KEGG   Symphalangus syndactylus (siamang): 129474865
Entry
129474865         CDS       T10134                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ssyn  Symphalangus syndactylus (siamang)
Pathway
ssyn00562  Inositol phosphate metabolism
ssyn01100  Metabolic pathways
ssyn04015  Rap1 signaling pathway
ssyn04020  Calcium signaling pathway
ssyn04022  cGMP-PKG signaling pathway
ssyn04062  Chemokine signaling pathway
ssyn04070  Phosphatidylinositol signaling system
ssyn04071  Sphingolipid signaling pathway
ssyn04072  Phospholipase D signaling pathway
ssyn04081  Hormone signaling
ssyn04082  Neuroactive ligand signaling
ssyn04261  Adrenergic signaling in cardiomyocytes
ssyn04270  Vascular smooth muscle contraction
ssyn04310  Wnt signaling pathway
ssyn04371  Apelin signaling pathway
ssyn04540  Gap junction
ssyn04611  Platelet activation
ssyn04613  Neutrophil extracellular trap formation
ssyn04621  NOD-like receptor signaling pathway
ssyn04713  Circadian entrainment
ssyn04720  Long-term potentiation
ssyn04723  Retrograde endocannabinoid signaling
ssyn04724  Glutamatergic synapse
ssyn04725  Cholinergic synapse
ssyn04726  Serotonergic synapse
ssyn04728  Dopaminergic synapse
ssyn04730  Long-term depression
ssyn04742  Taste transduction
ssyn04750  Inflammatory mediator regulation of TRP channels
ssyn04911  Insulin secretion
ssyn04912  GnRH signaling pathway
ssyn04915  Estrogen signaling pathway
ssyn04916  Melanogenesis
ssyn04918  Thyroid hormone synthesis
ssyn04919  Thyroid hormone signaling pathway
ssyn04921  Oxytocin signaling pathway
ssyn04922  Glucagon signaling pathway
ssyn04924  Renin secretion
ssyn04925  Aldosterone synthesis and secretion
ssyn04926  Relaxin signaling pathway
ssyn04927  Cortisol synthesis and secretion
ssyn04928  Parathyroid hormone synthesis, secretion and action
ssyn04929  GnRH secretion
ssyn04933  AGE-RAGE signaling pathway in diabetic complications
ssyn04934  Cushing syndrome
ssyn04935  Growth hormone synthesis, secretion and action
ssyn04961  Endocrine and other factor-regulated calcium reabsorption
ssyn04970  Salivary secretion
ssyn04971  Gastric acid secretion
ssyn04972  Pancreatic secretion
ssyn04973  Carbohydrate digestion and absorption
ssyn05010  Alzheimer disease
ssyn05016  Huntington disease
ssyn05017  Spinocerebellar ataxia
ssyn05022  Pathways of neurodegeneration - multiple diseases
ssyn05142  Chagas disease
ssyn05143  African trypanosomiasis
ssyn05146  Amoebiasis
ssyn05163  Human cytomegalovirus infection
ssyn05200  Pathways in cancer
ssyn05415  Diabetic cardiomyopathy
ssyn05417  Lipid and atherosclerosis
Module
ssyn_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ssyn00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    129474865 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    129474865 (PLCB4)
   04310 Wnt signaling pathway
    129474865 (PLCB4)
   04371 Apelin signaling pathway
    129474865 (PLCB4)
   04020 Calcium signaling pathway
    129474865 (PLCB4)
   04070 Phosphatidylinositol signaling system
    129474865 (PLCB4)
   04072 Phospholipase D signaling pathway
    129474865 (PLCB4)
   04071 Sphingolipid signaling pathway
    129474865 (PLCB4)
   04022 cGMP-PKG signaling pathway
    129474865 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    129474865 (PLCB4)
   04081 Hormone signaling
    129474865 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    129474865 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    129474865 (PLCB4)
   04613 Neutrophil extracellular trap formation
    129474865 (PLCB4)
   04621 NOD-like receptor signaling pathway
    129474865 (PLCB4)
   04062 Chemokine signaling pathway
    129474865 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    129474865 (PLCB4)
   04922 Glucagon signaling pathway
    129474865 (PLCB4)
   04929 GnRH secretion
    129474865 (PLCB4)
   04912 GnRH signaling pathway
    129474865 (PLCB4)
   04915 Estrogen signaling pathway
    129474865 (PLCB4)
   04921 Oxytocin signaling pathway
    129474865 (PLCB4)
   04926 Relaxin signaling pathway
    129474865 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    129474865 (PLCB4)
   04918 Thyroid hormone synthesis
    129474865 (PLCB4)
   04919 Thyroid hormone signaling pathway
    129474865 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    129474865 (PLCB4)
   04916 Melanogenesis
    129474865 (PLCB4)
   04924 Renin secretion
    129474865 (PLCB4)
   04925 Aldosterone synthesis and secretion
    129474865 (PLCB4)
   04927 Cortisol synthesis and secretion
    129474865 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    129474865 (PLCB4)
   04270 Vascular smooth muscle contraction
    129474865 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    129474865 (PLCB4)
   04971 Gastric acid secretion
    129474865 (PLCB4)
   04972 Pancreatic secretion
    129474865 (PLCB4)
   04973 Carbohydrate digestion and absorption
    129474865 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    129474865 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    129474865 (PLCB4)
   04725 Cholinergic synapse
    129474865 (PLCB4)
   04728 Dopaminergic synapse
    129474865 (PLCB4)
   04726 Serotonergic synapse
    129474865 (PLCB4)
   04720 Long-term potentiation
    129474865 (PLCB4)
   04730 Long-term depression
    129474865 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    129474865 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    129474865 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    129474865 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    129474865 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129474865 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    129474865 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    129474865 (PLCB4)
   05142 Chagas disease
    129474865 (PLCB4)
   05143 African trypanosomiasis
    129474865 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    129474865 (PLCB4)
   05016 Huntington disease
    129474865 (PLCB4)
   05017 Spinocerebellar ataxia
    129474865 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    129474865 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    129474865 (PLCB4)
   05415 Diabetic cardiomyopathy
    129474865 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    129474865 (PLCB4)
   04934 Cushing syndrome
    129474865 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ssyn04131]
    129474865 (PLCB4)
Enzymes [BR:ssyn01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     129474865 (PLCB4)
Membrane trafficking [BR:ssyn04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    129474865 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    129474865 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 129474865
NCBI-ProteinID: XP_055122669
LinkDB
Position
24:complement(66531417..66945186)
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRTLPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM
MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKASD
DLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAALASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNCLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSM
KLQNAN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gcagttttcgacagatacgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgagtttggcttctttctgacatggaaaagtgaaggcaaggaaggacaggtgcta
gaatgctccctcatcaacagtattcggtcgggagccataccaaaggatcccaaaatcttg
gctgctcttgaagctgttggaaaatcagaaaatgatctggaagggcggatagtttgtgtc
tgcagtggcacagatctagtgaacattagttttacctacatggtggctgaaaatccagaa
gtaactaagcaatgggtagaaggcctgagatcaatcatacacaacttcagggccaacaat
gtcagtccaatgacatgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagttagaagtattaccagaacatttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cccgcggcattttcttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaagatcttttcaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgattgaatgaaattttattt
ccattttatgatgccaaaagggcaatgcagatcattgagatgtatgaacctgatgaagat
ttgaagaaaaaaggccttatatcaagtgatgggttttgcagatatctgatgtcagatgaa
aatgccccagtcttcctagatcgtttagaactttaccaagaaatggaccatcctctggct
cactacttcatcagttcttcccataacacttatctcactggcagacagtttggcgggaag
tcttcggtagaaatgtacagacaggttctcctggctggttgcagatgtgttgaacttgac
tgctgggatggaaaaggtgaagaccaagaaccaataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgtaattcaagccatcaaggaaactgcatttgtcacatca
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggcaggactttgccatcccccaatgacctcaaaagaaaaatactcata
aaaaacaagcggctgaaacctgaagttgaaaaaaaacagctggaagctttgagaagcatg
atggaagctggagaatctgcctccccagcaaacatcttagaggacgataatgaagaggag
atcgaaagtgctgaccaagaggaggaagctcaccctgaattcaaatttggaaatgaactt
tctgctgatgacttgggtcacaaggaagctgttgcaaatagcgtcaagaaggcttcagat
gaccttgaacatgaaaacaacaaaaagggcctggtcactgtagaagatgagcaggcgtgg
atggcatcttataaatatgtaggtgctaccactaatatccatccatatttgtccacaatg
atcaactacgcccagcctgtaaagtttcaaggtttccatgtggcagaagaacgcaatatt
cattataacatgtcttcttttaatgaatcagtcggccttggctacttgaagacacatgca
attgaatttgtcaattacaacaaacggcaaatgagtcgcatttaccccaagggaggccga
gttgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttca
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcgtgcgggtaccttctcaaaccagatttcatgaggcggcctgatcgaacatttgac
cccttctctgaaactcctgttgatggcgttattgcagccacttgctcggtgcaggttata
tcaggtcaattcttatcagataagaaaattggcacctatgtagaagtagatatgtatggg
ttgcccactgacaccatacgtaaggaattccgaactcgcatggttatgaataacggactc
aatccagtttacaatgaagagtcattcgtatttcggaaggtgatcctgccggacctagct
gtcttgagaatagctgtgtatgatgataacaacaagctgattggccagaggatcctccca
cttgatggcctccaggcaggatatcgacacatttcccttcgaaacgagggaaataaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgatgggttt
ggagatattgtggatgctttatcagatccaaagaaatttctctcaattacagaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagccgatgtgcccagtgac
acttccaaaaatgacaagaaaggaaaggccaacaccgccaaagcaaatgtgacccctcag
agtagctctgaactcagaccaacaaccacggctgccctggcctctggtgtggaagccaag
aaaggtattgaacttatccctcaagtaaggatagaagacttaaagcagatgaaggcttac
ttgaagcatttaaagaaacagcagaaggagctaaattgtttaaagaagaaacatgcaaag
gaacacagtaccatgcagaagttacactgcacgcaagttgacaaaattgtggcacagtat
gacaaagagaagtcgactcatgagaaaatcctagagaaggcaatgaagaagaagggggga
agtaattgtctcgaaatgaaaaaagaaacagaaatcaaaattcagacgctgacatcagat
cacaaatctaaggtcaaagagattgtagcacagcacacgaaggaatggtcagaaatgatc
aatacccacagtgctgaggagcaagaaatccgagacctgcacctcagccagcagtgtgag
ctgctgaaaaagctactcatcaatgcccatgagcagcaaacccagcagctgaaactgtcc
catgacagggaaagcaaagaaatgcgagcacaccaggctaagatttctatggaaaatagc
aaagccatcagccaagataaatctatcaagaataaagcagaacgggaaaggcgagtcagg
gagttaaacagcagcaacactaaaaagtttctggaagaaagaaaaagactcgcaatgaag
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacatctagaattcctagag
aaacagaatgagcagcttttgaaatcctgtcatgcagtgtcccaaacgcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagtagtatg
aaactccaaaatgcaaactga

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