Streptomyces sp. ICC4: DRB89_23280
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Entry
DRB89_23280 CDS
T10587
Name
(GenBank) D-alanine--D-alanine ligase A
KO
K01921
D-alanine-D-alanine ligase [EC:
6.3.2.4
]
Organism
stic Streptomyces sp. ICC4
Pathway
stic00470
D-Amino acid metabolism
stic00550
Peptidoglycan biosynthesis
stic01100
Metabolic pathways
stic01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
stic00001
]
09100 Metabolism
09106 Metabolism of other amino acids
00470 D-Amino acid metabolism
DRB89_23280
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
DRB89_23280
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
DRB89_23280
09180 Brite Hierarchies
09181 Protein families: metabolism
01011 Peptidoglycan biosynthesis and degradation proteins [BR:
stic01011
]
DRB89_23280
Enzymes [BR:
stic01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.4 D-alanine---D-alanine ligase
DRB89_23280
Peptidoglycan biosynthesis and degradation proteins [BR:
stic01011
]
Precursor biosynthesis
Amino acid ligase
DRB89_23280
BRITE hierarchy
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Paralog
Gene cluster
GFIT
Motif
Pfam:
Dala_Dala_lig_C
Dala_Dala_lig_N
CPSase_L_D2
ATP-grasp
ATP-grasp_4
ATPgrasp_ST
Motif
Other DBs
NCBI-ProteinID:
AWZ07059
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Position
4987477..4988634
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AA seq
385 aa
AA seq
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MSSENLPQTPEQQGRKPRVAVVFGGRSSEHAISVVTAGAVLRSIDRSKYEVLPIGITTDG
RWALTADEPARMAISGGRLPNVGQLAESEDGAVVLSVDPASREVVYTEPGAVPKALGEVD
VVFPVLHGPYGEDGTLQGLLELSGIPYVGSGVLASAVGQDKDYMKRVFTSFGLRVGPYVT
IRPREWENDREGALARIADFAGEHGWPLFIKPARAGSSIGITKVDDASGLDAAIREARRH
DPKIIVEALLHGREIECGVLEFEDGPRASVPAEIPPVSSHDFYDFEAKYIDAASGIVPAP
LTPEQTAEVQRLAIEAFDAASCEGLVRADFFLTEDGTFVINEINTMPGFTPISMYPRMWQ
ESGIEYPELVDRLIQAALRRSTGLR
NT seq
1158 nt
NT seq
+upstream
nt +downstream
nt
atgagcagcgagaacctcccccagacccctgagcagcagggccgcaagccccgcgtggcc
gtcgtgttcggcggccgcagctcggaacacgccatctcggtcgtcaccgcgggcgccgtc
ctgcgctccatcgaccgctccaagtacgaggtgctgcccatcggcatcaccacggacggc
cgatgggcgctgaccgccgacgagcccgcccggatggccatctccggcggccggctcccc
aatgtggggcagctcgccgagtccgaggacggcgccgtggtgctctccgtcgacccggcc
agccgcgaggtcgtctacaccgagccgggcgccgtccccaaggccctgggcgaggtcgac
gtcgtcttccccgtcctgcacggcccgtacggtgaggacggcacgctccagggcctcctg
gagctctccggcatcccgtacgtcggctcgggcgtcctcgcctcggccgtcggccaggac
aaggactacatgaagcgggtcttcacgtccttcgggctgcgcgtcggcccgtacgtgacc
atccgcccccgcgagtgggagaacgaccgcgagggcgccctcgcccgcatcgcggacttc
gccggcgagcacggctggccgctgttcatcaagcccgcgcgggccggctcctcgatcggc
atcaccaaggtcgacgacgcctccgggctggacgcggcgatccgcgaggcccgccgccac
gacccgaagatcatcgtggaggcactgctgcacggccgcgagatcgagtgcggggtcctg
gagttcgaggacgggccgcgcgcgagcgtgcccgccgagatcccgccggtctccagccac
gacttctacgacttcgaggcgaagtacatcgacgccgcctccgggatcgtgcccgccccg
ctcaccccggagcagaccgccgaggtccagaggctcgcgatcgaggccttcgacgccgcg
tcctgcgagggactggtgcgcgccgacttcttcctgaccgaggacggcaccttcgtcatc
aacgagatcaacacgatgccgggcttcacccccatctccatgtacccgcggatgtggcag
gagtcgggcatcgagtacccggagctggtggaccgcctgatccaggccgccctgcgccgc
tccaccggactgcgctag
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