Solea solea (common sole): 131456633 Help Entry 131456633         CDS       T10853                                  Symbol obscnb Name (RefSeq) obscurin   KO K17531   obscurin-RhoGEF [EC:2.7.11.1] Organism ssoe  Solea solea (common sole) Pathway ssoe04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:ssoe00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     131456633 (obscnb)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:ssoe01001]     131456633 (obscnb)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:ssoe04131]     131456633 (obscnb) Enzymes [BR:ssoe01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      131456633 (obscnb) Protein kinases [BR:ssoe01001]  Serine/threonine kinases: CAMK group   Trio family [OT]    131456633 (obscnb) Membrane trafficking [BR:ssoe04131]  Others   Rho GTPase associated proteins    Rho guanine nucleotide exchange factors (GEFs)     131456633 (obscnb) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  I-set Ig_3 ig Ig_2 V-set Ig_5 Ig_4 Ig_6 Izumo-Ig fn3 SOS1_NGEF_PH RhoGEF C1-set Ig_DSCAM-DSCAML_C C2-set_2 PH IQ Pur_ac_phosph_N Motif Other DBs NCBI-GeneID:  131456633 NCBI-ProteinID:  XP_058481105 LinkDB All DBs Position 1:15195014..15249385 Genome browser AA seq 6746 aa AA seqDB search MDPNLFGGAPRFLTRPKAFSVCAGKDATLSCTIVGNPTPLITWEKDKLKLTSGGRFKRVE DGDVYRLTIYNPTLEDSGQYICRAKNSVGEAYAAVTIKVALPTEMPQRAPVFTLKPTSTR VGLGGDVVFQCRVVAFPEANFEWEKDGRYLGETNRIRVVSDTDSSTLKIQSVRNLDSGTY TCRAQNTVGRAHAAAALVVDAQDAHYLASDKDTSRLTHLQKRKEEMNKDISIYRTEESSS FSSSKANISDSLSSLSLEHELRASVLAKLPKGVFTRTCTVTEGKHAKLSCFVTGHPKPHI IWRKDGINISEGRRHVIYEDQAENFILKVLYCKQTDNGLYTCNATNMAGQTYSAVLVTVK EPKVPFRRKLQDVDVQEKTSAILMCEVPLTITHANWFMEETMLEQSTKYRMEEEGTLRRL TIHNVTMNDDGVYICEMKEGSRTVAELTVLGNITKKLPRRTIVPVSDTVIFCVELEHPYA DAYWTRNGEKLKEDSRISIACVLRQYTLTIRECQADDSGEVAFVAGDCKTSTRFTVTAAR KHPPDPPVDAVVHNKTDSSITIQWSPPESDRPVPIKSYIVERRKIATQTWQRCNAGETLI STEITISNFKEEATYQFRISAMNDFGQSPYLEVPGSFYLEPTAEIRKGLNNNTAFSGEEF SVSVELSAVCSGFWSLNGRLLRSGADYLITRSKTTHTLLIRVVTMEMNGTEIKFVGGGSQ SSCIMSVKAPPVRFTNKSHVMEVVTCKAQASAQLTAEVSDYETQVVWMKNGRELKMGKKY EYVITDHKRILMVHNVTEEDVGIYECVLADDKMSLQLSLKDEPAKFLNKARGPMGASTSL KGDLELSCEVSPASAIVVWRKDQVEITEDQRTTFISKGTQRKLIIKNAKKIDEGHYSCET AADKITFQVKIKETQALAAFSNKESVQTEVKATLSQKATLSCGVSDSKTEVKWYKDGKLL ISSRTIYSEVKGNTRQLVIEKVEKSDAGEYTCEAGGDKLVFKLSVSEAQSAFFNKESVHR EVKSIISQKAILSCEVADTKTEVKWYKDGTLLTSSRTIHAESKGKSRQLVFDSVEKKDVG EYICEAGTEKLAFKIQVTEPQSYFFSKESVQKEVKATLSQKASLSCEVSDSKTEVKWYKD GKVLTSTRAIHVESKGKSRQLVIDSVEKKDAGEYICEVGTEKLVFKLQVADTQIQSAFSK KESVQKEVKTTLSQKTTLSCEVADTKTEVKWYKDGKLLTSSKTIHAESKGKSRQLVIDSV EKKDAGEYICEVGTEKLVFKLQVADTQIQSAFSKKESVQKEVKTTLSQKTTLSCEVADTK TEVKWYKDGKLLTSSKTIHAESKGKSRQLVIDSVEKKDAGDYICEVGTEKLGFTIHVAEI QAKPAFSNKESIQKEVKATLSQKATMSCEVADTSTEVKWYKDGKLLPSTKTIHAESKGKA RQLVVEKIEKKDAGEYICEAGTEKLVFKLQVTDVAVKFQKRPVKDTCTVQASELIVLTTE LTTESGSVKWYRDGVEVKEGNKYEMKKDGRSRSLIVKSTESKDSGTYTCQTADDKLDFKV QVKDSALKFVVPLKSVEVELGGTLSLMCELNQASGDVVWHHDGHEIKPGGSYCVRTDGTK RILTVSAMAKEDDGEYSCECRNDKTSAKISSKAPRVVRLTTKLNNVAAVEGKQAIFKCSV TPADLSVKWFHNNIPITAGPKYKLEHGGNTYSLTIMSVTQTDAGEISIDAEGKSCKATLQ VQHEPVTFKKKLENLTVEEQSEVKLEVELSKVSDEVKWMKNSVVLQPAGNLEIRVNGAKQ ALVFKSVTYADRGIYSCETLDDKTQAKLSVERRVKKIQVVKGLKETKSYETETVTLEVEL SQADVEGSWTRDGARLKSGANCRITALGKKHALTLSNIKREDAGIIAFQADGIHTSGKLI VTEPPAMISKPIIDISVPEKEKGTFECEVSRTNADVKWFKGDVELKPGKSISIHTLGRKR SLVINKCSPEDTGTYICRTTDDNTSAKLTVNARDIKIIKKLENVEVMEKESAAFVCEISH DEVDCQWYKGSTKLKVSDNIKMRQEGRNYVLLFKSVSPEDMGDIKFTAEKASSTAKLKVK ELPVTFVKKLRDKIAMYKHRGYLECQVSRASAKVKWYKNKAEIKPSKKYEITSEDIYRKL TINDVDAGDEDTYTCDATDDKTSCKLLVEEQSISIVRELSSVEVTEPFAAVFEAEISVEL VKPPTWTLNGVAVQESADAEMEREGMMHRLTFKKTKASMTGPVQFTAGKSKSLAQLTVKE RPLEIAEPIKDVKAKEKSAALFSCKFSASPKEVTWFKGQVPLAASDKYNMKQDGTRAQLT IQNLTEEDSGEYRCLSGPAETKGKLTVEVREIKITKHLADTEVDEDNDAVFVCEINYADE EAQWFLKDKVLFTNEVNTITHEGKVHKLMLKNLAPQDGGTITFKVRKVKESVTLKVKEKR AVFLKSLDDVIGEEKGMITLACEASKPRVSPTWRKEGKVLKAGPKYELLHTGKSLGLIIK DVTKDDAGEYMCDLGTEVSKAKVTVREIGIGITKWLKPAEVNEGETCSFECILSRENTDE CSWTLNGQSISNGGRYKVTSKGRKYMLTIKDVTPSDAGEVVFNIKDLSSKTTLTVEGRAS SVSKGLQNVSAVQGEDAVFTCEVTQASYTVRWAKEDKAIKKSQKYAISQEDKVMKLTIHD VSAQDSGEYICEVVGGATTKAQLEVKDPIHKFIKPLKDSQADEKSCVTLQCETAQIPSTV IWLKGHTELKSGGRYEMSQKDGSLKLTIRHLEEEDTDIYTCDVVTAKSMAKVTVKALPPT FTQSLKNQEAEEEASVTLSCELSKAGVPVEWKKGSQVLKSGEKYQMKQRASMNELLINKV LPEDSGDYSCVCGDQKTTTSLKVKAQPATFKQKLESQEAEEGTSVTLFCELTKAGVTVEW KKGAQLLKSGEKYQMKQKASVNELIINKVLPEDSGDYSCVYGDQKTTASLKVKAQPATFK QKLESQEAEEGTSVTLRCELTKDGVTVEWKKGAQVLKSGEKCQMRQRASMNELIINKVVP EDSGDYSCVCGDQKTTASLKIKAQPVIFKKKLESQEAEEGADITLSCELSKAGVPVEWKK GSQVLKSGEKYQMKQKASVNELIINKVLPEDSEDYSCVCGDQKTTANLKVKAQPVIFKRK LESQEAEEGVNITLSCELSKAGVPVEWKKGSQVLNSGEKYQMKQKASANELLITKVLPED SGDYSCVYGDQKTTASLKVKAQPATFKQKLESQEAEEGTSVTLRCELNKDGVTVEWKKGA QVLKSGEKCQMRQRASVNELIINKVVPEDSGDYSCVCGDQKTTASLKIKAQPVTFKQKLE SQEAEEGTSVTLRCELTKDGVTVEWKKGSQVLKSGEKCQMRQRASVNELIINKVVPEDSG DYSCVCGDQKTVASLKIKAQPVMFKQKLESQEAEEGTSVTLSCELTKPGVPVEWKKGAQL LKSGEKYQMKQKASVCELLINKVVPEDTGDYSCVCGDQKTTASLKIKAAKPSAPLSPAKL ETIRQDTKETMGAKTIEVSTIAVKDKHTSMQEIHEKVEVVTLQTTGQTPQHQLLLQESHR DSQEVKKTDAAVSMKQWATGTFTAEMSTDSAVTFKLQPEEQESKKRVEVLPAIFIRELES LEAEEGSSVTLHCELSKPGLTVEWKKGSEVLSLGEKFQMRQTGFSYELQIHNLTPGDAGN YTCCSEDTTSSSSLAVIAAPVTFTKELESLTADEGDSVTLHCELSKSGVLLEWRKGELGL CPCAKYEISQTGQLAMLIIHDVDPQDSGSYTCDTGDHQSTAQVFVKAQPVLFKTLLQNLE RQAGEIASLCCETTKPGAIVVWRRGDSVLESTSKYHLKQEGTVAELVIYKLRGADSGEYS CDTGSQRTSAVLTVREAEISILKFLESCVVFEGEDVHFECQVSHKEVPSAQWKLQGVPLQ NNEMNLIKTEGQIHSLTLRGVTTADSGTVTFTVENHTSTASLTVRAAPVSFKKELENQEA IEGGKASLSCETSSPDCKVIWRKGSSVLTSGEKYTIEQRATTHTLVIHKLNVEDRGEYIS DTGDKKSTATLTVKEHVRIIRELCDITVTTGQDAVFEVELSHSGVTNGEWWLGDNLLQNN DLNQMSSQGRVHRLVLKMVTTDESGDVAFVVGEEKSVACLLVEEKPKVLIIERPQNTVAL EDETVTLACTISDPKATVTWMRNNVAIQAGLKYDLKKSGASHQLHIYHVLPEDSGVYTFD TGDAQCEVTLTVKGIPVSFRKELMNQDAMEGDDIILHCELTKPGVRVEWRKGGMILQPNK KYEMRQEGCVRKLCINNAEPDDSGYYTCDAGDQLTTASLAVQVKEVYIVSGLKTTDVFVG EWATFSCQLSGRAPGKVYWWLDGTLLENSPLSEIGMSQGHIYTLTLKNLATDDSGTVTFK TDNLSSTAKLLVKDPTVEVVSEMEDLCVVENQPAEFICQYSRPVRAQWKKDGQPLQPDGR RVVVEQDWNVARLYISCVSAEDRGTYSCEAEGTCVFASLNVEGKPINIVQGLENAETFDG GEALFECALSRPESKDFRWLLDGKPVKESPNAEIVTFESGRRHLLLLKELHVHDSCTVTF KAGTASTSAQLSVKGWKLDVVKGLEDKVAAVGEKVEFCVELTEPIPSTEVAWYANGVELK PSDLWSMRVDGCSYRLVLRKAPLLPQQEITFAARDALSLAKLSIIAVPDPPEDPEVLSKT KNSVNLSWFTPLHDGGSPILGYKVEMRLVDSGLWLPCHSELVCNTEFVVENLSPGSSYRF RVAAVNRAGTGEPVELPQTVQLEPAVQPQIVSGIKTKQVETEALGQPSLPPEAVEEGDVH ELWEESAKKRRMSQDPTLDSITEQPEEGAKRGQTKSEQKEVKSSDEAEIKSREKEQVTVP AKQTESKVCVSSEDESVPGGSSLVSYLKKSSKSSVTTATEGETMTPERFFAHFQMAEERT VHQTEVKTATIQQTDTKQVSKEETDVMVISKEDEPDLRDAAIKIQAAFKGYKARKDMRPV FKDVFKDQTKEPGGTIHLECVVEGKPEKVRWLKDGEPLTDSKHHHIDIYNDGTCSLVITA ITTKDTGVYTCEVTNKFGVASHSSKVTVGTVRESSKQRPLTVGYSADSEPESSSGSEMDE SLRQASKRLRRLLHTRLPPNVEEEPFISADEGDLRPPDPHSYREDDSYIYIRFDTRTDAV VASKRFQEMFTIHGVPVETAILEAGPLKVELRIKKMGYIQDGTQTPTQERQPPAFMAGPH AAPVFLTELQSQEVPDGNPVSFDCVVIGKPPPTVRWYKDGKVLEENDHYMINEDLEGCHQ LIITTVLPIDMGVYRCTAENSSGIAATKAELRVDMSCSSDYDTAADATETSSYVSAKGYM SRETETFESVAEDDQLPQVVEELCDVHVCPGSPIAKMQLKVKGFPKPRLYWFKDGLPLRP SNRILLLSERDYHSLEILEVKREDMGEYSAYISNAAGSAYSSARLIVLSPGEKLPQDKKD SKEPLVPPRFLERFSNRKVKQGTSITLSVKVEGSPTPMVSWLKEESLEDVLWIKPDTKGY KIASSGRQHSLILMDVGTEYTGAYTCIATNRAGQSICTAHLEVDDTQQLKKEAKASEVLG ITVSPPEGEGSSTKEGKMPYIGEVGTEEFLMKLTSQITEIVSAKISQDSLQNYEVLQWMK SWPKTTTSLRVPGVDSDDETKTPSPSPHHGRSRPPSLIADSSSESDEGDARGEMFDIYVA TADYNPTIASKESISLKEGQYVEVLDSAHPLKWLVRTKPTKMTPSRQGWVSPAYLDKKLK LSADAGDLPETSAEEVSEGEYKRKLFQLIQELMNGESEFVKEMNFFTSHHMKHADSPDTP PDVSSQKETIFRNIDDIKSFHSKAFLPKLHDCDTDDDVAMCFLKNKDGFEQYLQYLVSQG QAESAVGDKAVHRFFKEYTEKEQAVADPADPPVRSINAYIQQPLERIQKYKAFLKELIRN KARNGQNCCLLEEAYAMVSALPQRSENTHHVSMIENYPATLEILGEPIRQGPFQVWEGAP GIRSSRGHHRHAFLFKNYCIICKPKRDSNTDTQAYVFKNMMKLNDIDVNETVEGDDRAFE IWHEREDSVRKYTLQARTVTIKNSWLRDFRELQQRYSMPAWSPPDFDEILANCTAELGQT VKLACKVTGVPKPTVTWYKDGRAVEADPHHIIIEDPDGSCTLILDNMTADDSGQYMCFAT SSAGNASTLGKITVQVPPRFVNKMRNAIFFAGEDAQFTCVIQSAPSPKIRWFKDGRLLTD QEKYQTYSELRSGVLVLVIKNLTERDLGHYECELSNRLGSAKCAADLVLPSAVARTGEQA ITIEVTEQETRIPKKTIIIEETITTVVKNPRMRRHRSPGLTLVGTHRSETSTPEPPSVRV RRVPTPRKTTIPTLYVTHAEGAQARVIESKPRWVEVEEVIEYKVNKSPRLPRRRGVSPAV SDRVATPSRPKRSPPENPNANNSNNKLVEQAQAELQTDVSSQPLSWEEVEGNASSSSSAA EPQELSTDLTPAGEDSDDLDDQQTVIFEPDDEDNDLDLFRKQEPKILKHGDRVLTLEDLE DYVPEEGETYGSSSVAAEKPCEISVLQREIGGSTVGQPVLLNVGRPVAAPRQRSSFFGRF KDHLASNLLSSTVTPASGTQSRVERCVPIQVSHANLEVKPSYCSEVQRGEGRQQSFKTKV STQTYGYTSVGNPVTLQIRDQNYQNQ NT seq 20241 nt NT seq  +upstreamnt  +downstreamnt atggatccgaacctgtttggaggagcccccagatttcttactcgcccaaaggcattctcg gtgtgtgcaggcaaagatgccacactcagctgtaccatcgtgggtaatcccacccctctg atcacctgggagaaagacaagctgaagctgacatctgggggccgcttcaagagagtggag gatggcgatgtgtatcgtttgaccatctacaatccaactctggaggatagcggacagtac atatgccgggccaagaacagtgtaggggaggcttatgctgctgtaaccatcaaagtggcc ttgccaacagagatgcctcaaagggcccccgttttcacattgaagccgacttctacacgt gtgggtttgggaggggatgttgttttccagtgccgggttgtggctttccctgaggctaac tttgagtgggaaaaggatgggcgctacctgggggagacaaaccgcatcagagttgtttct gacactgacagcagcaccttgaagatccaaagtgtacgaaacctggacagcggcacctac acctgcagggcccagaacaccgttggccgcgcacatgctgcagcagctctcgtcgtcgat gcccaggatgcccactatctggcttcagacaaggacacttctcgtctcactcacctacaa aagcgcaaggaggagatgaataaggacatctcaatctatcgtactgaagaaagctcttca ttttcctcctccaaggctaacatctcagatagtttgagctctctgagtctggagcatgag ctgagggcatctgtgctcgcaaagctgcccaaaggtgtcttcacccgtacctgcacagtg actgagggcaagcatgccaaactcagctgctttgtgacaggtcaccccaaacctcacatt atctggaggaaggatggaataaacatcagcgagggccgtaggcatgtcatttatgaggac caagctgagaacttcatcctcaaggtcttgtactgcaagcaaactgacaatggtctctac acttgcaatgcaaccaatatggcggggcagacctacagtgctgtgttggtaacagtcaaa gagcctaaggtgccattcaggaggaagctgcaagatgttgacgtgcaagagaaaacatca gccatactgatgtgtgaggtgcctctcactatcactcacgccaactggttcatggaggaa acaatgcttgagcaaagtaccaaatatcgaatggaggaggagggcaccttgcgacgtctc accatccacaatgtcaccatgaacgatgatggggtctacatctgtgaaatgaaagaaggc agccgcactgtggctgagctcactgtcctgggcaatattaccaagaagctcccccggcgg acgatagttcctgtcagtgacactgtcattttttgtgtggagctggagcatccctacgca gacgcctactggacccgcaatggggagaagctgaaagaagattcccgaatttccattgcc tgtgtgctaagacagtacaccctcaccatcagagagtgccaggcagatgactcaggagaa gtggcctttgtggctggagactgcaagacatccacgcgattcactgtcactgctgcaagg aagcatccccccgatcccccagttgatgctgtggtgcataacaagactgactcatccatc accattcagtggtctccacctgaaagcgatcgtcctgtgccaattaagagttatattgta gaaagaagaaaaattgccactcagacatggcagaggtgcaatgctggggaaaccctcatt tccacagagatcaccatctccaacttcaaagaagaagccacctaccaattccgtatctct gcaatgaatgattttggccagagtccctacctggaggtgcctggaagcttctaccttgaa ccgacagcagaaatcaggaaaggcctgaataacaacactgcattctctggcgaggagttc tctgtctctgtggagctgtctgctgtttgttccgggttctggtctctaaatggccgcctc ctgcgcagtggagctgattacctcatcaccaggtccaagaccacacacactctgctcatc cgtgtcgtgaccatggaaatgaacggaactgaaatcaagtttgtggggggaggttcacaa agcagttgtatcatgtctgtgaaagctcctcctgttaggttcactaacaagtcacatgtg atggaggtggtgacatgcaaggcccaagcctctgctcagctgaccgctgaagtgtcagat tacgagacgcaggtggtttggatgaagaatgggcgagagttgaaaatgggcaagaagtat gaatacgtcatcaccgatcacaagagaatcttgatggtgcacaatgtcacagaggaagat gtgggcatctacgagtgtgttttagctgatgacaagatgtccctgcaactctctcttaaa gatgaacctgccaagtttctgaacaaggccagaggtcccatgggagcgtcaacgtccctt aaaggagatctggaactaagctgtgaggtatctcctgcaagtgctatcgttgtgtggaga aaagatcaggtggagatcactgaggaccaaagaactaccttcatctccaaagggactcaa aggaaactcatcatcaagaatgccaagaaaatcgatgaaggacattactcctgtgagaca gcagcagacaaaatcacattccaggtcaagataaaagaaactcaagccttggcggccttc tccaacaaggagtcagtccagacggaggtgaaagccactctttcccagaaagcaactctt agttgcggtgtgtcggatagcaagacagaggtgaagtggtacaaagatggaaagctgttg atttccagcaggaccatatactcagaagtaaaaggcaacactcgtcagctggtgattgaa aaagttgaaaaaagtgatgcaggagaatatacctgtgaagctggaggtgataagttggtt ttcaagttatctgtgtcagaggcccagtcagccttcttcaacaaagagtcagtccacagg gaggtgaaatctattatctctcagaaagctattttaagctgtgaagtagctgatacaaag accgaagtgaaatggtataaggatggcacactcctcacttccagtaggacaatccatgca gaatcgaagggcaagagtcgccagctggtttttgacagcgtggagaaaaaagatgtcgga gagtacatctgtgaggcagggacagagaagttggcttttaagattcaggtgacagagccc cagtcttacttcttcagcaaagagtcagtccagaaggaggtgaaagccactctctcccag aaggcttctctgagctgcgaggtctctgattcaaagacagaggtgaaatggtacaaggat ggcaaggtcctcacttctaccagggcaatccatgtagagtcgaagggaaagagtcgccag ctggtgattgacagtgttgagaagaaggatgctggagagtacatctgtgaggttgggaca gagaagttggtcttcaaactccaggtggcagacacacagattcagtctgcattctccaaa aaggagtctgtccaaaaggaggtgaaaactactctctcccagaaaaccacactgagctgt gaggtagctgataccaagacagaagtgaaatggtataaggatggcaagctgctcacctcc agcaagacaatccatgctgagtctaagggcaagagtcgccagctggtgatagacagtgtg gagaagaaggatgcaggagagtacatctgtgaggttgggacagagaagttggtcttcaaa ctccaggtggcagacacacagattcagtctgcattctccaaaaaggagtctgtccaaaag gaggtgaaaaccactctctcccagaaaaccacactgagctgtgaggtagctgataccaag acagaagtgaaatggtataaggatggcaagctgctcacctccagcaagacaatccatgct gagtctaagggcaagagtcgccagctggtgatagacagtgtggagaagaaggatgcagga gattacatttgtgaggttgggactgagaagctaggttttacgattcacgtggcagagatt caggccaagccggccttctccaacaaggaatccatccaaaaggaggtgaaagctactctc tcccagaaagccacgatgagctgtgaggtagctgataccagcacagaggtgaaatggtac aaggatggcaagctgctcccctccaccaagacaatccatgcagagtctaagggcaaggcg cgccagctggtggttgaaaaaattgagaaaaaagatgctggagagtacatatgcgaggct ggtacagagaagctggtattcaagcttcaggttacagatgtagctgtcaagttccagaag aggcctgtcaaagacacatgcactgttcaagcaagtgaactgatagttttgaccactgag ctgaccacagagagtggtagtgtaaagtggtatagagatggtgtggaggtcaaggagggc aacaagtatgaaatgaaaaaagatggacgctctcgttccctgatagtaaaatccactgaa agtaaagacagtggtacatatacctgtcagacagctgatgacaaactggatttcaaagta caggttaaagattcagctttgaagtttgttgtccccttgaaatctgttgaagtggagttg gggggcacactcagcctgatgtgtgaactaaatcaagcctcaggggatgttgtctggcac catgatggtcatgaaattaaacctggaggcagttactgtgtcaggactgatggtaccaag cgaatcctcactgtgagtgccatggctaaggaggatgatggagaatacagctgtgaatgt cgaaatgacaagacctctgccaaaatctcctcaaaagcacccagagttgtaaggttgacc accaaactgaacaatgtggctgcagtggaaggaaaacaagccattttcaagtgctcagtc accccagcagatctcagtgtgaaatggttccacaacaatatacccatcactgccggaccc aagtataagcttgagcatggtggcaacacttactcactcaccatcatgtctgtcacccag acagatgctggagagattagcattgatgctgaaggcaaaagctgtaaagctactttacaa gtccaacatgagcctgttacatttaagaaaaagctggaaaacctgacagtagaggagcag agtgaagtgaagctggaggtggagctcagtaaggtatcagatgaagtgaagtggatgaag aacagcgtcgtgctgcagcctgctggaaacctggagattcgggtgaatggagccaaacag gcactggtcttcaagagtgtgacttatgctgaccgtggcatctactcctgtgaaactctg gatgacaagacccaggctaaactcagcgtagagagaagggtgaagaagattcaggtggtt aagggcctaaaagaaactaagtcatatgagacggagacagtaacacttgaggtcgaactt agccaggctgatgttgaaggctcgtggacaagagacggggccagattaaagtcaggggcg aactgcagaatcacagctttggggaagaagcatgcgctcacattgtccaatatcaagaga gaagatgcaggaataattgcatttcaagcagatggtatccatacatctggcaaactgatt gtcacagagccgcctgccatgatctccaagcccattatagatatcagtgttcctgagaag gagaagggtacttttgaatgtgaagtgtccagaacaaatgcagatgttaaatggttcaag ggtgacgtggaactgaaaccagggaaaagcattagcatccacaccttgggccgaaagcgt tctttggtcatcaacaaatgctcccctgaagatacaggcacttacatctgtcgcaccact gatgacaacacctcggccaagctcaccgttaatgcccgagatatcaagataattaagaaa ctggagaatgtggaggtgatggagaaggagagtgccgcatttgtctgtgaaatctcacat gatgaagtggactgccagtggtacaaaggaagtactaaactcaaagtcagtgacaacatt aagatgagacaagagggcagaaactatgtactgctgttcaagtctgtctccccagaggat atgggcgatattaaattcacagctgagaaggcctcttcaactgcaaaactcaaagttaaa gagctgcctgtcacgtttgtgaagaaactcagggataagatagcgatgtataagcatcgt ggttatcttgaatgccaagtgtcacgtgccagtgcaaaagtgaagtggtacaagaacaag gcagaaattaaacccagcaagaagtacgagatcacaagtgaggatatctaccgaaaactc accatcaacgatgtggatgccggggatgaggacacatatacctgtgatgccactgacgac aaaacatcctgtaaactgcttgtagaagagcagtccatcagcattgtgcgggagcttagt tcagtagaagtgacagaaccctttgcagctgtttttgaagctgagatcagcgtggaactg gtgaaacctcctacatggactctgaatggagttgctgtgcaggagagtgctgatgcagaa atggagagagagggcatgatgcaccgtctcactttcaaaaagaccaaagcatcaatgacg ggacctgtgcaatttacagctgggaagagcaaatctcttgcccaactcacagtaaaagag cgcccacttgagattgcagagcccatcaaggacgtgaaagcaaaggagaaaagtgcagcc ctgttcagctgcaagttttctgcatctccaaaagaggttacatggtttaaaggccaggtt cctctggcagcatcagacaagtataacatgaagcaagacggtacaagggctcagctcacc attcaaaacctaacagaggaagacagtggagagtaccgctgtctgtccggacctgcagag accaaaggcaaacttactgttgaagtgcgtgaaattaaaatcaccaagcacttggcagac acggaggttgatgaagacaacgatgcagtgtttgtgtgtgagattaactatgcagatgag gaggcacagtggttcctgaaggataaggtgctcttcaccaatgaagtcaacaccatcact catgaggggaaggttcataagctcatgctgaagaacttggcaccccaggatgggggcact atcacttttaaagtacgcaaggttaaagagtctgttacactcaaggttaaagagaagcgt gctgtcttcctcaagtctctagacgatgtcataggtgaggaaaaaggtatgataactctg gcgtgtgaggcgtccaagcccagagtttctcccacatggaggaaagagggtaaagtcttg aaggcggggccaaagtatgagcttcttcacacaggaaagtctttgggacttatcatcaag gatgtcaccaaagatgacgctggggaatacatgtgtgatctggggactgaagtttctaaa gcaaaggtcactgtaagagagataggtattggaatcaccaagtggctgaagccagctgag gtgaatgagggagagacatgcagctttgagtgcatcctgtctcgtgagaacactgacgag tgctcctggactcttaatggccaatccatttcaaatggaggccgttacaaagtcaccagc aaaggccgcaagtacatgctaacaattaaggatgtcaccccatctgatgccggtgaggtg gtcttcaacattaaagacttgagctccaaaaccacattaacagtggaaggcagagcttca tctgtgtccaaaggactacaaaatgttagtgctgttcaaggagaagatgctgtatttacc tgtgaggtaacacaagctagctacactgtaaggtgggcaaaggaagacaaagccatcaaa aagagccagaagtatgccatcagccaagaagataaggtcatgaagctcaccattcatgat gtctctgctcaagactctggagagtacatctgtgaagtcgttggaggtgcaacaaccaaa gcccaactggaagttaaagatcccatccataaattcattaaaccattaaaagacagccag gcggatgagaaaagttgcgtgactttgcagtgcgagacggcgcaaatcccatccacagtg atatggcttaaaggtcacacagagctcaagtcaggagggcgatatgagatgtcccagaaa gacgggtccctaaagctcaccatcagacacttggaggaggaagacactgatatctacact tgtgatgtggtcactgcaaagagcatggcaaaggtgacagtcaaagcattgccaccgacc ttcacacagagcctgaagaaccaagaagcagaggaggaagccagtgttactttgagctgt gagctctctaaagctggagtcccagtggagtggaagaagggatcacaggtcctgaagtct ggagaaaagtatcagatgaagcagagagcatctatgaatgaacttctcatcaacaaggtg ttgccagaagacagtggagactacagctgtgtgtgtggagaccagaagaccacaacaagc ctcaaggtcaaggcccaaccagcaaccttcaaacagaagttggagagccaggaagcagag gagggcaccagtgttactctgttctgtgagctcactaaagctggagtcacagtggagtgg aagaagggagcacagttgctgaagtctggagaaaagtaccagatgaagcagaaggcatct gtgaatgaactcatcatcaacaaggtgttgccagaagacagtggagactacagctgtgtg tatggagaccagaagaccacagccagtctgaaggtcaaggcccaaccagcaaccttcaaa cagaagttggagagccaggaagcagaggagggaaccagtgttactctgcgctgtgagctc actaaagatggagtcacagtggagtggaagaagggagcacaggtgctgaagtctggagaa aagtgccagatgaggcagagagcatctatgaatgaactcatcatcaacaaggttgtacca gaagacagtggagactacagctgtgtgtgtggagaccagaagaccacagccagcctcaag atcaaggcccaaccagtaatcttcaaaaagaagttggagagccaggaagcagaggaggga gctgacattactctgagctgtgagctctctaaagctggagtcccagtggagtggaagaag ggatcacaggtcctgaagtcgggagaaaagtaccagatgaagcagaaggcatctgtgaat gaactcatcatcaacaaggtgttgccagaagacagtgaagactacagctgtgtgtgtgga gaccagaaaacaacagcaaaccttaaagtcaaggcccaaccagtaatcttcaaaaggaag ttggagagccaggaagcagaggagggagtcaacatcactctgagttgtgagctctctaaa gctggagtcccagtggagtggaagaagggatcacaggtcctgaattctggagaaaagtac cagatgaagcagaaggcctctgcgaatgaacttctcatcaccaaggtgttgccagaagac agtggagactacagctgtgtgtatggtgaccagaagaccacagccagtctgaaggtcaag gcccaaccagcaaccttcaaacagaagttggagagccaggaagcagaggagggaaccagt gttactctgcgctgtgagctcaataaagatggagtcacagtggagtggaagaagggagca caggtgctgaagtctggagaaaagtgccagatgaggcagagagcatctgtgaatgaactc atcatcaacaaggtggtaccagaagacagtggagactacagctgtgtgtgtggagaccag aagaccacagccagcctcaagatcaaggcccaaccagtgaccttcaaacagaagttggag agccaggaagcagaagagggaaccagtgttactctgcgctgtgagctcactaaagatgga gtcacagtggagtggaagaagggatcacaggttctgaagtctggagaaaagtgccagatg aggcagagagcatctgtgaatgaactcatcatcaacaaggtggtaccagaagacagcgga gactacagctgtgtgtgcggtgatcaaaagactgtagccagcctcaaaatcaaggcccaa ccagtgatgttcaaacagaagttggagagccaagaagcagaggagggaaccagtgtcact ctgtcctgtgagctcactaaacctggagtcccagtggagtggaagaagggagcacagttg ctgaaatctggagaaaagtaccagatgaagcagaaagcctctgtgtgtgaactcctcatc aacaaggtggtgccagaagacactggagactacagctgtgtgtgtggagaccagaagacc acagccagcctcaagatcaaggctgcaaagccgtcagctcctctttcacctgctaaactg gaaacgataaggcaggacaccaaggaaacaatgggagccaagaccattgaagtttcaacc atagctgttaaagacaagcacacatccatgcaggagatacatgaaaaagtagaagtggtg actctacaaactacgggacagactcctcaacatcagctccttctacaggagagtcacaga gattcacaggaagttaagaagactgatgctgcagtatctatgaagcagtgggccacaggg acatttacagcagagatgtcaacagattcagcagtgaccttcaaacttcaacctgaggag caggaatccaaaaagagggttgaagttcttccagccatattcattcgagagctagagagc ctggaggctgaggagggaagtagtgttactcttcactgtgagctttctaaacctggactc actgttgagtggaagaaaggaagtgaagtccttagtttgggagaaaagttccagatgagg cagacaggattcagttacgagctacagatccacaacttgacacctggagatgcagggaac tacacctgctgttcagaggacacaacaagctcatcctctcttgcagtaattgctgcacca gtcacatttacaaaagagttggaaagcctaacagctgatgagggggacagtgtcaccctg cactgtgagctttctaaatctggtgttcttttggagtggaggaaaggagaacttggtctt tgtccttgtgccaagtatgaaattagtcagacaggacaacttgccatgctaataatccat gatgtagacccacaggattctggaagttacacatgtgacactggtgaccatcaaagcact gcacaagtgtttgtgaaggcccagcctgtcctttttaaaaccctgctgcagaaccttgaa agacaggcaggggagatagctagtctctgctgtgagactacaaaaccgggggctattgtg gtctggagacgtggtgacagtgtgctggaatccactagcaagtatcacctgaaacaggaa gggacggtagccgagcttgtcatctacaaactacggggtgcagactcaggagaatactcc tgtgatacaggcagccagaggacgtcagctgttctcactgtgcgggaggccgagattagc attctgaaattcttggagagctgcgttgtcttcgagggtgaagatgtccactttgagtgt caggtttctcacaaggaagtaccttcggcccagtggaagcttcagggggtcccgctacag aataatgagatgaacctgatcaagactgagggccaaatacacagcctcacactcagaggt gtcaccacagctgactcaggaacagtcactttcacagtggaaaaccacacgtccactgct tctcttacagtcagagctgctcctgtgtcattcaagaaggagcttgaaaatcaagaggcc attgaaggaggtaaagccagcctgtcctgcgagacatccagtcctgattgcaaggtaatc tggcgaaagggctcatctgtgctcaccagtggggagaagtacactattgagcagcgagct accacccacaccctggttatacacaagctgaatgtggaggacaggggggagtatatcagc gatacgggagacaagaaaagcactgcaacactgactgtgaaagagcatgtgcgcatcatc cgggaactctgcgatatcactgttaccaccgggcaagatgcagtctttgaggttgagctg tcacattcaggcgtgacaaatggggaatggtggcttggagacaacctgctccaaaataat gacctgaatcaaatgagcagccagggccgagtgcaccgtctggtcctgaagatggtaacc acagatgaatcaggggatgttgccttcgtagttggagaagagaagagtgtggcctgtctg ctggtggaggagaaacccaaagtgctaataatagagagaccacaaaacactgtggcatta gaagatgaaactgtcactctggcctgtaccatctccgaccccaaggccactgtcacctgg atgagaaataacgtagccattcaagcaggtctcaaatatgacctgaagaagagtggagca tcccatcagcttcatatctaccatgtgttacctgaagattcaggagtgtacacctttgac actggagatgcacagtgtgaggtcaccttgactgtgaaaggtattccagtgtccttccgg aaagagctaatgaaccaggatgccatggagggtgatgatattatccttcactgtgagctg actaagccaggtgttcgtgttgaatggaggaaaggaggcatgatcctccagcccaataag aagtatgagatgaggcaggaagggtgtgttcgaaagctctgtataaataacgcggagcct gacgacagtggctactacacctgtgacgcaggggatcagctcactacagcttctttggca gtgcaagtgaaagaagtctacattgtttctggtcttaagaccaccgacgtctttgttggg gaatgggcaactttctcctgccagctgtctggtagagcacctggcaaggtgtattggtgg ctggatggcaccttgctggagaacagccctttaagtgagatagggatgagccaaggccac atctacacactcaccttaaagaacctggccacagatgactctggcactgtcacattcaaa actgacaatttatcatcaaccgccaagctcttagtcaaagatcccacagttgaagtggtg agcgagatggaggacctttgtgtggtcgagaaccaaccggctgagttcatctgccagtac tcaagaccagtcagggctcagtggaagaaagacgggcagccattgcagcctgatggccga agggtggtagtggagcaggactggaatgtggctcgcttgtacattagctgtgtgtccgct gaggacagaggcacatactcctgtgaggcagaggggacctgtgtgtttgcttcacttaat gtggaaggcaaacctattaacatcgttcagggtctggagaatgcagaaacctttgatgga ggcgaagccctgtttgagtgtgccttgtctcgtcctgagagtaaagatttccgctggctt cttgatggcaaaccagtgaaggaatctcccaatgctgagattgttacatttgagagtggt cgtcgtcatctgctccttcttaaagagttgcatgttcatgacagttgtacagtgacattt aaagctggcacagcatccacatctgcccagctctcagtcaagggatggaagctggatgtt gttaagggtctggaagacaaagtggctgctgtgggagagaaggttgagttttgtgttgag ctgaccgagcccataccatctacagaagtagcttggtatgcaaatggcgttgagctcaag cccagcgatctctggtctatgagggttgatggctgctcttatcgccttgtcctgagaaag gcaccacttttgccccagcaggaaattacattcgctgctcgagatgctctctctttggct aagctttccatcattgctgtacctgatcctccagaggacccagaggtcctcagtaagact aaaaattctgttaacctctcttggttcactccactacatgatggagggagtcccattctt ggctacaaggtggagatgcgactggtagacagtggtctctggcttccatgccattcagaa cttgtgtgcaacacagagtttgtggttgaaaatcttagccccgggagtagctacaggttt agagtagcagccgtcaacagagctgggactggagagcctgttgagttgcctcagactgtg cagctcgaaccagctgtgcagccacaaattgtctcaggtataaagacaaaacaggtagag acagaggcactgggacagcccagtctgcctccagaagctgttgaagagggtgatgtccat gagctatgggaggagtcggctaaaaaacggcgcatgagtcaagaccccactttggactcc atcactgaacaacctgaagagggcgctaaacgtggtcaaacaaaatcagaacagaaggaa gtaaagtcctcagatgaagctgaaataaaatctagagagaaggagcaagtcactgtgcct gcgaagcagactgaatccaaagtgtgtgtcagctcagaggatgaatctgtcccgggaggc tcatcacttgtgtcctatctcaagaagagcagcaaatcttctgtcactacggccactgaa ggagagacaatgacccctgagaggttctttgcacatttccagatggcagaggagagaaca gtgcatcagactgaagtgaaaacagccacaattcagcagacagatacgaaacaggtatct aaagaggagactgacgtaatggtaatcagtaaagaagatgagcctgatctcagagatgct gccattaaaattcaagctgcttttaagggttacaaggcccgcaaggacatgcgacctgtc ttcaaagatgttttcaaagaccagaccaaagaaccaggtggcacaatacatctggaatgt gtggtagaaggtaaacctgaaaaggtgcgttggctaaaggatggagaaccacttacagat agcaagcaccaccatattgatatttataatgatggtacttgctcactggtcatcactgcc atcaccacaaaggatactggagtttacacttgtgaagttaccaacaagtttggagttgcc tcacacagtagtaaggtgacagtaggaacagtgagagaatcgtctaaacaacggccactg acagtgggctatagtgctgacagtgagccagagagctcctcaggcagtgaaatggatgag tcactgaggcaggcaagcaaacgtctgcgacgtctgttgcacacacgtctcccaccaaat gttgaagaagaaccatttatcagtgcagatgaaggagacctgcgtcccccagatccacac tcttaccgtgaggatgacagttacatatacattcgctttgatacgcggactgatgctgta gttgcctctaagaggttccaagagatgtttacaattcatggggttcctgtagagacagcc atcctggaggcagggcctcttaaagtggagctgcgtattaaaaagatgggctatatccaa gatggcacacagacccccacacaagaaagacaacctcctgctttcatggctggaccccac gctgctccagtcttcttgacagagctacaaagccaggaggttccagatggcaatccagtc agttttgactgtgttgtgattggcaagccccctccaactgttcggtggtataaggatggc aaagtgctggaggaaaatgaccattacatgatcaatgaagacctggagggttgccaccaa ctgatcattactactgtgctgcccattgacatgggtgtctatcgctgcacagctgaaaac agcagtggcatcgcagccactaaggctgaactcagggttgacatgtcttgtagctcagat tatgacactgctgctgatgccactgagacctcttcctatgtcagtgccaaaggctacatg tctagggaaactgagacatttgagtctgtggctgaagatgatcagctaccgcaagttgtg gaagagctttgtgatgttcatgtatgtccagggtcacctattgctaaaatgcaactcaag gttaagggcttccccaaacccagattatactggttcaaggatggcctgcctctgcggccc tcaaacaggatcctgttactgtcagaaagagattatcacagcttggagattctggaggtg aagagagaagatatgggggagtactctgcttacatcagcaatgcagccggttctgcttac tcctctgccagactcatagttctgagtcctggggagaaattgccacaagacaagaaagac tccaaagaacctctggtgcctccacgcttccttgaaaggttcagcaacaggaaggtgaaa caaggaacaagcatcactctgtctgtcaaagttgaagggtctcccactcctatggtgtcc tggctaaaggaggaatctttggaggatgtcctgtggatcaagcctgataccaagggatac aaaatagcaagctctggacgccagcacagtctcatcctgatggatgtgggcacagagtac actggcgcctacacctgtatagctacaaatagagcaggacagtccatctgcactgcacac cttgaggtggatgacacacaacaactgaagaaagaggctaaagcttcagaggttcttggt atcacagttagtcctccagaaggggagggtagcagcacaaaagagggtaaaatgccctac ataggtgaagtaggtacagaggaattccttatgaaactcacctcccagatcactgaaatc gtatcggccaagatcagccaggacagcttacagaattatgaagtgctccagtggatgaaa tcttggcccaaaactaccacttcactacgtgtacctggggttgacagcgatgacgagacc aagactccttctccatcgcctcatcacggtcgctctcgccctccctccctcatagctgac tcctcctcagagtctgatgagggggacgccaggggggagatgtttgacatctatgtggcc acagctgactacaaccccaccatagcgagcaaagagtctatttctctgaaggagggacag tatgttgaggttttggactcggctcatccactcaaatggttagtccggaccaaaccaacc aaaatgactccatcccgccaaggctgggtctcacctgcctatttggacaagaaactcaaa ctctcagctgatgcaggtgaccttccagagacaagtgcagaggaggtgtcagagggtgaa tacaaaaggaaactattccaactgatccaggaactgatgaatggtgaatcagagtttgta aaggagatgaacttcttcacctcccatcacatgaagcacgcagacagccctgacacacca cctgatgtcagtagccaaaaagaaactattttcaggaacattgatgacatcaagtccttc cacagcaaggcattcctcccaaagttacacgactgtgacacagatgatgatgtagccatg tgtttcctgaagaacaaggacggctttgagcagtatctccagtatcttgttagtcagggt caggcagaatctgctgtcggtgacaaggcagtacatcgcttcttcaaggagtacactgag aaagaacaggctgtcgcagaccctgctgatccccctgtacgtagcatcaacgcctacatc caacaaccgctggagagaattcagaagtacaaggctttcctcaaggagctcattcgaaac aaggcgaggaacggtcagaactgctgcctcctggaagaagcttatgcaatggtgtctgcg ctccctcagcgctcggagaacacccaccatgtctccatgatcgagaactatcctgccaca ctggaaatacttggagagccaataagacagggacccttccaagtgtgggagggagctccg ggaattaggtcctctagaggtcaccaccgccacgccttcctctttaagaactactgtata atctgcaaacccaagagagacagcaacactgatacacaagcatatgtctttaagaacatg atgaagctgaacgacattgacgtgaacgagacagtggagggcgatgaccgcgcctttgaa atctggcatgagcgcgaggactcggtgaggaaatatactttgcaggctcgaactgtcacc atcaagaactcctggctgagagacttcagagaactgcagcagcgatacagcatgcctgcg tggagtccccctgacttcgatgaaattctggcaaactgcactgcagagctgggacagact gtaaaactggcctgcaaagttactggagtacccaaacctacagtcacctggtacaaagat ggacgtgcagtggaggcagatcctcatcacatcatcattgaggatccagatggttcttgc acactgatcctggacaacatgacagcagatgattctggccagtacatgtgctttgccaca agctcagctggcaacgctagcactcttggaaagatcacagttcaagtgcctcctcgtttt gtgaataaaatgaggaacgctatcttttttgctggtgaggacgcacagtttacctgtgtc atacagagcgcccccagccctaagatcaggtggttcaaagatggcagacttctgactgac caagaaaaatatcagacctacagcgagctccgtagcggggttctggtcttggtaataaaa aacctgacagagagagacttgggacactatgagtgtgagctgtcaaatcgtctgggcagt gccaagtgtgctgctgatttagtcctaccctctgctgtggcccgaactggtgaacaggcc atcactattgaagttactgagcaggagacaagaataccaaagaaaaccatcatcattgag gagacaataaccactgtggtgaagaaccctcgtatgaggaggcacagatcccccggtttg actcttgttgggacccaccgctctgagacttccaccccagagcccccgtctgtccgggta aggagggttcccactccacggaagacaaccatccctaccctttatgttactcatgctgag ggtgctcaagccagagtcatagaaagcaagccccggtgggtagaggtcgaagaggtcatt gagtacaaggtgaataaatctcccaggctccccaggaggagaggcgtctcacctgcagtg tctgatcgcgtagccactccatccagacctaaaaggtctccacctgaaaaccccaacgct aacaattcaaacaacaagctggtggagcaggctcaggctgagctgcagacagacgtcagc agtcagcccctctcctgggaagaagtggagggtaatgctagctcaagttcttcagctgca gagccacaagagctctcaactgacctcactccagctggagaggacagcgacgacctagac gatcaacaaacggtcatctttgaacccgatgatgaggataatgatctcgatttgttcaga aagcaggaaccaaagatcctgaaacacggagaccgtgttttgaccctcgaggacttggag gattacgtaccagaagaaggagagacctatggctcgtccagtgttgctgctgaaaagcca tgcgagatctccgtgttgcagcgggagatcggcggctccacggtgggacagccagtgctt ctcaacgtggggcggcctgttgctgcgccgaggcagaggagcagcttcttcggccgcttc aaggaccatctcgccagtaaccttctctcctccactgtcactccagccagcggaacgcag tccagggtggagaggtgcgtcccgatccaagtgagccacgccaacctggaagtgaagcct tcatactgctcagaggtgcagagaggtgagggcaggcagcagagctttaaaaccaaagtg tcaactcagacctacggctacacatcagtgggaaacccagtcacccttcaaattagagat cagaattatcagaaccagtag

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