Streptomyces alfalfae: A7J05_26445
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Entry
A7J05_26445 CDS
T05110
Name
(GenBank) UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
ssia
Streptomyces alfalfae
Pathway
ssia00300
Lysine biosynthesis
ssia00550
Peptidoglycan biosynthesis
ssia01100
Metabolic pathways
ssia01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
ssia00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
A7J05_26445
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
A7J05_26445
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
A7J05_26445
Enzymes [BR:
ssia01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
A7J05_26445
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
DUF561
DUF2126
Motif
Other DBs
NCBI-ProteinID:
APY88759
UniProt:
A0A1P8TMD0
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All DBs
Position
6262577..6263992
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AA seq
471 aa
AA seq
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MIALSLAEIATVVGGQTYDIPDPAIMVTGPVVRDSREVAPGSLFVAFVGERVDGHDYAAD
VVAAGAVAVLASRPVGVPAIVVDDVQAALGALARHVVKRLGATLVALTGSVGKTSSKDLL
AQVLRRKAPTVFTPGSLNNEIGLPLTALSATDETRFLVLEMGARGIGHIRYLAELTPPKI
GLVLNVGTAHIGEFGGREQIAIAKGELVEALPEDGAAVLNADDPLVRAMASRTKARVILF
GEADDADVRAENVRLTGNGQPSFTLHTPSGCSDVTLRLYGEHHVSNALAAAAVAHELGMS
VEEIALALSEAGTLSRWRMEVTERPDGVTVVNDAYNANPESMRAALRALAAMGKGRRTWA
VLGHMAELGDEGLAEHDAVGRLAVRLNVSKLVAVGGREASWLQLGAYNEGSWGEESVHVS
DAQAAIDLLRSELRPGDVVLVKASRSVGLEKVATALLDDAAGSSEGQVSGR
NT seq
1416 nt
NT seq
+upstream
nt +downstream
nt
gtgatcgccctctccctcgccgagatcgccaccgtcgtcggcgggcagacgtacgacata
ccggatccggccatcatggtgaccggaccggtcgtccgtgactcccgcgaagtggcgccc
ggcagcctcttcgtcgccttcgtcggcgagcgcgtcgacggccacgactacgcggccgac
gtggtcgccgcgggcgcggtcgccgtactggcttcccgcccggtcggcgtgcccgccatc
gtcgtggacgatgtgcaggccgcgctcggcgccctcgcccgccacgtggtgaagcggctc
ggcgcgaccctcgtggcgctgacgggctccgtcggcaagaccagctccaaggacctgctc
gcgcaggtgctccggcgcaaggcgcccacggtcttcacgccgggatcgctcaacaacgag
atcggcctgccgctgaccgcgctgagcgccaccgacgagacgcgcttcctcgtcctggag
atgggggcgcgcggaatcggccatatccgctacctcgcggaactgacgccaccgaagatc
ggcctcgtcctgaacgtcgggaccgcccacatcggcgagttcggcggccgcgagcagatc
gcgatcgcgaagggcgagctggtcgaggcgctgcccgaggacggggccgccgtcctcaac
gccgacgacccgctggtgcgcgccatggcctcgcgcacgaaggcccgggtgatcctcttc
ggagaggccgacgacgccgacgtacgtgccgagaatgtccggctcacgggcaacggacag
ccttcttttacgctgcacacaccctccgggtgcagcgacgtgaccttgcggctgtacggt
gagcaccacgtgtcgaacgcgcttgccgcggccgccgtcgcccatgagctgggcatgtcc
gtggaagagatcgccctcgcgctctccgaggcgggcacgctgtcccgctggcggatggag
gtcaccgagcgcccggacggtgtgacggtcgtcaacgacgcctacaacgcgaaccccgag
tccatgcgagcggcgctgcgcgcgctcgcggccatgggcaagggacgtcgtacgtgggcg
gtgctcggtcacatggccgagctcggggacgagggtctcgccgagcacgacgcggtcgga
cgccttgccgtccggctcaacgtgagcaagctcgtggcagtcgggggcagggaagcgtcc
tggctccaactgggcgcatacaacgagggttcgtggggtgaggagtcggtgcacgtgtcc
gacgcacaggcggcgatcgacctgttgcgcagcgagctgcgcccaggagacgtcgtgctg
gtgaaggcgtccaggtcggtcggtctcgagaaggtcgccacggcgctgctcgacgacgcc
gcagggtcttctgaggggcaggtctccggccgatga
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