Streptomyces sp. HP-A2021: MQE23_32620
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Entry
MQE23_32620 CDS
T11535
Name
(GenBank) UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
sthp Streptomyces sp. HP-A2021
Pathway
sthp00300
Lysine biosynthesis
sthp00550
Peptidoglycan biosynthesis
sthp01100
Metabolic pathways
sthp01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
sthp00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
MQE23_32620
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
MQE23_32620
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
MQE23_32620
Enzymes [BR:
sthp01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
MQE23_32620
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GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
DUF561
Motif
Other DBs
NCBI-ProteinID:
UOB13506
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Position
7223784..7225199
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AA seq
471 aa
AA seq
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MIALSLAEIAEVVGGQTYDIPDPTVQVTGPVVRDSREAGPGSLFVAFAGERADGHDFAAA
VVEAGAVAVLGTRPVGVPAIVVDDVQTALGALARHVVRRLGATLVALTGSAGKTSTKDLI
AQVLQRKAPTVFTPGSLNNEIGLPLTALSATEETRFLVLEMGARGIGHIAYLTGLTPPKI
GLVLNVGSAHIGEFGGREQIAQAKGELVESLPSEADGGTAVLNADDPYVRAMATRTKAKV
IFFGESGEADVRGENVRLTDTGQPAFRLHTPSGASDVTMRLYGEHHVSNALAAAAVAHEL
GMSADEIAVALSEAGSLSRWRMEVTERPDGVTVVNDAYNANPESMKAALRALVAIGKGRR
TWAVLGQMAELGDEALAEHDAVGRLAVRLNVSKLVAVGGREAAWLQLGAYNEGSWGEESV
HVSDAQAAVDLLRSELRPGDVVLVKASRSVGLERVAQALLESGAEGEVSAR
NT seq
1416 nt
NT seq
+upstream
nt +downstream
nt
gtgatcgccctctccctcgccgagatcgcagaagtcgtcggcgggcagacgtacgacata
ccggatccgaccgtccaggtcaccggcccggtcgtccgggactcccgcgaggcggggccg
ggcagcctgttcgtggccttcgccggggaacgcgcggacggccacgacttcgcggcggcg
gtcgtcgaggcgggagcggtggccgtgctcggcacccggcccgtcggcgtgcccgcgatc
gtcgtggacgacgtccagaccgccctcggcgccctcgcgcggcacgtcgtacgacgtctc
ggtgccacgctcgtcgccctcaccggctcggccggcaagaccagcaccaaggacctcatc
gcgcaggtgctccagcgtaaggcgccgacggtgttcacgcccggctcgctcaacaacgag
atcgggctgccgctgaccgcgctcagcgccaccgaggagacccggttcctcgtcctggag
atgggcgcccgcggcatcgggcacatcgcctacctcacgggtctgacgcccccgaagatc
ggcctcgtcctgaacgtcggcagcgcccacatcggcgagttcggcggccgggagcagatc
gcacaggccaagggcgaactcgtcgagtccctgccgtccgaggccgacggcggcacggcc
gtcctcaacgcggacgacccctacgtacgggccatggccacccgtacgaaggcgaaggtg
atctttttcggagagtccggcgaagcggacgttcgcggcgagaacgtgcgactcacggac
accggacagcccgccttcaggcttcacacaccctccggtgcaagtgatgtgaccatgcgc
ctgtacggtgagcaccacgtgtcgaacgcgctcgccgcggccgccgtcgcccacgagttg
ggcatgtccgcagacgagatcgccgtcgcgctctccgaggcgggctccctctcccgctgg
cggatggaggtcaccgagcgcccggacggcgtgacggtcgtcaacgacgcctacaacgcg
aaccccgagtccatgaaggccgcgctgcgtgcgctcgtggccatcggcaaggggcgtcgt
acgtgggcggtgctcggccagatggccgagctcggggacgaggctctcgccgagcacgac
gcggtcggacggctcgccgtccggctcaacgtcagcaagctcgtcgcggtcggtggcagg
gaagccgcctggctgcaactgggcgcatataacgagggttcgtggggtgaggagtcggtg
cacgtgtccgacgcacaggcggcggtcgacctgttgcgcagcgagttgcgcccgggggac
gtcgtgctcgtgaaggcgtcccgttcggtcggcctcgagcgcgttgcccaggcgctgctc
gagtccggtgccgagggtgaggtttccgcccgatga
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