KEGG   Symphalangus syndactylus (siamang): 129466472
Entry
129466472         CDS       T10134                                 
Symbol
AKT2
Name
(RefSeq) RAC-beta serine/threonine-protein kinase isoform X3
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
ssyn  Symphalangus syndactylus (siamang)
Pathway
ssyn01521  EGFR tyrosine kinase inhibitor resistance
ssyn01522  Endocrine resistance
ssyn01524  Platinum drug resistance
ssyn04010  MAPK signaling pathway
ssyn04012  ErbB signaling pathway
ssyn04014  Ras signaling pathway
ssyn04015  Rap1 signaling pathway
ssyn04022  cGMP-PKG signaling pathway
ssyn04024  cAMP signaling pathway
ssyn04062  Chemokine signaling pathway
ssyn04066  HIF-1 signaling pathway
ssyn04068  FoxO signaling pathway
ssyn04071  Sphingolipid signaling pathway
ssyn04072  Phospholipase D signaling pathway
ssyn04140  Autophagy - animal
ssyn04150  mTOR signaling pathway
ssyn04151  PI3K-Akt signaling pathway
ssyn04152  AMPK signaling pathway
ssyn04210  Apoptosis
ssyn04211  Longevity regulating pathway
ssyn04213  Longevity regulating pathway - multiple species
ssyn04218  Cellular senescence
ssyn04261  Adrenergic signaling in cardiomyocytes
ssyn04370  VEGF signaling pathway
ssyn04371  Apelin signaling pathway
ssyn04380  Osteoclast differentiation
ssyn04510  Focal adhesion
ssyn04517  IgSF CAM signaling
ssyn04518  Integrin signaling
ssyn04550  Signaling pathways regulating pluripotency of stem cells
ssyn04611  Platelet activation
ssyn04613  Neutrophil extracellular trap formation
ssyn04620  Toll-like receptor signaling pathway
ssyn04625  C-type lectin receptor signaling pathway
ssyn04630  JAK-STAT signaling pathway
ssyn04660  T cell receptor signaling pathway
ssyn04662  B cell receptor signaling pathway
ssyn04664  Fc epsilon RI signaling pathway
ssyn04666  Fc gamma R-mediated phagosome formation
ssyn04668  TNF signaling pathway
ssyn04722  Neurotrophin signaling pathway
ssyn04725  Cholinergic synapse
ssyn04728  Dopaminergic synapse
ssyn04810  Regulation of actin cytoskeleton
ssyn04910  Insulin signaling pathway
ssyn04914  Progesterone-mediated oocyte maturation
ssyn04915  Estrogen signaling pathway
ssyn04917  Prolactin signaling pathway
ssyn04919  Thyroid hormone signaling pathway
ssyn04920  Adipocytokine signaling pathway
ssyn04922  Glucagon signaling pathway
ssyn04923  Regulation of lipolysis in adipocytes
ssyn04926  Relaxin signaling pathway
ssyn04929  GnRH secretion
ssyn04931  Insulin resistance
ssyn04932  Non-alcoholic fatty liver disease
ssyn04933  AGE-RAGE signaling pathway in diabetic complications
ssyn04935  Growth hormone synthesis, secretion and action
ssyn04936  Alcoholic liver disease
ssyn04973  Carbohydrate digestion and absorption
ssyn05010  Alzheimer disease
ssyn05017  Spinocerebellar ataxia
ssyn05132  Salmonella infection
ssyn05135  Yersinia infection
ssyn05142  Chagas disease
ssyn05145  Toxoplasmosis
ssyn05152  Tuberculosis
ssyn05160  Hepatitis C
ssyn05161  Hepatitis B
ssyn05162  Measles
ssyn05163  Human cytomegalovirus infection
ssyn05164  Influenza A
ssyn05165  Human papillomavirus infection
ssyn05166  Human T-cell leukemia virus 1 infection
ssyn05167  Kaposi sarcoma-associated herpesvirus infection
ssyn05168  Herpes simplex virus 1 infection
ssyn05169  Epstein-Barr virus infection
ssyn05170  Human immunodeficiency virus 1 infection
ssyn05200  Pathways in cancer
ssyn05205  Proteoglycans in cancer
ssyn05207  Chemical carcinogenesis - receptor activation
ssyn05208  Chemical carcinogenesis - reactive oxygen species
ssyn05210  Colorectal cancer
ssyn05211  Renal cell carcinoma
ssyn05212  Pancreatic cancer
ssyn05213  Endometrial cancer
ssyn05214  Glioma
ssyn05215  Prostate cancer
ssyn05218  Melanoma
ssyn05220  Chronic myeloid leukemia
ssyn05221  Acute myeloid leukemia
ssyn05222  Small cell lung cancer
ssyn05223  Non-small cell lung cancer
ssyn05224  Breast cancer
ssyn05225  Hepatocellular carcinoma
ssyn05226  Gastric cancer
ssyn05230  Central carbon metabolism in cancer
ssyn05231  Choline metabolism in cancer
ssyn05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ssyn05415  Diabetic cardiomyopathy
ssyn05417  Lipid and atherosclerosis
ssyn05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ssyn00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    129466472 (AKT2)
   04012 ErbB signaling pathway
    129466472 (AKT2)
   04014 Ras signaling pathway
    129466472 (AKT2)
   04015 Rap1 signaling pathway
    129466472 (AKT2)
   04370 VEGF signaling pathway
    129466472 (AKT2)
   04371 Apelin signaling pathway
    129466472 (AKT2)
   04630 JAK-STAT signaling pathway
    129466472 (AKT2)
   04668 TNF signaling pathway
    129466472 (AKT2)
   04066 HIF-1 signaling pathway
    129466472 (AKT2)
   04068 FoxO signaling pathway
    129466472 (AKT2)
   04072 Phospholipase D signaling pathway
    129466472 (AKT2)
   04071 Sphingolipid signaling pathway
    129466472 (AKT2)
   04024 cAMP signaling pathway
    129466472 (AKT2)
   04022 cGMP-PKG signaling pathway
    129466472 (AKT2)
   04151 PI3K-Akt signaling pathway
    129466472 (AKT2)
   04152 AMPK signaling pathway
    129466472 (AKT2)
   04150 mTOR signaling pathway
    129466472 (AKT2)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    129466472 (AKT2)
   04518 Integrin signaling
    129466472 (AKT2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    129466472 (AKT2)
  09143 Cell growth and death
   04210 Apoptosis
    129466472 (AKT2)
   04218 Cellular senescence
    129466472 (AKT2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    129466472 (AKT2)
   04550 Signaling pathways regulating pluripotency of stem cells
    129466472 (AKT2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    129466472 (AKT2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    129466472 (AKT2)
   04613 Neutrophil extracellular trap formation
    129466472 (AKT2)
   04620 Toll-like receptor signaling pathway
    129466472 (AKT2)
   04625 C-type lectin receptor signaling pathway
    129466472 (AKT2)
   04660 T cell receptor signaling pathway
    129466472 (AKT2)
   04662 B cell receptor signaling pathway
    129466472 (AKT2)
   04664 Fc epsilon RI signaling pathway
    129466472 (AKT2)
   04666 Fc gamma R-mediated phagosome formation
    129466472 (AKT2)
   04062 Chemokine signaling pathway
    129466472 (AKT2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    129466472 (AKT2)
   04922 Glucagon signaling pathway
    129466472 (AKT2)
   04923 Regulation of lipolysis in adipocytes
    129466472 (AKT2)
   04920 Adipocytokine signaling pathway
    129466472 (AKT2)
   04929 GnRH secretion
    129466472 (AKT2)
   04915 Estrogen signaling pathway
    129466472 (AKT2)
   04914 Progesterone-mediated oocyte maturation
    129466472 (AKT2)
   04917 Prolactin signaling pathway
    129466472 (AKT2)
   04926 Relaxin signaling pathway
    129466472 (AKT2)
   04935 Growth hormone synthesis, secretion and action
    129466472 (AKT2)
   04919 Thyroid hormone signaling pathway
    129466472 (AKT2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    129466472 (AKT2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    129466472 (AKT2)
  09156 Nervous system
   04725 Cholinergic synapse
    129466472 (AKT2)
   04728 Dopaminergic synapse
    129466472 (AKT2)
   04722 Neurotrophin signaling pathway
    129466472 (AKT2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    129466472 (AKT2)
  09149 Aging
   04211 Longevity regulating pathway
    129466472 (AKT2)
   04213 Longevity regulating pathway - multiple species
    129466472 (AKT2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129466472 (AKT2)
   05205 Proteoglycans in cancer
    129466472 (AKT2)
   05207 Chemical carcinogenesis - receptor activation
    129466472 (AKT2)
   05208 Chemical carcinogenesis - reactive oxygen species
    129466472 (AKT2)
   05230 Central carbon metabolism in cancer
    129466472 (AKT2)
   05231 Choline metabolism in cancer
    129466472 (AKT2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    129466472 (AKT2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    129466472 (AKT2)
   05212 Pancreatic cancer
    129466472 (AKT2)
   05225 Hepatocellular carcinoma
    129466472 (AKT2)
   05226 Gastric cancer
    129466472 (AKT2)
   05214 Glioma
    129466472 (AKT2)
   05221 Acute myeloid leukemia
    129466472 (AKT2)
   05220 Chronic myeloid leukemia
    129466472 (AKT2)
   05218 Melanoma
    129466472 (AKT2)
   05211 Renal cell carcinoma
    129466472 (AKT2)
   05215 Prostate cancer
    129466472 (AKT2)
   05213 Endometrial cancer
    129466472 (AKT2)
   05224 Breast cancer
    129466472 (AKT2)
   05222 Small cell lung cancer
    129466472 (AKT2)
   05223 Non-small cell lung cancer
    129466472 (AKT2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    129466472 (AKT2)
   05170 Human immunodeficiency virus 1 infection
    129466472 (AKT2)
   05161 Hepatitis B
    129466472 (AKT2)
   05160 Hepatitis C
    129466472 (AKT2)
   05164 Influenza A
    129466472 (AKT2)
   05162 Measles
    129466472 (AKT2)
   05168 Herpes simplex virus 1 infection
    129466472 (AKT2)
   05163 Human cytomegalovirus infection
    129466472 (AKT2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    129466472 (AKT2)
   05169 Epstein-Barr virus infection
    129466472 (AKT2)
   05165 Human papillomavirus infection
    129466472 (AKT2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    129466472 (AKT2)
   05135 Yersinia infection
    129466472 (AKT2)
   05152 Tuberculosis
    129466472 (AKT2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    129466472 (AKT2)
   05142 Chagas disease
    129466472 (AKT2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    129466472 (AKT2)
   05017 Spinocerebellar ataxia
    129466472 (AKT2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    129466472 (AKT2)
   05418 Fluid shear stress and atherosclerosis
    129466472 (AKT2)
   05415 Diabetic cardiomyopathy
    129466472 (AKT2)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    129466472 (AKT2)
   04932 Non-alcoholic fatty liver disease
    129466472 (AKT2)
   04931 Insulin resistance
    129466472 (AKT2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    129466472 (AKT2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    129466472 (AKT2)
   01524 Platinum drug resistance
    129466472 (AKT2)
   01522 Endocrine resistance
    129466472 (AKT2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ssyn01001]
    129466472 (AKT2)
Enzymes [BR:ssyn01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     129466472 (AKT2)
Protein kinases [BR:ssyn01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   129466472 (AKT2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 Seadorna_VP7
Other DBs
NCBI-GeneID: 129466472
NCBI-ProteinID: XP_055106009
LinkDB
Position
17:21882784..21936283
AA seq 481 aa
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM
DYKCGSPSDSSVAEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
E
NT seq 1446 nt   +upstreamnt  +downstreamnt
atgaacgaggtgtctgtcatcaaagaaggctggctccacaagcgtggtgaatacatcaag
acctggaggccacggtacttcctgctgaagagcgacggctccttcattgggtacaaggag
aggcccgaggcccctgatcagaccctaccccccttaaacaacttctctgtagcagaatgc
cagctgatgaagaccgagaggccgcgacccaacacctttgtcatacgctgcctgcagtgg
accacagtcatcgagaggaccttccatgtggattctccagatgagagggaggagtggatg
cgggccatccagatggtcgccaacagcctcaagcagcgggccccaggcgaggaccccatg
gactacaagtgtggctcccccagtgactcctccgtggctgaggagatggaagtggcggtc
agcaaggcacgggctaaagtgaccatgaatgacttcgactatctcaaactccttggcaag
ggaacctttggcaaagtcatcctggtgcgggagaaggccactggccgctactacgccatg
aagatcctgcggaaggaagtcatcattgccaaggacgaagtcgctcacacagtcaccgag
agccgggtcctccagaacaccaggcacccgttcctcactgcgctgaagtacgccttccag
acccacgaccgcctgtgcttcgtgatggagtacgccaacgggggtgagctgttcttccac
ctgtcccgggagcgtgtcttcacagaggagcgggcccggttttatggtgcagagatcgtc
tcagctcttgagtacttgcactcgcgggacgtggtataccgcgacatcaagctggaaaac
ctcatgctggacaaagatggccacatcaagatcactgactttggcctctgcaaagaaggc
atcagtgacggggccaccatgaaaaccttctgtgggaccccggagtacctggcgcctgag
gtgctggaggacaatgactatggccgggccgtggactggtgggggctgggcgtggtcatg
tacgagatgatgtgcggccgcctgcccttctacaaccaggaccatgagcgcctcttcgag
ctcatcctcatggaagagatccgcttcccgcgcacgctcagccccgaggccaaatccctg
cttgccgggctgcttaagaaggaccccaagcagaggcttggtggggggcccagcgatgcc
aaggaggtcatggagcacaggttcttcctcagcatcaactggcaggacgtggtccagaag
aagctcctgccacccttcaaacctcaggtcacgtccgaggtcgacacaaggtacttcgat
gatgaattcaccgcccagtccatcacaatcacaccccctgaccgctatgacagtctgggc
ttactggagctggaccagcggacccacttcccccagttctcctactcggccagcatccgc
gagtga

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