPSLEGAQSFNPRPTDMSNVTLSRDTQSMAELLAENYH NIWAKKKKIELEAKGGGTHPLLVPFDTLTAKEKLKDRQKAQDILKFLQINGYTVSRGVKS QELDSPATEKRFAYTFLLQLIQNVDQAHEHMMKFDISRTRQKGVKSPHEQQMKFFGKVVL PLVDQYFKNHRMYFLSTSIHPISSGGHASNKEKEMVTSLFCKLGVLVRNRISLFGNNATS IVNCLQILGQSLDARTVMKTGLDSVKTALQSYFDSAAEALEKTQENLKLGQFTHSKEQPR GVPQIINYTTFGLLPILSSLFEHIGKNNFGEDLILDEVQVSCYRILNSLYFLGTNESIFV ERHRPALGKCLAAFSAAFPVAFLEPHVDHFNNFSIYNNKRPKDRNDHGLPGQVLDMCPMI PNLEKLLEEIIEVAESGIKYTQMPHVMEVVLPVLCSYMSHWWEDGPENNPDQADSCCTSV TSEHMNILLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISKAKSQLLKTHFLPLMKKLRK KAAVVLTDEEQSKAEGRGEISETELLIMDQFSVLVRDIYAFYPLLIRFVDYNRATWLKES DPEAEVLFHMVAEVFIFWAKSHNFKREEQNFVVQNEINNMSFLISDSNSKMSKGIVSYQE RKKLRRKGERYSMQTSLIVAALKRLLPVGLNVCVPGEQELIALAKNRFSQKDTEDEVRQV IRNNLNLQGKLQDPATRWQRALYRDILNHSDNTFDPEKNVDRVLDMAHVLFHLDQVEHPQ RSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIEAEEHFFEDKL IEDLAKSGEQEPFEEVEGMKRFDPLHQLIQLFSRTALTEKCKLDEDHLYMAYADIMAKSC HDEEDEDGEEVKSFEEKEMEKQRLLYQQERLHDRGAAEMVLQTISASKGEMGPMVASTLK LGIAILNGGNSTVQSKMLDYLKNRKDVGFFQSLAGLMQLCSVLDLNAFERQNKAEGLGMI TEEGSGEKVMQDDKFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLR VQESISDFYWYYSGKDVIDEQGQRNFSKAIHVAKQVFNTLTEYIQGPCTGNQQSLAHSRL WDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMMEGNVVNGTIGKQMV DMLVESSNNVEMILKFFDMFLKLKDVTSSEAFKEYDPDGKGVISKRDFQKAMENHKHYTQ SETEFLLSCAETDENELLDYEEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDNRLHTFLE LAESVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEG GEKEKMELFVNFCEDTIFEMQLAARMSDTGERSAVKDDSEQDRPDVENPETSFFSVTTVH MALVALRVNVILLIKVLSMKSLKKKMKKIKSMTSKDLLTTLLSFYLSVLQGLLHMVFSVF RGFCRILYNSIFGANQVDGTKSIKVSELLANMPDPTQDAIRLEGEDKERKSYDRSSVNED LAYLAVNTSDSELLSDIFGLDLRREGGQYKLSPHNPNASLTEMLNSPLPSPPPSEPRQRQ QLNSSSLDEEKEGRPVNPCEIKKKSDEKQEKNEKMKAKVKRRRVWKDEPDLQESVVSKKI VAYQRKVLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSSVAEEVISTNQADSSIQW DPLGGEPMVEIKDGVTDDPKEPLKLAMVHFVLEEGSGYMEPTLRILAILHTVISFFCIIG YYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFV KRKVMDKYGEFYGHDRISELLGLDKAALAFSDAHKKRKPRKDSYLAAVLNSIDVKYQIWK LGVVFTDNSFLYLAWYMTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVL TVGLLAVVVYLYTVVAFNFFRKFYNKSEDGELPDMKCDDMLTCYMFHMYVGVRAGGGIGD QIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCF ICGIGNDYFDTVPHGFETHTLQEHNLANYLFFVMYLINKDETEHTGQESYVWKMYQERCW EFFPAGDCFRKQYEDQLN NT seq 14817 nt NT seq  +upstreamnt  +downstreamnt atggctgacggagaaggcgaggatgaaattcagtttctgcgaactaacgatgaggtggtc ctccagtgttcggccacaatacataaggagcaacagaaactctgcctagctgctgaaggc ttcggaaacaggctgtgtttccttgaatccatctcaaactccaagaatgttcctccagat ctgtcaatctgtacttttgtcttggagcagtcactgtcagttcgagctcttcaggagatg ctggctagtaatgaagagaagactggaggaataatccaaggtggtggtcatcgcacttcg ttatacggacacgcgatacttctccgacactcgtacagtggaatgtacttgtgttgtcta tccacctcgcgatcatccacagataaattagcttttgatgtagggctgcaggaggacacc acaggtgaggcatgctggtggaccattcatccagcatcaaagcaacgttctgagggagag aaggttagagtgggggatgatctcatccttgtcagcatctcatccgagagatatctgcat ctgtcctatggcaaccagtgtcaaaatgtagacgctgcattccagcagacgctctggagc attactccaatctgttccggtagtgaagtagcacaaggtttcttgataggaggagatgtc ttgcgcctccttcatggtcacatggatgagtgtttaaccgttccatcagaagaccacggg gaggagcagaagagaacggtgcattatgagggcggagcagtgtccagccatgccaggtcg ctgtggaggctggagacactccgagttctatggagcggtagtcatattcgctggggtcag ccgttccgactgagacatgtgacaagtgggcggtacctaagtctgacggagaaatcatta ctcctaatggaaaaagacaaggccgatgccaagtcgacagccttttgtttccgatcatcc aaggaaaaggttgaccttggtgtaaaaaaggaagtggacggaatggggacgcctgatatt aaatatggcgactcggtgtgttacattcaacatgtcgacaccggtctgtggctcacgtat cagactgctgatgcgaaatctgcacgcattggtgacattcaaagaaaggccctcatgcac catgaaggtcacatggacgacgggctgaccttatctcgttcccaacatgaagaaagtcac actgccagagtcatccgcagtaccgtcttcttattcaacctgttcataaggagtctcgat acattacgagcaaaaggaaagagcgcaagtttcgatatcccaattgactccatcagcctg agtcttcaggatctgattggctacttccagccgcctgatgatcacctggaccatgaagac aagcagaatcttcttcgagctttgaaaaaccggcagaacctctttcaagaagagggaatg atctccctggttctggagtgtatcgatcgactccacgcctatagcagcgcggcccatttc acggaagctgctggaaaggaggcaggagaagcctggagctccagccttaactccctctac caactacttgctgcacttatcagggggaacagaaagaactgcgctcagttctccggttcc ttagactggctcgtcagcaggctggagagactggaggcctcctcaggcatacttgaggtc cttcattgtgtcctggtggaaagtcccgaagcactgaatcttatcaaagaaggacatatt aaatccatcatttctcttttggataaacatggacgcaatcataaggttctcgacgtgttg tgttcactttgcgtgtgtcacggcgtggccgtacgctccaaccagcacttgatctgtgat aatttacttcccggaagagatttgttacttcagacacgcctgatcaattacgtaagcagc atgtgtcctaatatcttcctgggtgtcagtgaaggttctgcgcagtataaaaagtggtac tatgagttgattgtagaccaagcgctcccgtttgtcaccgctgaggcatctcacctcaga gtaggctgggccaacaccaacggttatatgccgtgccccagcggcggagaagtttggggc ggcaatggagtgggcgatgatctttactcctttggttttgatggcctccatctttggaca ggatgtatcgcaaagagtgttaactcgcccaatcagcaccttctgaaagcagatgatgtg gtcagctgctgcttggacctcagcgtgcccagtatctccttcaggatcaacggacaacca gttcagggcatgtttgagaacttcaactctgatgggctttttttcccggtggccagcttc tcagctggagttaagcttcgtttccttctcgggggtcgccacggagagtttaagttcctc cctcctccaggttacgctccttgctttgaggctgtattgccaagagaaaaactgaaactg gagcccagtcaacaccagactgctgccagagaccttctggggccgactatcacaatgagc caggcagcattcacgccgatgccggtgaacaccagtcagattgttttgccatttcactta gagaagatcaaggagaaacttgcagagaacatccatgagctgtgggtgatgaacaagatt gaaattggatggacttatggtgtcgtacgagatgataccaaacggcaacacccatgcctg gtggagttttctaaattaccggaacaggaacgaagttacaacttacagatgtctgtggaa actctgaaaactcttcttgctttggggtgccatgttggtcttgcagatgaacatgctgtg gagaaagtcaaaagtttaaaactgtcttcaagctatgagttgtctagtggttacaaacct gctccactggacctctgtcacatcaaattgacctccactcaggaagccatggtggacaaa ttggctgaaaatgcacacaacgtctgggccagagaccgcatccgtcagggttggacctat ggcattcaacaggatgtgaagagtcgccgaaatcctcgcctggtgccctacagtctcttg gatgagaggaccaagaagtcaaacaaagacagtttgagagaagccgtcagaactctgctt ggctatggatacaacttggaagctcctgaccaggaccacactctctttgaccatagcaat atgtctgctgaaaggttccggattttcagagcggaacgatcttattgcgtgaatgccgga aaatggtactttgagcttgaggtattaactgctggagagatgagggtcggttgggcaaga ccaggatgtctaccagatctcgaattgggttcagatgaacaggcttttgtctttgatgga ttcaaggttcaacggtggcatcaaggcaatgagcactttggacgtgcctggcaggcagga gatgttgttggctgtatggtggacttaaatgaacacaccatgatgttcaccctgaatgga gaaatcctgcttgatgactctggatcggaactggctttcaaagattttgacgttggtgaa ggtttcatcccagtgtgcagtttgggtgtctgccaagctgggaggattgactttggtaaa catgtcagcaccctgaaatacttcaccatatgtggtctgcaggaaggctatgaacctttt gctgtcaacatgaaccgtgatgtcactatatggctcagtaaaaggcttcctcagtttgta cctatacctccagaccaccaacatatagaggtgacaagaatagatgggacagtggattct tgtccttgtctgaaggtcacacaaaagtcatttagttcacaaaacagcaacacggacatt acgttctacagactgagcatgcccattgaatgcgccgaatccttctccaaacctccgtcg acctctgacctcttgtcacttaagacagatctcgaagactttgaaagcgattttgaggtc ctcgtgaaaacacctcatggccataatggtccaagtggtccagatagaggtgaattcaac aaccacaaagattaccaccaagagaaaacctccaaactcaaaccaagcaggtttttgttg aagaagaataaagcagagaacctttatcgcagccctccctgtctatcagaagacgtgatg gttgatgacaggaatgaatatgaagtactcatgcaagcatctactcactcctactccgtg aggatcttccctggccaggagcccagcaacgtgtgggtgggctgggtcacctctgacttc catcagtacgaacctggctttgggttggacaaggtccaaactgtaaccgtgactttggga gatgagaaaggcaaagttcacgagagtataaaacgtagtaattgttacatggtgtgggct ggagagagcagcagtcctgaaggaaggaacaacaacggtttggagattggatgtttgctc gacacggcaaacggactgctctccttcaccgctaacggcaaagaactcagcacatactac cagttggagcccagtaccaaactcttcccagccgtctttgccaaggctaccagtcccaat gtgttccagtttgaacttgggcaaatgaagaatgtgatgcctctgtcggctggtttattt aaaagcgagaggaagaactcaatccctcaatgtcctccaaggctgcacgtccaatttctc acacctgttttatggagtcgtgttcccaacgactatcccaaggtgtcagtatcccgttcg aacgaccgacacggctggctggtccaatgtcatgaacctttacagtttttatctctgcac atccctgaagagaacaggtcactggacgtcttggagctgacggagaggagagatttatta aagttccactaccataccctccgattgtattccgcaatctgtgcgttggggaacaaccgg gtcgctcatgcactttgctcccatgtggatgaggcgcagcttcttcacgccatagagagt aaatatatgccaggttggcttcgtgcaggctactacgacctcctgatcgacatccacctg agcaattacgcaaccgctcgtcttatgatgaacaacgagtacattgttccgatgaccggc gagactaagagtatcaccctttttccaaacgaggaaaaaaaacacggcgtgcccggcatc gggctcagcacttccctgagaccgagaatgcaattcgcatcgccgaatttcgtcagtggt tccggatcgtcgcaatttacgactaatctcaacaacggcgcaatcgattcttgccagtac agtcctgaattccccttggatgtattaaaaacgaaaaccgtcgagatgctgactgaggca gtgtgtgaggggaacatgcatgtcagagatcctatagggggcagcactgaatttctcttc gtgccgctcattaagcttttttacaccatgctcatcatgggtgttttccaaaacggagat ctgaagaaaatactgcgactcatcgagccgtctgtgttctccgagaaattcgaggaggaa atgcagaagaagttgggaagtgaggaaggaaaagatgatgaagggcaaagcgtacccaag gagggattgttgcaaatgaaactaccagaacctgtcaaacttcagatgtgccacgttctt cagtatctgtgcgactgccaggtgcgtcatcgtatcgaagcagtcgtggccttttccgat gatttcgtagcttgtctccaagaaaatcagcgctttcgctacaatgaagtcatgctggcg ctcaacatgtctgctgctctcaccgccaaaaagaccaaggagttccgatcgccacctcag gagcagatcaacatgttgctgaacttcaagaaggagatgcaagagtgtccctgtcctcaa tatatccgagaacagctgctggacttccatgaggacctcatgaaacactgtggaatcgaa atcatcgaagacagctctttagacggagacagtaatttcaactttcgaggtcgactgatg tccttggtggaaaaagtgtcttacctgaagaacaagattgtcaacccgccgaaggaaaac accgatcgaaaacccagtactttacagcagttggtttcagagaccatggtccggtgggct caggaatctgtgatcgaggatccagaacttgtcagagccatgtttgtcctgttgcaccga cagtatgatggcattggaggacaggttcgggctctccccaagacttacacaatcaactct gtttcaatcgaggacaccatcaacctgctcgctgctcttggccagataagatcgttgctg agtgtacgaatgggaagagaagaggagaagctgatgataagaggactgggtgatattatg aacaataaagtgttctaccagcatcctaacttgatgagagcgttggggatgcatgagact gtcatggaggtcatggtgaacgtgctcagtggaggagtttcaaaggaaatcacctttcct aaaatggtggccaactgttgtcggtttctttgttacttctgtcgaatcagtcgtcaaaac cagaaagccatgtttgatcatctcagctacttgctggagaacagcagcgttggccttgca tctccatccatgcgaggagccacgcctcttgatgtggctgctgcatcagtgatggacaac aatgagttggctcttgctttgagagaaccagatttggagaaggtggttcagtatctcgct ggctgtggtctgcagagctgcaccatgctggtgtgtaaaggatatcccgacattggctgg aaccctgtggaaggagaacgctaccttgactttttacgttttgctgtattttgcaacggt gaaagtgtggaagagaacgctaacgttgtggtgagacttcttatccgccgaccggaatgt tttggcccagcacttcggggagaaggtggagatggattgttggccacgatggaagaagca attaagatctccctcgatcctttacgagatggtccttccttggcatcggaaagcagcaat attcctaatgacggacgacaggaagaagatgacaccatccacttggggaatgccatcatg accttctatgcagctctgattgacctgcttggacgttgtggtccggagatgcatttgata catgctgggaaaggtgaagcaatccgcatcagagctattttaaggtctctcattcccatc gaagatctcgtgggggtcatctgcatcccgttctcgatgccgagcctgggaaaggatggg ctggtgttggagccggacatgtcagctggcttctgtccggatcataaagcggccatggtg ttgtttttggatcgggtctatggtgtacaagaccagaatttcctccttcatcttctagaa gttggcttcttaccagatctcagagctgcagcttcgttggatactgcagctcttagtgcc acagatatggctcttgccctcaacagatatctctgcacggcggtattaccacttctaacc aaatgcgcgccgttgtttgcggggacggagccgttcgcgtcactcatcgattccctcctt cacaccgtttaccgattatccaaaggctgctgccttaccaaagctcagagagattccatt gaagaatgccttctcgcagtttgtggtaaattaagaccttcaatgatgcagcatctcctg aggaggctcgtgtttgacattcccttgctgaatgaacacaccaagatgcctttgaagctt ttgaccaatcactacgagcgttgttggaagtactactgcctgactgcaggctggggaagt tttggtgttgcatctgatgaagaacttcatctttccaggaaattattctggggaatattt gacgctctctctcataaaccatacgaccaggagctgtttaagattgcgttgtcgtgcctc agcgcagtgggaggagctcttcctccagattatatggagtctaattacatggccatgatg gacaaacaatcatctctggactccgaaggaaacttcacgccgcaacctgcagacactgcc aatgtaacagtaccagaaaatttggacattttcatagccagatacgcagaacataaccat gagaagtggtgtttcgaaaagttatccaatggctggtcatacggggaaaatgcatgtgaa atatccaggagccacaatttattaaaatcatttaaagcactctctgataaggataaagag ttctactgtttgccaatcagagagtgtctaaagaccatgctttcttggggatggagcatc aacaggatacgagaaagtgacactgccaacctccataacaaatcgaggaggatctcgctg gccagccagccgtccttggaaggagctcagagtttcaatcccagacctactgatatgagc aatgttacattgtccagggacacacagtcaatggcagagctgctggctgagaactatcac aacatctgggccaagaaaaagaaaattgagcttgaagccaaaggtggaggaactcacccc ttattggttcccttcgatacactgaccgccaaggagaaattaaaagacagacaaaaagca caggatatcctcaagttcctccagatcaatggttacactgtatcaagaggtgtgaagtcg caggagttggactcgccagccacagagaaacgattcgcctacactttccttttgcaactc atccaaaacgtcgaccaggcccacgagcacatgatgaagttcgacatatcgagaacgaga caaaagggagtaaagagtcctcatgaacaacagatgaagttctttggaaaggttgtcttg ccattggtggatcaatacttcaaaaaccatcggatgtacttcctatctacatccatccat cccataagcagtggtggacatgcctccaacaaggagaaagagatggtaacaagtcttttc tgcaaactgggagtacttgtcagaaataggatatccttatttggtaataatgccacatcc atagtaaactgtttgcagatactgggacaaagtctggacgccagaacggtgatgaagaca ggcttggattcagtcaagacggcacttcagtcctacttcgacagtgcagcggaagctttg gagaagactcaagagaacttaaaacttggtcaatttactcacagcaaagaacaacccaga ggcgtccctcaaatcatcaactataccacctttggcctgctccccatcttgtcttccttg tttgaacacattgggaagaataattttggagaagatctaatattggatgaggtccaggtt tcctgctaccgaatcctcaacagtctctactttctgggaaccaatgaaagcatatttgta gagagacatcgtccggcattaggaaaatgtttggctgctttctcagcagccttcccagtc gccttcctcgaacctcacgttgaccatttcaacaacttctccatctacaacaataaaaga cctaaagacagaaatgatcatggtctgccaggccaggtcctagacatgtgtccaatgatt ccaaatttggagaagttactggaagaaatcattgaggtggcagagtctggaattaaatat actcaaatgcctcatgtcatggaggtggttttaccagttttgtgcagctacatgtctcac tggtgggaagacggaccagagaacaacccggatcaagccgacagctgttgcacatctgtg acctctgaacatatgaatatattactagggaacatcttgaagatcatctacaacaattta gggatcgacgagggggcttggatgaaaagacttgctgtgttttctcagccaatcatcagc aaggccaaatctcagttgctcaagacccactttctgcctctgatgaagaaactccgaaaa aaagcagccgtcgtgctcacggatgaggaacaaagcaaggcggaggggaggggtgagatc tcagaaaccgagcttctcatcatggaccaattctcagttctcgtcagggacatctacgct ttttatcctcttctcatacgatttgtcgactacaacagggccacgtggttgaaggagtcc gatccagaagcagaagtgttattccacatggtggctgaagttttcatcttctgggccaag tctcacaacttcaagagagaagaacagaattttgtggtccagaatgaaatcaacaatatg tctttcctcatctcagattccaactcgaagatgtcaaagggaatcgtttcataccaggag agaaagaagttgaggagaaagggcgagcgatattcaatgcagacgagtctgatcgtggca gctctcaagcgactactacctgtcggacttaacgtttgcgttcctggtgagcaagaactc attgctcttgccaagaaccgattttcccagaaagatactgaggatgaagtgcgtcaagtc attcgaaacaacctcaatctccaaggaaagttacaggaccccgctactcgctggcaaaga gccctgtacagagacatcctgaatcactcggataacacctttgaccccgagaagaacgtg gacagagtgctggacatggctcatgtcctcttccacctcgaccaggttgagcatcctcag cgcagtaaaaaggccgtgtggcataaattactgtcgaaacagaggaagagagctgtggtt gcttgcttcaggatggctcctctctacaatctacccaggcatcgagctgtcaacttgttt cttcagggctatgagaaatcctggattgaagcagaagaacatttctttgaggataaactc atagaggatcttgctaaatcaggagaacaagagcctttcgaagaggtggagggaatgaaa cgttttgatccgctacaccagctcatccaacttttcagtcgaacggctcttacagagaag tgtaaactggatgaagatcatctctacatggcttacgcagatatcatggccaagagctgc catgatgaagaagatgaagatggggaggaagtgaaaagttttgaagagaaggagatggaa aagcagaggctgttataccagcaggaaaggctgcatgatcgtggagctgctgaaatggtt cttcagaccattagtgccagtaaaggtgagatgggtcccatggttgcctcaactctaaaa ctgggcattgcaattctcaatggaggaaactcgactgtccaatcgaaaatgctggattat ctgaagaacagaaaggacgtgggcttctttcagagtcttgctggactcatgcagttgtgc agtgttctagatctaaatgcatttgagagacagaacaaagcagaaggacttgggatgatc accgaggaaggatccggtgagaaggtgatgcaggatgataagttcacctgcgacctcttc cgcttccttcagcttctctgtgaaggacacaactcggatttccaaaactatttaaggact caaacagggaacaatacaactgtcaacatcatcatctcaactgttgactaccttctcaga gttcaggagtcgatcagtgatttctactggtattactcgggcaaagatgtgattgatgag caaggacagaggaacttctcaaaggctattcatgttgccaagcaggttttcaacacgctc acagagtatatccagggtccatgtactggcaatcagcagagtttggcacacagtcgtctg tgggatgctgtcgttgggttcctccacgtctttgctcatatgcagatgaagttgtctcag gactcgagtcagattgagctactgaaggaattgatggaccttcagaaagacatggtggtc atgttgctttcaatgatggagggcaacgtggtcaacgggacgatcggaaagcagatggtt gacatgctggtggaatcgtcaaacaatgtggagatgattttgaagttctttgatatgttc ctcaagctgaaagatgtcacctcgtcagaagcctttaaagagtacgaccctgatggaaaa ggtgtcatatccaagagggacttccagaaggcgatggagaaccataagcactatacccag tctgagactgagtttcttctctcatgtgctgaaacggatgaaaatgaactcctggactat gaggaatttgtcgagcgctttcatgaaccagccaaggacatcggcttcaacgtggcggtg ttgttgaccaacttgtcggagcacatgcctcatgacaaccgactgcacacctttctggag ctggcggagagtgttctcaactacttccagccctacctgggtaggatcgagatcatgggc agcgccaagcgtatcgagagggtctactttgagatcagcgagtccagcaggacgcagtgg gagaaaccgcaggtgaaagaatccaagcggcagttcatcttcgacgtggtgaacgaagga ggcgagaaggaaaaaatggaattgtttgtgaatttctgcgaggacaccatctttgaaatg caactggccgctcggatgtccgacaccggggagcgctcggcggtgaaagacgacagcgag caagacagaccggatgtggaaaatcccgagacgagcttcttttcggttaccaccgttcac atggcactcgtcgcgctgcgggtcaatgtgatccttttgattaaggtgctgtccatgaag agtttgaagaagaaaatgaagaagatcaaaagcatgacgtcaaaagaccttctcaccacc ctgctttcgttctacttgtctgtactgcaaggcctccttcacatggtcttcagtgtgttt cgaggattttgcagaattttatataatagtatttttggagctaatcaggttgatggcacc aagagcataaaggtgtctgagctactggcgaacatgcctgacccgacccaggatgcaatc agactggagggagaagataaagaaagaaaatcctacgacagaagctcagtgaacgaggac ctggcgtacttggctgtcaatacaagtgactcggagctgctgtcggacattttcggcttg gatttacggagagagggaggacaatataaactcagtccccacaaccctaatgccagtctc actgaaatgctcaattctccacttccttccccgccaccttctgagcccagacaaaggcaa cagttgaacagttcttctttggatgaggagaaggaaggaagaccggtgaatccatgtgaa ataaagaaaaagagcgatgagaaacaggagaagaatgagaagatgaaggcaaaagttaaa aggcgtagggtctggaaggatgaacctgatttacaggagtcggtggtctcaaagaagatt gttgcgtatcagcgaaaagtcctgaactattttgcgaggaacttctacaacatgaggatg ctagctctatttgtcgcatttgccatcaacttcattctcctcttctacaaggtttctaca tcatcatctgtggccgaggaagtgatctcaaccaatcaagcagacagctccattcagtgg gatccactgggtggtgagcccatggtcgaaatcaaagacggggtcacggatgaccccaaa gagcccttgaagttagccatggtccattttgttttggaagagggcagcggatacatggag ccgacattgcggatcttggctatccttcacacagtcatctctttcttctgcattatcgga tattactgcctcaaggttcctctggtgatctttaagcgtgaaaaggaggtcgccaggaag ttggagtttgatggactttacataacggagcaaccatctgaggatgatatcaaaggacag tgggaccgattggttattaacacgcaatctttccccaacaactactgggataaatttgtg aagcgaaaggtgatggataaatatggagaattttatggtcatgacaggatcagtgaactt ctgggattggataaggctgccttggccttcagtgatgctcataaaaaaaggaagcccaga aaagacagctacctggcagctgtgctgaactccattgatgtcaagtaccaaatctggaag ttgggcgtggtgttcactgacaattcgttcctgtatctggcctggtatatgaccatgtcc atcctgggtcactacaacaattttttctttgccgcgcatctgcttgacatcgcaatgggt ttcaagacactccggactatcctgtcttcagtcacgcacaacggcaaacagttggtgtta acagtcggcctattagcggtggttgtgtatctgtacaccgtcgtagcgttcaacttcttc cgaaagttctacaacaagagtgaagatggagaattacctgacatgaaatgtgatgacatg ttgacatgctacatgttccacatgtatgtaggtgtccgagcaggggggggcatcggtgac cagattgaggacccggcaggagacgaatacgagatctatcgcatcatatttgacatcacc ttcttcttctttgtcattgtaattctgctggcaatcatccaaggtttaatcattgatgct tttggagaactgcgggatcagcaagaacaagtgaaagaggacatggagacaaaatgtttt atctgcggaataggcaacgattatttcgacacagtgccgcatggatttgaaacacacact ctgcaggagcacaacttggctaattacctattctttgtgatgtatcttatcaacaaagat gaaacagagcacacaggacaggaatcttatgtttggaagatgtaccaggaacgttgttgg gagttcttcccggctggagattgtttccggaaacagtatgaagatcagctgaactga

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