Streptomyces sp. SirexAA-E: SACTE_1517
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Entry
SACTE_1517 CDS
T01601
Name
(GenBank) UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate/D-alanyl-D-alanyl ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
ssx
Streptomyces sp. SirexAA-E
Pathway
ssx00300
Lysine biosynthesis
ssx00550
Peptidoglycan biosynthesis
ssx01100
Metabolic pathways
ssx01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
ssx00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
SACTE_1517
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
SACTE_1517
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
SACTE_1517
Enzymes [BR:
ssx01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
SACTE_1517
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
DUF561
Motif
Other DBs
NCBI-ProteinID:
AEN09433
UniProt:
G2NBQ2
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Position
complement(1697254..1698675)
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AA seq
473 aa
AA seq
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MIALSLAEIADIVGGQPHDMPDRSLTVTGPVVIDSREVRQGSLFAAFAGERVDGHDYARA
AVEAGAVAVLAARPVGCPAIVVDDVVAALGALACAVVERLGTAVVALTGSAGKTSTKDLI
AQLLERKAPTVWTPGSLNNEIGLPLTALTATAETRHLVLEMGARGVGHIHYLAQLTPPTI
GLVLNVGSAHLGEFGSREAIAQAKGELVEALPEDGVAVLNADDPLVRAMAARTQARVVLF
GEAPDADVRGENVRLTDDGRPAFALHTPTGCSDVTLRLYGEHHVSNALAAAAVAHELGMS
VTEIAEALSVAGTLSRWRMEVTERPDGVTVVNDAYNANPESMKAALRALAAMGKAARAEG
GRTWAVLGQMAELGDASLAEHDAVGRLAVRLNVSKLVAVGGREASWLQLGAYNEGSWGEE
SVHVSDAQAAVDLLRSELRPGDVVLVKASRSVGLEKVALALLENATEGEVAVR
NT seq
1422 nt
NT seq
+upstream
nt +downstream
nt
gtgatcgccctttccctcgccgagatcgccgacatcgtcggcgggcagccgcacgacatg
ccggaccggtccctcaccgtcaccggccccgtcgtcatcgactcccgggaggtgcgccag
ggatccctgttcgccgcgttcgcgggcgagcgcgtcgacggccacgactacgcgcgcgca
gccgtcgaggcgggcgccgtggccgtgctggcggcccgtcccgtcggctgcccggcgatc
gtcgtcgacgacgtcgtggccgccctcggcgccctcgcgtgtgccgtcgtcgagcgcctg
ggcaccgccgtcgtcgccctgaccggctcggcgggcaagacctccaccaaggacctgatc
gcccagctcctggagcgcaaggcgccgacggtctggacccccgggtcactcaacaacgag
atcggcctgccgctcaccgcgctgaccgccaccgcggagacccgccacctggtgctggag
atgggtgcccggggtgtcggccacatccactacctcgcccagctgaccccgcccacgatc
ggcctggtcctgaacgtgggcagcgcccacctcggcgagttcggcagccgcgaggcgatc
gcccaggccaagggcgagctcgtggaggcgctccccgaggacggcgtggccgtgctcaac
gccgacgacccgctcgtgcgggccatggccgcccgcacacaggcacgggtcgtcctcttc
ggggaggccccggatgcggacgtacggggagagaacgtccggctcacggacgacgggcgc
cccgctttcgcgcttcacacacccaccgggtgcagcgacgtgaccttgcgcctgtacggt
gagcaccacgtgtcgaacgcgctcgccgcggccgccgtcgcccatgagttgggcatgtcc
gtgactgagatcgccgaggcgctctccgtggcgggcaccctctcccgctggcgcatggag
gtcaccgagcgtccggacggtgtgacggtcgtcaatgacgcctacaacgcgaaccccgaa
tccatgaaagccgcactccgtgcgctggccgccatgggcaaagccgcacgggcggaaggg
gggcgcacgtgggcggtgctcggtcagatggccgagctcggggacgcgtcactcgccgag
cacgacgcggtcggacggctcgccgtccggctcaacgtcagcaagctcgtcgctgtcggg
ggaagagaagcctcctggctgcaactgggcgcatataacgagggttcgtggggtgaggag
tcggtgcacgtgtccgacgcacaggcggccgtcgacctgttgcgcagtgaactgcgcccg
ggagacgtcgtgctggtgaaggcgtcccggtcggtcggcctggagaaggtcgccctggca
ctgctggagaacgcgaccgagggcgaggtcgccgtccgatga
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