KEGG   Symphalangus syndactylus (siamang): 129493473
Entry
129493473         CDS       T10134                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
ssyn  Symphalangus syndactylus (siamang)
Pathway
ssyn00562  Inositol phosphate metabolism
ssyn01100  Metabolic pathways
ssyn01521  EGFR tyrosine kinase inhibitor resistance
ssyn04012  ErbB signaling pathway
ssyn04014  Ras signaling pathway
ssyn04020  Calcium signaling pathway
ssyn04062  Chemokine signaling pathway
ssyn04064  NF-kappa B signaling pathway
ssyn04066  HIF-1 signaling pathway
ssyn04070  Phosphatidylinositol signaling system
ssyn04072  Phospholipase D signaling pathway
ssyn04360  Axon guidance
ssyn04370  VEGF signaling pathway
ssyn04380  Osteoclast differentiation
ssyn04611  Platelet activation
ssyn04613  Neutrophil extracellular trap formation
ssyn04625  C-type lectin receptor signaling pathway
ssyn04650  Natural killer cell mediated cytotoxicity
ssyn04662  B cell receptor signaling pathway
ssyn04664  Fc epsilon RI signaling pathway
ssyn04666  Fc gamma R-mediated phagocytosis
ssyn04670  Leukocyte transendothelial migration
ssyn04722  Neurotrophin signaling pathway
ssyn04750  Inflammatory mediator regulation of TRP channels
ssyn04919  Thyroid hormone signaling pathway
ssyn04933  AGE-RAGE signaling pathway in diabetic complications
ssyn04935  Growth hormone synthesis, secretion and action
ssyn05167  Kaposi sarcoma-associated herpesvirus infection
ssyn05169  Epstein-Barr virus infection
ssyn05170  Human immunodeficiency virus 1 infection
ssyn05171  Coronavirus disease - COVID-19
ssyn05200  Pathways in cancer
ssyn05205  Proteoglycans in cancer
ssyn05206  MicroRNAs in cancer
ssyn05214  Glioma
ssyn05223  Non-small cell lung cancer
ssyn05225  Hepatocellular carcinoma
Module
ssyn_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ssyn00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    129493473 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    129493473 (PLCG2)
   04014 Ras signaling pathway
    129493473 (PLCG2)
   04370 VEGF signaling pathway
    129493473 (PLCG2)
   04064 NF-kappa B signaling pathway
    129493473 (PLCG2)
   04066 HIF-1 signaling pathway
    129493473 (PLCG2)
   04020 Calcium signaling pathway
    129493473 (PLCG2)
   04070 Phosphatidylinositol signaling system
    129493473 (PLCG2)
   04072 Phospholipase D signaling pathway
    129493473 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    129493473 (PLCG2)
   04613 Neutrophil extracellular trap formation
    129493473 (PLCG2)
   04625 C-type lectin receptor signaling pathway
    129493473 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    129493473 (PLCG2)
   04662 B cell receptor signaling pathway
    129493473 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    129493473 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    129493473 (PLCG2)
   04670 Leukocyte transendothelial migration
    129493473 (PLCG2)
   04062 Chemokine signaling pathway
    129493473 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    129493473 (PLCG2)
   04919 Thyroid hormone signaling pathway
    129493473 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    129493473 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    129493473 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    129493473 (PLCG2)
   04380 Osteoclast differentiation
    129493473 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129493473 (PLCG2)
   05206 MicroRNAs in cancer
    129493473 (PLCG2)
   05205 Proteoglycans in cancer
    129493473 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    129493473 (PLCG2)
   05214 Glioma
    129493473 (PLCG2)
   05223 Non-small cell lung cancer
    129493473 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    129493473 (PLCG2)
   05171 Coronavirus disease - COVID-19
    129493473 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    129493473 (PLCG2)
   05169 Epstein-Barr virus infection
    129493473 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    129493473 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    129493473 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ssyn04131]
    129493473 (PLCG2)
Enzymes [BR:ssyn01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     129493473 (PLCG2)
Membrane trafficking [BR:ssyn04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    129493473 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    129493473 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 SH3_9 PH PH_12 EF-hand_PLCG1 SH2_1 SH3_2 PH_14 EF-hand_like GDPD
Other DBs
NCBI-GeneID: 129493473
NCBI-ProteinID: XP_055155673
LinkDB
Position
11:127191234..127369250
AA seq 1265 aa
MSTIVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFFLSTLSLAADSKEDAV
NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC
WDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKA
FKEVFGDLLLMKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY
LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML
MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADVEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY
MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKAIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALIKEFNVNENQLQLYQEKCNKRLREKRVSN
SKFYS
NT seq 3798 nt   +upstreamnt  +downstreamnt
atgtccaccatagtcaatgtggattcccttgcggaatatgagaagagccagatcaagaga
gccctggagctggggacggtgatgactgtgttcagcttccgcaagtccacccctgagcgg
aggaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagaccgctgacaag
atcgagggcttcttggatatcatggaaataaaagaaatccgcccagggaagaactccaaa
gatttcgagcgagcaaaagcagttcgccagaaagaagactgctgcttcaccatcctgtat
ggcactcagttcttcctcagcacgctcagcttggcagctgactctaaagaagatgctgtt
aattggctctctggcttgaaaatcttacaccaagaagcgatgaatgcgtccacacccacc
attatcgagagttggctgagaaagcagatatattctgtggatcaaaccagaagaaacagc
atcagtctccgagagttgaagaccatcttgcccctgatcaactttaaagtgagcagtgcc
aagttccttaaagataagtttgtggaaataggagcacacaaagatgagctcagctttgaa
cagttccatctcttctataaaaaacttatgtttgaacagcaaaaatcgattcttgatgaa
ttcaaaaaggattcgtccgtgttcatcctggggaacactgacaggccggatgcctccgcg
gtttacctgcatgacttccagaggtttctcatacatgaacagcaggagcattgggctcag
gatctgaacaaagtccgtgagcggatgacaaagttcattgatgataccatgcgtgaaact
gctgagcctttcttgtttgtggatgagttcctcacatacctgttttcacgagaaaacagc
atctgggatgagaagtatgatgcggtggacatgcaggacatgaacaaccccctgtctcat
tactggatctcctcgtctcataatacgtacctcacaggtgaccagctgcggagcgagtca
tccccggaagcttacatccgctgcctgcgcatgggctgtcgctgcattgaactggactgc
tgggacgggcccgatgggaagccggtcatctaccacggctggacgcggaccaccaagatc
aaatttgacgacgtcgtgcaggccatcaaagaccacgcctttgttacctcgagcttccca
gtgatcctgtccattgaggagcactgcagcgtggaacagcagcgtcacatggccaaggcc
ttcaaggaagtgtttggcgacctgctgctgatgaagcccacggaggccagcgctgaccag
ctgccctcacccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccc
cgaggcgacgtggatgtcaacgtggaggacaagaaggatgagcacaagcaacagggagag
ctgtacatgtgggattccattgaccagaaatggactcggcactactgcgccatcgccgat
gccaagctgtccttcagtgatgacattgaacagactatggaggaggaagtgccccaggat
ataccccccacagagctacattttggggagaaatggttccacaagaaggtagagaagagg
acgagtgccgagaagttgctgcaggaatactgcatggagacggggggcaaggatggcacc
ttcctggttcgggagagcgagaccttccccaatgactacaccctgtccttctggcggtca
ggccgggtccagcactgccggatccgctccaccatggagggcgggaccctgaaatactac
ctgactgacaacctcaccttcagcagcatctatgccctcatccagcactaccgcgagacg
cacctgcgctgcgccgagttcgagctgcggctcacggaccctgtgcccaaccccaacccc
cacgagtccaagccgtggtactatgacagcctgagccgtggagaggcagaggacatgctg
atgaggattccccgggacggagccttcctgatccggaagcgagagggaagcgactcctac
gccatcaccttcagggctaggggcaaggtgaagcactgtcgcatcaaccgggacggccgg
cactttgtgctggggacctctgcctattttgagagcctagtggagctcgtcagttactac
gagaagcattcactctaccgaaagatgagactgcgctaccccgtgacccccgagctcctg
gagcgctacaatatggaaagagatataaactccctctacgatgtcagcagaatgtatgtg
gatcccagtgaaatcaatccgtccatgcctcagagaacggtgaaggctctgtatgactac
aaagccaagcgaagcgatgagctgagcttctgccgtggcgccctcatccacaatgtctcc
aaggagcccgggggctggtggaaaggagactatggaaccaggatccagcagtacttccca
tccaactacgtcgaggacatttcaactgcagatgtcgaggagctagaaaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatattggacctcaatacctataacgtt
gtgaaagcccctcagggaaaaaaccagaagccctttgtctttatcctggagcccaagaag
cagggcgatcctccggtggagtttgccacagacagggtggaggagctctttgagtggttt
cagagcatccgagagatcacctggaagattgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctctgacctggttgtctactgcaaaccaacc
agcaaaaccaaggacaacttagaaaatcctgacttccgagaaatccgctcctttgtggag
acaaaggctgacagcatcatcagacagaagcccgtcgacctcctgaagtacaatcaaaag
ggcctgactcgcgtctacccaaagggacaaagagttgactcttcaaactacgaccccttc
cgcctctggctgtgcggttctcagatggtggcactcaatttccagacagcagataagtac
atgcagatgaatcacgcgttgttttctctcaatgggcgcacgggctacgttctgcagcct
gagagcatgaggacagagaaatatgacccgatgccacccgagtcccagaggaagatcctg
atgacgctgacggtcaaggttctcggtgctcgccatctccccaaacttggacgaagtatt
gcctgtccctttgtagaggtggagatctgtggagccgagtatgacaacaacaagttcaag
acaacggttgtgaatgataatggcctcagccctatctgggctccaacacaggagaaggtg
acgtttgaaatttatgacccaaacctggcatttctgcgctttgtggtttacgaagaagac
atgttcagcgatcccaactttctcgcccatgccacttaccccattaaagcaatcaaatca
ggattcaggtctgttcctctgaagaatgggtacagcgaggacatagaactggcttccctc
ctggttttctgtgagatgcggccggtactggagagcgaagaggaactttactcctcctgt
cgccagctgaggaggcggcaagaagaactgaacaaccagctctttctgtatgacacgcac
cagaacttgcgcaatgccaaccgggatgccctgattaaagagttcaatgttaatgagaac
cagctccagctgtaccaggagaaatgcaacaagaggttaagagagaagagagtcagcaac
agcaagttttattcatag

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