Streptomyces sp. HP-A2021: MQE23_13435
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Entry
MQE23_13435 CDS
T11535
Symbol
leuC
Name
(GenBank) 3-isopropylmalate dehydratase large subunit
KO
K01703
3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:
4.2.1.33
4.2.1.35
]
Organism
sthp Streptomyces sp. HP-A2021
Pathway
sthp00290
Valine, leucine and isoleucine biosynthesis
sthp00660
C5-Branched dibasic acid metabolism
sthp01100
Metabolic pathways
sthp01110
Biosynthesis of secondary metabolites
sthp01210
2-Oxocarboxylic acid metabolism
sthp01230
Biosynthesis of amino acids
Module
sthp_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
sthp00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00660 C5-Branched dibasic acid metabolism
MQE23_13435 (leuC)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
MQE23_13435 (leuC)
Enzymes [BR:
sthp01000
]
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.33 3-isopropylmalate dehydratase
MQE23_13435 (leuC)
4.2.1.35 (R)-2-methylmalate dehydratase
MQE23_13435 (leuC)
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Paralog
GFIT
Motif
Pfam:
Aconitase
DUF4946
Motif
Other DBs
NCBI-ProteinID:
UOB10008
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All DBs
Position
complement(2985957..2987387)
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AA seq
476 aa
AA seq
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MGRTLAEKVWDDHVVRRAEGEPDLLFIDLHLLHEVTSPQAFDGLRKSGRKVRRLDLTIAT
EDHNTPTLDIDKPIADPVSRIQLETLRKNAADFGVRLHPLGDVEQGVVHVVGPQLGLTQP
GTTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPMSRPKTMAITVNGELPEGVTA
KDLILAIIARIGTGGGQGYVLEYRGEAIEKLSMEARMTICNMSIEAGARAGMIAPDETTF
AYLKGRPHAPEGADWDAAVEYWKTLRTDADAEFDAEVVIEAAELSPFVTWGTNPGQGAPL
SASVPDPASYEDASERYAAEKALEYMGLEAGQPLRSIKVDTVFVGSCTNGRIEDLRAAAE
LLKGRKVADGVRMLVVPGSARVGLQAVSEGLDVVFKEAGAEWRHAGCSMCLGMNPDQLAP
GERSASTSNRNFEGRQGKGGRTHLVSPQVAAATAVLGHLASPADLSAADTRTPAGV
NT seq
1431 nt
NT seq
+upstream
nt +downstream
nt
atgggtaggacactcgcggagaaagtctgggacgaccatgtcgtccggcgcgcggagggc
gagcccgaccttctcttcatcgatctgcacctgctgcacgaggtgaccagcccgcaggcc
ttcgacggcctgcgcaagagcggccgcaaggtccggcgcctcgacctcaccatcgcgacc
gaggaccacaacacccccaccctcgacatcgacaagccgatcgcggacccggtctcccgg
atccagctggagacgctgcgcaagaacgccgccgacttcggcgtgcggctgcacccgctg
ggcgacgtcgagcagggcgtcgtgcacgtcgtcggcccgcagctgggtctgacccagccg
ggcaccaccgtcgtctgcggtgactcccacacctccacgcacggcgccttcggcgcgctg
gcgttcggcatcggcacctcccaggtggagcacgtgctggccacccagacgctgccgatg
tcccgcccgaagaccatggccatcacggtcaacggcgaactgcccgagggcgtcaccgcc
aaggacctgatcctggcgatcatcgcccggatcggtaccggcggcggccagggctacgtc
ctggagtaccgcggcgaggccatcgagaagctctcgatggaagcgcgcatgaccatctgc
aacatgtcgatcgaggccggcgcccgcgcgggcatgatcgccccggacgagaccaccttc
gcgtacctcaagggccgcccgcacgcccccgagggcgcggactgggacgccgccgtcgag
tactggaagacgctgaggacggacgcggacgccgagttcgacgccgaggtcgtcatcgag
gccgccgaactgtcgccgttcgtcacctggggcaccaaccccggccagggcgcaccgctt
tcggcatcggtccccgaccctgcttcgtacgaagacgcatcggagcgctacgccgccgaa
aaggccctggaatacatggggttggaggccggtcagccgctgcgctccatcaaggtggac
accgtcttcgtaggctcctgcaccaacggccgcatcgaggacctgcgcgccgcggccgag
ctgctcaagggccgcaaagtcgccgacggcgtacggatgctggtcgtcccgggctccgcg
cgggtcggtctccaggccgtctccgaggggctggacgtcgtcttcaaggaggccggcgcc
gagtggcggcacgcgggctgctcgatgtgtctgggcatgaaccccgaccagctggccccc
ggcgagcgctccgcgtccacctccaaccgcaacttcgaaggccggcagggcaagggcggt
cgtacgcacctggtgtcgccgcaggtcgcggccgctacggccgtcctgggccacctggcc
tccccggccgacctgtccgccgccgacacccgtacgcccgctggagtctga
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