KEGG   Symphalangus syndactylus (siamang): 129482364
Entry
129482364         CDS       T10134                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
ssyn  Symphalangus syndactylus (siamang)
Pathway
ssyn01521  EGFR tyrosine kinase inhibitor resistance
ssyn01522  Endocrine resistance
ssyn04010  MAPK signaling pathway
ssyn04012  ErbB signaling pathway
ssyn04014  Ras signaling pathway
ssyn04015  Rap1 signaling pathway
ssyn04022  cGMP-PKG signaling pathway
ssyn04024  cAMP signaling pathway
ssyn04062  Chemokine signaling pathway
ssyn04066  HIF-1 signaling pathway
ssyn04068  FoxO signaling pathway
ssyn04071  Sphingolipid signaling pathway
ssyn04072  Phospholipase D signaling pathway
ssyn04114  Oocyte meiosis
ssyn04140  Autophagy - animal
ssyn04148  Efferocytosis
ssyn04150  mTOR signaling pathway
ssyn04151  PI3K-Akt signaling pathway
ssyn04210  Apoptosis
ssyn04218  Cellular senescence
ssyn04270  Vascular smooth muscle contraction
ssyn04370  VEGF signaling pathway
ssyn04371  Apelin signaling pathway
ssyn04380  Osteoclast differentiation
ssyn04510  Focal adhesion
ssyn04540  Gap junction
ssyn04550  Signaling pathways regulating pluripotency of stem cells
ssyn04613  Neutrophil extracellular trap formation
ssyn04620  Toll-like receptor signaling pathway
ssyn04650  Natural killer cell mediated cytotoxicity
ssyn04660  T cell receptor signaling pathway
ssyn04662  B cell receptor signaling pathway
ssyn04664  Fc epsilon RI signaling pathway
ssyn04666  Fc gamma R-mediated phagocytosis
ssyn04668  TNF signaling pathway
ssyn04720  Long-term potentiation
ssyn04722  Neurotrophin signaling pathway
ssyn04725  Cholinergic synapse
ssyn04726  Serotonergic synapse
ssyn04730  Long-term depression
ssyn04810  Regulation of actin cytoskeleton
ssyn04910  Insulin signaling pathway
ssyn04912  GnRH signaling pathway
ssyn04914  Progesterone-mediated oocyte maturation
ssyn04915  Estrogen signaling pathway
ssyn04916  Melanogenesis
ssyn04917  Prolactin signaling pathway
ssyn04919  Thyroid hormone signaling pathway
ssyn04921  Oxytocin signaling pathway
ssyn04926  Relaxin signaling pathway
ssyn04928  Parathyroid hormone synthesis, secretion and action
ssyn04929  GnRH secretion
ssyn04934  Cushing syndrome
ssyn04935  Growth hormone synthesis, secretion and action
ssyn05010  Alzheimer disease
ssyn05022  Pathways of neurodegeneration - multiple diseases
ssyn05034  Alcoholism
ssyn05132  Salmonella infection
ssyn05135  Yersinia infection
ssyn05160  Hepatitis C
ssyn05161  Hepatitis B
ssyn05163  Human cytomegalovirus infection
ssyn05164  Influenza A
ssyn05165  Human papillomavirus infection
ssyn05166  Human T-cell leukemia virus 1 infection
ssyn05167  Kaposi sarcoma-associated herpesvirus infection
ssyn05170  Human immunodeficiency virus 1 infection
ssyn05200  Pathways in cancer
ssyn05205  Proteoglycans in cancer
ssyn05206  MicroRNAs in cancer
ssyn05207  Chemical carcinogenesis - receptor activation
ssyn05208  Chemical carcinogenesis - reactive oxygen species
ssyn05210  Colorectal cancer
ssyn05211  Renal cell carcinoma
ssyn05212  Pancreatic cancer
ssyn05213  Endometrial cancer
ssyn05214  Glioma
ssyn05215  Prostate cancer
ssyn05216  Thyroid cancer
ssyn05218  Melanoma
ssyn05219  Bladder cancer
ssyn05220  Chronic myeloid leukemia
ssyn05221  Acute myeloid leukemia
ssyn05223  Non-small cell lung cancer
ssyn05224  Breast cancer
ssyn05225  Hepatocellular carcinoma
ssyn05226  Gastric cancer
ssyn05230  Central carbon metabolism in cancer
ssyn05231  Choline metabolism in cancer
ssyn05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ssyn00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    129482364 (MAP2K1)
   04012 ErbB signaling pathway
    129482364 (MAP2K1)
   04014 Ras signaling pathway
    129482364 (MAP2K1)
   04015 Rap1 signaling pathway
    129482364 (MAP2K1)
   04370 VEGF signaling pathway
    129482364 (MAP2K1)
   04371 Apelin signaling pathway
    129482364 (MAP2K1)
   04668 TNF signaling pathway
    129482364 (MAP2K1)
   04066 HIF-1 signaling pathway
    129482364 (MAP2K1)
   04068 FoxO signaling pathway
    129482364 (MAP2K1)
   04072 Phospholipase D signaling pathway
    129482364 (MAP2K1)
   04071 Sphingolipid signaling pathway
    129482364 (MAP2K1)
   04024 cAMP signaling pathway
    129482364 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    129482364 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    129482364 (MAP2K1)
   04150 mTOR signaling pathway
    129482364 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    129482364 (MAP2K1)
   04148 Efferocytosis
    129482364 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    129482364 (MAP2K1)
   04210 Apoptosis
    129482364 (MAP2K1)
   04218 Cellular senescence
    129482364 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    129482364 (MAP2K1)
   04540 Gap junction
    129482364 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    129482364 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    129482364 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    129482364 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    129482364 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    129482364 (MAP2K1)
   04660 T cell receptor signaling pathway
    129482364 (MAP2K1)
   04662 B cell receptor signaling pathway
    129482364 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    129482364 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    129482364 (MAP2K1)
   04062 Chemokine signaling pathway
    129482364 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    129482364 (MAP2K1)
   04929 GnRH secretion
    129482364 (MAP2K1)
   04912 GnRH signaling pathway
    129482364 (MAP2K1)
   04915 Estrogen signaling pathway
    129482364 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    129482364 (MAP2K1)
   04917 Prolactin signaling pathway
    129482364 (MAP2K1)
   04921 Oxytocin signaling pathway
    129482364 (MAP2K1)
   04926 Relaxin signaling pathway
    129482364 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    129482364 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    129482364 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    129482364 (MAP2K1)
   04916 Melanogenesis
    129482364 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    129482364 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    129482364 (MAP2K1)
   04726 Serotonergic synapse
    129482364 (MAP2K1)
   04720 Long-term potentiation
    129482364 (MAP2K1)
   04730 Long-term depression
    129482364 (MAP2K1)
   04722 Neurotrophin signaling pathway
    129482364 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    129482364 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129482364 (MAP2K1)
   05206 MicroRNAs in cancer
    129482364 (MAP2K1)
   05205 Proteoglycans in cancer
    129482364 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    129482364 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    129482364 (MAP2K1)
   05230 Central carbon metabolism in cancer
    129482364 (MAP2K1)
   05231 Choline metabolism in cancer
    129482364 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    129482364 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    129482364 (MAP2K1)
   05212 Pancreatic cancer
    129482364 (MAP2K1)
   05225 Hepatocellular carcinoma
    129482364 (MAP2K1)
   05226 Gastric cancer
    129482364 (MAP2K1)
   05214 Glioma
    129482364 (MAP2K1)
   05216 Thyroid cancer
    129482364 (MAP2K1)
   05221 Acute myeloid leukemia
    129482364 (MAP2K1)
   05220 Chronic myeloid leukemia
    129482364 (MAP2K1)
   05218 Melanoma
    129482364 (MAP2K1)
   05211 Renal cell carcinoma
    129482364 (MAP2K1)
   05219 Bladder cancer
    129482364 (MAP2K1)
   05215 Prostate cancer
    129482364 (MAP2K1)
   05213 Endometrial cancer
    129482364 (MAP2K1)
   05224 Breast cancer
    129482364 (MAP2K1)
   05223 Non-small cell lung cancer
    129482364 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    129482364 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    129482364 (MAP2K1)
   05161 Hepatitis B
    129482364 (MAP2K1)
   05160 Hepatitis C
    129482364 (MAP2K1)
   05164 Influenza A
    129482364 (MAP2K1)
   05163 Human cytomegalovirus infection
    129482364 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    129482364 (MAP2K1)
   05165 Human papillomavirus infection
    129482364 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    129482364 (MAP2K1)
   05135 Yersinia infection
    129482364 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    129482364 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    129482364 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    129482364 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    129482364 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    129482364 (MAP2K1)
   01522 Endocrine resistance
    129482364 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ssyn01001]
    129482364 (MAP2K1)
Enzymes [BR:ssyn01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     129482364 (MAP2K1)
Protein kinases [BR:ssyn01001]
 Serine/threonine kinases: STE group
  STE7 family
   129482364 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 129482364
NCBI-ProteinID: XP_055134048
LinkDB
Position
5:complement(39584463..39686480)
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctctgcagtt
aacgggaccagctctgcggagaccaacttggaggccttgcagaagaagctggaggagcta
gaacttgatgagcagcagcgaaagcgccttgaggcctttcttacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggggctggcaatggcggt
gtggtgttcaaggtctcccacaagccttctggcctggtcatggccagaaagctaattcat
ctggagatcaaacccgcaatccggaaccagatcataagggagctgcaggttctgcatgag
tgcaactctccgtacatcgtgggcttctatggtgcattctacagcgatggcgagatcagt
atctgcatggagcacatggatggaggttctctggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaagcacaagatcatgcatagagatgtcaagccctccaacatcctagtcaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tctgtgcagtcagacatctggagcatgggactctctctggtagagatggcggttgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagaccccacccaggccaaggacccccgggaggccccttagctcatat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccaaaactgcccagtggggtgttcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacaccaacccatgctgctggcgtctaa

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