Symphalangus syndactylus (siamang): 129458731
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Entry
129458731 CDS
T10134
Symbol
JAK1
Name
(RefSeq) tyrosine-protein kinase JAK1 isoform X1
KO
K11217
Janus kinase 1 [EC:
2.7.10.2
]
Organism
ssyn Symphalangus syndactylus (siamang)
Pathway
ssyn01521
EGFR tyrosine kinase inhibitor resistance
ssyn04151
PI3K-Akt signaling pathway
ssyn04217
Necroptosis
ssyn04380
Osteoclast differentiation
ssyn04550
Signaling pathways regulating pluripotency of stem cells
ssyn04620
Toll-like receptor signaling pathway
ssyn04621
NOD-like receptor signaling pathway
ssyn04630
JAK-STAT signaling pathway
ssyn04658
Th1 and Th2 cell differentiation
ssyn04659
Th17 cell differentiation
ssyn05140
Leishmaniasis
ssyn05145
Toxoplasmosis
ssyn05152
Tuberculosis
ssyn05160
Hepatitis C
ssyn05161
Hepatitis B
ssyn05162
Measles
ssyn05163
Human cytomegalovirus infection
ssyn05164
Influenza A
ssyn05165
Human papillomavirus infection
ssyn05166
Human T-cell leukemia virus 1 infection
ssyn05167
Kaposi sarcoma-associated herpesvirus infection
ssyn05168
Herpes simplex virus 1 infection
ssyn05169
Epstein-Barr virus infection
ssyn05171
Coronavirus disease - COVID-19
ssyn05200
Pathways in cancer
ssyn05203
Viral carcinogenesis
ssyn05212
Pancreatic cancer
ssyn05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
ssyn00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
129458731 (JAK1)
04151 PI3K-Akt signaling pathway
129458731 (JAK1)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
129458731 (JAK1)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
129458731 (JAK1)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
129458731 (JAK1)
04621 NOD-like receptor signaling pathway
129458731 (JAK1)
04658 Th1 and Th2 cell differentiation
129458731 (JAK1)
04659 Th17 cell differentiation
129458731 (JAK1)
09158 Development and regeneration
04380 Osteoclast differentiation
129458731 (JAK1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
129458731 (JAK1)
05203 Viral carcinogenesis
129458731 (JAK1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
129458731 (JAK1)
09162 Cancer: specific types
05212 Pancreatic cancer
129458731 (JAK1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
129458731 (JAK1)
05161 Hepatitis B
129458731 (JAK1)
05160 Hepatitis C
129458731 (JAK1)
05171 Coronavirus disease - COVID-19
129458731 (JAK1)
05164 Influenza A
129458731 (JAK1)
05162 Measles
129458731 (JAK1)
05168 Herpes simplex virus 1 infection
129458731 (JAK1)
05163 Human cytomegalovirus infection
129458731 (JAK1)
05167 Kaposi sarcoma-associated herpesvirus infection
129458731 (JAK1)
05169 Epstein-Barr virus infection
129458731 (JAK1)
05165 Human papillomavirus infection
129458731 (JAK1)
09171 Infectious disease: bacterial
05152 Tuberculosis
129458731 (JAK1)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
129458731 (JAK1)
05140 Leishmaniasis
129458731 (JAK1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
129458731 (JAK1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ssyn01001
]
129458731 (JAK1)
Enzymes [BR:
ssyn01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
129458731 (JAK1)
Protein kinases [BR:
ssyn01001
]
Non-receptor tyrosine kinases
JAK family [OT]
129458731 (JAK1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
FERM_F2
Jak1_Phl
SH2_1
FERM_F1
ABC1
SH2
FERM_C_FAK1
Motif
Other DBs
NCBI-GeneID:
129458731
NCBI-ProteinID:
XP_055090882
LinkDB
All DBs
Position
12:47584796..47831025
Genome browser
AA seq
1153 aa
AA seq
DB search
MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEEL
CIKAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
WFHSNDSGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKKLKRKKLENKHKKDEEKNKIRE
EWNNFSYFPEITHIVIKESVVSINKQDNRKMELKLSSHEEALSFVSLVDGYFRLTADAHH
YLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTC
FEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLK
RCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGT
LMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV
ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL
LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT
TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI
MRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT
GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS
GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD
FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSD
SSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTT
FQNLIEGFEALLK
NT seq
3462 nt
NT seq
+upstream
nt +downstream
nt
atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg
agctccaagaagactgaggtgaacctggaggcccctgagccaggggtggaagtgatcttc
tatctgtcggacagggagcccctccggctgggcagtggagagtacacagcagaggaactg
tgcatcaaggctgcacaggcatgccgtatctctcctctttgtcacaacctctttgccctg
tatgacgagaacaccaagctctggtatgctccaaatcgcaccatcaccgttgatgacaag
atgtccctccggctccactaccggatgaggttctatttcaccaattggcatggaaccaac
gacaatgagcagtcagtgtggcgtcattctccaaagaagcagaaaaatggctacgagaaa
aaaaaggttccagatgcaacccctctccttgatgccagctcactggagtatctgtttgct
cagggacagtatgatttggtgaaatgcctggctcctattcgtgaccccaagactgagcag
gatggacatgatattgagaacgagtgtctggggatggctgtcctggccatctcacactat
gccatgatgaagaagatgcagttgccagaactgcccaaggacatcagctacaagcgatat
attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgcggata
aataatgttttcaaggatttcctaaaggaatttaacaacaagaccatttgtgacagcagc
gtgtccacacatgatctgaaggtgaaatacttggctaccttggaaactttgacaaaacat
tacggtgctgaaatatttgagacttccatgttactgatttcatcagaaaatgagatgaat
tggtttcattcgaatgacagtggaaacgttctctactacgaagtgatggtgactgggaat
cttggaatccagtggaggcataaaccaaatgttgtttctgttgagaaggaaaaaaaactg
aagcggaaaaaactggaaaataaacacaagaaggatgaggagaaaaacaagatccgggaa
gagtggaacaatttttcttacttccctgaaatcactcacattgtaataaaggagtctgtg
gtcagcattaacaagcaggacaacaggaaaatggaactgaagctctcttcccacgaggag
gccttgtcctttgtgtccctggtagatggctacttccggctcacagcagacgcccatcat
tacctctgcaccgacgtggcccccccgttgatcgtccacaacatacagaatggctgtcat
ggtccaatctgtacagaatacgctatcaataaattgcggcaagaaggaagcgaggagggg
atgtacgtgctgaggtggagctgcactgactttgacaacatcctcatgaccgtcacctgc
tttgagaagtctgagcaggtgcagggtgcccagaagcagttcaagaactttcagatcgag
gtgcagaagggccgctacagtctgcacggttcggaccgcagcttccccagcttgggagac
ctcatgagccacctcaagaagcagatcctgcgcacagataacatcagcttcatgctaaaa
cgctgctgccagcccaagccccgagaaatctccaacctgctggtggctactaagaaagcc
caggagtggcagcccgtctaccccatgagccagctgagtttcgatcggatcctcaagaag
gatctggtgcagggtgagcaccttgggagaggcacgagaacacacatctactctgggacc
ctgatggattacaaggatgacgaaggaacttctgaagagaagaagataaaagtgatcctc
aaagtcttagaccccagccacagggatatttccctggccttcttcgaggcagccagcatg
atgagacaggtctcccacaaacacatcgtgtacctctacggcgtctgtgtccgcgacgtg
gagaatatcatggtggaagagtttgtggaagggggtcctctggatctcttcatgcaccgg
aaaagcgatgtcctcaccacaccgtggaaattcaaagtcgccaaacagctggccagtgcc
ctgagctacctggaggataaagacctggtccatggaaatgtgtgtactaaaaacctcctc
ctggcccgtgagggcatcgacagtgagtgtggcccattcatcaagctcagtgaccccggc
atccccattacggtgctgtctaggcaagagtgcattgaacgaatcccgtggattgccccc
gagtgtgttgaagactccaagaacctgagtgtggctgctgacaagtggagctttggaacc
acgctctgggaaatctgctacaatggcgagatccccttgaaagacaagacactgattgag
aaagagagattctatgaaagccggtgcaggccagtgacgccatcatgtaaggagctggct
gacctcatgacccgctgcatgaactacgaccccaatcagaggcccttcttccgagccatc
atgagagacattaataagcttgaagagcagaatccagatattgtttcagaaaaaaaacca
gcaactgaagtggaccccacacattttgaaaagcgcttcctaaagaggatccgtgacttg
ggagagggccactttgggaaggttgagctctgcaggtatgaccccgaaggggacaataca
ggggagcaggtggctgttaaatctctgaagcctgagagtggaggtaaccacatagctgat
ctgaaaaaggaaatcgagatcttaaggaacctctatcacgagaacattgtgaagtacaaa
ggaatctgcacagaagacggaggaaacggtattaagctcatcatggaatttctgccttcg
ggaagccttaaggaatatcttccaaagaacaagaacaaaattaacctcaaacagcagcta
aaatatgccgttcagatttgtaaggggatggactatttgggttctcggcaatacgttcac
cgggacttggcagcaagaaatgtccttgttgagagtgaacaccaagtgaagattggagac
ttcggtttaaccaaagcaattgaaaccgataaggagtattacaccgtcaaggatgaccgg
gacagccctgtgttttggtatgctccagaatgtttaatgcaatctaaattttatattgcc
tctgacgtctggtcttttggagtcactctgcatgagctgctgacttactgtgattcagat
tctagtcccatggctttgttcctgaaaatgataggcccaacccatggccagatgacagtc
acaagacttgtgaatacattaaaagaaggaaaacgcctgccgtgcccacctaactgtcca
gatgaggtttatcaacttatgaggaaatgctgggaattccaaccatccaatcggacaacc
tttcagaaccttattgaaggatttgaagcacttttaaaataa
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