Streptomyces sp. ICC4: DRB89_23245
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Entry
DRB89_23245 CDS
T10587
Symbol
leuC
Name
(GenBank) 3-isopropylmalate dehydratase large subunit
KO
K01703
3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:
4.2.1.33
4.2.1.35
]
Organism
stic Streptomyces sp. ICC4
Pathway
stic00290
Valine, leucine and isoleucine biosynthesis
stic00660
C5-Branched dibasic acid metabolism
stic01100
Metabolic pathways
stic01110
Biosynthesis of secondary metabolites
stic01210
2-Oxocarboxylic acid metabolism
stic01230
Biosynthesis of amino acids
Module
stic_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
Enzymes [BR:
stic01000
]
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.33 3-isopropylmalate dehydratase
DRB89_23245 (leuC)
4.2.1.35 (R)-2-methylmalate dehydratase
DRB89_23245 (leuC)
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NCBI-ProteinID:
AWZ07052
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Position
4981303..4982736
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AA seq
477 aa
AA seq
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MGRTLAEKVWDDHVVRRAEGEPDLLFIDLHLLHEVTSPQAFEGLRQAGRKVRRLDLTIAT
EDHNTPTIDIDKPIADPVSRTQLETLRKNCAEFGVRLHSLGDVEQGVVHVVGPQLGLTQP
GTTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPKTMAITVTGALAEGVTA
KDLILAIIAKIGTGGGQGYILEYRGEAVEQLSMEARMTICNMSIEAGARAGMIAPDQTTF
DYLEGRDHAPVGEDWDAAVAYWKTLRTDEDAVFDAEVVVDGTTLAPFVTWGTNPGQGSPL
SANVPDPASYEDASERHAAEKALEYMGLTAGQPLRDIKVDTVFVGSCTNGRIEDLRAVAG
IIEGRKVANGVRMLVVPGSVRVALQAVAEGLDKVFKEAGAEWRHAGCSMCLGMNPDQLAP
GERSASTSNRNFEGRQGKGGRTHLVSPQVAAATAVLGHLASPADLAGSSAATAPAGV
NT seq
1434 nt
NT seq
+upstream
nt +downstream
nt
atgggtaggacactcgcggagaaggtctgggacgaccatgtcgtccggcgcgcggagggc
gagcccgatctcctcttcatcgatctgcacctgctgcacgaggtgaccagcccgcaggcc
ttcgaagggctgcgccaggccggccgcaaggtccgccgtctcgacctcaccatcgcgacc
gaggaccacaacacccccacgatcgacatcgacaagccgatcgccgatccggtctcccgg
acccagctggagacgctgcgcaagaactgcgccgagttcggcgtgcgcctgcactcgctg
ggcgacgtcgagcagggtgtcgtccacgtcgtggggccgcagctgggcctgacccagccg
ggcaccaccgtggtctgcggtgactcgcacacctccacgcacggcgccttcggcgcgctg
gccttcggcatcggcaccagccaggtcgagcacgtgctggcgacccagacgctgccgctg
gcccgccccaagacgatggcgatcaccgtcaccggcgcgctggccgagggcgtcaccgcc
aaggacctgatcctggccatcatcgccaagatcggcaccggcggcggccagggctacatc
ctggagtaccgcggcgaggccgtcgagcagctgtcgatggaagcccgcatgaccatctgc
aacatgtcgatcgaggccggcgcccgcgcgggcatgatcgcccccgaccagaccaccttc
gactacctcgagggccgcgaccacgccccggtgggcgaggactgggacgcggcggtcgcg
tactggaagaccctgcgcaccgacgaggacgcggtcttcgacgccgaggtcgtcgtcgac
ggcaccacgctggccccgttcgtcacctggggcaccaacccgggccagggctcgccgctg
tcggccaacgtccccgaccctgcttcgtacgaagacgcttcggagcgccacgccgccgaa
aaggccctggagtacatggggttgacggccggacagccgctgcgcgacatcaaggtcgac
accgtcttcgtaggttcctgcaccaacggccgcatcgaggacctgcgcgccgtcgccggc
atcatcgagggccgcaaagtcgccaacggcgtacggatgctggtcgtcccgggctccgtc
cgggtcgccctgcaggccgtggcggagggcctggacaaggtcttcaaggaggccggcgcc
gaatggcggcacgcgggctgttcgatgtgcctgggcatgaaccccgaccaactggcgccc
ggtgagcgctccgcgtccacctccaaccgcaacttcgagggccggcagggcaagggcggg
cgcacccacctggtctccccgcaggtggcagccgccaccgccgtactgggccacctggcc
tcgcccgccgacctggccggctcgtcggccgcgaccgcccccgcaggagtctga
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