KEGG   Symphalangus syndactylus (siamang): 129468569
Entry
129468569         CDS       T10134                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X3
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
ssyn  Symphalangus syndactylus (siamang)
Pathway
ssyn01522  Endocrine resistance
ssyn04010  MAPK signaling pathway
ssyn04015  Rap1 signaling pathway
ssyn04068  FoxO signaling pathway
ssyn04071  Sphingolipid signaling pathway
ssyn04114  Oocyte meiosis
ssyn04148  Efferocytosis
ssyn04218  Cellular senescence
ssyn04261  Adrenergic signaling in cardiomyocytes
ssyn04370  VEGF signaling pathway
ssyn04380  Osteoclast differentiation
ssyn04550  Signaling pathways regulating pluripotency of stem cells
ssyn04611  Platelet activation
ssyn04613  Neutrophil extracellular trap formation
ssyn04620  Toll-like receptor signaling pathway
ssyn04621  NOD-like receptor signaling pathway
ssyn04622  RIG-I-like receptor signaling pathway
ssyn04625  C-type lectin receptor signaling pathway
ssyn04657  IL-17 signaling pathway
ssyn04658  Th1 and Th2 cell differentiation
ssyn04659  Th17 cell differentiation
ssyn04660  T cell receptor signaling pathway
ssyn04664  Fc epsilon RI signaling pathway
ssyn04668  TNF signaling pathway
ssyn04670  Leukocyte transendothelial migration
ssyn04714  Thermogenesis
ssyn04722  Neurotrophin signaling pathway
ssyn04723  Retrograde endocannabinoid signaling
ssyn04728  Dopaminergic synapse
ssyn04750  Inflammatory mediator regulation of TRP channels
ssyn04912  GnRH signaling pathway
ssyn04914  Progesterone-mediated oocyte maturation
ssyn04917  Prolactin signaling pathway
ssyn04926  Relaxin signaling pathway
ssyn04932  Non-alcoholic fatty liver disease
ssyn04933  AGE-RAGE signaling pathway in diabetic complications
ssyn04935  Growth hormone synthesis, secretion and action
ssyn04936  Alcoholic liver disease
ssyn05014  Amyotrophic lateral sclerosis
ssyn05020  Prion disease
ssyn05022  Pathways of neurodegeneration - multiple diseases
ssyn05132  Salmonella infection
ssyn05133  Pertussis
ssyn05135  Yersinia infection
ssyn05140  Leishmaniasis
ssyn05142  Chagas disease
ssyn05145  Toxoplasmosis
ssyn05152  Tuberculosis
ssyn05161  Hepatitis B
ssyn05163  Human cytomegalovirus infection
ssyn05167  Kaposi sarcoma-associated herpesvirus infection
ssyn05169  Epstein-Barr virus infection
ssyn05170  Human immunodeficiency virus 1 infection
ssyn05171  Coronavirus disease - COVID-19
ssyn05205  Proteoglycans in cancer
ssyn05208  Chemical carcinogenesis - reactive oxygen species
ssyn05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ssyn05415  Diabetic cardiomyopathy
ssyn05417  Lipid and atherosclerosis
ssyn05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ssyn00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    129468569 (MAPK12)
   04015 Rap1 signaling pathway
    129468569 (MAPK12)
   04370 VEGF signaling pathway
    129468569 (MAPK12)
   04668 TNF signaling pathway
    129468569 (MAPK12)
   04068 FoxO signaling pathway
    129468569 (MAPK12)
   04071 Sphingolipid signaling pathway
    129468569 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    129468569 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    129468569 (MAPK12)
   04218 Cellular senescence
    129468569 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    129468569 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    129468569 (MAPK12)
   04613 Neutrophil extracellular trap formation
    129468569 (MAPK12)
   04620 Toll-like receptor signaling pathway
    129468569 (MAPK12)
   04621 NOD-like receptor signaling pathway
    129468569 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    129468569 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    129468569 (MAPK12)
   04660 T cell receptor signaling pathway
    129468569 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    129468569 (MAPK12)
   04659 Th17 cell differentiation
    129468569 (MAPK12)
   04657 IL-17 signaling pathway
    129468569 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    129468569 (MAPK12)
   04670 Leukocyte transendothelial migration
    129468569 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    129468569 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    129468569 (MAPK12)
   04917 Prolactin signaling pathway
    129468569 (MAPK12)
   04926 Relaxin signaling pathway
    129468569 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    129468569 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    129468569 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    129468569 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    129468569 (MAPK12)
   04722 Neurotrophin signaling pathway
    129468569 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    129468569 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    129468569 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    129468569 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    129468569 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    129468569 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    129468569 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    129468569 (MAPK12)
   05161 Hepatitis B
    129468569 (MAPK12)
   05171 Coronavirus disease - COVID-19
    129468569 (MAPK12)
   05163 Human cytomegalovirus infection
    129468569 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    129468569 (MAPK12)
   05169 Epstein-Barr virus infection
    129468569 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    129468569 (MAPK12)
   05135 Yersinia infection
    129468569 (MAPK12)
   05133 Pertussis
    129468569 (MAPK12)
   05152 Tuberculosis
    129468569 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    129468569 (MAPK12)
   05140 Leishmaniasis
    129468569 (MAPK12)
   05142 Chagas disease
    129468569 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    129468569 (MAPK12)
   05020 Prion disease
    129468569 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    129468569 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    129468569 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    129468569 (MAPK12)
   05415 Diabetic cardiomyopathy
    129468569 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    129468569 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    129468569 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    129468569 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    129468569 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ssyn01001]
    129468569 (MAPK12)
Enzymes [BR:ssyn01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     129468569 (MAPK12)
Protein kinases [BR:ssyn01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   129468569 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kinase-like
Other DBs
NCBI-GeneID: 129468569
NCBI-ProteinID: XP_055110275
LinkDB
Position
18:9642708..9653736
AA seq 519 aa
MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFRWGRSGREDPPCPCP
AADHPGTHTLSAKSEGPGQGRPGEGSRRLLPDLQSYLVMPFMGTDLGKLMKHEKLGEDRI
QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRW
YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFV
QRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAAEALAHPY
FESLHDTEDEPQVQKYDDSFDDVDRTLDEWKREWGAPGRACVDPSGGLRAGPVWTQVGGS
GQGLYGPVSGGLLARPVWTRVGVSGQGLCGPHGPCAGGQPQSPRSRSLGCRSGEEDGRSE
GSVGPCGLVEMTNGWSWKMKGGCSWQAQHRDWHRRSWEW
NT seq 1560 nt   +upstreamnt  +downstreamnt
atgagctctccgccgcccgcccgcagtggcttttaccgccaggaggtgaccaagacggcc
tgggaggtgcgcgccgtataccgggacctgcagcccgtgggctcgggcgcctatggcgcg
gtgtgctcggccgtggacagccgcaccggcgctaaggtggccatcaagaagctgtatcgg
cccttccagtccgagctgttcgccaagcgcgcctaccgcgagctgcgcctgctcaagcac
atgcgccacgagaacgtgatcgggctgctggacgtattcactcctgatgagaccctggat
gacttcacagacttcaggtgggggagaagcggcagggaggacccaccctgcccctgccct
gcagccgaccaccccgggactcacaccttgtcggccaagagtgaagggccaggccaagga
aggcctggagagggcagcaggcgcctcctgcctgacttgcagagttacctggtgatgccg
ttcatgggcactgacctgggcaagctcatgaaacatgagaagctaggcgaggaccggatc
cagttcctcgtgtaccagatgctgaaggggctgaggtatatccacgctgccggcatcatc
cacagagacctgaagcccggcaacctggctgtgaacgaagactgtgagctgaagatcctg
gactttggcctggccaggcaggcagacagtgagatgactgggtacgtggtgacccggtgg
taccgagctcccgaggtcatcttgaattggatgcgctacacgcagacggtggacatctgg
tctgtgggctgcatcatggcggagatgatcacaggcaagacgctgttcaagggcagcgac
cacctagaccagctgaaagagatcatgaaggtgacagggacgcctccggctgagtttgtg
cagcggctgcagagcgatgaggccaagaactacatgaagggcctccctgaattggagaag
aaggattttgcctccatcctgaccaatgcaagccctctggctgtgaacctcctggagaag
atgctggtgctggatgcggagcagcgggtgacggcggccgaggcgctggcccatccctac
ttcgagtccctgcacgacacggaagatgagccccaggtccagaagtatgatgactccttt
gacgacgtggaccgcacactggatgaatggaagcgtgagtggggggctccgggcagggcc
tgtgtggacccgagtggggggctccgggcagggcctgtgtggacccaagtagggggctcc
gggcagggcctgtatggaccagtgagtggggggctcctggcacggcctgtgtggacccga
gtgggggtctccgggcagggcctgtgtgggccccatgggccctgtgcaggtggccagcct
cagagtcctagatcccggtccctgggatgcaggtcaggtgaggaggacgggaggtcagag
ggcagcgtggggccgtgtggcctggtggagatgaccaatggctggagctggaagatgaag
ggagggtgttcctggcaggctcagcacagagactggcacagaaggagctgggaatggtga

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