Streptomyces subrutilus: CP968_24240
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Entry
CP968_24240 CDS
T07087
Symbol
murF
Name
(GenBank) UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
ssub
Streptomyces subrutilus
Pathway
ssub00300
Lysine biosynthesis
ssub00550
Peptidoglycan biosynthesis
ssub01100
Metabolic pathways
ssub01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
ssub00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
CP968_24240 (murF)
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
CP968_24240 (murF)
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
CP968_24240 (murF)
Enzymes [BR:
ssub01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
CP968_24240 (murF)
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
DUF561
PhageMin_Tail
Motif
Other DBs
NCBI-ProteinID:
QEU80984
UniProt:
A0A5P2UU13
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Position
5460439..5461863
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AA seq
474 aa
AA seq
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MIALSLAEIADITGGRPHDIPDHSVRIVGPVVIDSRQVEAGSLFAAFDGEHVDGHDYAGR
AVAAGAAAVLAARPVGVPAIVVPDVERALGALARAVVERLGTDVVALTGSAGKTSTKDLI
AQVLQAHAPTVWTPGSLNNEIGLPLTALKATEETRHLVLEMGARGIGHIRYLTGLTPPRI
GLVLNVGTAHIGEFGGREQIAQAKGELVEALPSEAEGGIAVLNADDPLVRAMSARTKART
VLFGEAGDADVRATGVRMGPGGQPAFTLHTPTGCGEVTLRLYGEHHVSNALAAAAVAHVL
GMSVEEIATALSGAGTLSRWRMEVTERADGVTIVNDAYNANPESMRAALRALAAMGGAAR
ANGGRTWAVLGPMAELGDASLAEHDAVGRLAVRLNVSKLVAVGGREASWLQLGAYNEGSW
GEESVVVSDAQAAVDLLRSELRPGDVVLVKASRSIGLERVALALLEREGEVAER
NT seq
1425 nt
NT seq
+upstream
nt +downstream
nt
gtgatcgccctctccctcgccgagatcgccgacatcaccggcggccggccccacgacata
ccggatcactcggtacggatcgtcgggcccgtcgtcatcgactcccgccaggtggaggcc
ggcagcctcttcgccgccttcgacggcgagcacgtcgacggccacgactacgccgggcgc
gcggtggccgccggcgccgcggccgtcctcgcggcccggcccgtcggcgtgcccgcgatc
gtcgtgcccgacgtggagagggcgctcggcgccctcgcacgggccgtcgtcgagcggctc
ggcaccgacgtggtggccctcaccggctccgccgggaagacctccaccaaggacctcatc
gcgcaggtgctccaggcccacgcgcccacggtgtggacgcccggatccctcaacaacgag
atcggcctgccgctcaccgcgctcaaggccaccgaggagacccgccacctcgtcctggag
atgggcgcccgcgggatcggccacatccgctacctcaccggcctgaccccgccgcgcatc
ggactcgtcctgaacgtcggcaccgcccacatcggggagttcggcggccgcgagcagatc
gcccaggccaagggggaactggtcgaggccctgccgtccgaggccgagggcgggatcgcc
gtcctcaacgccgacgacccgctcgtgcgcgccatgtccgcccgtacgaaggcccgtacg
gtcctgttcggagaggccggggacgccgacgtccgggccaccggcgtacggatgggcccc
ggggggcagcccgccttcacactccacacccctaccgggtgcggcgaagtgaccttgcgg
ctgtacggtgagcaccacgtgtcgaacgcgctcgccgcggccgccgtcgcccatgtactg
ggcatgtccgtcgaggagatcgccaccgcgctctccggggcgggcaccttgtcccggtgg
cggatggaggtcaccgagcgggcggacggcgtgacgatcgtcaacgacgcctacaacgcg
aacccggagtccatgcgggccgccctgcgcgcgcttgccgcgatgggcggcgccgccagg
gcgaacgggggacgcacgtgggcggtgctcggccccatggccgaactcggtgacgcatcg
ctggcggagcacgacgcggtgggacggcttgccgtccggctcaacgtgagcaagctcgtc
gcagtcgggggcagggaagcgtcctggctgcaactgggcgcatataacgagggttcgtgg
ggtgaggagtcggtggtcgtgtccgacgcgcaagcggcggtcgacctgttgcgcagtgaa
ctgcgcccgggtgacgtcgtgctggtgaaggcttcgaggtcgatcggtctggagcgggtc
gcgctggcgttgctggagcgcgagggcgaggtcgccgagcgatga
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