Solea solea (common sole): 131448469 Help Entry 131448469         CDS       T10853                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism ssoe  Solea solea (common sole) Pathway ssoe04020   Calcium signaling pathway ssoe04260   Cardiac muscle contraction ssoe04261   Adrenergic signaling in cardiomyocytes ssoe04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ssoe00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     131448469 (ryr2a)    04020 Calcium signaling pathway     131448469 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     131448469 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     131448469 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ssoe04040]     131448469 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:ssoe04990]     131448469 (ryr2a) Ion channels [BR:ssoe04040]  Voltage-gated cation channels   Ryanodine receptor    131448469 (ryr2a) Domain-containing proteins not elsewhere classified [BR:ssoe04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    131448469 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 DUF7701 Motif Other DBs NCBI-GeneID:  131448469 NCBI-ProteinID:  XP_058476937 LinkDB All DBs Position 21:complement(19190585..19269380) Genome browser AA seq 5029 aa AA seqDB search MSAEGGEEDEVQFLRTDDEVVLQCSATIHKEQQKLCLAAEGFGNRLCFLESISNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKADGHVDVEIWTAQGGGHRTLLYGHAVLLRHSY SGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVS VSSERYLHLSYGNSSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHMDECL TVPSGEHGDEQRRTVHYEGGAVSSHARSLWRLETLRVVWSGSHIRWGQPFRLRHVTTGKY LSLIEDKSLLLMDKEKADVKSTAFCFRSSKEKLDPGVKKEVDGMGVPDIKYGDSVCYVQH VDTCLWLTYQTVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFL FNLFIRGLDTLRKKGRGSTLDLPIDSVSLSLQDLIGYFQPPGDHLEHEDKQNRLRALKNR QNLFQEEGMISLVLECIDRLHVYSSAAHFAEVVGREAGEAWSSILNSLYQLLAALIRGNR KNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHG RNHKVLDVLCSLCVCHGVAVRSNQNLICDNLLPGRDLLLQTRLVSHVSSMRPNIFLGVSE GSAQYRKWYYEMIVDQALPFVTAESTHLRVGWANTSGYAPYPSGGEGWGGNGVGDDLYSY GFDGLHLWSGCIARTVSSPNHHVLRSEDVVSCCLDLSVPSISFRINGQPVQGMFENFNSE GLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPRDKLKLEASQDQTAARE LLGPTVTLSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWTYGAVRD DNKRQHPCLVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGLADEHAVEKVRRMKLSPT YELSSGYKPAPLDLGHIKLTSTQEAMVDKLAENAHNVWARDRIHQGWTYGIQQDVKNRRN PRLVPYILLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAAQADLNNISAERFRIFR AEKTYCVNAGKWYFELEVLTAGEMRVGWASPGCLPDQELGSDDQAFVFDGFKVQRWHQGN EHFGRAWQTGDVVGCMVDLNEHTMMFTLNGEVLLDDSGSELAFKDFEAGEGFIPVCSLGV GQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDVTMWLSKRLPQFVPVPPNHQHIE VVRIDGTVELCPCLKVTQRSFGSQNSHTDITFYRLSMPIECSESFSRSRPNSGLFSPKRE LEDFETVSDFEVLMKSPHGPSGPNGPDRDEFNNHKDYNQEKPSKLKQRFTLKRNKPDNSC PTSARLSEEVMADDRDDYDFLFQASTVKSHYYYSVRIFPGQEPSSVWVGWVTSDFHQYDT GFELHKVRTVTVTLGDEKGKVHESIKRSNCYMVWAGESSSPGQGRNNNGLEIGCLVDTTN GLLTFTANGKELSSYYQVEPSTKLFPAVFAKATSPNVFQFELGRMKNVMPLSAGLFKSER KNSVPQCPPRLHVQFLTPVLWSRVPNHFLKVSASRVNDRHGWLVECKRPLQFMSLHIPEE NRSMDILELSERRDLLKFHYHTLRLYSAICALGNNRVAHALCSHVDEAQLLQAIENKYMP GLLRAGYYDTLIDIHLSSYATARLMMNNEYIVPMTDETKSITLFPDDEKKHGLPGIGLST SLRPRMHFSSPSFVCGAGSLYRNHNNGGSGDCFQYSPEFPLEILKVKTIEMLTEAVREGS MHVRDPIGGSTEFLFVPLIKLFYTMLIMGVFQNGDLKNILQLIEPFVFSERRDGGHVTQK EAESEGGVDGGRSLPKEGLLQMKLPEPVKLQMCHVLQYLCDCQVRHRIEAVVAFSDDFVA SLQENQRFRYNEVMLALNMSAALTAKKTKEFRSPPQEQINMLLNFKEEKQECPCAEDIRE QLLDFHEDLMRHCGIELDEDRGLDSDSDFTIRGRLLSLVEKVSYLKKKMANLSNEKKDRK PSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINSVSIE DTIHLLAALGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEV MVNVLSGGDSKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSM RGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCVMLVRKGYPDIGWNPVE GERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGDGLLAAMKEAIKIS EDSTRDGPSPTSESSKTLSDMEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGK GEAIRIRAILRSLIPIEDLVGVISIPFSMPSLAKDGMVVEPDMSAGFCPDHKAAMVLFLD RVYGIEDQNFLLHLLEVGFLPDLRAAASLDTVALSATDMALALNRYLCTAVLPLLTKCAP LFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLAVCGKLRPSMMQHLLRRLV FDVPLLNEHTKMPLKLLTNHYERCWKYYCLVGGWGNFGAASDEELHLSRKLFWGIFDALS HKRYDQELFKLALPCLSAVAGALPPDYMESNYMAMMEKQSSMDSEGNFTPQPADTTNVTV PEKLDYIISRYAEHNHEKWCIEKFSSGWSHGEQLCDISKCHPLLKPYKGLSEKDKESYCW SVRESLKTMLSWGWSIDRIRDGDPASLHNKSRRISQASQLSFEGNPAFSPRPIDMSNVTL SRDMQVKGHGRQDHQTRLCLFLTHGCFLFQSMAELLAENYHNIWARKKKTELEAKGGGNH PLLVPYDTLTAKEKSKDREKAQDILKFLQINGYTVSRGVKSQELDTPAIEKRFAYTFLQQ LITYVDQAHQHMMEFDAGPRLKGENVPHEQQIKFFGKVVLPLVDQYFKNHRLYFLSTAIH PISSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNNATSIVNCLQILGQSLDARTVMKT GLESVKVALRSFFDSAAEDLEKTQENLKLGQFTHSREQPRGVTQIINYTTFALLPVLSSL FEHIGQNMFGEDLILDDVQVSCYRILNSLYLLGTNKSIYVERQRPALGKCLAAFSAAFPV AFLEPHMNKFNSFSIYNSKGTKDRGSLGLPGHVGEVCAVIPNLDKSLEEIMELAESGLRY TQMPHVMEVVLPMLCSYMSHWWEHGPENHVDTCDSCCTAVTSEHMNSLLGNILKIIYNNL GIDEGAWMKRLAVFSQPIISKANAQLLKTHFLPLMEKLKKKAAVVLMDEEHSKAEGRGEM SETELLIMDQFTVLVRDLYAFYPLLIRFVDYNRARWLKESNPGAEELFRMVAEVFIFWAK SHNFKREEQNFVVQNEINNMSFLITDTKCKMSKGIVSDQERKKMKRKGDRYSMQTSLIVA TLKRLLPVGLNMCAPGEQELITLAKNRFTQKDTEDEVRDIIRNNLHLHGKLEDPAIRWQM ALYRDFPNHCDAAADPEKTVERVLDIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVV ACFRMAPLYNLPRHRAVNLFIQGYDKSWIEAEEHYFEDKLIEDLAKPGEQEPPEDEEGVK HIDPLHQLIQLFSRTALTEKCKLDEDILYMAYADIMAKSCHDEEDEDGEVKSFEEKEMEK QKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVASTLKLGIAILNGGNSTVQQKMLDYL KNKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSVISHERGEKVMQDDEF TCDLFRFLQLLCEGHNSDFQNYLRTQTGNNMTVNIIISTVDYLLRVQESISDFYWYYSGK DVIDEQGQRNFSKAINVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQ MKLSQVSSDQCVSFYSLNIHSFSVSEVKVSHLSSPQDSSQIDLLKELMDLQKDMVVMLLS MLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGVIS KRDFHKAMESHKHYTQSETEFLLSCAETDENELVDYEEFVERFHEPAKDIGFNVAVLLTN LSEHMPHDTRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQWEKPQ VKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMSDAGERSAVKEESEREKL DEENPDLGFFSVTTVCMALLALRYNVMMLIKVLSMKSLKKQMKKIKNMTVKDMVTTLVSV YWSVLLGFLHVAFSVARGFCRIFYNTFMGGNLVEGAKTIKVSELLANMPDPTQDEVRGEG EDREKRPSDRSSAKEDLADLAVNTSETDLLSDIFGLDLRREGGQYKITPHNPNASLTELL NSPVTSPTTPTAPPPELRHRHQSKGSSSEEKESVPEPECDPEKTSAAEHEEEPEKQPKSE KVKPKVRRLHKSKSDEPDLQESAFFKKIIAYQRKLLNYFARNFYNMRMLALFVAFAINFI LLFYKVSTSSSVVEDRDTAFTGSQPGSSVQWSPLGGADVVEAKKEVVEETGETHKPVTVR FVLEESSGYMEPMLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYIT EQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMDKAALD FSDAHKKRKPRRDSSLAAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMTMSILGHYNNFF FAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSED GELPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVIL LAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANY LFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 15090 nt NT seq  +upstreamnt  +downstreamnt atgtccgcggagggaggagaagaggacgaggtccagttcctgaggaccgacgatgaggtg gtgctacagtgctcggcaacgatccataaggagcaacagaaactgtgtttggctgccgaa ggcttcggaaacagactctgcttcctcgagtccatctccaactccaagaatgtgcctcca gatctttccatctgcaccttcgtcctggagcagtcgctgtcggtgcgagcgcttcaggag atgctggccaacactgaggagaaggctgacgggcatgtagatgtggagatctggacggct cagggtggcggtcatcgtaccttgctgtatggacacgctgtcctgctgagacactcatac agtggaatgtacctctgctgtctgtccacctcccgctcgtccacagacaaactggctttt gatgttggactgcaggaggacaccacaggcgaggcgtgctggtggaccatccatccagca tcaaagcagcgttcagagggagagaaggtcagagtgggagatgatctcatcctggtcagt gtctcctctgaaagatacctgcatctctcctacggcaacagcagcctccacgtggacgca gcgttccagcagacgctgtggagcgtcgcccccatctgttctggaagtgaagtcgcacaa ggtttcctcataggtggcgacgtcctgcgtctccttcatggccacatggacgagtgtttg accgttccatctggagaacatggagacgagcagaggaggacggttcactatgagggcgga gccgtttctagccacgcccgctccctgtggcggctggagacactgcgggtcgtgtggagc gggagccacatccgctggggtcaaccgttcagactgagacacgtgaccacggggaagtac ctgagtctcatcgaggacaagtctctgctgctgatggacaaggagaaagccgacgtcaag tccacggccttctgcttcaggtcgtccaaggaaaagttggaccccggcgtgaagaaggag gtggacggcatgggcgtccccgacatcaaatacggcgactcggtgtgttacgtccagcac gtggacacgtgtctgtggctcacgtaccagacggtcgacgccaagtgtgctcgcatgggc ggagtccagaggaaggcgatcatgcatcacgagggtcacatggacgacgggctgacgctg tcgcgctcgcagcacgaggagagtcgcacggccagagtcattcgcagcacggtgtttctg ttcaacctcttcatcaggggtctggacacgctgaggaaaaaggggcggggctccacctta gatctgccaatcgactcggtcagcctgagtctgcaggacctgatcggctacttccaacca cccggagatcacctggaacacgaggacaagcagaaccgactgagagcgctgaagaaccga cagaacctgtttcaggaggagggcatgatcagcctggtgctggagtgcatcgaccgcctc cacgtctacagcagcgccgctcacttcgccgaggtcgtgggacgagaagcaggagaagcc tggagctccatcctcaactccctctatcagctgctggctgcactgatcagaggaaacagg aagaactgtgctcagttctcggggtctctggactggctcatcagcagactggagcggctg gaggcttcttctgggatcctggaggttcttcactgtgtgctagtggaaagtcctgaagcg ctgaacatcatcaaagaaggacacatcaagtccatcatctctctgctggacaaacacgga cgcaaccacaaggtcctggatgtgttgtgttctctgtgtgtgtgtcacggtgtcgccgtt cgatcgaaccagaacttaatctgtgacaatctgctgccaggacgagacctgctgctgcag acccggctcgtcagccacgtcagcagcatgcgtccaaacatcttcctgggcgtcagtgaa ggctccgcccagtacaggaagtggtactatgaaatgatcgtggaccaggcgctgcccttt gtcacagcggagtccactcacctgagagtgggctgggccaacaccagcggctacgctccc taccccagcggcggggaggggtggggtggcaatggcgttggcgacgacctttactcgtac ggctttgacggacttcacctgtggtcaggctgcatcgctcggaccgtcagctcgccgaat catcacgtgttgcggtcagaggacgtggttagctgctgcctggacctcagcgtgcccagc atctccttcaggatcaacggacagccggtccagggcatgtttgagaacttcaactctgaa ggcctcttcttccccgtggtcagcttctctgccggagtcaaggtgcgtttcctccttggc ggtcgtcatggcgagttcaagttcctccctcccccgggttacgcgccttgctacgaggca gtgttgcccagggacaagctgaagctggaggcgagtcaggatcagacggcagccagagag ctgctgggacccacggtcaccctgagccaggcagcgttcacacccacacctgtggacacc agccagatcgtgttgcctcctcacctggagaggatcagggagaaactggcagaaaacatc catgaactgtgggtgatgaacaagatagaactgggctggacttatggtgccgtgcgagac gataacaagcggcagcacccgtgtctggtcgagttctccaagcttcctgagcaggaacgg agctacaacctgcagatgtcgctggagactctcaagactctcctggctctgggttgccat gtcggcctcgcagacgaacacgcggtggagaaagtcaggaggatgaaactgtcgccgacc tacgagttgtccagcggttacaaacctgctcctctggacctgggtcacatcaaactgacc tccacccaggaggccatggtggacaaactggctgagaacgcacacaacgtgtgggcgaga gaccgcatccatcagggctggacctacggcatccagcaggacgtaaagaatcgcaggaac ccccgtctggttccgtatattctgctggacgagaggaccaagaagtccaacaaggatagt ctccgtgaggccgtcaggactctgctgggatacggttacaaccttgaagctcctgaccag gaccatgcagctcaggctgacctgaacaacatctccgccgagaggttccgcatcttcaga gcagagaaaacctactgtgttaacgcagggaagtggtattttgagctggaggtcttgacg gcgggagagatgagggtgggctgggccagtccaggctgcctcccagaccaggagctgggg tctgatgaccaggccttcgtctttgatggattcaaggtccagcgatggcaccagggtaac gagcactttgggcgggcgtggcagacgggcgacgtggtcgggtgcatggtggatctgaac gagcacaccatgatgttcacgctgaacggagaagtgctgctggacgactcgggctctgaa ctcgccttcaaggactttgaagctggtgaagggttcatcccggtgtgcagtctgggcgtg ggtcaggtggggaggatgaactttgggaaagacgtcagcacgctgaagtacttcaccatc tgcggcctgcaggaaggctatgagccattcgccgtcaacatgaaccgcgacgtgaccatg tggctcagcaagaggcttcctcagtttgtgccggttcctccgaatcaccagcacattgag gtggtgaggatcgatggcacggtggagctgtgtccatgccttaaggtcacgcagaggtcg tttggctctcagaacagtcacacggacatcaccttctacagactaagcatgcccatcgag tgttccgagtccttctccaggtccaggcctaacagtggcctcttctcaccaaagagggag ctggaggactttgagaccgtctcagacttcgaggtcctgatgaagtcacctcatggtccc agtggacccaacggacccgatagggacgagttcaacaaccataaggattacaaccaggag aagccgtccaaactgaagcaacggttcacactgaagagaaacaaaccggacaacagctgt ccgacgtccgcacggctgtcggaggaagtgatggccgacgacagagacgactacgacttc ctgtttcaagcctccacggtgaagtctcactattactactccgtgcggatctttccgggt caggagccgagcagcgtctgggtcggctgggtcacctccgacttccatcagtacgacacg gggttcgagctgcacaaggtccgcacagtcaccgtgaccctgggagacgagaagggaaaa gttcatgagagtattaagcgcagtaactgttacatggtgtgggccggagagagcagcagt cccggtcaggggaggaacaacaacggcttagagatcggatgtttggtggacacgacaaac ggacttctgacgttcacggcgaacggcaaagaactcagctcatattatcaggtggagccc agcactaaactgtttcccgccgtcttcgccaaagccacgagccccaatgtcttccagttt gaactggggcgaatgaagaatgtgatgcctctgtcagccggtctgttcaagagcgagagg aagaactccgtccctcagtgtcctccacgtctccacgtccagttcctcacaccggtttta tggagtcgagttcccaaccacttcctcaaggtgtcggcgtccagagtgaacgacagacac ggctggttggtggagtgtaaacgacctctgcagttcatgtccctgcacatacctgaggag aacaggtcgatggacatcctggaattgtccgaacgcagagacttattaaagttccactac cacaccctcaggctgtactctgccatctgtgcgctgggaaacaaccgcgtggctcacgct ctgtgttcacatgtggacgaagcacagctgctgcaggccatcgagaataagtacatgcca ggtttgctccgcgccggttactacgacaccctgatcgacatccacctgagcagctacgcc acggcgcgcctcatgatgaacaacgagtacattgtgcccatgacggacgaaaccaagagc atcacgctgttccccgacgacgagaagaagcacgggctgcccggcatcggcctcagcacc tcgctgcgacccagaatgcacttctcgtcgccgagcttcgtctgcggggccggctcgttg tatcgtaaccacaacaacggcggctcaggcgactgcttccagtacagccccgagtttccc ttagagatcctgaaggtcaagaccatcgagatgctgacggaggcggtgcgcgagggaagc atgcacgtgcgggatcccatagggggcagcaccgagttcctgttcgtgccgctcatcaag ctcttctacaccatgctcatcatgggcgttttccagaacggagacctgaagaacatcctg cagctcatcgagccgttcgtcttctccgagaggcgggacggcggtcacgtgacgcagaag gaggcggagagtgagggaggcgtggacggggggaggagcctgcccaaagaaggattgtta cagatgaagctgccggagcctgtgaagcttcagatgtgtcacgtgctgcagtacctgtgc gactgtcaggtgcgtcaccgcatcgaggcggtcgtcgccttctccgatgactttgtggcg agtctccaggagaaccagcgcttccgctacaacgaggtgatgctggcgctcaacatgtcg gcggcgctgaccgccaagaagaccaaagagttcaggtcgccgccacaggagcagatcaac atgctgctgaacttcaaggaggagaagcaggagtgtccctgtgccgaggacatccgagaa cagctgctggacttccacgaggacctgatgagacactgtggtatagagttggacgaggac agagggttggacagtgacagtgacttcaccatacgtggtcgtctcctgtcgctggtggag aaggtgtcctacctgaagaagaagatggccaacctgtccaacgagaagaaagaccggaaa cccagtacgctgcagcagctcatttcagacacgatggtccgctgggctcaggagtcggtt atcgaggacccagaactggtccgagccatgtttgtcctgctgcaccgtcagtatgacggc attggtggactggtccgggctcttcccaagacctacaccataaattcagtttccatcgag gacaccatccacctgctggcagctctgggtcagatcagatctctgctgagtgtgcgcatg ggaagagaggaggagaagctaatgatccgagggctgggagacatcatgaacaacaaagtc ttctaccagcatccgaacctgatgagagctttggggatgcacgagaccgtcatggaggtc atggtcaacgtgctcagcggaggagactcaaaggaaataacgttccctaaaatggtggcc aactgttgtcgctttctctgttacttctgccgaatcagccgtcagaaccagaaggccatg tttgaccatctcagctacctgctggagaacagcagcgtcggccttgcttctccatccatg cgaggttctactcctctggatgtggcggcagcatcagtcatggacaacaatgagttggct ctggctctgagagaacccgacctggagaaggtggttcagtacctggccggctgtggtctg cagagctgtgtgatgctggtacgtaaaggataccctgacatcggctggaatcctgtggag ggcgaacgctacctggacttcctgcgatttgccgtcttttgcaacggtgaaagcgtggag gagaacgccaacgtcgtggtgaggcttctgattcgtcggccagaatgtttcggacccgcg cttcgtggcgaaggcggcgacgggttgctcgcggcaatgaaggaagctattaagatttcg gaggattcgaccagggacggtccttcaccaacgtctgagagcagcaaaacactcagtgac atggaggaagaggaggacgacaccatccacatgggaaatgccatcatgaccttctacgct gctctcattgacctgttggggcgctgtgctccagagatgcacctgatccacgcaggtaaa ggtgaagcgatccgtatccgagccatcctccggtccctcatccccattgaagacctggtg ggagtcatcagtattccattctccatgcccagtctggctaaagatgggatggtggtggag cccgacatgtccgccgggttttgtccggaccataaagcagccatggttctgttcctggac cgggtctatggtatcgaagaccagaatttcctgctccacttgctggaagtgggattctta ccagacctgagagctgcagcctcactggacaccgtggctctcagtgccacagacatggcc ctggccctcaacaggtacctgtgcacggccgtgctgcctcttctcaccaagtgtgcgccg ctgtttgccggcacggagccgttcgcctcgctgattgattccctcctgcacacggtttac cgtctgtccaagggctgctgcctcaccaaggcccagagggacgccatcgaggagtgcctg ctggccgtgtgtgggaagctgagaccctccatgatgcagcatctgctgaggaggctggtg ttcgacgttcctctgctcaatgaacacacaaagatgcctctgaagctgctgaccaatcac tacgagcgctgttggaagtattactgcctggtcggaggttggggaaactttggagctgcg tcagatgaagaacttcatctctccaggaaactgttctgggggatttttgacgctctgtcg cacaagcgttacgaccaggagctgtttaagctggcgttgccgtgtctcagcgctgtggcg ggcgctctgcctccggactacatggagtccaactacatggccatgatggagaaacagtcg tccatggactcggagggaaacttcactcctcagccggccgacaccaccaacgtgaccgta cctgagaagctggactacatcatcagcagatacgccgagcacaaccacgagaagtggtgc atcgaaaagttttccagcggctggtcgcacggtgagcagctgtgtgacatcagcaaatgt caccctctactgaagccgtacaaaggcctgagcgagaaggataaggagtcgtactgctgg tcggtcagagagtctcttaagaccatgctgtcgtggggctggagcatcgacaggatcaga gacggagacccggctagtctccacaacaagtccagacgcatatcacaggccagccagttg tcttttgagggaaatcccgcctttagcccacgaccaatcgatatgagcaacgtcacgctg tccagagacatgcaggtaaaaggtcacggacgtcaggatcatcagacacgtctctgtctc tttcttacacacgggtgttttttgtttcagtcgatggccgaactgctcgcagagaattat cataacatctgggccaggaagaagaaaacagagctggaagccaaaggtggaggaaatcac ccgctcctggttccgtacgacacgctgacggccaaagagaaatccaaagaccgagaaaag gcacaagacatcctcaagttcctgcagatcaacggttacaccgtgtccagaggagtgaaa tcccaggagctggacactccggctatcgagaagagattcgcctacacgttcctgcagcag ctcatcacatatgtggaccaggctcatcagcacatgatggagtttgacgcaggaccgaga ctgaagggagaaaatgttcctcacgagcagcagatcaagttctttgggaaggtggttttg ccgctggtggatcaatactttaaaaaccaccgcctgtacttcctgtccacggcaattcac cctatcagcagcggcggccatgcctctaacaaggagaaggagatggtgacaagtcttttc tgcaaactgggagttcttgtcagacataggatttccttgtttggtaacaacgccacgtct atcgtcaactgtctgcagatactgggacaaagtctggacgccaggacggtgatgaagacc ggcctggagtcggtgaaggtggcgctgcgctcgttctttgacagcgcggcagaggatctg gagaagacacaggagaacctgaagctcggccagttcactcacagccgagagcagccgaga ggcgtcacccagatcatcaactacaccacgttcgccctcctgcctgtcctgtcctcgctg ttcgaacacatcgggcagaacatgttcggagaagacctcatactggatgatgtccaggtg tcctgctacagaatcctcaacagtctttacttactgggaaccaacaaaagcatctacgta gaaagacagcggccggcgttaggaaagtgtctcgccgccttctctgcggcgttccccgtc gcctttctggagcctcacatgaacaagttcaacagcttctccatctacaacagcaaagga accaaagacagaggctctctcggtcttccgggacacgtcggagaagtctgtgctgtgatt ccaaacctggacaagtccctggaggagatcatggagctggcagagtctggtttgagatac actcagatgcctcatgtcatggaggtggtgctgcccatgttgtgcagctacatgtctcac tggtgggaacacggacccgagaaccacgtggacacatgcgacagctgctgcaccgcggtg acgtccgagcacatgaactctctgctggggaacatcctcaagatcatctacaataacctt ggcatcgacgagggagcatggatgaaaagactcgccgttttctctcagccaatcatcagc aaggccaacgctcagctgctcaagactcatttcctgcctctgatggagaaactgaaaaaa aaagccgcggtcgtgttgatggacgaggagcacagcaaagccgaggggaggggcgagatg tcggagacggagcttctcatcatggaccagttcaccgtcctggtcagagacctgtacgcc ttctacccgctcctcatccgctttgttgactacaacagggctcggtggctgaaagagtcc aaccccggggctgaggaactgttccgcatggtggccgaggttttcatcttctgggccaag tctcacaacttcaagagggaggagcaaaactttgtggtccagaatgagatcaacaacatg tctttcctcatcaccgacaccaagtgtaagatgtcaaagggaatcgtttccgaccaggag cggaagaagatgaagaggaagggggatcggtactcgatgcagacgagtctgatcgtggca actctgaagcgcctcctgcctgtcggactcaacatgtgcgcgcccggagaacaggagctc atcacgctggccaagaaccgcttcactcagaaagacacggaggacgaagtccgtgacatc atcaggaacaatctgcatttacacggaaagctagaagaccctgcgatccgttggcagatg gctctgtacagagactttcctaatcactgtgacgccgccgcagacccagagaagactgtg gagcgagtcctggacatcgctcacgtcctcttccacctcgaccaggtggaacaccctcag cgcagtaaaaaagcagtgtggcacaaactcctgtccaaacagaggaagcgagcagtggtg gcctgcttcaggatggcgccgctctataacctgcccaggcaccgagctgtgaacctgttc attcagggctatgacaagtcctggatcgaggcagaggagcactactttgaagataaactc atcgaagacctggctaaacccggtgaacaggagccgcctgaggacgaggagggcgtgaag cacatcgatccactgcatcagctcatccagctgttcagcagaacagcgctcacggagaag tgtaaactggatgaagatattctgtacatggcttacgccgacatcatggcgaagagctgc cacgatgaagaagatgaagatggagaagtgaagagttttgaggagaaggagatggagaag cagaagctgttgtatcaacaggctcggcttcacgaccgcggcgccgctgagatggttctc cagaccatcagcgccagcaagggtgagatgggtcccatggtggcgtccacactgaagctg ggcatcgcaatcctcaatggcggaaactcgaccgtacagcagaaaatgttggattatctg aaaaacaagaaggacgtaggattttttcagagcctggctggtctcatgcagtcatgcagt gtcctggatctaaatgcctttgagagacagaacaaagctgaaggactggggatggtgaca gaggagggatcagtcatcagtcatgagcgtggtgagaaggtcatgcaggatgatgagttc acctgtgaccttttccgcttcctgcagctgctctgtgaaggacacaactcagacttccag aactacttaaggacacaaacgggaaacaacatgaccgtgaacatcatcatctctactgtc gactatctcctcagagtacaggagtccatcagtgatttctactggtattactctgggaag gacgttattgacgagcagggacagaggaatttctctaaggccataaatgtggccaagcag gttttcaacactctcactgagtacatccagggtccgtgcacgggtaaccagcagagtttg gctcacagtcgtctgtgggacgccgtggttggttttctccacgtcttcgctcatatgcag atgaaactgtctcaggtgagttcagatcagtgtgtcagtttttattccctaaacattcac agttttagtgtaagtgaagtaaaagtgtctcacctgtcttcacctcaggactccagtcag atcgatttgttgaaggagctgatggatctgcagaaagacatggtggtcatgctgttgtcc atgctggaaggtaacgtggtgaacgggacgattgggaagcagatggtggacatgttggtg gagtcgtccaacaatgtggagatgatcctcaagttcttcgacatgttccttaagcttaaa gatctgacctcctctgatgccttcaaggagtacgatcctgatgggaaaggtgtcatctca aagagggacttccacaaagccatggagagccacaaacactacacccagtcagagaccgag ttcctgctctcctgtgctgagaccgatgagaatgaattagtggactatgaagaatttgtg gagcgctttcatgaacccgctaaggatattggctttaacgtggcggttctgctgaccaac ctgtcggagcacatgcctcatgacactcgtctgcagacgttcttggagctggcagagagt gtcctcaactacttccaaccctacctgggccggattgagatcatgggcagcgccaaacgc attgagcgggtttactttgagatcagtgagtccagtaggacgcagtgggagaaacctcag gtcaaagaatccaagcgtcagttcatctttgacgtggtgaatgagggaggggagaaggag aagatggagctgtttgtgaacttctgcgaggacaccatctttgaaatgcagctggccgcg cagatgtccgacgcaggcgagcgctcggcggtgaaagaggagagcgagcgggagaaactg gacgaggagaatcctgacctgggctttttctctgtcaccactgtgtgcatggctctgtta gctctgcgctacaacgtcatgatgctgataaaggtgctgtccatgaagagcctgaagaag cagatgaagaagataaagaatatgacggtgaaggacatggttaccacactggtgtccgta tactggtctgtgttactgggattcctccatgtggccttcagcgtggcccgaggattctgc cgaatcttctacaacaccttcatgggcggaaatctggtagagggcgccaagaccatcaag gtgtcagagctgctcgccaacatgcctgaccccacccaggacgaggtgcgaggggaaggg gaggacagggagaagagaccgtctgaccgcagctcggcgaaagaggacctggccgatctg gccgtcaacaccagcgagacggatctactgtcggacatctttggcctggacttaagaaga gagggaggccagtacaagatcacaccccacaaccccaacgctagtctgaccgaactgctc aactcccccgttacctcgccaactacacccacagcgccgccacctgagctcagacacagg catcagtcaaaaggatcttcctccgaggagaaggaatcggtaccagagcccgaatgtgac cccgagaaaacatcagcggcggaacacgaggaggaaccagagaaacaaccaaagagcgag aaagtgaagccaaaagtgaggagacttcacaagtcaaagtctgacgagccagatctgcag gagtctgcgttcttcaagaagatcattgcctaccagaggaaactgctgaactactttgcc aggaacttctacaacatgaggatgttggccctgtttgttgcgtttgcaatcaacttcatc ctcttattctataaggtgtccacgtcctcctctgtggttgaggacagagacacagcgttc accggcagccagcccggcagcagtgttcagtggagtccactgggaggagcagatgtggtg gaggcgaagaaggaggtggtggaggagacgggggagacgcacaaacccgtgactgtcagg tttgtcctggaggagagcagcgggtacatggagcccatgttacgaatcctggccatcctg cacacggtcatctccttcttctgtatcatcggatactactgtctgaaggtgcctctggtg atctttaagcgggagaaggaagtggccaggaagctggagtttgacggtctttacatcaca gaacaaccgtctgaggacgacatcaaaggacagtgggacagactggtcatcaacacacaa tctttcccaaacaactactgggacaagtttgtgaagaggaaggtcatggacaaatatggc gagttctacggacacgaccgcatcagcgagctgctggggatggacaaggccgcgctggac ttcagtgacgctcacaagaagagaaaacccaggagagacagctcactggctgctgttttg aactccatcgacgtcaaataccagatctggaaactgggcgtcgtcttcacagataattcc ttcctgtatctagcctggtacatgaccatgtccatcctcggccactacaacaacttcttc tttgctgctcatctgctcgacatcgccatgggcttcaagacgctcagaaccatcctgtcg tccgtcacgcacaacggcaaacagctggtgttgaccgtcggcctgttagccgtggtcgtt tacctctacacggtcgtggccttcaacttcttcaggaagttctacaacaagagcgaagac ggagaactgcccgacatgaagtgtgacgacatgctgacgtgctacatgttccacatgtac gtcggcgtcagagctggcggaggcatcggcgaccagatcgaagacccggcgggcgacgag tatgagatctaccgcatcatctttgacatcaccttcttcttctttgtcatcgtcatcctg ctggccatcatccagggcttgatcatcgatgcgtttggagaactgagagatcaacaggaa caagtgaaagaggacatggagaccaaatgtttcatctgtggaatcgggaacgattacttc gacacggtcccacacggctttgagacgcacacgctacaggagcacaatttagctaattac ctattctttgtgatgtatctcatcaacaaagatgaaacagagcacacaggacaggagtct tacgtatggaagatgtaccaggaacgttgctgggaattcttccccgccggcgactgtttc cggaaacagtacgaggatcagctcaactga

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