Symphalangus syndactylus (siamang): 129475310 Help Entry 129475310         CDS       T10134                                  Symbol SYNE1 Name (RefSeq) nesprin-1 isoform X8   KO K19326   nesprin-1 Organism ssyn  Symphalangus syndactylus (siamang) Pathway ssyn04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:ssyn00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     129475310 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:ssyn03036]     129475310 (SYNE1) Chromosome and associated proteins [BR:ssyn03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     129475310 (SYNE1) SSDB OrthologParalogGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 SYNE1 KASH CH Spectrin_SYNE1_2 SR_desmoplakin_3 SYNE3 Motif Other DBs NCBI-GeneID:  129475310 NCBI-ProteinID:  XP_055123412 LinkDB All DBs Position 2:complement(129850489..130378835) Genome browser AA seq 8700 aa AA seqDB search MWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALL KWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLEKVKGRSNRENLEDAFTI AETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNAGTDGQEDDEILPGFPSF ANSIQNFKREDRLIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQT EHIMQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVAL REEITIQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDM AERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVS FIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVR SMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGN FLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFAT EAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQFKIITKTAHLITKESPQEEGKEM FATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREA QSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADVH VAFQSMVKKTGDWKKRVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTE FFSQLDQRVLSAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKID VEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELC VKLPVRDPVRDTPGTCHMTLRELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNET QLKGIKGEAIDTANLGEVKRAIEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGD ELAKLSSSFKALVTLLSEVEKMLSTFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDT ENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGRLPDRGHEELRKLESTLDGLE RSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEF SKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVK TKWDHFGSNFETLSVWITEKEKELKALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEE EAQSFAQFVTTGESARIKAKLTQIRRYWEELREHAQCLEGTILGHLSQQQKFEENLRKIQ QSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSC VQEAAALQQQYEDILRRAKEKQTALENLLAHWQRLEKELSSFSTWLERGEAIASSPEMDI SADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEKLDER WRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTR HKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQL ALSHLAEFLQSHASLSGILHQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVS LDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQD QKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKARQI AQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENA SSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFS MVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSSRDEIEGWSNNSVPQIAENIS NLDNRLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLRQKL EHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWLTKVEESLIICAQTETCEGLKKVKDI QKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAMSQLCSKTQASLQE SLEKHFSESTQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDA VTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHR KLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWSWVKAIQD RLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQT QLETLKEVWADIMSSSIHAQSTLESVISQWNDYLERKNQLEQWMESVDQKVEHPLQPQPG LKEKFVLLDHFQSILSEAEDHTRALHHLIAKSRDLYEKTEDESFKDTAQEELKTQFNDIM TVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDTSGDSSATQKKLSKIKE LIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLE NLVSQMALSEQEFSGQVAQLEQALEEFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEI LDALQKAEPKTEDLKSQLNELCRFSRDLSAYSGKVSGLIKEYNCLCLQASKGCQNKEQIL QQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNVMV SKGELLSALLTKEKAKGIQAKVAAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPI QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQA ASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDS YCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQS VKDMWASLLSAGIRCKSQLEGALSKWTSYQDDVRQFSGWMDGMEANLNESERQHAELRDK ITMLGKAKLLNEEVVSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVT KSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDVHTHETTLRDLQELQVHCAEG QALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTHFNNVVNKLRLMEQ KFQQVDEWLKTAEEKVSPRTRRQSNRATKELQLHQMKKWHEEVTGYRDEVEEVGARAQEI LDESQVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTH KNFKNVATKIDKVDTAMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAER LRKEIHDHMERLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEP KMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQD LCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAH HKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQ RVYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAVKQVKHFRALQEQ ARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQRLIQAQNLTQGWEEIKHLKADLWIY LQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEES PEHKEINHLNDQWLDVCHQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLAR SDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW FQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEAVKQSPPPDMAQNLLM DHLAICSELEAKQMLLKSLIKDADRVMVDLGLNERQVIQKALSDAQSHVNCLSDLVGQRR KYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKT YQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNFVSRK HFKEDFDKACHWLKQADIVTFPEINLMNESTELHTQLAKYQHILEQSPEYENLLLTLQRT GQTILPSLNEVDHSYLSEKLNALPQQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQ SLSELEAQFLRMSKVPTDLAVEEALSLQDDCRAILDEVAGLGEAVDELNQKKEGFRSTGQ PWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLEGQLKSVKEEQSKVN EETLPAEEKLKMYHSLAGSLQDSGSLLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQEEL KLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLSLQDIQEEIR KIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIHEALRTRQ ATLTEIYSQCQRYYQVFQAANDWLEDAQEMLQLAGNGLDVESAEENLKSHMEFFSTEDQF HSNLEELHSLVATLDPLIKPTGKEDLEQKMASLELRSQRMSQDSGAQVDLLQRCTAQWHD YQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEK ASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATE MIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQALSMLQDGAAP TPGGEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEY LGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKDKYLGLYTILPSELSLQLAEVAL DLKIRDQIQDKIKEVEQSKATSQELSRQIQKIAKDLTTILTKLKAKTDNLVQAKTDQKVL GEELDGCNSKLMELDAAVQKFSEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQA ASHLEEYNEILELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSDLEA MTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQ AALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVAS LPLCHAALRLQEEASRLQHTAIQQCNIMQEAVVQYEQYEQEMKHLQQLIEGAHREIENKP IATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLA EGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPV ANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWE TLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPSRSPESQMAEHQS FLQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKA SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEA QLVDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKNEAEQLAGKLRRLKGSLLELQR ALHDKQLNMQQGTAQEKEENDVDLTATQSPGVQEWLAQARTTWTHQRQSSLQQQKELEQE LAEQKSLLRSVASRGEEILIQHSAAETSSDAGEKPDVLSQELGMEGEKSSAEDQMRMKWE SLHQEFSTKQKLLQNVLEQEQEPVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQ AFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEEHLFVATALLPEETEACLFNQE ILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMK ERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKELDAGI IELKRRGDKLQVEQPSVQELSKLQDMYDELMMTIGSRRSGLNQNLTLKSQYERALQDLAD LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET QFHTELMAQASAVLKQAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGERWLNNT NKVSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN AFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSHIDSQWTDLLTNIPAVQE KLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGFKAIHEYLQKYKGFKIDI NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL LESWSEYENNVQCLKTWFETQEKRLKQQYRIGDQASVQNALKDCQDLEDLIKAKEKEVEK IEQNGLALIQNKKEDVSGVVMSTLRELSQTWANLDHMVGQLKILLKSVLDQWSNHKVAFD KINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKE CHPPVTETLTNTLKEVNMRWNNLLEEIAEQLHSSKALLQLWQRYKEYSKQCASTVQQQED RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFVLHELGEQLKQQVDASAAS AIQSDQLSLSQHLCALEQALCKQQASLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLI SSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELF QAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDS QIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGS YILTVEAGKQLLLSADSGAEAALQAELTEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEK GIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLTLLKDTLSA YISADDISILNERIELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME SKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELK KFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSIL RRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNH NKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEH DLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNPSLSLAQPLRSERSGRDTPASVDS IPLEWDHDYDLSRDLESAVSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLT ENAIKNTSGDHSALESQIRQLGKALDDSRLQIQQTENIIRSKTPTGPELDTSYKGYMKLL GECSGSIDSVKRLEHKLKEEEESLPGFVNLHSTEAQTAGVIDRWELLQAQALSKELRMKQ NLQKWQQFNSDLNSIWAWLGDTEEELEQLQHLELSTDIQTIELQIKKLKELQKAVDHRKA IILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHE MSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIRHELLESQLRVASLQDMSC QLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE LDTSGSVSPASGTSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSG RAFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL NT seq 26103 nt NT seq  +upstreamnt  +downstreamnt atgtggaccattattctatatttccagattgaagagttgaccagcaacctgccccagctc cagtctttgtccagcagcgcttcctccgtggacagcatagttagctctgagactcccagc ccaccaagtaaacggaaggtgaccaccaagatccaaggaaatgctaagaaggctttatta aagtgggttcagtacacggctggcaagcagactggaatagaagtaaaagattttgggaag agttggagaagcggggttgcctttcattcagttattcatgccattcgacccgaactggtg gacttggagaaagtgaaaggcagatccaaccgagaaaatctggaggatgctttcactatc gccgaaacggaactggggatcccaagactgctagatcctgaagatgttgatgtggataaa ccagatgagaagtctattatgacctatgtagcccagtttctgaaacattatcctgacatc cacaatgcaggcactgatgggcaagaggatgatgaaatacttccaggtttcccatctttt gcaaattctatacaaaattttaagagagaagacaggctaatttttaaggaaatgaaagtt tggatagaacaatttgagagagatttgacaagagcacagatggtggaatcaaatttacag gataaatatcagtcatttaagcacttcagagttcaatatgaaatgaagaggaaacagact gaacatataatgcaaccattacatagagacggtaaattgtcacttgaccaagcattggta aaacaatcttgggatagagtgacctccaggctctttgactggcatatacagcttgataaa tctcttcctgcacctctgggcaccataggtgcctggctctacagagcggaggtggccctg agagaggaaataaccattcagcaggtccatgaggaaacagcaaacacgatacaacggaaa cttgagcaacataaggatctgcttcaaaacacagatgcccacaaaagagcattccatgaa atctaccggaccaggtctgttaacgggattccagtgccacctgatcaattagaggacatg gctgagaggtttcattttgtttcctccacatcagagctacacctaatgaaaatggaattt ttagaattaaagtaccgtctgctctcactgctggttcttgcagagtcaaagctgaagtct tggatcattaagtacgggaggagagagtcagtggagcagcttctacaaaactacgtgtct tttatagaaaacagcaagttctttgaacaatatgaagtgacataccagatcttgaaacag acagctgagatgtatgtcaaagcagatggttcagtggaagaagctgagaatgtgatgaaa ttcatgaatgaaaccactgctcagtggaggaatctctcagtagaagtcaggagtgtgagg agcatgctggaagaagtgatctctaactgggatcgctatggcaatacggtggctagtctg caagcctggctagaggatgctgagaaaatgctcaatcaatcagaaaatgccaaaaaggat ttttttcgaaatttacctcattggattcagcagcatactgccatgaacgatgctggcaat tttctaattgaaacctgtgatgagatggtttcccgtgacctgaagcagcaattactgttg ctaaatgggcggtggagggagttgtttatggaagtcaagcaatatgctcaagctgatgag atggacagaatgaagaaggaatacacagactgtgttgttaccctgtctgcttttgcaacg gaagcccataagaaactttctgaacccttagaagtctcttttatgaatgtcaagttatta attcaagacttggaggatattgagcagagggtgcctgtgatggatgcccaattcaagata attacaaagacagcacacctcattaccaaagaaagcccccaagaagaaggaaaagaaatg tttgcaaccatgtcaaagctcaaagagcagctaaccaaggtcaaagaatgttactcccca ctcctttatgagtctcagcagctgttgattccgttggaggaattagaaaagcagatgacg tccttttatgactcacttgggaaaatcaatgaaattatcacagttcttgagcgtgaggca caatcgagtgctctttttaaacaaaaacatcaggaactgttagcttgtcaagaaaactgt aagaaaaccttgacacttattgagaaaggcagtcaaagtgttcaaaagtttgtgaccttg agcaacgtgttaaagcattttgatcagacgaggctacaaagacagattgcagatgttcat gttgcttttcagagtatggtaaagaaaactggagattggaagaagcgtgtggaaaccaac agtcgcttgatgaagaagtttgaggagtctcgagcagagttggagaaggtactgcggatt gctcaggagggtctggaggaaaagggggatccggaggagctcctgcggagacacactgag tttttcagtcagctggatcagagggtgctcagtgctttcctgaaagcttgtgatgaactc accgacatccttccagagcaggagcagcaggggctgcaggaagctgttcgaaagctccac aaacaatggaaggatcttcaaggagaagctccttatcatttgcttcatctgaagattgat gtggagaagaataggttcttagcctctgtagaagaatgcagaactgagctggatcgagag accaagctgatgccccaggaaggcagtgaaaagataattaaagagcacagggttttcttc agtgacaaaggtcctcatcatctctgtgagaaaaggttacagctcatcgaggaactctgt gtgaaactcccagtccgggacccagtaagggacacacctggaacctgtcacatgacactc agagagctcagagctgccattgacagcacctacaggaagctcatggaagacccagacaag tggaaggactacactagcagattctctgagttctcatcttggatatctacaaatgagaca caattaaaggggatcaagggtgaggccatcgatactgccaaccttggagaggttaaacgt gccattgaagagatcagaaatggtgttaccaaaaggggtgagaccctcagctggctgaaa tccaggctgaaagttttgacagaagtttcttctgagaatgaagcccaaaagcagggagat gagctggcaaaattatccagctctttcaaggctcttgtgacgctgctgtcagaggttgaa aagatgctaagcacttttggggactgtgtccagtataaagaaatagtcaaaaattctctt gaagaattaatttctggctctaaagaagtccaggaacaagctgagaagatcttggatact gaaaatctttttgaagcacagcagttacttcttcatcaccagcaaaagacaaagcggatc tcagcaaagaagagagacgtgcaacagcagattgcgcaggcgcagcagggagaagggcgg ctgcctgaccgaggccacgaggagctgcggaagctggagagcaccctggatggcctggag cgcagccgggagaggcaggagcgccgcatccaggtcacattaagaaaatgggagcgattc gaaacaaacaaagaaacagtagtaagatacctttttcaaacaggttccagtcacgaacgc ttcttgagttttagcagtttggaaagtttatcttcagaactggaacaaacaaaggagttt tctaaacggacagaaagtattgcagtccaggctgagaaccttgtaaaggaagcttcagag ataccgcttgggccccaaaataagcagctgcttcaacagcaggccaagtcaatcaaagaa caagtcaaaaaattagaagacacgcttgaagaagatattaaaaccatggaaatggtgaaa accaagtgggatcattttggcagtaattttgagactctgtccgtctggataactgagaaa gagaaagaactcaaggccttggaaacttcgtcatctgccatggacatgcaaatcagccaa attaaggtcacaattcaggaaatagaaagtaagctcagcagcattgtaggattagaagaa gaagcccagtcttttgctcaatttgttaccactggagaatctgctcgaattaaagccaag ttgacacaaataagaagatactgggaagagcttcgagaacatgcacagtgtctggaagga acaatcctgggacatttatctcagcagcaaaagtttgaagagaaccttagaaagatccag caatctgtgtctgaatttgaagataaacttgctgttccaattaaaatatgttcttcagct acagaaacatacaaagttcttcaagaacatatggatctctgccaggccctggagtcactg agcagcgcgatcactgccttctcagccagtgccaggaaggttgtgaatagagactcctgt gttcaggaggctgcggctctacagcagcaatacgaggacatcctaaggagggcaaaggag aaacagactgcgctggagaatctgctggcccactggcagaggctagagaaagaactatca 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gaagggacagaggacctggatggggagctcctccccacgccttcggcccacccctctgtg gtcatgatgactgcaggtcgctgtcacactttgctgtcaccggtcactgaggagtctggg gaggagggaaccaacagtgagatttcctctccacctgcctgtcgctccccttcacctgtg gctaatacagatgcttctgttaaccaggacattgcatattaccaagccttgtctgctgag aggttgcagacagatgctgcaaaaattcaccccagcacatctgcatcccaggagttctat gaaccaggattggagccatccgctactgccaaactgggtgatttgcagcgttcttgggaa accttaaagaatgtgatcagtgagaagcagcgcacactctatgaagctttggaacgccag cagaagtaccaggactccctccagtccatctctacgaagatggaggccattgagctgaaa ctcagtgagagcccagagcccagcaggagtccagaaagccagatggctgaacatcagtct ttcctccaggcattgatggatgagattctcatgctccaggatgaaatcaacgagctccag tcctctctcgcagaggagctggtatccgagtcttgtgaggccgaccccgcggagcagctg gccttgcagtccacgctcactgtcttagccgagcgaatgtccaccatcaggatgaaagcc tcagggaaacggcagcttttggaggagaagttgaatgatcagctggaggaacaaaggcag gaacaggccctgcagaggtatcgctgtgaagccgatgagctggacagctggctcttgagt accaaggccactctggacactgcgctgagtccacccaaggagcccatggacatggaggcc cagcttgtggactgccagaatatgctggtggaaatagagcagaaggtggtggctttatca gaactgtcagtccacaatgagaacctgctgctggagggcaaagctcacaccaagaacgag gcggagcagctggccggaaagctgagaaggctcaaggggagcctgctagagctgcagaga gccctgcacgataagcagctcaacatgcagcagggaacagcacaggagaaggaggagaac gatgttgacctaacagccacgcagagccccggcgtccaggaatggctggcccaagctcgc accacatggacccaccagcggcagagcagtctccagcaacaaaaagagttagaacaggaa ttagccgagcagaagagtctccttcgctcggtagccagtcgtggagaggagattctaatt caacattcggcggcagagacttctagtgacgctggcgaaaaacctgatgtgttatcccag gagttggggatggaaggggagaaatcatccgcggaagaccagatgagaatgaaatgggaa agcctacatcaagaatttagtaccaagcagaaactactacagaatgttctggaacaggaa caagagccagtgctttatagcaggccaaatcgactcttgtctggtgtgccactgtacaaa ggggacgtgccgacccaagataaatctgcagttacatctttgctggatggactgaaccaa gccttcgaggaggtttcatcccagagtggaggggcaaagaggcagagtatacacttggag cagaagttgtatgatggggtctcagccacctctacttggttggatgatgttgaagaacat ttatttgttgccacagcacttttaccagaagaaacagaggcttgtctcttcaaccaagag attcttgccaaagacattaaggaaatgtctgaagaaatggataagaacaaaaacttgttt tcccaagctttcccagagaatggtgataatcgagatgttattgaagatactttgggttgt cttttgggcaggttatccttgctagactcagtagtgaatcaacgatgccatcagatgaaa gaaagacttcagcaaatactaaatttccagaatgatctgaaagtgctgtttacatcactg gctgacaacaaatacatcattctgcagaaactggcaaatgtgtttgaacagcccgttgca gaacaaatagaggcaatacagcaggctgaagatggactcaaagaattggatgcaggaatc attgaattaaagaggcgtggtgacaagttacaagtcgagcagccgtccgtgcaagaactc tccaagctccaggacatgtatgatgagctgatgatgaccattggctcccggaggagtggt ctgaaccagaaccttacactcaagagccagtatgagagggccctacaagatctagctgac ctgctagaaactggtcaggagaagatggcaggagaccagaaaatcatcgtgtcttccaaa gaggaaatccagcaattacttgacaaacataaggaatactttcagggcctggaatctcat atgatcttgactgaaacactcttcagaaagataatcagctttgcagtccaaaaggaaacc cagttccatacagagctgatggctcaggcttctgctgtactgaaacaggctcacaagagg ggtgtggagctggagtacattctagagacgtggtcccatctggatgaagaccagcaggag ctcagcagacagctggaggtggtggaaagcagcatcccaagcgtgggtctggtggaggag aatgaggacaggcttattgaccgcataacactctaccagcatttaaaatctagccttaat gaataccagcccaaattatatcaagtattagatgatgggaaacgacttctgatatccatc agctgctcagatctagaaagccaactaaatcaacttggagaacgctggctaaataacacc aataaagtgtctaaggaacttcacagattggaaacaatattgaaacactggaccagatat caaagtgaatctgcagatctaattcactggttacaatctgcaaaagacaggctagaattt tggactcagcaatctgtgacagtcccacaagagctggaaatggtccgtgatcatctaaat gctttcctggagttttctaaagaagtggatgcccaatcttccctgaaatcatctgttctg agtactggaaatcagctccttcgactaaaaaaggtggacacagccacgctgcgctctgag ctgtcacacattgatagccagtggactgacctgctaaccaatatcccagccgtccaggag aagctccaccagctccagatggataaactgccttcccgccatgccatttctgaagtcatg agttggatttctctaatggaaaatgttattcagaaggatgaagataatattaaaaattcc ataggtttcaaggcaattcatgaataccttcagaaatataagggttttaagatagacatt aactgtaaacagctgacggtggattttgtgaaccagtccgtgctacaaatcagcagtcag gatgtggaaagtaaacgtagtgataagactgattttgctgagcaacttggagcaatgaat aaaagttggcaaattctgcaaggtctagtaactgagaagatccagctattggaaggctta ttggaatcttggtcagaatatgaaaataatgtacaatgtctgaaaacatggtttgaaacc caggaaaagagactaaaacaacagtatcgaattggagatcaggcttctgttcaaaatgca ctgaaagactgtcaggatctggaagatttgattaaagcaaaagaaaaagaagtagagaaa attgagcagaatggacttgctttgattcagaacaagaaagaagacgtctctggcgttgtc atgagcacgctgcgagagctcagccaaacctgggcgaatttagatcacatggttggacaa ttaaagatactgctgaaatcagtgcttgaccaatggagtaatcacaaagtggcctttgac aagataaacagttaccttatggaggccagatactctctttcccgattccgtctgctgact ggctccttagaagctgtgcaagttcaggtggacaatcttcagaatctccaagacgatctg gaaaaacaggaaaggagcttacagaaatttggctctatcaccaaccaattattaaaagag tgtcacccacctgtgacagaaactcttaccaatacactgaaagaagtcaacatgagatgg aataacttgttggaagagattgctgagcagctacactccagcaaggccctacttcagctt tggcaaagatacaaggagtactccaaacagtgtgcttcgacagttcagcagcaggaggat cgaaccaatgagctgttgaaggcagccacaaacaaggacatcgccgatgatgaggttgct acatggattcaagattgcaacgacctcctcaaaggactgggcacagttaaagattccctc tttgttctccatgagctgggagagcaactgaagcaacaagtggatgcttcagcagcatca gctattcaatcggatcaactctctttgagtcaacacttgtgtgccctggagcaggctctc tgcaaacagcaggcttcgttacaggctggagttcttgattatgaaacgtttgccaagagt ttagaagctttggaggcctggatagtggaagctgaagaaatactacaagggcaggaccct agccactcatctgacctctccacaatccaggaaaggatggaagaacttaagggacagatg ttaaaattcagcagcatggctccagatttagaccgtctaaatgagcttggatataggtta cccttgaatgataaggaaatcaaaaggatgcagaatctgaaccgccattggtctctgatc tcctctcagactacagaaagattcagcaagttgcagtcatttttgctacaacatcagact ttcttggaaaaatgtgaaacatggatggaattcctagttcagacagaacaaaagttagca gtagagatttcaggaaattaccagcaccttttggaacagcagagagcacacgagttgttt caagccgagatgttcagtcgtcagcagattttgcactcaatcattattgatgggcaacgt cttctagaacaaggtcaagttgatgacagggatgaattcaacctgaaattgacactcctc agtaatcaatggcagggagtgattcgcagggcccagcagaggcgggggatcattgacagc cagattcgccagtggcagcgctatagggagatggcagaaaagcttcgtaaatggttggtt gaagtgtcctacctccccatgagtggtctcggaagtgttcctataccactgcaacaagca aggaccctctttgatgaagtgcagttcaaagaaaaggtgttcctgcggcaacaaggcagc tacatcctgactgtggaggctggcaagcaactccttctctcggcggacagtggcgccgag gccgccttgcaggccgaactcactgaaatccaagagaaatggaaatcagccagcatgcgg ctggaagaacagaagaaaaaactagccttcttgttgaaagactgggaaaaatgtgagaaa ggaatagcagattccctggagaaactacgaactttcaaaaagaagctttcccagtcccta ccagatcaccatgaagagctccatgcagaacaaatgcgttgcaaggaattagaaaatgca gttgggagctggacagatgacttgacccagttgaccctgctgaaggacaccctttctgcc tatatcagtgctgatgatatctccattcttaatgaacgcatagagcttctacaaaggcag tgggaagaactatgccaccagctctccttaagacggcagcaaataggtgaaagattgaat gaatgggcagtcttcagtgaaaagaacaaggaactctgtgagtggttgactcaaatggaa agcaaggtttctcagaatggagacattctcattgaagaaatgatagagaagctcaagaag gattatcaagaggaaattgctattgctcaagagaacaaaatacagctccaacaaatggga gaacgacttgctaaagccagccatgaaagcaaagcatctgagattgaatacaagctggga aaggtcaacgaccggtggcagcatctcctggacctcattgcagccagggtgaagaagctg aaggagaccctggtagccgtgcagcagcttgataagaacatgagcagcctgaggacctgg ctcgctcacatcgagtcagagctggccaagccaatagtctatgattcctgtaactcggaa gaaatacagagaaagcttaatgagcagcaggagcttcagagagacatagagaagcatagt acaggtgttgcatctgtcctcaacctgtgtgaagtcctgctgcacgactgtgacgcctgt gccactgatgccgagtgtgactctatacagcaggctacaagaaacctggaccggcggtgg agaaacatttgtgctatgtccatggaaaggaggctcaaaattgaagagacgtggcgattg tggcagaaatttctggatgactattcacgttttgaagattggctgaagtcttcagaaagg acagctgcttttcccagctcttctggggtcatctatacagttgccaaggaagaactaaag aaatttgaggctttccagcgacaggtccacgagtgcctgacgcagctggaactgatcaac aagcagtaccgccgcctggccagggagaaccgcactgattcagcgtgtagcctcaaacag atggttcacgaaggcaaccagagatgggacaacctgcaaaagcgtgtcacctccatcttg cgcagactcaagcattttattggccagcgtgaggagtttgagactgcacgagacagcatt ctggtctggctcacagagatggatctgcagctcactaatattgaacatttttctgagtgt gatgttcaagctaaaataaagcaactcaaggccttccagcaggaaatttcactgaaccac aataagattgagcagataattgcccaaggagaacagctgatagaaaagagtgagcccttg gatgcggcgatcatcgaggaggaactagatgagctccgacgctactgccaggaggtcttc gggcgtgtggaaagataccataagaaactgatccgcctgcctctcccagacgatgagcac gacctctcagacagggagctggagctggaagactctgcagctctgtcggacctgcactgg cacgaccgttctgcagacagcctgctttctccacagccttcctccaacccctccctctcg ctcgctcagcccctccggagcgagcggtcaggacgagacaccccggctagtgtggactcc atccccctggagtgggatcacgactatgacctcagtcgggacctggagtctgcagtgtcc agagctctgccctctgaggatgaagagggtcaggatgacaaagatttctacctccgggga gctgttggcttatcagacgtaatgatccccgaaagccctgaggcctatgtaaaactcaca gaaaatgcaatcaaaaatacctccggagaccacagtgccctagagtcacagatccgacaa ctgggcaaagccctggatgatagccgccttcagatacagcaaaccgaaaatatcattcgc agcaaaactcccacggggccggagctagacaccagctacaaaggctacatgaaactgctg ggcgaatgcagtggcagtatagactccgtgaagagactggagcacaaactgaaggaggaa gaggagagccttcctggctttgttaacctgcatagtaccgaagcccaaacggctggtgtg attgaccgatgggagcttctccaggcccaggcattgagcaaggagttgaggatgaagcag aacctccagaagtggcagcagtttaactcagacttgaacagcatctgggcctggctgggg gacacggaggaggagttagaacagctccagcatctggaactcagcactgacatccagacc atcgagctccagatcaaaaagctcaaggagctccagaaagccgtggaccaccgcaaagcc atcatcctctccatcaatctctgcagccccgagttcacccaggctgacagcaaggagagc cgggacctgcaggatcgcttgtcgcagatgaatgggcgctgggaccgagtgtgctccctg ctggaggagtggcggggcctgctgcaggatgccctgatgcagtgccagggtttccatgaa atgagccatggtttgcttcttatgctggagaacattgacagaaggaaaaatgaaattgtc cctattgattctaaccttgatgcagagatacttcaggaccatcacaaacagcttatgcaa ataaggcatgagctgttggaatcccaactcagagtagcctctttgcaagacatgtcttgc caactactggtgaatgctgaaggaacagactgtttagaagccaaagaaaaagtccatgtt attggaaatcggctcaaacttctcttgaaggaggtcagtcgtcatatcaaggaactggag aagttattagacgtgtcaagtagtcagcaggatttgtcttcctggtcttctgctgatgaa ctggacacctcagggtctgtgagtcccgcatcaggaacgagcaccccaaacagacagaaa acgccacgaggcaagtgtagtctctcacagcctggaccctctgtcagcagtccacatagc aggtccacaaaaggtggctccgattcctccctttctgagcctgggccaggtcggtccggc cgcgccttcctgttcagagtcctccgagcagctcttccccttcagcttctcctgctcctc ctcatcgggctcgcctgccttgtaccaatgtcagaggaagactacagctgtgccctctcc aacaactttgcccggtcattccaccccatgctcagatacacgaatggccctcctccactc tga

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