Solea solea (common sole): 131473936 Help Entry 131473936         CDS       T10853                                  Name (RefSeq) ryanodine receptor 2-like   KO K04962   ryanodine receptor 2 Organism ssoe  Solea solea (common sole) Pathway ssoe04020   Calcium signaling pathway ssoe04260   Cardiac muscle contraction ssoe04261   Adrenergic signaling in cardiomyocytes ssoe04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ssoe00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     131473936    04020 Calcium signaling pathway     131473936  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     131473936    04261 Adrenergic signaling in cardiomyocytes     131473936  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ssoe04040]     131473936    04990 Domain-containing proteins not elsewhere classified [BR:ssoe04990]     131473936 Ion channels [BR:ssoe04040]  Voltage-gated cation channels   Ryanodine receptor    131473936 Domain-containing proteins not elsewhere classified [BR:ssoe04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    131473936 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_1 EF-hand_6 EF-hand_7 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  131473936 NCBI-ProteinID:  XP_058507541 LinkDB All DBs Position 15:20772053..20838549 Genome browser AA seq 4950 aa AA seqDB search MRDSGDVDDEFQFLRTGDEVVLQSTLTSQEEHVKLCLAAEGFGSRLCRLESTSNCKNVPP DLSVCGFVLAQCLSVRALQERLAHSQHLAAEIEAGGSHRTLLYGQAVLFQHSYSGMYLCC LTASQSSTDKLAFDVGLQEDIAGETCWWTVHPASRQRSEGEKVRVGDDLILVNVSSERYL HMSFGTVFDNRSLSDSLIVNAAFQQTLWSVAPICSGGGVAQGYLKGGDTLRLLHSHSDAC LTVPSSEQGEELQRMMHYETGSVSSHARSLWRLEILRVVWSGRHTCWGQPFRLCHVTTGR YLGLTEEKGLQLIDRDKADIDTTSFCFRSSKEKTDSGMKTGADGMGIPEIKYGDSMCYVQ HVYSGLWLTYQSTDANSSRMRLTQRKAILHSEGHMDDGLTLSRSQREESHTARLIRSAIL LFTRFIRKLDGCSHQGTLPHVTLSMETVMCSLQDLIKYFQPPLDELGHEAKQNIMTAVKS RQNLFQEEGVIVLVLDCIDRLHQYSSSSHFAEAVQCEKGEEWETILSRFYELLAALIRGN RVNCAHFSGSLDWLISRLDQMEASSGALEVLHCILVESPEALNVIKEGHINSIISFLDQH GCNYKVLEVLCSLCVCNGVAVRSNQNHICDNLLSDRDLLLQTRLVNQVTSVRPNIFLAMG DDSAQPRRWYYELVVDHVDPFLTPEPTHLRVGWACTEGFYPRPTGGDGWGGNGVGDDLCS YGFDGLHLWSGCVGRRVNSPWPHLLKNDDVVSCCLDLTAPCISYRVNGLPVQGMLENFSA HGLLHPVVSFSAGVKFRFLFGGRHGEFRFLPPPSFAPCTEALLPRVKLKVQPCWKHILDY RKGIKVLIGPAVPVTPVTFTPTPVDISKIDLPLQLEDIREKMAENIHELWVTDKIDLGWT HGTVRDEGKRHDPCIVEFSKLPEQERNHNLQVAQDTLRTLTALGFHLGLTDDNAVERVKY MRLATKYEQPGGYRPAPVDLSQVTLSSSHEDMVNMLAENDHNVWARERIKQGWTYGPQQD VKAKRSPYLVPYSLLDERSKRVGRESVREAVCTLLAYGYSLEPLNQEQTTSSNARLFSAE KYTVFRPDKSYAVTQGKWYFEFEVLTAGKMRVGWARPGCCPDKELGSDDQAYVFDGSEAQ WYHQGGELLGRPWQRGDVVGCLVDMDECTMVVTLNGEVLFNDRGSELAAKDFDIRDGVLP VVSVAVNQVGRLNLGRHMDSLQYFAVCGQQEGFKPFAVNMARDPSLWMSWGRPHFTPILP DDHNFKVTKTSGSVESVSSLRVSQQLFAHRGGGSEMGFYRLSMSLGCAAVLTSPAANVLP VAANSPAPSSHGRKEQEEVDSDFEVLMKSAHSFAGSRDELNHKDHSQDKTSRLKQRFLLK RTKPGLVSSNSSARLLEDVVVDKEICDHLIQSSRYYYSVRVLPGQEPFNVWVGWVTSDFH HNDMTFDTDYVNTVTVTLGDDGGKVQESVKRCSCYMVCAGEATGLSQSRRSAGLEIGCLI DTATGLLSFTSSGVEMATFYQVEASTKLFPAVFVKPTTSSMFQFQLGCIKNVMPLSTGLL RSQSRNATPQCPPRIQVQHLTPVSWTRVPDCALQVLVDRPDEHHGWSVQCSEPLQVMTLH IPDENRCVDILELSELDDLLKFHHHTLLLYCSLCTLGNTRVCHSLCSYVDQSQILHAIQN PNLPGPIRSAFYQLLTEVYLSSHTSACLMMNHEYIVPMTEQTRQVTLYPSPANGGQLPAC IPNTSLSTSLKPQMHFSTPCFVTSDGIEAGDAVKIVYTDSPEIPLDILKCLTMEMLIAGV WAVGQGVRDPVGGSIELLLVPLIKLFYTLLVMGVFGNKDLGIVLSLIEPGVFSIDAKTPE EEEEEEAIYANEKGWKNSNKTEYDTPSQGLLQMKLPEAVKLELCHLLSYLCDSQVRHRVE AVVAFSDTLVGQLQENQRFRYNQVMQALNMSAALTARKTKEFRSPPQEQINMLLNFREDE QQEHCPCPVKIQQLLQDFHHLLSTHCGIELDSESEDEEDAEMPVKDWLLSLVVRAFEVRK SSTQVEESRPRSAKSLKKLISETMVRWTEECEIEDPELVRAVFSLLHRQCQGLGGQMEGP LCRAYTISQASVEDTMMLLSSLAQIRSLLSVRMGKEEEKLTIRRLGDIMNNKVFYQHPNL MRVLGMHETVMEVMVNVLGEGESKEITFPKMVASCCRFLCYFCRISRHNQGALFDHLSYL LENSSVGLASPSMRGATPLDVAAASVMDNNELALALKEPDLEKVVQYLAGCGLQSCPLLL EKGYPDIGWNPVEGERYLDYLRFAVFCNGESVEENAYVVLRLLIRRPECFGPALRGDGGN GLLAAMEEAIKISEDLSMDGPYTTFQSNRTQDIVQDHVDDDLVHMGHAIMSFYSALIDLL GRCAPEMHLIQGGKGEAIRIRAILQSLVPIQDLEGVISISFQVPSVSKDGLVVESDLSTV FCPDHKAAMVLFLDRVYGIESRHFFLRLLEVGFLPDLQAAVSLDTADLGSTDMALALNRY LCTSVLPLLIKCSSLFCGLDDHTLLVDSLIQAVYSLSRALSLTKAQRDITEECLLAVCSK LQPSMMQPLLRRLVLDVPHLTDHSKIPLRLLTSHYEERWKYLKTGGQGDQNSASEVELHL STTLFWGVLKALAKRPYEPQLFKLCIRCLAAVAKALPPDHMDSVSPTERKSFMDTDGHFD PQPVDTSNISVPERLEFVVNKYAEHTHEKWSLDKFANGWVHGEQLCENSKVHPLLKPYRA LAEKEKEAYRWAIKETIKSMLAFGWNIERTNEGDASGAHTCRRRISQSGQLSFEGASTFS PKPMDVSSITLSWEQCAMAEHLAGNYHNAWAKRKKSELESKVGGHSMLVPYDTLTAKEKT KFREKAQDILKFLQLNGYTVWRDRKTVDMDFPATANCFSYTLLQKLLRHTEEVQEHMLEL EVMQARGQMSKGEKGPHQQQIHFFSKVILPLLEEFVKSHQMYFLSTSLCSSGNRAYATKK EKEMIACLFCKLAALVRHRVSLFGNDASSVASCLHVLAQALDARMLMQFASDSIQASLHS FFEAAAADLEMTVENLSVALVSVPQGRSQQARGVAKVLSYTTSILLPTLTSLFQHLGNQN YGVDILVGGIQVSCYRIINSLYSLGNSSNVYMEGQKPAAGACLAALTGAFPLCYLEPALN QNNPYSIYNTQSVTEREDLGLPDEVVDACPLLPSLEQALSEVEKLAGAGAGARQSHYIHV TEVTLPMLCSYMSCWWPWGPEGQSGLPICSSVTPKHVSDLLGHILRIIHNHVGTSQGDWM KQLAVFSQPIIFKACPELLKSHFLPLMEKLRKKAECVLLEEEQMKSEGWCASEAELKIQE KFTVLVRDLYAFYPLLIPFMDSYRASWLKVSNPEAEQLFSMVAEVFIFWAKSHNFKWEEQ NYVVQNEINNLAFLVNNDKMSKYNHEKSMKRKGDRYSMQSSLIVASMKRLLPVGLRIFFP NEQNLIMSAKNSFTQNKTEDEICEQVFHGLLQSQASNSLEQEQMSQSAAITDSQRSVDRI VGLARVLYYLDQVEHPQRSKKPLLHKVLSKRRKRAVVACLRMAPLYNLPRHRAVNLFLQG YNKSWISAEDHSFEEKLVEDLARGRGVMELCGGNRGEEREVKECAKPIDPLLQLITLFSR SALTESSNLGNDGLYISYAAIMAKSCHRADDNCEKQEVESFEVKEMEKQKLLYQQARLHL HGASEMVLQTISASKGAMGATIAPTLKLGIALLNGGNPTVQQKMLDYLGQKRDVGFFQSM AGLMRSCSVLDLNAFERQNKAEGLGMAMDEHSGDKVMPDKEITCDLFRFLQLLCEGHNSD FQNYLRTQSGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEHGQHNFSKAIKVS KQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSRQIELLKELMD LQKDMVVFLLSMLEGNVVNGTIGKQMVDMLVESSGNVEMILRFFDMFLKLTDFTSSHDFR EYDPDQKGQISRKEFQKAMENCKRFSLTETNFLLSCTDKSEIVDYKAFVDRFHEPAKDIG FSIAVLLTNLSEHMPNDSRLRTFLELAECVLTYFQPYLGRIEILGSGKRIERVYFEISES NRTQWEKPQVKESKRQFIFEVINEGGEKEKMEMFVNFCEDTIFEMQLAAQISDTVGERYA GKEANEKIMVEDENEKRGMCFISQWWLLLTCLFSLKNLKSLMRMTLKDILLSTLCFVRSI LMAQVRCICVVFRTIAYVLYLVFVNGGLIEGAKGMRISDLFGGILEPTLDEVMDVPSGVN RLRKYSACFSSQGELREIGQVAAVTSQREVDVISDIFGLKVKKERGQYRLMTSDLTASLS DLFNISSRPTVSADFSQKHQRTKQFKTHTATEDNQEDENISELENTNRGNESDKTTRNEK VEAGWRVKRSSNKSKEAESHHSDLREMINTCNLSLLNYFARNFYNMRLLALFVAFAINFI LLFYKVTSLPASQEEDGVVTVVYSSGEDPPAAEYKTKGRDYFVLEESSGYMEPSLCFLAV AHTIISFCCIIGYYCLKVPLVIFKREKEVARRLEFDGLYVRRQPPEEDIKGQWDRLVINT PSFPSNYWDKFVKRKIMDKYGKLYGCEKISELLGLEQAALDFSSERNERKWLKRETAWGT LFSSIDMKYQIWKLGVVFTDHSFLYLAWYMAISVLGHYNSFFFAVHLLDIAMGFKTLRTI LSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSDDKDTQDMKCNDMLTCYMFH MYVGVRAGGGIGDEIDDPAGDEFEVERIFFDITFFFFVIIILLAIIQGLIIDAFGELRDQ QEQVKEDMETKCFICGVGSEYFDMVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQ ESYVWKMYQERCWEFFPVGDCFRKQYEDQL NT seq 14853 nt NT seq  +upstreamnt  +downstreamnt atgagagactctggagatgtagatgatgaattccagtttctacggacgggagatgaggtg gttttgcagagtaccttaacatcccaggaggaacatgtgaagctctgtcttgctgcagag ggatttggcagcagactgtgcaggctggagtccacgtcaaactgcaagaatgtaccgcca gatttgtctgtatgtggctttgtccttgcccagtgtctctctgtccgagccctgcaagag aggctggcacacagccagcacctggctgcagagattgaagctggaggaagccatcgtacc cttctttatggccaggcagtgttattccaacattcgtacagtggcatgtatctatgctgc ttgactgcatctcagtcttcaacagacaaacttgcttttgatgttgggctgcaagaggat atagcaggtgagacatgttggtggactgtacacccagcatcccgacagaggtcagagggt gagaaggtgcgtgttggagatgaccttatactggtcaatgtgtcctcagaaaggtatctg cacatgtcctttggtactgtatttgacaacagaagcttgagtgacagcctgattgtgaat gcagccttccagcagactctctggagtgttgctcccatctgctctgggggtggagtcgct caaggatacctgaaggggggcgacacattacggctgctccacagccacagtgacgcatgc ctgacagttccctcctcagagcagggggaggagctgcagaggatgatgcattatgaaact ggatccgtctccagccatgcccgctctctatggaggctcgagattctccgtgttgtttgg agtggtaggcatacatgctgggggcagcctttcagactgtgccatgttactactgggcgg tacctgggtctaacggaggagaaaggcctgcagctcatcgatcgggacaaagcggacatc gacacaacctccttctgtttccgttcctcgaaggagaagactgactctggcatgaagact ggtgctgatggtatggggatcccagagatcaagtatggagattccatgtgttatgtccag catgtttactctgggctgtggctcacctaccaatccactgacgccaattcttcacgcatg agattaactcagcgaaaggccattttgcacagtgagggtcatatggacgatgggctgaca ctgtctcgttctcagagggaagaatctcacactgccagactcattcggagtgctattctc ctctttactcgcttcatcaggaaactagatggatgtagccatcaaggaaccctacctcat gtcaccctgtcgatggagactgtgatgtgcagtctgcaggatctaataaaatatttccag cctccactggacgagctgggccatgaagctaaacagaacatcatgacagctgtaaaaagt cgccaaaacctgtttcaggaagagggtgtgatagttttggtcctcgactgtattgatcgc ttgcaccagtacagtagttcttctcactttgctgaagctgttcagtgtgagaagggagaa gagtgggagacgatcctcagccgtttctatgagctactggctgctttgatccgggggaac cgtgtgaactgtgcacatttctctggttctttggactggctgatcagcagactagaccaa atggaggcctcttctggagccttggaggttctacactgtatccttgtggaaagtcctgaa gcgctcaatgtcatcaaagaaggacacattaattcgatcatctcatttcttgaccagcat ggatgcaattataaggtactagaggtgctgtgctctctgtgtgtgtgcaatggtgtggca gtgcggtccaatcagaaccacatctgcgacaacctgctgtcagacagagacttgctgctc caaacacgtctggttaatcaggtcaccagtgtgagaccaaatatcttcctggctatgggg gatgattcagctcagcctcggaggtggtactatgagctggttgtagatcacgttgacccc ttcctcacacctgagcccactcacctgcgtgttggttgggcttgcactgagggcttctac cccagacccacaggaggagatggctgggggggaaatggggtgggagacgacctctgctcc tatggcttcgatgggcttcacctctggtctggctgtgtgggccgcagagtgaactctccc tggccccacctgctgaaaaatgacgatgtggtcagctgctgtcttgacctcacagctccc tgcatctcctaccgggtcaatggtctacctgtgcagggcatgctggaaaacttcagtgct catggtcttcttcatcctgtggtcagcttctcagctggagtcaaatttcggtttctattt gggggaagacatggtgaatttcgcttcttaccaccacctagttttgctccatgcacagag gcactgctccctagagtcaagctgaaggtacagccatgttggaaacacatcttggattat agaaaggggattaaagtgctcatcggccccgcagtacctgtcactccagttaccttcact ccaacaccagtggacatcagtaagatagatctgcccttacaacttgaggacatacgagaa aaaatggctgagaatatccatgaactgtgggtgacggacaagattgatcttggatggaca catggaactgttagagatgagggtaaaagacatgacccttgtattgtggagttctccaag ctgccggagcaggagaggaaccacaaccttcaggtggcccaggacacactcaggactctc actgctcttggattccaccttggtttgactgatgacaatgctgtggagagagtcaaatac atgagactagccaccaagtatgagcagcccggtggctacagacctgccccagtggacctg agccaggttactctgagctcgtctcatgaggacatggttaacatgctggcagagaatgat cacaatgtgtgggccagagagcgtatcaaacagggatggacatatggaccccagcaggat gtgaaagccaagcggagtccttacctcgtgccatacagccttcttgatgaaagaagtaag agagtgggtagggagagtgttagagaggccgtctgtaccctgctggcctacggttacagc ctggaacccctcaaccaggaacagaccacatcatcaaatgcacgtctcttctctgctgag aaatacacagtgttccgaccagataaatcctacgctgtgacccaggggaagtggtatttt gaatttgaggtactgacagcagggaagatgagagtgggctgggccagaccaggctgttgt ccagataaagaactcggctcagatgaccaggcatatgtctttgatggatctgaggctcag tggtaccaccagggcggcgaactgttgggccgtccatggcagagaggagatgtggtggga tgtttggtggacatggatgaatgcaccatggtggtcacgttgaatggagaagtgctgttt aatgacagaggatcagagctggctgcaaaggactttgatatcagagacggtgtgttgcca gtggtgagtgttgcagttaatcaggtggggaggctgaacctgggtcgccacatggactca ctgcagtactttgctgtgtgcggtcagcaggagggctttaagccatttgctgtcaacatg gccagagatccatctctgtggatgagttggggaagacctcactttacccccatactacct gatgatcacaattttaaggtcactaaaaccagtggttcagtggagtctgtatccagcctg agggtttctcagcagttgtttgcacaccgtggtggaggcagtgagatgggcttttaccgg ctcagcatgtctcttggctgtgctgctgtcctcacaagccctgcagcgaatgtgcttcca gtagcagccaacagccccgctccaagttcacatggaaggaaagagcaggaggaagtggac tctgactttgaagtgcttatgaagtcggctcacagctttgctggctcaagagacgagctc aaccataaggatcatagccaagacaaaacatccagattgaaacagcggttcttgctgaag aggactaaaccaggcctcgtcagcagcaactcatctgcacggcttctcgaagatgttgta gttgacaaagagatctgtgaccacctcatccagagctccagatattactactcagtgagg gttctcccaggacaggagccatttaatgtgtgggtgggctgggtgacctctgactttcat cataatgacatgacatttgacacagactatgtcaacactgtgactgtcaccctgggagat gacggtggtaaagtccaggaaagtgtgaagcggtgcagctgttacatggtgtgtgctgga gaagcaacaggtttgtctcagagccgaagaagtgcaggtttagaaattggctgtttgatc gacacggccactggtctgctctccttcacctccagtggagtggagatggccaccttctat caagtggaagccagcacaaaactgtttcctgccgtttttgtcaagccaaccacgagcagc atgtttcagtttcaactgggatgcattaagaatgtgatgccactgtcaacaggattgctt cgcagccaaagcagaaatgccactcctcagtgtcctccaaggattcaggttcagcatcta accccggtttcatggacaagagtaccagactgtgcattacaggtgttagtagatcgacca gatgaacatcatggctggagtgtccagtgctctgagcccctgcaagtcatgacccttcac atccctgatgaaaacaggtgtgtcgacattttggagttgtctgaactcgatgacctcttg aaatttcatcatcacacactcctcctctactgctctttgtgcacccttgggaacaccaga gtttgtcactccctctgcagttatgtggaccagtctcagatccttcatgccattcagaat cccaacctccctggcccaattcgatctgcattttaccagctccttactgaggtttacctc agcagccacacctcagcatgtctaatgatgaaccatgaatacattgtgcctatgacagaa cagaccagacaggtcaccctttatcccagccctgctaatggtggtcaacttcctgcttgc attcccaacactagtcttagcacatctcttaaaccacaaatgcacttctcaaccccatgt tttgtgacaagtgatgggatagaagcaggcgatgcagttaaaatagtctacacagacagc ccagaaatccccctggacatactaaagtgtctgaccatggagatgctgattgcaggagta tgggctgtgggtcagggtgtgagggatcctgtaggaggcagcattgagcttctgcttgtt cccttaattaaactgttctataccctgctggtaatgggtgtatttggtaataaagatctc ggcatagttttgagtctgatagagcctggagttttctccatagatgctaaaacccctgag gaggaagaggaagaagaagcaatttatgctaatgaaaaaggatggaaaaacagcaacaag acagaatatgacactccttcacaaggactccttcagatgaagcttccagaagctgtcaaa cttgagctctgccatttgttgtcctatctgtgtgatagccaggtgcgccacagggtggag gctgtggttgccttctctgacactttggtggggcagctacaggagaaccaacgttttcgc tacaaccaggtcatgcaggcactcaacatgtctgctgccttaactgcacggaaaaccaag gagttccgctcccctccacaggaacagatcaacatgctgctgaacttcagagaggatgag cagcaggagcattgtccatgtccagtgaaaatccagcagcttctccaagactttcatcac ctcctgagcacacactgtggcattgaattggacagtgagtcagaggatgaggaggatgct gagatgccagtaaaagattggctgctcagtctagtggtgagagcctttgaagtgaggaag tcttccacacaggtagaggagagtagaccgcggagtgccaagtccctcaaaaagctgatt tctgaaacaatggtgcgctggactgaagagtgtgagatagaggaccctgaacttgttaga gcggtcttctcattgcttcaccgccagtgtcagggccttgggggtcagatggaaggacca ctctgcagagcctatacaatcagccaggcttctgtggaagatacgatgatgctactgtcc tccctggctcaaatccgctctctccttagtgtccgcatggggaaagaggaggagaagctg acgatcaggaggcttggagacatcatgaataataaagttttctaccaacaccccaaccta atgagggtattggggatgcatgagaccgtgatggaggtgatggttaatgttctcggagaa ggggaatcgaaggagattacatttcccaagatggtggccagctgttgtcgattcctttgt tacttttgtcgtatcagccgtcacaatcagggagcactgtttgaccatctcagctacctt ttggaaaacagcagtgttggactggcttcaccgtccatgcgtggagccactcctctagac gtggcagcagcctctgtgatggataataatgaactggccttagcactaaaggaacctgac ctagagaaggtggtgcagtatctggctggctgtggtcttcagagctgcccgttgctactg gagaaaggctaccccgatattggatggaacccggtggagggcgagcgttacttggattac ctacgttttgctgttttctgcaacggtgagagtgtggaggaaaatgcctacgtggtgttg agattgctgattcgtcggcctgagtgttttggccctgctctgcgaggtgatggcgggaac ggtcttctagcagccatggaggaggccatcaagatctctgaggacctgtctatggacgga ccctacaccactttccagtccaacagaacacaagatattgtccaggaccacgttgatgac gaccttgttcacatgggacatgccatcatgagcttctactcagcccttattgacttgctg gggcgctgtgctccagagatgcatttaattcaaggaggcaaaggagaagccatccgcatc cgcgccattctccagtcactcgtccccattcaggatcttgagggagtcatcagcatctcc tttcaagtcccttcagtgtcaaaagatggtctggtggttgagtctgacctgtctacagtt ttctgcccagaccataaggcagctatggttctgttccttgaccgggtttatggcatcgag agcaggcactttttcctccggctgctagaagttggttttctgcctgaccttcaggctgcc gtctcacttgacactgcggatttgggatccactgacatggctctggccctcaacagatac ttgtgtacatctgtgctccccctgctcatcaaatgttcatctctcttctgtggtttggac gaccataccttgttggtggattctctcattcaggcagtctacagcctctccagagctctc agtttgaccaaggctcagagagacattacagaggagtgtttgttggctgtgtgcagtaaa ctgcaaccatccatgatgcagcctcttctacgtcgccttgtccttgatgttcctcatctc acagaccacagcaagatacctctaaggctcttgaccagtcactatgaggagaggtggaag tacttgaaaaccggtgggcagggtgaccagaattcagcctctgaagtggagctgcacctg tccactacattgttctggggagtgttaaaggctttggcaaaaaggccctatgagcctcag ttattcaagctttgtatccggtgtctggctgcagtggccaaggcccttcctcctgaccac atggactccgtgtctccaactgagagaaaatctttcatggacacagatggacactttgac ccccagcctgtcgatacctccaacatatcggtaccagagagactggagtttgtagtgaac aagtatgcagagcatactcatgagaagtggtcactggacaagtttgcaaacggctgggtt cacggggaacagctctgcgagaacagcaaggttcaccctctcctgaagccttacagggct ctggctgagaaggagaaggaagcataccggtgggctattaaagagacaataaagagcatg ctggcctttggatggaatatagagaggactaatgaaggagatgcgtctggcgcacatacc tgtaggcggagaatctctcagtctggacagctgtcttttgaaggagcatcaaccttcagc ccaaaaccaatggacgtgagcagcatcaccttatcatgggagcagtgtgctatggctgaa catttagctggaaactatcacaatgcctgggctaagaggaagaaatccgaacttgaaagt aaagtgggtggccattcaatgcttgtaccttatgacacactgactgcaaaggagaagacc aaattcagagaaaaagcccaggacatccttaagtttcttcagctcaatggctacactgtg tggagggacaggaagactgtggacatggactttccagccacagccaactgcttcagctac accctccttcagaagctgctgcgtcacactgaggaggttcaagagcacatgttggagctg gaggtgatgcaagccagaggacagatgtctaaaggggagaaaggcccacaccagcaacaa atacatttcttttccaaggtcatccttcctcttctggaagaatttgtgaaaagccaccaa atgtatttcctgtccacttctctgtgctcgagtggaaacagagcctatgccacaaaaaaa gaaaaggagatgattgcttgcctcttttgcaaacttgctgccttagtgagacacagagtc tcactctttggaaatgacgcttcatcagttgcaagctgcctccacgttttggctcaagct ctggatgccaggatgttgatgcagttcgcttcagattctatccaagcatctctgcactcg ttctttgaggcagcagcagctgatctggagatgaccgtggaaaacctgtctgtcgcgttg gtctctgtgcctcagggcaggagtcaacaagctagaggagtagcgaaggttcttagctac acaacctccatacttcttcccactcttacttccctctttcagcatcttggcaaccagaac tatggagtagatatccttgtgggtggcatccaggtgtcctgttacagaatcatcaacagc ctctactcacttggcaacagtagcaacgtctacatggaggggcaaaagccagcagcaggt gcgtgtctggcagccctgactggtgcttttcctctttgttacctggagccagccctcaat caaaacaacccttattccatttacaacacccagagtgttactgagagagaggacctgggg ctaccagatgaggtggtggatgcgtgtcctctgctgccttctctagaacaggccctgagt gaagtggagaagttggcaggtgctggagctggagctcgccagtcccactatatccatgtc actgaggtcaccttgcccatgctgtgcagctatatgtcctgttggtggccctggggccca gagggccagtcgggcctcccgatctgctcctccgtcactcctaagcatgtcagtgaccta cttggccacatccttcgcatcatccacaaccatgtggggactagccagggtgactggatg aagcagctggcagtattttctcagccaattatatttaaagcttgccctgagctgctaaag agccatttcttgccattgatggagaagttgaggaagaaagcggagtgtgtgctgctggag gaggagcagatgaaatcggaggggtggtgtgcctcagaggcggagctgaagatacaggag aagttcactgtgctggtgcgagacctctatgccttctatccccttctcattccattcatg gattcttatcgagccagctggttgaaagtgtcaaaccctgaggctgagcagctgttcagc atggtggcagaggtctttatattctgggccaaatctcataatttcaaatgggaggaacag aactatgtggtacagaatgaaattaacaacttggccttcttggtcaataatgacaaaatg tccaagtacaaccatgagaagagtatgaaaagaaagggggaccgatattccatgcaatcc tctcttattgtggcttccatgaagagactgcttcccgttggccttaggattttttttcca aatgagcagaaccttattatgtcggcaaagaacagcttcactcagaacaagaccgaagat gagatttgtgagcaagttttccatggacttcttcagagtcaggcatcaaacagcttggag caggaacaaatgagccagtcagctgccatcactgactcccaaaggagtgtagacaggatt gtgggattagctcgtgttctttattacctggaccaggtggaacacccacagagaagtaaa aaaccattgttgcacaaagtcctgtctaaacggaggaaacgagcagttgtggcctgccta aggatggctcctctctacaaccttccgaggcacagagctgtcaacctgttcctccaaggc tacaacaaatcctggatatcagctgaggaccacagcttcgaggagaagcttgtggaggat ttagctagaggacgaggagtgatggagctgtgtggaggcaacagaggagaagaaagggag gtgaaagaatgtgccaaaccaatcgatccccttctacaactcattacactcttcagtcga agcgcccttacagaaagcagtaaccttggaaatgacggtctgtatatatcctatgctgct ataatggccaagagttgccacagagcggatgataactgcgagaaacaggaggtggaaagc tttgaagtgaaagaaatggagaagcagaagttgctgtaccagcaggccaggttgcatcta catggagcttctgagatggtccttcaaactatcagtgccagcaaaggagccatgggggcc acgattgctcctacactgaagctgggcattgctcttctcaatggaggaaatcccacagtt caacagaaaatgctggattatctcggacagaagagagacgttggcttttttcagagcatg gcaggactcatgcggtcatgtagtgttctggatctaaatgcatttgagaggcagaacaaa gcagaaggattaggcatggccatggacgagcactcaggagacaaggtgatgcctgacaaa gagataacctgtgacctatttcgctttctacagctgctctgcgaaggacacaactcagat ttccagaattacttgagaacacaatctggcaacaacaccactgtgaacatcattatttcg actgtggactatttactgagagtgcaggaatctatcagtgacttctactggtactactcg ggcaaagatgtgattgatgaacatggccagcacaacttttccaaggccattaaagtatcc aaacaggtcttcaacacacttactgagtacatacagggaccatgtactgggaaccagcag agtcttgctcacagtcgtctgtgggatgctgttgtgggattccttcatgtctttgcccac atgcagatgaagctgtcacaggattcgaggcaaattgagctcctgaaagagctgatggat ttacaaaaggacatggttgtgtttttgctttcaatgttggaaggtaatgttgtcaatggg acaattggaaagcagatggtggacatgctggtggaatcatcaggcaatgttgagatgatc ctcaggttttttgacatgttcctcaagcttacagacttcacctcctcacatgacttcaga gagtacgaccctgatcagaagggccagatatccaggaaggagtttcagaaagccatggaa aactgcaagcgtttctccctcactgagaccaatttcctcctctcatgcacagataaaagt gaaatcgtagattacaaggcctttgtggatcgcttccatgagccggccaaagacatcggc ttcagcattgctgttctcctcaccaatttatccgaacacatgcctaacgactcaagactg cggactttcttggagctagcagagtgcgtcttaacttattttcagccttacttaggacgc attgagatcctgggcagcgggaaacgaattgaacgcgtctactttgagatcagtgaatcc aaccgcacacagtgggagaagccacaggtgaaagagtctaagaggcagttcatttttgag gtcatcaatgagggtggagagaaggagaaaatggagatgtttgtcaatttctgtgaggac accatctttgagatgcaacttgcagcgcagatatctgacactgtgggagagaggtatgct ggaaaagaagcaaacgaaaagatcatggttgaagatgaaaatgaaaaaaggggaatgtgt ttcatctctcaatggtggctgctgctgacatgtcttttttctttgaaaaacctcaagtcg ttaatgaggatgactctgaaggacatccttttgtcaactctttgctttgtaagatcaatt ttgatggctcaggtgcggtgcatttgtgttgtatttcgcaccatcgcatatgttctatat ctggtctttgtcaatggtggtctcatagaaggagccaaaggcatgagaatatcagacttg tttggcggtatccttgagccaactcttgatgaggtcatggatgtgccaagtggtgtgaat cggctgagaaagtactcggcctgtttctcctcccagggagaattgagggagattgggcag gtggcagctgtgacctcccagagggaggtggatgtaatatcagacatattcggcctgaaa gtgaagaaggagagaggtcaatacagacttatgacatcagacctcactgccagtctgagt gacctgttcaacataagctccaggccaactgtctctgctgatttttctcaaaagcatcag cggacgaagcagtttaagacccacactgccacagaggacaatcaagaagatgagaacatt tctgaactggagaacacaaacagagggaatgaatctgataagacaaccaggaatgagaaa gttgaggcaggatggagagtaaagagatcctctaataagtcaaaggaagcagagagccat cattctgatcttagggagatgataaacacttgcaacttgagcctgctgaactactttgca aggaatttttataacatgcgtttattggctctctttgtggcatttgcaatcaacttcatc ctcctcttctacaaggtaacatcgttacctgcatcacaagaagaggatggagtggtcaca gttgtttacagctcaggagaggacccccctgctgctgaatacaaaacaaagggcagagat tattttgtgctggaggagagcagtggatacatggagccatctctctgcttcttagctgtc gctcacacaatcatctccttctgttgtattattggttattactgcctaaaggtacctttg gtgattttcaaacgtgagaaggaagtggcacgacggctggagtttgatggactgtacgtg agaagacagccccccgaggaggatatcaaagggcaatgggaccgactggtcatcaataca ccatcatttccaagtaattactgggataaatttgtgaaaagaaagataatggataagtat ggtaagctttatggctgtgagaaaatcagtgaactcctgggattggaacaggctgcttta gacttcagctctgagagaaatgaaaggaagtggctcaagagagagactgcctggggtaca ctattttcgtccattgacatgaagtatcaaatctggaaacttggagttgtgttcactgac cactccttcttgtacttggcttggtacatggccatatcagttctgggtcattataacagc ttcttctttgctgttcacctgttggacatcgccatgggcttcaagacgcttcgtaccatc ctttcctcagtcacgcacaatgggaaacagttggtcctgactgtcggcctgttggcagtt gtggtgtatctgtacactgttgtggccttcaacttcttcaggaaattttacaacaaaagc gacgacaaagacactcaagacatgaagtgcaatgacatgcttacttgttacatgttccac atgtatgtgggagttcgtgcgggcggaggcatcggtgatgagatcgatgaccccgctgga gatgagtttgaagtggagcgtattttctttgacatcacctttttcttctttgtcatcatt attcttctggccatcattcaaggcttgataatcgacgccttcggggaactccgtgaccaa caggaacaggtgaaggaggatatggagaccaaatgttttatatgtggagttggaagtgaa tattttgatatggtccctcatggctttgagacacacactctgcaggagcacaacttggcc aactatctattttttctgatgtacctcattaacaaggacgaaactgaacacacggggcag gaatcctatgtgtggaaaatgtaccaggagcgttgctgggaattctttcctgtgggagat tgtttccgtaagcaatatgaggatcaactatag

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