Symphalangus syndactylus (siamang): 129458002 Help Entry 129458002         CDS       T10134                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism ssyn  Symphalangus syndactylus (siamang) Pathway ssyn04020   Calcium signaling pathway ssyn04024   cAMP signaling pathway ssyn04260   Cardiac muscle contraction ssyn04261   Adrenergic signaling in cardiomyocytes ssyn04371   Apelin signaling pathway ssyn04713   Circadian entrainment ssyn04911   Insulin secretion ssyn04921   Oxytocin signaling pathway ssyn04972   Pancreatic secretion ssyn05020   Prion disease ssyn05022   Pathways of neurodegeneration - multiple diseases ssyn05410   Hypertrophic cardiomyopathy ssyn05412   Arrhythmogenic right ventricular cardiomyopathy ssyn05414   Dilated cardiomyopathy ssyn05415   Diabetic cardiomyopathy Brite Ion channels [BR:ssyn04040]  Voltage-gated cation channels   Ryanodine receptor    129458002 (RYR2) Domain-containing proteins not elsewhere classified [BR:ssyn04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    129458002 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  129458002 NCBI-ProteinID:  XP_055089413 LinkDB All DBs Position 12:81476847..82260882 Genome browser AA seq 4970 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV CYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSG TGERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAG GLSGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ CLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEYIVPMTEETKSITLFP DENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKAKTIQMLTEAVK EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEE SDTLEKELSVDDAKLQGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDFTIRGRLLSLVEKVTYLK KKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVR ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQML VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG NGLLAAMEEAIKIAEDPSRDGPSPNSGSTKTLDTEEEEDDTIHMGNAIMTFYAALIDLLG RCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQL RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY KLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHG YSPRAIDMSNVTLCRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAK EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI LEFDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNI YSIYNTKSSRERAALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP MLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFT TLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEQLFRMVAEVFIYWSKSHNFKREEQNFV VQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNI CAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTDD TSDPEKTVERVLDIANVLFHLEQKSKRVGRRHYCLGSTVEHPQRSKKAVWHKLLSKQRKR AVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEG TKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEK EMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKM LDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTC DLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDV IDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMK LSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFF DMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENET LDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIE IMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTI FEMQLAAQISESDLNERSANKEESEKERPEEQGPRMAFFSILTVKSALFALRYNILTLMR MLSLKSLKKQMKKVKKMTVKDMVTAFFSSYWSIFMTLLHFVASVFRGFFRIICSLLLGGS LVEGAKKIKVAELLANMPDPTQDEVRGDGEEGERKPLEAALPSEDLTDLKELTEESDLLS DIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKS EPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFAR NFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSENAKVTSLDSSSHRIIAV HYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYI TEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAAL DFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNF FFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSE DGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVI LLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLAN YLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14913 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgagggcgaagacgagatccagttcctgcgaactgatgatgaagtg gttctgcagtgcaccgcaaccatccacaaagaacaacagaagctatgcttggcagcagaa ggatttggcaacagactttgtttcttggagtccacttccaattccaagaatgtcccccca gacctctccatctgcacctttgtgctggagcagtccctctctgtccgggcgctgcaggag atgctggctaacaccgtggagaaatcagaagggcaagttgatgtggaaaaatggaaattc atgatgaagactgctcaaggtggtggtcatcgaacactcctctacggacatgccatattg ctgcgccattcctatagtggcatgtatctttgctgcctgtccacctcccggtcttcaact gataagctggcttttgatgttggcttgcaagaggacaccacaggtgaggcttgttggtgg accatacaccctgcctctaagcagcgatcagaaggagaaaaagtacgagttggagatgac ctcatcttagttagcgtgtcctctgaaaggtacttgcacttgtcttacggcaatggaagc ttacacgtggatgccgctttccagcagactctctggagcgtggccccaatcagctcggga agtgaggcagcccaagggtatctcattggtggtgatgtcctcaggttgctgcatggacac atggacgagtgtctcactgtcccttcaggagaacatggtgaagagcagcggagaactgtt cattatgaaggtggcgctgtgtctgttcatgcacgttccctttggagactagagacgcta agagttgcgtggagtggaagccacataagatggggacagccattccgactacgccatgtc acaacaggaaaatacttgagtctcatggaagacaaaaaccttctgctcatggacaaagag aaagctgatgtaaaatcaacagcatttaccttccggtcttccaaggaaaaattggatgta ggggtgagaaaagaagtcgatggcatgggaacatccgaaataaaatacggtgactcagta tgctatatacaacatgtagacacaggcctatggcttacttaccagtctgtggacgtgaaa tctgtgagaatgggatctatacaacgtaaggctattatgcatcatgaaggccacatggat gatggcataagtttatcgagatcccagcatgaagaatcacgcacagcacgagttatccgg agcacagtcttccttttcaatagatttataaggggccttgatgctctcagcaagaaagcg aaggcttccacagtcgatttgcctatagagtccgtaagtctaagtctgcaggatctcatt ggctacttccaccccccagatgagcatttagagcatgaagacaaacagaacagactacga gccctgaagaatcggcaaaatctcttccaggaagagggaatgatcaacctcgtgctcgag tgcatagaccgtttgcacgtctacagcagcgcagcacactttgctgatgttgctgggcga gaagcaggagagtcttggaaatccattctgaattctctgtatgagttgctggcggctcta attagaggaaatcgtaaaaactgtgctcaattttccggctccctcgactggttgatcagc agattggaaagactggaagcttcttcgggcattctggaagttttacactgtgttttagta gaaagtccagaagctctaaatattattaaagaaggacatattaaatccattatctcactt ttagacaaacatggaagaaatcacaaggttctggatgtcttgtgctcactctgtgtttgc catggcgttgcagtccgttctaaccagcatctcatctgtgacaacctcttaccaggaaga gatttgttattgcagacacgtcttgtgaaccatgtcagcagcatgagacccaatattttt ctgggcgtcagtgaaggttctgctcagtataagaaatggtactatgaattgatggtggac cacacagagccctttgtgacagctgaagcaactcacctgcgagtgggctgggcttccact gaagggtattctccctaccctggagggggcgaagagtggggtggaaatggtgttggagat gatctcttctcctatggatttgatggccttcatctctggtcaggttgtattgctcgtact gtaagctcaccaaaccaacatctgttaagaaccgatgatgtcatcagttgctgtttagat ctgagtgccccaagcatctcgttccgaattaatggacaacctgttcaaggaatgttcgag aatttcaacatcgacggcctcttctttccagtcgttagtttctctgcaggaataaaagta cgctttctgcttggggggcgacatggagaattcaaatttcttcctccacctggatatgct ccttgttacgaagctgttctgccaaaagaaaagttgaaagtggaacacagccgagagtac aagcaagaaagaacttacacacgcgacctgctgggccccacagtttccctgacacaagct gccttcacgcccatccccgtggataccagccagatcgtgttgcctcctcatctagaaaga ataagagaaaaactggcagagaatatccatgaactctgggttatgaataaaattgagctt ggctggcagtatggtccggttagagatgacaacaagagacaacacccatgcctggtggag ttctccaagctgcctgaacaggagcgcaattacaacttacaaatgtcgcttgagaccctg aagactttgttggcattaggatgtcatgtgggtatatcagatgaacatgctgaagacaag gtgaaaaaaatgaagctacccaagaattaccagctgacaagtggatacaagcctgcccct atggacctgagctttatcaaactcaccccgtctcaagaagcaatggtggacaagttggca gaaaatgcacacaacgtgtgggcacgggatcgaatccggcagggctggacttacggcatc caacaggatgtaaagaacagaagaaatcctcgccttgttccctacactcttctggatgac cgaaccaagaaatccaacaaggacagcctccgcgaggctgtgcgcacgctgctggggtac ggctacaacttggaagcaccggatcaagatcatgcagccagagccgaagtgtgcagtggc actggggaaaggttccgaatcttccgtgccgagaagacctatgcagtgaaggccggacgg tggtattttgaatttgagacggtcactgctggagacatgagggttggttggagtcggcct ggttgccaaccggatcaggagcttggctcggatgaacgtgcctttgcctttgatggcttc aaggcccagcggtggcatcagggcaatgaacactatgggcgctcttggcaagcaggcgat gtcgtggggtgtatggttgacatgaacgaacacaccatgatgttcacactgaatggtgaa atccttcttgatgattcaggttcagaactggctttcaaggactttgatgttggcgatgga ttcatacctgtgtgtagccttggagtggctcaagtgggtaggatgaactttggaaaggat gtcagcaccttgaaatatttcaccatctgtggcttacaagagggctatgaaccatttgcc gttaatacaaacagggatattaccatgtggctgagcaagaggcttcctcagtttctccaa gttccgtcaaaccatgaacatatagaggtgaccagaatagacggcaccatagacagttcc ccatgtttaaaggtcactcagaagtcttttggttctcagaacagcaacactgatatcatg ttttatcgcctgagcatgccgatcgagtgcgcggaggtcttctccaagacagtggctgga gggctctctggggctggtctttttgggcccaagaatgatttggaagattatgatgctgat tctgactttgaggttctgatgaagacagctcatggccatctagtgcccgatcgtgttgac aaagacaaagaagctactaaaccagagtttaataaccacaaagattacgcccaggaaaag ccctctcgtctgaaacaaagatttttgcttagaagaacaaagccagattacagcacaagc cattcggcaagactcaccgaagatgtcctggctgatgatcgggatgactatgatttcttg atgcaaacatccacgtactattactcagtgagaatctttcctggacaagaacctgctaac gtctgggtgggctggattacatcagatttccatcagtatgacacaggctttgacttggac agagttcgcacagtaacagttactctaggagatgaaaaaggaaaagtgcatgaaagcatc aaacgcagcaactgctatatggtatgtgcgggtgagagcatgagccccgggcaaggacgc aacaataatggactggagattggctgtgtggtggatgctgccagcgggctgctcacgttc attgccaatggcaaggaactgagcacatactatcaggtggagccgagtacaaaattattt cctgcggtttttgcacaagctacaagtcccaatgttttccagtttgagttgggaagaata aagaatgtgatgcctctctcggcgggattgttcaagagtgaacacaagaaccccgtgccg cagtgccccccgcgcctccacgtgcagttcctgtcacacgtcctgtggagcagaatgccc aaccagtttttgaaggtagatgtgtctcgaataagtgaacgccaaggctggttggtgcag tgtttggatcctctgcagttcatgtctcttcatatccctgaggaaaacagatctgttgac atcttagagttgacagagcaggaggaattgctgaaatttcactatcacactctccggctc tactcagccgtctgtgctcttgggaaccaccgggtggcccatgccctgtgcagccatgtg gatgaacctcagctcctctacgccattgagaacaagtacatgccaggtttgctgcgtgct ggctactatgacctgctgatcgacatccacctgagctcctatgccactgccaggctcatg atgaacaacgagtacattgtccccatgacggaggagacgaagagcatcaccctgttccct gatgagaacaaaaagcacggccttccagggatcggcctcagcacctccctcaggccacgg atgcagttttcctcccccagttttgtaagcattagtaatgaatgttaccagtacagtcca gagttcccactggacatcctcaaggccaaaaccatacagatgctgacagaagctgttaaa gagggcagtcttcatgcccgggacccagttggagggactactgaattcctctttgtacct ctcatcaagcttttctataccctgctgatcatgggcatctttcacaatgaggacttgaag cacatcttgcagttgattgagcccagtgtgtttaaagaagctgccactccagaggaggag agtgacacgctggagaaagagctcagtgtggacgatgcaaagctgcaaggagctggtgag gaagaagccaaggggggcaagcggcccaaggaaggcctgctccaaatgaaactgccagag ccagttaaattgcagatgtgcctactgcttcaatacctctgtgactgccaggtccggcat cggatagaagccattgtagccttttcagatgattttgtagctaagctccaagacaatcaa cgtttccgatacaatgaagttatgcaagccttaaatatgtcagccgcactcacagccagg aaaacaaaggaatttagatcaccgcctcaagaacagatcaatatgcttctcaattttaag gatgacaaaagtgaatgtccatgtccagaagaaattcgtgaccaactattggatttccat gaagatttgatgacacattgtggaattgagctggatgaagatgggtctctggatggaaac agtgatttcacaattagagggcgtctgctatccctggtagaaaaggtgacatacctgaag aagaagcaagcagaaaaaccagttgagagtgactccaaaaagtcctccactctgcagcag ctgatctctgagaccatggtccgatgggctcaggagtctgtcattgaagaccccgagctg gtgagggccatgtttgtgttgctccatcggcagtatgacggcattgggggtcttgttcgg gccctgccaaagacctacacgataaatggtgtgtccgtggaagacaccatcaacctcctg gcatcccttggtcagattcgatccctgctgagtgtgagaatgggcaaagaagaagagaag cttatgattcgtggattaggggatattatgaataacaaagtgttttaccagcaccctaat ctcatgagggcactggggatgcacgagactgtgatggaggtcatggtgaacgtccttgga ggtggagagtccaaggaaatcacctttcccaagatggtggccaactgttgccgctttctc tgttacttctgtcgtataagtaggcagaatcaaaaagctatgtttgatcatctcagttat ttactggaaaacagcagtgttggtcttgcctccccagctatgagaggttcaacaccactg gatgtggctgcagcttcggtgatggataataatgaactagcgttagctctccgtgagccg gatctagaaaaggtagttcgttatttggctggttgtggactgcaaagttgccagatgctg gtgtctaagggctatccagacattgggtggaacccagttgaaggagagagatatcttgac tttctcagatttgctgtcttctgtaatggggagagtgtggaggaaaatgcaaatgtcgtg gtgagattgctcattcggaggcctgagtgttttggtcccgctttgagaggagaaggtggg aatgggcttcttgcagcaatggaagaagccatcaaaatcgccgaggatccgtcccgagat ggtccctcaccaaatagcggatccactaaaacacttgatacagaggaggaggaagatgac actatccacatggggaacgcgatcatgaccttctatgcagctttgattgacctcttggga cgctgtgctcctgagatgcatttgattcatgctgggaagggagaagccatcagaattagg tccattttgagatccctaattcccctgggagatttggtgggcgttatcagcatcgctttt cagatgccaacaatagccaaagatgggaatgtggtggaacctgacatgtctgcggggttt tgcccagatcacaaggcagccatggttttattccttgacagggtctatggaattgaagtt caagacttcctcctccatcttcttgaggttggctttctgccagatctccgggcggctgct tctttagatacggcagctttgagtgctacagacatggccttggccctcaatcggtacctc tgcacagccgtcttgccattgttaacaagatgtgctcctctctttgctggcacagagcac catgcttctctcattgactcattacttcatactgtgtatagactttctaagggctgttca cttaccaaagctcagcgggattccatagaagtttgtttactctctatttgtgggcaactg agaccttctatgatgcagcacttactcagaagattagtatttgatgttccattattaaat gaacatgcaaagatgcctcttaaactgctgacaaatcattatgaaagatgctggaaatat tactgcctgcctggagggtggggaaactttggtgctgcctcagaagaagaacttcattta tcaagaaagttgttctggggcatttttgatgccctatctcaaaagaaatatgaacaagaa cttttcaaactggcactgccttgcctgagtgcagttgcgggagctttgcctccagactac atggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaac tttaacccacaacctgttgatacctcaaatattacaattcctgagaagttggaatacttc attaacaaatatgcagaacactcccatgacaaatggtcaatggacaagttggcaaatgga tggatttatggagaaatatattcagactcttctaaggttcagccattaatgaagccatat aagctattgtctgaaaaggaaaaagaaatttatcgctggccaatcaaagaatctttaaaa actatgctggcttggggctggagaattgaaagaactcgggagggagacagcatggccctt tacaaccggactcgtcgtatttctcagacaagccaggtttctgtagacgctgcccatggt tacagtccccgcgccattgacatgagcaatgttacgctatgtagagacctgcacgctatg gcagaaatgatggctgaaaactaccataatatatgggcaaagaaaaagaaaatggagtta gagtccaaaggagggggaaaccatcctctgctggtgccctatgatacactgacggccaaa gagaaagccaaggatagagaaaaagcacaggacatcctcaagttcttgcagatcaatgga tatgctgtatccagaggatttaaggacctggaactggacacgccttctattgagaaacgg tttgcttatagtttcctccaacaactcattcgctatgtggatgaagcccatcagtatatc ctggagtttgatggtggcagcagaggcaaaggagaacatttcccttatgaacaagaaatc aagttctttgcaaaagtcgttcttcctttaattgatcagtatttcaaaaaccatcgttta tacttcttatctgcagcaagcagacctctctgctctggaggacatgcttccaacaaagag aaagaaatggtgactagcctattctgcaaacttggagttcttgtcaggcataggatttca ctatttggcaatgatgcaacatcaattgtcaactgtcttcatattttgggtcagactttg gatgcaaggacagtgatgaagactggcctggagagtgttaaaagtgcactcagagctttt ctggacaatgccgcagaggatctggagaagaccatggaaaacctcaagcagggccagttc actcacacccgaaaccagcccaaaggggttactcagattatcaattacaccacagtggcc ctgctgccaatgctgtcatcattatttgaacatattggccagcatcagtttggagaagac ctaatattggaagatgtccaggtgtcttgttatagaattctgactagcttatatgctttg ggaaccagcaagagtatttatgtggagaggcaacgttctgcattaggagaatgtctagct gcctttgctggtgcctttcctgtagcatttttggaaactcatctggacaaacataatatt tactccatctacaatacaaagtcttcacgagaaagagcagctctcagtttgccaactaat gtggaagatgtttgtccaaacataccgtctttggagaaactcatggaagaaatcgtggaa ttagctgagtccggcattcgctacactcaaatgccacatgtcatggaagtcatactgccc atgctttgcagctacatgtctcgttggtgggagcacggacctgagaacaatccagaacgg gccgagatgtgctgcacagccctgaactcagagcacatgaacacacttctagggaacata ttgaaaatcatatataataacttggggattgatgagggagcctggatgaagaggctagcg gtgttttcccagcctataataaataaagtgaaacctcagctcttgaaaactcatttcttg ccattaatggagaaactcaagaaaaaggcagctatggtggtgtctgaggaagaccacctg aaggccgaggccaggggggacatgtcagaggctgaactcctcatcctagatgagttcacc acactggccagagatctctatgccttctaccctctcttgattagatttgtggactataac agggcaaagtggctaaaggagcctaacccagaagcagagcagctcttccgcatggtggct gaagtgtttatctactggtcgaagtcccataatttcaaaagagaagagcagaacttcgtt gtgcagaatgaaatcaacaatatgtctttccttattactgataccaagtcaaagatgtca aaggcagctgtttctgatcaggaaaggaagaaaatgaagcgcaaaggagatcggtattcc atgcagacctctctgattgtagcagctctgaagcggttactgcccattgggttgaacatc tgtgcccctggggaccaggagctcattgctctggccaaaaatcgatttagcctgaaagat actgaggatgaagtacgagatataatccgcagcaatattcatttacaaggcaagttggag gatcctgctattagatggcaaatggctctttacaaagacttaccaaacaggactgatgat acctcagatccagagaagacggtagaaagagtattggatatagcaaatgtgctttttcat cttgaacagaagtctaaacgtgtgggtcggagacattactgtctgggaagtacagtggag catcctcagagatctaaaaaggctgtatggcataaactactctctaagcagaggaaaagg gctgttgtagcctgcttccggatggcccccctctataatctgccaaggcatcgggctgtc aatctctttcttcagggatatgaaaagtcttggattgaaacagaagaacattactttgaa gataaactgatagaagatttagcaaaacctggggctgaacctccagaagaagatgaaggc actaagagagttgatcctctacatcagctgatccttctgtttagtcggacagctttaaca gagaaatgcaaactggaggaagattttttatatatggcctatgcagatattatggcaaag agttgtcatgatgaggaagatgacgatggtgaagaggaagtgaagagttttgaagaaaaa gaaatggaaaagcaaaagcttctataccagcaagcccgactccacgatcgtggtgcggct gagatggtgctacagacgatcagtgccagcaaaggtgaaactggaccaatggtagcagct actttgaaacttggaattgctattttaaatggtgggaactccacagtacagcagaaaatg cttgactacctcaaggagaaaaaggatgtgggcttctttcagagcctggccggcctgatg cagtcatgtagtgtccttgacctaaatgcatttgagcgacaaaacaaagctgaaggtctt gggatggtgacagaggaaggatcaggagaaaaggttctgcaggacgatgagttcacctgt gacctcttccgattcctgcaactactctgtgagggacacaactcagattttcagaattat ctgagaactcagactggcaataatacaactgtcaacataattatctccactgtggactac ctcctgagagttcaggaatcaattagtgacttttattggtattactctgggaaagatgtt attgatgaacaaggacaacggaatttctccaaagctattcaagtggcaaaacaagtcttt aacactcttacagagtatattcagggtccttgcactgggaatcaacagagtttggcacac agcaggctgtgggatgctgtggtcggctttcttcatgtgtttgcccatatgcagatgaag ctgtcgcaggattccagtcaaattgagctattaaaagaattaatggatctgcagaaggat atggtggtcatgttgctgtccatgttagaaggtaacgttgttaatggaacgattggcaaa cagatggtggatatgcttgtggaatcttccaacaatgtggagatgattctcaaatttttt gacatgttcttaaaactaaaagatttgacgtcgtctgatacttttaaagaatatgacccc gatggcaagggagtcatttccaagagggacttccacaaagcgatggagagtcataagcac tacacgcagtcagaaacggaatttcttttgtcttgtgcggagacggatgagaatgaaacc ctcgactatgaagagttcgtcaaacgcttccacgaacctgcgaaggacatcggcttcaat gtcgccgtccttctgacaaacctctctgagcacatgcccaacgatacccgacttcagact tttctagaattagcagagagcgtcctgaattatttccagccctttctgggccgcatcgaa atcatgggaagtgccaaacgcatcgagagagtctattttgaaatcagtgagtccagtcga acccagtgggagaagccccaggtcaaggagtccaaaagacagttcatatttgatgtggtc aacgaaggaggagaaaaagagaagatggaactctttgtgaacttctgcgaggacaccatc ttcgaaatgcagctggcggctcagatctcagagtcggatctgaacgagaggtcagcgaat aaggaagaaagtgagaaggagaggccagaagagcaggggccgagaatggccttcttctcc attctcacggtcaagtcggccctgtttgcactcaggtacaatatcttgacccttatgcga atgctcagtctgaagagcctgaagaagcagatgaaaaaagtaaaaaagatgaccgtgaag gacatggtcacggccttcttttcatcctactggagtatttttatgaccctcttgcacttc gtggccagcgttttcagaggctttttccgcatcatttgcagcctgctgcttgggggaagc ctggtcgaaggtgctaaaaagatcaaagttgcagaactgttagccaacatgccagacccc actcaggatgaggtgagaggagatggggaggagggagagaggaaacccctggaagccgcc ctgccctccgaggatctgaccgacttaaaggagctgacagaagaaagtgaccttctttcg gacatctttggcctggatctgaagagagaaggaggacagtacaaactaattcctcataat ccaaatgctgggctcagtgacctcatgagcaacccagtccccatgcctgaggtgcaagaa aaatttcaggaacagaaggcaaaagaagaagaaaaggaagaaaaagaagaaaccaaatct gaacctgaaaaagccgagggagaagatggagaaaaagaagagaaagccaaggaagacaag ggcaaacaaaagttgaggcagcttcacacacacagatacggagaaccagaagtgccagag tcagcattctggaagaaaatcatagcatatcaacagaaacttctaaactattttgctcgc aacttttacaacatgagaatgttagccttatttgtcgcatttgctatcaatttcatcttg ctcttctataaggtctccacttcttctgtggttgaaggaaaggagctccccactagaagt tcaagtgaaaatgccaaagtgaccagcctggacagcagctcccatagaatcatcgcagtt cactatgtactagaggagagcagcggctacatggagcccacgttgcgtatcttagctatt ctgcacacggtcatttctttcttctgcatcattggatactactgcttgaaagtcccattg gttatttttaagcgagaaaaggaagtggcacggaaattggaatttgatgggctttatatt acagaacagccttcagaagatgatattaagggccagtgggatagactcgtaatcaacaca cagtcatttcccaacaactactgggacaaatttgttaaaagaaaggttatggataagtat ggagagttctacggccgagacagaatcagtgaattacttggcatggacaaggcagctctg gacttcagtgatgccagagaaaagaagaagccaaagaaggacagctccctatcagctgta ctgaactccattgatgtgaagtatcagatgtggaaactaggagtcgttttcactgacaat tccttcctctacctcgcctggtatatgactatgtctgttcttggacactataacaacttt ttttttgccgctcaccttctcgacattgctatgggattcaagacattaagaaccatcttg tcctcagtaactcacaatggcaaacagctcgtattaaccgttggcttattagctgtcgtt gtatacctgtacactgtggtggcattcaattttttccgaaaattctacaataaaagtgaa gatggtgatacaccagacatgaaatgtgatgatatgctaacatgctatatgttccacatg tatgttggagttcgtgctggaggagggatcggggatgaaatcgaagacccagcaggagat gaatatgagatctatcgaatcatctttgacatcactttcttcttctttgttattgtcatt ctcttggccataatacaaggtctgattatcgatgcttttggagaactaagagaccaacag gaacaagtcaaagaagatatggaaaccaaatgcttcatctgtgggataggcaatgattac ttcgacacagtgccacatggctttgaaacccacactttacaggagcacaacttggctaat tacttgttttttctgatgtatcttataaacaaagatgaaacagaacacacaggacaggaa tcttatgtgtggaagatgtatcaagaaaggtgttgggaatttttcccagcaggggattgc ttccggaaacagtatgaagaccagctaaattaa

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