Streptomyces solisilvae: I1A49_05870
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Entry
I1A49_05870 CDS
T07406
Name
(GenBank) SDR family NAD(P)-dependent oxidoreductase
KO
K15670
rifamycin polyketide synthase modules 1, 2 and 3 [EC:
6.2.1.74
]
Organism
ssoi
Streptomyces solisilvae
Pathway
ssoi01051
Biosynthesis of ansamycins
ssoi01052
Type I polyketide structures
Brite
KEGG Orthology (KO) [BR:
ssoi00001
]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
01052 Type I polyketide structures
I1A49_05870
01051 Biosynthesis of ansamycins
I1A49_05870
09180 Brite Hierarchies
09181 Protein families: metabolism
01008 Polyketide biosynthesis proteins [BR:
ssoi01008
]
I1A49_05870
Enzymes [BR:
ssoi01000
]
6. Ligases
6.2 Forming carbon-sulfur bonds
6.2.1 Acid-thiol ligases
6.2.1.74 3-amino-5-hydroxybenzoate---[acyl-carrier protein] ligase
I1A49_05870
Polyketide biosynthesis proteins [BR:
ssoi01008
]
Polyketide synthase (PKS)
Modular type I PKS
cis-AT PKS
Rifamycin PKS
I1A49_05870
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ketoacyl-synt
Acyl_transf_1
Ketoacyl-synt_C
KR
AMP-binding
PP-binding
KAsynt_C_assoc
PKS_DH_N
CurL-like_PKS_C
SpnB_Rossmann
Thiolase_N
RhiE-like_linker
adh_short
AMP-binding_C
Epimerase
PS-DH
PKS_DE
ACP_syn_III
GDP_Man_Dehyd
SDR
Polysacc_synt_2
Motif
Other DBs
NCBI-ProteinID:
QPI54529
LinkDB
All DBs
Position
complement(1533510..1550021)
Genome browser
AA seq
5503 aa
AA seq
DB search
MLRTELIRPIQDLLTEQSRRFGTKTAYSDARRAISYAELETRTRRLAGHLAGLSLLPGDR
VAMFLGNRVEMVESYFAVVRASGIGVPVNPHVSQAELEHLLTVSGSQVVITDTAHLPLLR
RLNPGPSPLTVLVVGEDPVPAGSLSYERFATTEPGTPARDDHGLDDIAWMLFTSGTTSNP
KGVLATQRNCLWSVAASYVPALGLTAEDRVLWPLPLFHSLSHIVCVLAVTAVGATARITD
GHSAEDVLEQWGQERSTVIAGVPTLYHYLVRASKAPGFTAPELRVGLVGGAVTTAALRHS
VEDVFGAPLIDAYGSTETSGSIAINWPTGARVEGSCGLPVPGLALRLVDHRTGLDVPDGT
EGEVWVRGPNIMAGYHNQPEATAEALRDGWFHTGDLARRDRDGYLTITGRLKELIIRAGE
NIHPVEVEDVLRMAPGVADAAVVGKPHDVFGEVPVAFIVPAPGGFDPARALALCRERLSY
FKVPEELYEITRIPRTATGKVTRHRLLDGPARLRAVGNAYHDALFRTKWIPQPSAPRPSA
SPLSVARPRPGRWVLLGRRLPELAGLSRATGTEPAGRLDTADDVAGLRAAVATGGAPPAV
ALLPTPADTTEGVLREVETWLASAELSDALLVVLTRSAMATTTGEDVRNPEQAALWGLVR
SLQAAHPGRLAIVDLDEPEDELKGESDGEPDDEACVDALVAAVASGEPQSAVRSGVVLLP
RLERVALDRGLDGGPEAGADGGGDTERVSFVAFDPDGTAVVTGVDTRRGAVIARHLATGY
GIRRLLLIAPPGQGGLAGELCAQLTDAGADVQLVECDLDNRTKLRRALAKAKSPLSVVVH
AWEAVDEPSDGRVAAEARTLHELTRNADLTAFVLSSSTKGLLGAAGETTEAASAAFLDAY
AQHLRMRGTPARSIAWGPWQGETDETAGALSRQQALAALDAALTVDQAQLAAMKLDSTAV
PTGTTSPLLKDLLDIPARAATVDDAVTLALRERLMESHEAERDRLLTELVREHLADLLGL
ADKQAVEPDRAFTDLGLTSVTVVELRNRLSEATGLRLPATSAFDHPTPVALGSMLRRELL
GGSTAVASGLSTSLASAPVSVPASAPAVVAVDDPIAIVGMACRLPGGVGSPEELWELVLA
GGEGIGEFPADRGWDLEKLFDPDPDHAGTSYARRGGFLYDAGEFDADFFGISPREALAMD
PQQRVLLETSWEALERAGIDPVSLRGQDVGVFAGMMHQNYGVGAGEGTDAPVGLEGHLMT
GTSASVVSGRVSYVLGFEGPAVTVDTACSSSLVALHLAAQALRAGECSMALAGGVTVMAG
PDSFVEFSRQRGLAVDGRCKSFSASADGTGWAEGVGVVVLERLSAAERNGHRVLAVVRGS
AVNQDGASNGLTAPNGPSQQRVIRRALAGAGLVAADVDAVEAHGTGTPLGDPIEAQAVLA
TYGQDRPEGRPLLMGSLKSNIGHAQAAAGVAGVIKMVLALRYGVLPRTLHVDEPSRQVDW
SSGAVELLTEERVWPEVGRPRRAGVSAFGVSGTNAHVILEQAPDRPESGVPVPEAPGGVV
PLVVSGRGGAGLRGQARSLLDFMEHHPDVRVVELGAALASGRAALSDRAVVVAGDRGEAL
TGLAAVAEGGGPGSADVRGRVAFVFPGQGAQWVGMGAELLESSPVFAEGLRECAEALDPL
TGWSLLDVVRGVGGAPGLDRVDVVQPVSFAVMVGLARVWLAAGVVPSVVVGHSQGEIAAA
CVAGGLSLVDAVRVVVLRSRAVAAGLSGRGGMVSLAVGVAVAEGLVERWGGRVEVAAVNG
PSSVVVAGEPDALRELVLECGGAGVRARWVDVDYASHTAQVEAIEDELARSLSQIRPVSS
RIPFFSTVEAGWLDTAELDAGYWYRNLRSTVRFGPSIERLLEADFRAFVEVSAHPVLTMS
IEAAAEQADAGPVVATGTLRRDQGDMRRVLTSLAEAYVRGVPVDWTALFDDIPAHAAPDL
PTYAFQRQHYWLKSGRRTGEVTAVGLAGAQHPLLGAWVELPDMDGALFTSRLSLSTHPWL
ADHTVAGAVVLPGSAFVELAVRAGDEVGCGVVDELLIEAPLVFVEGMSVWLQVVVDGADD
SGRRRLTVHSRRQGHGSDGADWTRHATGTLAQAATTTAPEIDLAPWPPTGATPIDVDQVY
GDLARDGRGIGPAFRVLRSAWTRGADVFVEVELADDQQPDTTRYALHPALLEAVCHADTH
RWASALPATYRAVSLSATGASALRARISPDGQGGVTLELADSAGDAVGSVGSVTSRPLPA
EGLASGAGTAPHDALFQVEWFPLPVVSAAPALATSDPVMVTSPAELTTFAAQGDVPPFVR
AELTDTTLGLRALTSQALEWVQAWLAAPDSGSRLVIVTREITDPICAAVWGLVRSAQSEA
PDRLVLVAMDEDDASRALLPAALATGEPQIAINAGAASVPRLVRAAPDEEAPHRPLDPAG
TVLITGGTGALGRLLARHLAAEHGVRNLLLVSRRGPAAQGVAELESELAALGASVRTVAR
DIGDRTAVADLLDKIPADAPLTAVVHTAGVLDDGMVTAMTPGRLDTVLRPKADAAVILHE
LTCDMDLAAFVMFSSAAGVFGNPGQANYAAANAFLDALAERRGAAGLPATALAWGHWALS
SEMTAHLTTSDLRQHTRRFGMTSLSEETGLALFDAGLRSATPALVAARLDLAGLRADAAA
TPVVPLLHKLVPPGRRVVSPTVSPRTDLVRRLESSDPAERERTLLDLVTHHAAQVLGHSS
AEGIAARRAFRELGFDSLTSVELRNRLNAATALRLPSTLLYDHPSPLALTRHLHAELLGA
PSAPAAPQPAGEASDDGIAIVAMSCRFPGGVSSPEDFWRLISEGGDAVGDFPDDRGWDLS
ALYDSDPDHPGTSYVRHGAFLPDAAGFDADFFGISPREALAMDPQQRLLLETSWEVFERA
GIDPTTLGGSAVGVFTGMNTQDYAIRLRHVPHEVEGHRITGVSAAVLSGRVAYTLGLEGP
AVTVDTACSSSLVALHLAAQALRAGECSMALAGGVTVMAGPDAFVDFSRQRGLSVDGRCK
PFAASADGTGWAEGVGVLLLERLSDAERNGHQVLAVVRGSAVNQDGASNGLTAPNGPSQQ
RVIRQALASAGVAAADVDVVEAHGTGTALGDPIEAQAIIATYGQDRDRPLWLGSVKSNIG
HAQAAAGVAGVIKTVMAMRHGVLPRTLHVDAPTPEVDWSAGSVALLTEERPWPDAERPRR
AGVSAFGVSGTNAHVIVEQAPATVAAPAPEDPDTIPAVPWVISARSADALHGQAARFAEF
ARTHPELDPGDIAHSLITTRAALEHRAVVVGTGRAELLSGLEAITGPTDGPVARGVRSPG
RLAVLFTGQGSQHAGMGRELHARYPVFRDAFDAACARLDRHLVDAGHTTRPVRDVVFAQP
GSPEAELLDRTVFAQAGLFALEAALFRLYESWGVRPDILAGHSVGELIAAHVAGVLSLDD
AAALLAARARLMQALPGGAMVALNAPEAMVRSLLADAPGAVDIAAVNGPASVVVSGDEDA
VVAVERRCAAKGYRTKRLRVSHAFHSAHMDGMLDAFRAIAAGLTYAPPAVPIVSNVTGEL
ATTDQLCSPDYWVEHARRTVRFLDGVRTLHTRDVTTFLELGPGGVLTAMAQEALGDGADP
AMFVATVHGEQADPLAAVAALARLHVRGVPVDWTALLPGTSRPRVDLPTYAFQHRRYWPD
APASDALLSDAAAPGALVTDSGTAGELRPADRSLPEAAALQGGGATPFVERLMAGTEAER
HRLVLDLVLTSSAAVLGHDDASAIDGERAFQDLGFDSLNVVRLRNRLRELTGAELPTTLA
FDHPTPAALASFLHARLLGQHTGRTGSARPAGDPTEPIAIVGMACRLPGGVASPEDLWEL
VLAGGEGIGEFPADRGWDLEKLFDPDPDHAGTSYTRRGGFLYDAAEFDADFFGISPREAL
AMDPQQRLLLETSWEALERAGIDPVSLRGQDIGVFAGMVNHDYTSRLDTAPDGSEGYLMT
GGAGSVLSGRVSYVLGFEGPAVTVDTACSSSLVALHLAAQALRAGECSMALAGGVTVMAG
PDAFVEFSRQRGLAPDGRSKSFAAAADGTGWAEGVGVVLVERLSDAERNGHRVLAVVRGS
AVNQDGASNGLTAPNGPSQQRVIRRALAGAGLVAADVDAVEAHGTGTPLGDPIEAQAVLA
TYGQDRDRPLLMGSLKSNIGHAQAAAGVAGVIKMVLALRYGVLPRTLHVDEPSPQVDWSS
GAVELLTEQRVWPEVGRPRRAGVSAFGVSGTNAHVILEQPLDVPDSELPAPQLPGGLALL
PVSARGEGALRAQAQRLLSFLDQRPDQDLGELSLALGCGRAGLSDRGVVVAGGREELLVG
LGGLVRGEGGVGVVSGSVVRGRLGVLFAGQGCQRVGMGRGLYEVFPVFRDAFDAVCEVLD
RELGAGGVVGSVREVVFGGGGLLERTVFAQAGLFAVEVGLFRLVESWGVVVDVVGGHSVG
EVTAAYVAGVLSLEDAAVLVAARGRLMEALPEGGAMVAVAAGEEVVRPLLVSGVDIAAVN
GPAAVVLSGDEEPVLRVVRDLSDQGCRTRRLAVSHAFHSARMEPMLEEFREAIADLSFSA
PVIPLVSNVTGRLADAEVVCSPEYWVEHVRSAVRFADGVRALADYGVGTYLELAPDAVLS
AMVGDCLPEGSAAESVVVPSLRREGDEPRALMTAIAQLHVAGVPLDFGALFGGAVPPAHL
PDLPTYAFQRAHYWLHDTPPASPQGLATASDDTDARFWAAVEREDLGSVAEALELADGED
DRAALDAVGGALGVLSDWRRKRGEKSAADRLRYQATWKPLPGAASGIPNGTWLVVLPYGC
QDDDYAARVVPALNRQGLCTTNLRLDGAETADRTALAETLRSALADHEDFGGVLSLLALD
QRIRPGSATLTEGVAGTLTLVQALGDLGSSGSVGSASSLSSGHRLYCATRGAVSVGAADG
LIAPEQAAVWGLGLAVALEQPDRWGALVDLPEVFDDRAARALLGALADPGDEDQLAIRTT
GAFVRRLRSHPLPTDVAKPEWRPRGTVLVTGGTEGLGRHAARWLAGAGAEHLVLTVQSDP
EAPHVVALRDELSDQGAKVTVCPADLTDRDAVERLLTGPAAYPELSGVVHTADLARVAQA
DATGADELAETLAAKVDGLLHLDALLADRDLDLFVAFSSVASVWGGGGQGLIGAANAQLD
ALVERRRARGLAATSVAWGVIDGFGVAADATAQEQLRRRGVLPMAPEAAMAALTHAVRHD
DTLVAVADIDWSAFVPAFTSLRPSPLIADLPGVQEIVDSLRPDDATDESVSEFLRDLAGA
SDAERERALMKVVRENTALALGHSGVEAVKPQRAFQEMGFDSLAAVNLRNTLGAALGTQL
PATLVFDYPTPTALVEYLRTELLGDQGEDEITEADEEEIRRVLAAVPLSRFREAGVLDAL
RSLARTAAAAPDGSGSSADEELDLIDGMDIAGLVQRAFDGTQL
NT seq
16512 nt
NT seq
+upstream
nt +downstream
nt
atgctgcgcaccgaactgatccgcccgatccaggacctcctcacagagcagagccgccgc
ttcggcaccaaaaccgcctacagcgacgcccgtcgagccatcagctacgccgaactggag
acgcgcacccgccggctcgccggacatctcgccggactgagcctgctgccgggcgaccgc
gtcgccatgttcctcggcaaccgcgtcgagatggtggagagctacttcgccgtcgtccgc
gccagtggcatcggcgtcccggtcaatccgcatgtctcccaggccgaactggagcatctg
ctcacggtcagcggcagccaggtcgtcatcaccgacaccgcacacctgccgctgctacga
cggctgaaccccgggccgagtccgctgaccgtcctggtggtgggggaggacccggtcccc
gcgggcagtctgtcgtacgagcggttcgccaccaccgagccgggcaccccggcccgcgac
gaccacgggctcgacgacatcgcctggatgctcttcacctccggcaccaccagcaacccc
aagggcgtgctcgccacccagcgcaactgcctctggtcggtcgccgcgtcgtacgtgccc
gcgctcggcctcaccgccgaggaccgtgtgctctggccgctgcccctgttccacagcctc
tcccacatcgtatgcgtgctggccgtgacggcggtcggggccactgcccggatcaccgac
ggacactccgccgaggacgtgctggagcagtggggccaggagcgctccaccgtcatcgcc
ggagtccccacgctgtaccactacctcgtccgcgcctccaaggcgcccggattcaccgcc
ccggagctgcgggtgggcctggtcggcggcgccgtgaccaccgcggcgctgcggcactcg
gtcgaggacgtcttcggagccccgctcatcgacgcgtacggcagcaccgagacctccggt
tcgatcgccatcaactggccgaccggcgccagggtcgagggctcctgcggactccccgtc
cccggtctggcgctgcgcctggtcgaccaccgaaccggcctggacgtccccgacgggacc
gagggcgaggtgtgggtccgcggcccgaacatcatggccggctaccacaaccagcccgaa
gccaccgccgaggcgctgcgggacggctggttccacaccggagacctcgcccgccgcgac
cgggacggctatctgacgatcaccggccggctcaaggaactcatcatccgcgccggggag
aacatccaccccgtcgaggtcgaggacgtcctgcggatggcgcccggcgtggccgacgcg
gccgtggtcggcaagccgcacgacgtattcggcgaagtccccgtggccttcatcgtcccc
gcacccggcggcttcgaccccgcccgggcgctcgccctgtgccgggagaggctctcgtac
ttcaaggtccccgaggagctgtacgagatcacgcggatcccgcgtaccgcgaccggcaag
gtcacccggcaccggctgctggacggcccggctcggctgcgcgccgtgggcaacgcctac
catgacgcgctcttccggacgaagtggattcctcagccgtccgcgccgcggccgtccgcc
tctccgctgtccgtggcgcggccccggcccggccgttgggtcctgctcggacggcggctc
ccggaactggccggcctgtcgcgggccaccggcaccgaaccggccgggcgcctcgacacg
gctgacgacgtggccggactgagagcggcggtggccaccggaggcgccccgcccgccgtg
gccctgctgccgacccccgcggacaccaccgagggcgtcttgagggaagtcgaaacgtgg
ctggcctccgccgagctgtccgatgcgctcctggtggtcctcacccgaagtgccatggcc
accaccacgggcgaggatgtgcggaatccggagcaggccgcgctgtgggggctggtgcgc
tccctccaggccgctcatcccggccgcctcgccatcgtggacctcgatgagccggaagac
gagctgaagggcgagtcggatggtgagccggatgacgaggcgtgtgtcgatgcgctggtg
gcggcggtggcctcgggcgagccccagagcgcggtgcgctcgggcgtcgtgctgctgcca
cgccttgagcgcgtggccctggacagggggctggacgggggcccggaggcgggtgcggac
gggggcggggacaccgagcgggtctccttcgtggctttcgaccctgacggcaccgcggtc
gtcaccggagtggacacccggcgtggcgccgtcatcgcccggcatctggcgaccggctac
ggcatccgtcggctgctgctgatcgccccgccggggcagggcggtctggccggtgagctg
tgcgcacagctcaccgacgccggagccgatgtccaactcgtcgaatgcgacttggacaac
cgcacaaaactgaggcgggcgctggccaaggccaaaagccccttgagcgtcgtcgtacac
gcctgggaggccgtggacgagccgtccgacggacgagtggcggccgaggccagaacgctg
cacgagctcacccggaacgccgacctcaccgcgtttgtgctgtcctcctcgaccaagggg
ctgctgggcgcggcaggcgaaaccaccgaggccgcctccgccgccttcctcgacgcctac
gcccagcatctgcgcatgcggggcacaccggcccggtccatcgcctgggggccgtggcag
ggcgagaccgacgagacggccggtgctctgagcaggcagcaagcgctcgcggcactggac
gccgcgctgaccgtggaccaggcccaactcgcggcgatgaagctcgactcgaccgccgta
ccgaccgggacgacctccccgctgctgaaggacctgctcgacataccggcccgcgccgcc
accgtggacgacgccgtcacgctcgccctgcgggagcggctgatggagtcgcacgaggcc
gaacgggaccggctgctcaccgaactcgtccgagaacacctcgccgacctgctgggcctg
gccgacaaacaggccgtcgagcccgatcgggccttcacggacctgggcctgacctcggtc
accgtggtggagctgcgcaaccggctgagcgaggccaccgggctccgcctgcccgccacc
tccgccttcgaccaccccacaccggtggcgttggggagcatgctgcggcgggagctgctc
ggcggtagtacggcagtggcatcggggctgtcgacctccctggcttcggccccggtttcg
gttccggcttcggccccggcggtggtcgcggtcgatgatccgatcgcgatcgtggggatg
gcgtgccggttgccgggtggggtcggctcgccggaggagttgtgggagctggtgctggcc
gggggtgagggcatcggggagttcccggcggatcgggggtgggatctggagaagctgttc
gacccggatccggatcacgcggggacgagttatgcgcgtcggggcggatttctctatgac
gcgggggagttcgacgcggacttcttcgggatctcgccgcgtgaggcgctggcgatggat
ccgcagcagagggtgctcctggagacgtcatgggaggcgttggagcgggcggggatcgat
ccggtctcactgcggggccaggacgtgggcgtcttcgccgggatgatgcatcagaactac
ggagtcggcgccggcgaggggacagacgcaccggttggtctggaaggccatctgatgacc
ggcacctccgcgagcgtggtgtcgggtcgggtgtcgtatgtgttggggttcgaggggcct
gcggtgacggtggacacggcgtgttcgtcgtcgttggtggcgttgcatctggcggcgcag
gcgttgcgggcgggggagtgctcgatggcgctggcgggtggggtgacggtgatggccggg
ccggactcgtttgtggagttctcccgtcagcgcggacttgctgtcgatggccggtgcaag
tcgttctcggcgtcggcggacggcacgggctgggccgagggcgtgggtgtggtggtgttg
gagcggttgtctgctgcggagcggaacggccatcgggtgttggcggtggtgcggggcagt
gcggtgaatcaggatggtgcgtcgaatggtttgacggcgccgaatggtccgtcgcagcag
cgggtgattcggcgggcgttggctggtgcgggtcttgtggcggcggatgtggacgcggtg
gaggcgcatgggacgggtacgccgttgggtgatccgatcgaggcgcaggcggtgttggcg
acgtatggccaggatcggcctgaggggcggcctttgttgatggggtcgttgaagtcgaat
attggtcatgcgcaggcggctgcgggtgtggctggtgtgatcaagatggtgttggcgttg
cggtatggggtgttgccgaggacgttgcatgtggatgagccttcgcggcaggtggattgg
tcgtccggtgcggtggagctgttgaccgaggagcgggtgtggcctgaggtgggtcgtccg
cgccgggccggggtgtccgcgttcggggtcagtggcaccaacgcccatgtgattctggag
caggctccggaccggcctgagagtggtgttccggtgccggaggcccctggtggtgtggtg
ccgttggtcgtctcggggcgtggcggtgccgggttgcgcgggcaggcgcggagcctgttg
gacttcatggagcatcacccggacgtgcgcgtggtggaactgggagcggcgctggcttct
ggccgggcggcgttgtcggaccgtgcggtggtggtggcgggggatcggggtgaggcgctg
acgggtctcgcggcggtagcggagggcggtgggccgggaagtgcggatgtccggggtcgg
gtggcgttcgtcttccctggtcagggggcgcagtgggtggggatgggggcggagctgctg
gagtcctcgccggtgttcgcggaggggctgcgggagtgcgccgaggcgctggatccgctg
acggggtggtcgttgctggatgtggtgcggggcgttgggggtgcgccgggtttggatcgg
gtggatgtggtgcagccggtgtcgtttgcggtgatggtggggttggcgagggtgtggttg
gcggctggtgtggtgccgtcggtggtggtgggtcattcgcagggggagattgcggcggcg
tgtgtggcgggtgggttgtcgttggtggacgcggtgcgggtggtggtgttgcggagtcgt
gcggttgcggcggggttgtcgggccgtggcgggatggtgtcgctcgcggtgggtgtggcg
gtggcggaggggttggttgagcggtggggtggtcgggtggaggtggcggcggtgaatggg
ccgtcgtcggtggtggtggctggtgagccggatgccttgcgggagttggtgttggagtgt
gggggcgcgggggtgcgggcgcggtgggttgatgtggattacgcctcgcatacggcgcag
gtggaagcgatcgaggacgagctggcccggtcgttgtcgcaaattcgtccggtgtcctcg
cgtattccgttcttctcgacggtggaggcggggtggctggacacggccgagctggacgcc
gggtactggtatcggaatctccggagcaccgttcgttttggcccatccatcgagcgtctg
ctggaggcggacttccgggcgtttgtcgaagtgagcgcgcatccggtgctgacgatgagt
atcgaggcggcggcggagcaagcggacgccgggccggtcgtggcgaccgggacgctccgc
cgggatcagggtgatatgcgtcgcgtgctcacttccctggccgaggcgtacgtacgcggt
gtccccgtcgactggaccgccctgttcgacgacatcccggcacacgcggcgccggacctc
ccgacctacgccttccagcgtcagcactactggctgaagagtggccgccggaccggagag
gtgaccgccgtcggcctcgccggtgctcagcatccgctgctcggcgcatgggtggaactg
ccggacatggacggggcgttgttcacctcccggctgtctctgagcacccacccgtggctg
gccgaccacacggtggccggcgcggtcgtcctccccggatcggcctttgtggagctggcg
gtacgtgccggtgacgaggtcggctgcggtgtcgtggacgagttgctgatcgaggccccg
ctcgtgttcgtggaaggcatgagcgtgtggctacaggtggtcgtcgatggggcggacgac
tccggtcgacggcgcctcaccgtccactcccggcggcagggccacggatcggacggagcg
gactggacccgacacgccacgggcacgctggcccaggccgccaccaccaccgcacccgag
atcgacctcgcaccgtggccgccgaccggagcaacccccatcgatgtggaccaggtgtac
ggggatctggcgcgagacggacgtggcatcggcccggcgttccgcgtactgcgctcggcg
tggacccgcggcgccgacgtcttcgtcgaggtggaactggccgatgaccagcagcccgac
acgacgcgctacgcactgcacccggcactgctggaagccgtatgccatgccgacactcac
cgttgggcgtcggcgctgcctgccacctaccgcgcggtgtccctgtccgcgaccggggcg
agcgcactgcgtgcgcgcatcagcccggacggccagggcggggtgacactggagctggcg
gactccgccggagacgcggtcgggtccgtgggctcggtgacctcgcggccgctccccgcc
gagggactggcgtcgggggccgggactgctccacacgacgcgctgttccaggtggagtgg
ttccccctcccggtcgtgtcggctgcgcccgccctggccacctcggatccggtgatggtg
acgagcccggccgaattgacaacgttcgcagcccagggtgacgtaccgcccttcgtacgc
gcggagttgaccgacaccacactcggcctccgggcgctgacctcacaggcgcttgagtgg
gtccaggcgtggctggccgcgccggactccggttcgcggctggtcatcgtcacacgcgag
atcaccgatccgatctgcgccgcggtctggggactcgtgcgctcggcacagtcggaggcc
ccggaccggctggtcctggtggcgatggacgaggacgacgcctcccgcgcgctgctgcct
gccgcactggccaccggcgaaccgcagatcgccatcaacgccggggcggcatccgtaccg
aggctcgtacgcgccgcgccggacgaggaggcgccacaccggccgctggacccggcgggc
acggttctcatcaccggtggcaccggtgcgctgggccgcttgctcgcccggcaccttgcg
gccgagcacggtgtacgcaacctcctgctggtcagtcgccgtggccctgccgcccaaggc
gtggcggagctggagtcggaactcgccgcgctgggcgcgtccgtacgcaccgtggcccgc
gatatcggcgaccggaccgcggtggcggacctgctggacaagattccagccgatgcgccc
ctcacggctgtcgtccacaccgccggggtcctggacgacggcatggtcaccgccatgaca
ccgggacggctggacaccgtcctccgccccaaggcggacgcggccgtcatcctgcacgag
ctgacgtgtgacatggatctcgcggcgttcgtgatgttctcctcggccgcaggtgtcttc
ggcaaccccgggcaggcgaactatgccgccgccaacgccttcctggacgcactggccgag
cggcgcggggcggcgggcctcccggccaccgcgctcgcctggggccattgggcgctcagc
agcgagatgaccgcgcatctcaccacgtccgacctgcggcagcacacccggcgcttcggt
atgacgtccctgtcggaggagaccggtctggcgttgttcgacgccggtctgcgcagcgcc
acgcccgcgctggtggcggcccggttggacctcgcgggactgcgcgccgacgcggccgcc
accccggtcgtacccctgctgcacaagctggtgccaccgggccgccgggtcgtgagcccg
acggtatcgccgcggaccgatctcgtacggcggctggagtcctcggaccccgccgaacgg
gagcggacgctgctggacctggtcacacaccatgccgcccaggtgctcgggcactcctcg
gcggagggcatcgccgcccgacgggccttccgggagctggggttcgactcgctgacatcc
gtggaactgcgcaaccggctcaacgctgccaccgcgctccggctcccctcgaccctgctc
tacgaccaccccagcccactcgccctcaccaggcatctgcacgccgaactcctgggggcg
ccgagcgctcccgccgccccgcaacctgcgggcgaggcgtccgacgatggcatcgccatc
gtggccatgagctgccgctttccgggtggggtgagcagccccgaggacttctggcgcctg
atcagcgagggcggagacgccgtcggcgacttcccggacgaccggggctgggatctgtcg
gcgctctacgacagcgacccggaccaccccggcacctcctacgtccggcacggcgccttc
ctgcccgacgccgccgggttcgacgccgacttcttcggaatctccccccgtgaggcgctc
gcgatggatccgcagcagcggctgctgctcgagacctcatgggaggtgttcgagcgggcc
gggatcgacccgaccacattgggcggcagcgctgtcggagtgttcaccggaatgaacacc
caggactatgcgatacgtctgcgccacgttccgcacgaggtcgagggacaccggatcacc
ggggtctccgcggccgttctgtccggacgcgtggcctacaccctgggcctggagggaccc
gcggtcacggtggacaccgcgtgttcgtcatcgctggtggcgctgcatctggcggcgcag
gcgctgcgggcgggggagtgctcgatggcgctggccggtggggtgacggtgatggccggg
cccgacgccttcgtggacttctcccgtcagcgcggactgtcggtcgacggccgatgcaaa
ccctttgccgcctcggccgatggcacggggtgggccgagggcgtgggcgtactgctgctg
gagcggctgtcggacgcggagcggaacggtcaccaggtgctggcggtggtgcggggcagc
gcggtgaaccaggacggtgcgtcgaatggcctgaccgcccccaacggtccgtcgcagcag
cgtgtcatccgtcaggcgctggccagcgcgggtgtggcggccgcggacgtggacgtggtc
gaggcgcacggcacggggacggcactgggcgatcccatcgaggcgcaggccatcatcgcc
acctacggacaggaccgcgaccggccgctgtggctggggtcggtgaagtcgaacatcggt
catgcccaagccgccgcgggcgtggccggtgtgatcaagacggtcatggcgatgcggcac
ggtgtgctgccacggacgctgcatgtcgacgcccccaccccggaagtggactggtcggcg
gggtcggtggcgctgctgaccgaggaacggccgtggccggacgcggagcgcccgcgccgg
gccggggtgtccgcgttcggcgtcagtggcaccaacgcccatgtgatcgtggagcaggca
ccggccaccgttgccgcgcccgccccggaggatccggacacgatccccgccgtaccgtgg
gtgatctcggccaggagcgccgatgcgctgcacggccaggcggcccggttcgcggagttc
gcccgcacgcacccggagctcgacccgggcgatatcgcacactcgctgatcaccacacga
gccgcgctggaacaccgcgccgtggtcgtgggcacggggcgtgcggagttgctgagcggg
ctggaggccatcaccgggccgaccgacggtcccgtcgcacgaggtgtgcggagccccggc
aggcttgccgtgctgttcaccggacagggcagccagcacgcgggcatgggccgggaactc
catgcgcggtatcccgtgttccgcgatgccttcgacgcggcctgcgcgcgactggaccgg
catctggtcgatgccgggcataccacgcgccctgtccgggacgtcgtgttcgcccagccc
ggctcccccgaagcggaactgctcgaccggaccgtgttcgcccaggcggggctgttcgcg
ctggaggccgcgctgttccggctgtacgagtcctggggagtgcgccccgacatcctcgcc
ggacactccgtgggcgagctgatcgcggcgcatgtggcgggcgtgctgtccctcgacgac
gccgccgcgctgctggccgcgcgcgcacggctgatgcaggccctgcccggtggcgcgatg
gtcgcgctcaacgcccccgaggccatggtgcggtccctgctggccgatgcaccgggcgcc
gtggacatcgctgcggtcaacggccccgcctccgtcgtcgtctccggcgatgaggacgcc
gtagtggccgtcgagcggcggtgcgcggccaagggataccggaccaaacgcctacgggtc
agccacgccttccactccgcgcacatggacggcatgctcgacgcgttccgcgccatcgcc
gccgggctgacgtacgcgcctccggcggtgcccatcgtctccaacgtcacaggcgagttg
gccaccaccgaccagctgtgctcccccgactactgggtcgagcacgcacgcaggaccgtc
cgattcctcgacggtgtcaggacgctccacacccgggacgtcacgaccttcctcgaactg
ggccccggtggtgttctcaccgccatggcgcaggaagcgctgggcgacggcgccgacccg
gccatgttcgtggccacggtgcacggcgaacaggccgatccgctcgccgcggtggccgcg
ctcgcccggctgcatgtccggggcgtaccggtcgactggaccgccctgctcccggggacg
tcgcggcccagggtggacctgccgacgtacgccttccagcaccggcggtactggccggac
gcccccgcatcggacgccctcctgtcagacgccgccgcaccgggcgctctcgtaacggac
tccggcacggcaggtgagctgcgtccggccgaccggtcactgccggaggccgccgcactc
cagggcggcggggccacgcccttcgtcgagcggctgatggccggcaccgaggccgagcgc
caccggctggtcctggacctggtgctgaccagctcggccgcggtgctggggcacgatgac
gcgtcggcaatcgacggcgaacgggccttccaggacctcggcttcgactccctgaacgtg
gtacggctccgcaaccgcctccgggagctgaccggcgccgaactgccgaccacgctcgcg
ttcgaccatccgacacctgccgcgctcgcctccttcctgcacgcccggcttctcggacag
cacaccggacggaccggatcggctcggccggcgggcgatcccaccgagccgatcgcgatt
gtggggatggcttgccggttgccgggtggggtggcctcgcccgaggacttgtgggagctg
gttctggccgggggcgagggcatcggggagttcccggcggaccgaggctgggatctggag
aagctgttcgacccggacccggatcacgcggggaccagctatacgcggcgaggtggcttc
ctctacgacgcggccgagttcgacgcggacttcttcgggatctcgccgcgtgaggccctg
gcgatggatccgcagcagaggttgctgctggagacgtcatgggaggcgttggagcgcgcc
gggatcgacccggtctcgctgcgcggccaggacatcggtgtcttcgccggaatggtcaac
cacgactacaccagccgcctcgacacggcccccgacggctccgagggctacctcatgacc
ggcggcgcgggcagtgtgctgtcgggtcgggtgtcgtatgtgttggggttcgagggtcct
gcggtgacggtggacacggcgtgttcgtcgtcgttggtggcgttgcatctggcggcgcag
gcgttgcgggcgggggagtgctcgatggcgctggccggtggggtgacggtgatggccggg
ccggacgcctttgtcgagttctcccgtcaacgcgggctcgcccccgacggccgatccaag
tcgttcgcggccgcggcggacggtacggggtgggccgagggtgtgggtgtggtgctcgtg
gagcggttgtcggacgcggagcggaacggccatcgggtgttggcggtggtgcggggcagt
gcggtgaatcaggatggtgcgtcgaatggtttgacggcgccgaatggtccgtcgcagcag
cgggtgattcggcgggcgttggctggtgcgggtcttgtggcggcggatgtggacgcggtc
gaggcgcatgggacgggtacgccgctgggtgatccgatcgaggcgcaggcggtgttggcg
acgtatgggcaggatcgtgatcggcctttgttgatggggtcgttgaagtcgaatattggt
catgcgcaggcggctgcgggtgtggctggtgtgatcaagatggtgttggcgttgcggtat
ggggtgttgccgaggacgttgcatgtggatgagccttcgccgcaggtggattggtcgtcc
ggtgcggtggagctgctgacggagcagcgggtgtggcctgaggtgggtcgtccgcgccgg
gccggggtgtccgcgttcggggtcagtggcaccaacgcccacgtcatcctggaacagccc
ttggacgtccctgactcggagctacccgcaccgcagttgccgggtggtctggcgcttctt
ccggtgtccgcgcgaggcgagggcgcactgcgcgcccaggcacagcggctgttgtccttc
ctggatcagcgaccggaccaggatctcggcgagttgagcctcgcgttgggttgtggtcgg
gcggggttgtcggatcgtggggtggtggtggcgggtggtcgtgaggagttgttggtgggg
ttgggtgggttggtgcggggtgaggggggtgtgggtgtggtgtcgggttcggtggtgcgt
ggtcggttgggggtgttgtttgctggtcaggggtgtcagcgggtggggatggggcgtggg
ttgtatgaggtgttcccggtgttccgggatgcgtttgacgcggtgtgtgaggtgttggat
cgggagttgggtgcgggtggtgtggtgggttcggtgcgggaggtggtgttcgggggtggg
gggttgttggagcggacggtgtttgctcaggcggggttgtttgcggtggaggtggggttg
ttccggttggtggagtcgtggggtgtggtggtggatgtggtgggtgggcattcggtgggt
gaggtgacggcggcgtatgtggcgggtgtgttgtcgttggaggatgcggcggtgttggtg
gcggcgcgggggaggttgatggaggcgttgccggagggtggtgcgatggtggcggtggct
gcgggtgaggaggtggtgcgtcctctgctggtgtcgggggtggatattgcggcggtgaac
ggtcctgcggcggtggtgctctccggtgatgaggaaccggtactacgggttgtgcgcgat
ctgtcggatcaggggtgtcggacgaggcgtttggcggtttcgcatgcgttccattccgcc
cgtatggagccgatgctggaggagttccgggaagcgatcgctgatctgtcgttctcggcg
ccggtgattcctttggtgtcgaatgtgaccgggcggttggcggatgcggaggtggtgtgt
tcgccggagtactgggtggagcatgtgcgctctgccgtgcggtttgcggacggtgtgcga
gcactcgccgactatggtgtgggcacctatctggagttggcgccggatgcggtgttgtcc
gcgatggtgggtgattgcctgccggaagggtcggctgctgagagtgtggtggtgccgtcg
ttgcggcgggagggcgacgagccccgtgcgctgatgaccgccatcgctcagctgcatgtg
gcaggcgtacccctcgacttcggcgctctgttcggcggcgccgttccacccgcccacctc
cccgatctgcccacgtacgccttccagcgtgcgcactactggctccatgacaccccgccc
gcttccccccagggcctcgccactgcctccgacgacaccgacgcccggttctgggccgcg
gtcgaacgtgaggatctcggctcggtggccgaggcgctggagctggcggacggtgaggac
gaccgtgccgctctggacgccgtgggcggtgcgctcggcgtgctgtcggactggcggcgc
aagcgcggtgagaagtccgctgctgaccggctgcgctatcaggccacctggaagccgctt
cccggcgccgcctccggcatacccaacggcacctggctggtcgtcctgccgtacggctgc
caggacgacgattacgcggcccgggtggtcccggcgctgaatcgccaaggtctgtgcacc
acgaacctgcggctcgacggggccgaaacggcggaccgcaccgctctcgccgagacgttg
cgcagcgcactggcggaccacgaggacttcggcggtgtgctgtccctgctcgcgctcgac
cagcgcatacgtcccggatccgcgaccctcaccgagggggtcgccggcactttgacgctg
gtgcaggccctcggcgacctgggctcatcgggctcggtgggctcggcgagctcgctgagc
tccgggcatcgtctgtactgcgccacccgaggcgcggtgagtgtcggcgccgcggacggg
ctcatcgccccggaacaggcggccgtgtgggggctcggcctggccgtggcgctggagcag
ccggatcgatggggggcgctggtggacctcccggaggtgttcgacgaccgggccgcgcga
gcgctgctcggcgcgctggccgatccgggcgacgaggaccagctcgcgatccgtaccacg
ggtgccttcgtacgcaggttgcggagccatcccctgcccaccgacgtggcgaagccggag
tggcggccacgtggcaccgtcctggtcaccggcggtacggagggtctcggcaggcacgcg
gcgcgctggctggccggtgccggtgccgagcacctggtgctgacggtccagtcggatccg
gaggcgccgcatgtggtggccctgcgggacgagttgagcgaccagggcgcgaaggtgacg
gtgtgcccggcggacctcaccgaccgggacgcggtcgagcgtctgctcaccggccccgcc
gcgtaccccgagctctccggcgtcgttcacaccgccgacctcgcacgggtcgcccaggcc
gacgccaccggcgccgatgaactggcggagacgctggcggccaaggtcgacggtctgctc
catctggacgcgctcctggccgatcgcgatctggatctgttcgtggccttctcatcggtc
gccagtgtctggggcggtggcggccaagggctgatcggcgcggcgaacgcgcagctcgac
gccttggtcgagcgccgccgcgccaggggtctggcggccacctcggtggcctggggtgtg
atcgacggcttcggcgtggccgccgacgccacggcccaggagcagttgcgccgccgtggg
gtgctgccgatggcgcccgaggcggccatggcggccctgacgcacgccgtccgccacgac
gacacgctcgtggccgtggcggacatcgactggtcggcgtttgtcccggccttcacctcg
ctgcggcccagcccgttgatcgccgacctgccgggcgtccaggagatcgtcgacagcctt
cgcccggacgacgccaccgacgagtccgtctcggagttcctgcgcgacctggccggagcc
tccgacgccgagcgcgagcgcgccctgatgaaggtggtgcgcgagaacacggccctcgca
ctggggcacagcggcgtcgaggccgtcaaaccgcagcgtgccttccaggagatgggattc
gactccctcgcggcggtgaacctgcgcaacaccctcggcgccgcgctgggcacccagctg
ccggccaccctcgtcttcgactaccccacgcccaccgcgctggtggagtacctgcgcacc
gagctcctgggagaccagggcgaggacgagatcaccgaggccgacgaggaggagatccgc
cgcgtactggccgccgtgccgctcagccggttccgcgaggccggagtgctcgatgcgctg
cggtcgctggccagaaccgctgcggccgcaccggacgggagcggctcgtccgccgatgaa
gagctcgatctgatcgatggaatggatatcgccggactggtccaaagggcattcgacgga
acccagttgtaa
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