Symphalangus syndactylus (siamang): 129490428 Help Entry 129490428         CDS       T10134                                  Symbol JAK2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism ssyn  Symphalangus syndactylus (siamang) Pathway ssyn01521   EGFR tyrosine kinase inhibitor resistance ssyn04062   Chemokine signaling pathway ssyn04081   Hormone signaling ssyn04148   Efferocytosis ssyn04151   PI3K-Akt signaling pathway ssyn04217   Necroptosis ssyn04550   Signaling pathways regulating pluripotency of stem cells ssyn04630   JAK-STAT signaling pathway ssyn04658   Th1 and Th2 cell differentiation ssyn04659   Th17 cell differentiation ssyn04725   Cholinergic synapse ssyn04917   Prolactin signaling pathway ssyn04920   Adipocytokine signaling pathway ssyn04933   AGE-RAGE signaling pathway in diabetic complications ssyn04935   Growth hormone synthesis, secretion and action ssyn05140   Leishmaniasis ssyn05145   Toxoplasmosis ssyn05152   Tuberculosis ssyn05161   Hepatitis B ssyn05164   Influenza A ssyn05167   Kaposi sarcoma-associated herpesvirus infection ssyn05168   Herpes simplex virus 1 infection ssyn05200   Pathways in cancer ssyn05207   Chemical carcinogenesis - receptor activation ssyn05235   PD-L1 expression and PD-1 checkpoint pathway in cancer ssyn05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:ssyn00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     129490428 (JAK2)    04151 PI3K-Akt signaling pathway     129490428 (JAK2)   09133 Signaling molecules and interaction    04081 Hormone signaling     129490428 (JAK2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     129490428 (JAK2)   09143 Cell growth and death    04217 Necroptosis     129490428 (JAK2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     129490428 (JAK2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     129490428 (JAK2)    04659 Th17 cell differentiation     129490428 (JAK2)    04062 Chemokine signaling pathway     129490428 (JAK2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     129490428 (JAK2)    04917 Prolactin signaling pathway     129490428 (JAK2)    04935 Growth hormone synthesis, secretion and action     129490428 (JAK2)   09156 Nervous system    04725 Cholinergic synapse     129490428 (JAK2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     129490428 (JAK2)    05207 Chemical carcinogenesis - receptor activation     129490428 (JAK2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     129490428 (JAK2)   09172 Infectious disease: viral    05161 Hepatitis B     129490428 (JAK2)    05164 Influenza A     129490428 (JAK2)    05168 Herpes simplex virus 1 infection     129490428 (JAK2)    05167 Kaposi sarcoma-associated herpesvirus infection     129490428 (JAK2)   09171 Infectious disease: bacterial    05152 Tuberculosis     129490428 (JAK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     129490428 (JAK2)    05140 Leishmaniasis     129490428 (JAK2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     129490428 (JAK2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     129490428 (JAK2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     129490428 (JAK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:ssyn01001]     129490428 (JAK2) Enzymes [BR:ssyn01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      129490428 (JAK2) Protein kinases [BR:ssyn01001]  Non-receptor tyrosine kinases   JAK family [OT]    129490428 (JAK2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl SH2 ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M Motif Other DBs NCBI-GeneID:  129490428 NCBI-ProteinID:  XP_055150291 LinkDB All DBs Position 9:complement(134627301..134777418) Genome browser AA seq 1132 aa AA seqDB search MGMACLTMTEMEGTSTSSVYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQF SQCKATARNLKLKYLINLEALQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR EALSFVSLIDGYYRLTADAHHYLCKEVAPPKVLENIQSNCHGPISMDFAISKLKKAGNQT GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI RNEDLIFNESLGQGTFTKIFKGTRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYMKKNKNCINILWKLEVAKQLAWA MHFLEENSLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG NT seq 3399 nt NT seq  +upstreamnt  +downstreamnt atgggaatggcctgccttacgatgacagaaatggagggaacatccacctcttctgtatat cagaatggtgatatttctggaaatgccaattctatgaagcaaatagatccagttcttcag gtgtatctttaccattcccttgggaaatctgaggcagattatctgacctttccatctggg gagtatgttgcagaagaaatctgtattgctgcttctaaagcttgtggtatcacacctgtg tatcataatatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaaccat gtcttccatatagatgagtcaaccaggcataatgtactctacagaataagattttacttt cctcgttggtattgcagtggcagcaacagagcctatcggcatggaatatctcgaggtgct gaagctcctcttcttgatgactttgtcatgtcttacctctttgctcagtggcggcatgat tttgtgcatggatggataaaagtacctgtgactcatgaaacacaggaagaatgtcttggg atggcagtgttagatatgatgagaatagccaaagaaaacgatcaaaccccactggccatc tataactctatcagctacaagacattcttaccaaaatgtattcgagcaaagatccaagac tatcatattttgacaaggaagcgaataaggtacagatttcgcagatttattcagcaattc agccaatgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaagct ctgcagtctgccttctacacagagaaatttgaagtaaaagaacctggaagtggtccttca ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgcgatttt cctaatattattgatgtcagtattaagcaagcaaaccaagagggttcaaatgaaagccga gttgtaactatccataagcaagatggtaaaaatctggaaattgaacttagctcattaagg gaagctttgtctttcgtgtcattaattgatggatattatagattaactgcagatgcacat cattacctctgtaaagaagtagcacctccaaaagtgcttgaaaatatacaaagcaactgt catggcccaatttcgatggattttgccatcagtaaactgaagaaagcaggtaatcagact gggctgtatgtacttcgatgcagtcctaaggactttaataaatattttttgacttttgct gtcgagcgagaaaatgtcattgaatataaacactgtttgattacaaaaaatgagaatgaa gagtacaacctcagtgggacaaagaagaacttcagcagtcttaaagatcttttgaattgt taccagatggaaaccgttcgctcagacaatataattttccagtttactaaatgctgtccc ccaaagccaaaagataaatcaaaccttctagtcttcagaacgaatggtgtttctgacgta ccaacctcaccaacattacagaggcctactcatatgaaccaaatggtgtttcacaaaatc agaaatgaagatttgatatttaatgaaagccttggccaaggcacttttacaaagattttt aaaggcacacgaagagaagtaggagactacggtcaactgcatgaaacagaagttctttta aaagttctggataaagcacatagaaactattcagagtctttctttgaagcagcaagcatg atgagcaagctttctcacaagcatttggttttaaattatggagtatgtgtctgtggagac gagaatattctggttcaggagtttgtaaaatttggatcactagatacatatatgaaaaag aataaaaattgtataaatatattatggaaactcgaagttgctaaacagttggcatgggcc atgcattttctagaagaaaacagccttattcatgggaatgtgtgtgccaaaaatattctg cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct ggcattagtattacagttttgccaaaggacattcttcaggagagaataccatgggtacca cctgaatgcattgaaaatcctaaaaatttaaatttggcaacagacaaatggagttttggt accactttgtgggaaatctgcagtggaggagataaacctctaagtgctctggattctcaa agaaagctacaattttatgaagataggcatcagcttcctgcaccaaagtgggcagaatta gcaaaccttataaataattgtatggattatgaaccagatttcaggccttctttcagagcc atcatacgagatcttaacagtttgtttactccagattatgaactattaacagaaaatgac atgttaccaaatatgaggataggtgccctagggttttctggtgcctttgaagaccgggat cctacacagtttgaagagagacatttgaaatttctacagcaacttggcaagggtaatttt gggagtgtggagatgtgccggtatgaccctctacaggacaacactggggaggtggtggct gtaaaaaagcttcagcatagtactgaagagcacctaagagactttgaaagggaaattgaa atcctgaaatccctacaacatgataacattgtgaagtacaagggagtgtgctacagtgct ggtcggcgtaatctaaaattaattatggaatatttaccatatggaagtttacgagactat cttcaaaaacataaagaacggatagatcacaaaaaacttctgcagtacacatctcagata tgcaagggtatggagtatctcggtacaaaaaggtatatccacagggatctggcaacaaga aatatattggtggagaatgagaacagagttaaaattggagattttgggttaaccaaagtc ttgccacaagacaaagaatactataaagtaaaagaacctggtgaaagtcccatattctgg tatgctccagagtcactgacagagagcaagttttctgtggcctcagatgtttggagcttt ggagtggttctgtatgaacttttcacgtacattgagaagagtaaaagtccaccagcggaa tttatgcgtatgattggcaacgacaaacaaggacagatgatcgtgttccatttgatagaa cttttgaagaataatggaagattaccaagaccagatggatgcccagatgagatttatatg atcatgacagaatgctggaacaataatgtaaatcaacgcccctcctttagggatctagct cttcgagtggatcaaataagggataacatggctggatga

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