Streptomyces sp. ICC4: DRB89_26530
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Entry
DRB89_26530 CDS
T10587
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
stic Streptomyces sp. ICC4
Pathway
stic00860
Porphyrin metabolism
stic01100
Metabolic pathways
stic01110
Biosynthesis of secondary metabolites
stic01120
Microbial metabolism in diverse environments
stic01240
Biosynthesis of cofactors
Module
stic_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
stic_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
Enzymes [BR:
stic01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
DRB89_26530
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
DRB89_26530
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NCBI-ProteinID:
AWZ07574
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Position
5690576..5692243
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AA seq
555 aa
AA seq
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MNPTSPTTSAFPAVAVHGHVTFLGAGPGDPGLLTLRAVEALAAADVLIAEPEVLEVVRTH
ARAGVDTPQLTIADEKSAAAGVPVIRDAANLVMEAARSGRRVVRAVTGDPGLDGHAADEM
LACATEGIPFEVVPGVATAVGVPAYAGVPLSGKQGADVRFVNARSASQRCWSEAGASDGI
LVVSATLETVSAAAAELVSAGRKPDTPLTVTVAGTTTRQRTWSATLGTIAQVFKQGKILP
SPEGSRPVIAVVGEHGAAARREELSWFESKPLFGWRVLVPRTKEQAASLSDQLRSYGAVP
HEVPTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKFEEYGLDARAFAGI
KVAAVGEQTAAALVEFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPIDRVFLPRADIATE
TLVAGLIELGWEVDDVTAYRTVRASPPPQDTREAIKGGGFDAVLFTSSSTVRNLVGIAGK
PHNVTVIACIGPATAKTAEEHGLRVDVLSPEPSVGKLAEALAEYGAARREAAKEAGENVY
RPSERRPGARRRRTT
NT seq
1668 nt
NT seq
+upstream
nt +downstream
nt
ttgaaccccacaagtcccaccacctccgctttcccggcggtcgccgtccacgggcacgtc
accttcctcggtgccggtccgggcgacccgggtctgctgacgctgcgcgccgtcgaggca
ctcgccgccgcggacgtcctgatcgcggagcccgaggtgctcgaggtcgtacgtacgcat
gcgcgcgcgggggtggacacgccgcagctgacgatcgctgacgagaagtcagcagccgcc
ggggtcccggtgatccgagatgccgccaatcttgtcatggaggccgcacgctccggcagg
cgggtcgtccgtgccgtcaccggcgaccccggactcgacggacacgcggccgacgagatg
ctcgcctgcgccaccgagggcatccccttcgaggtcgtccccggcgtcgcgaccgccgtc
ggcgtgcccgcgtacgccggtgtgccgctcagcggcaagcagggcgcggacgtgcggttc
gtgaacgcacggagcgcctcccagcgctgctggagcgaggcgggcgccagcgacggcatc
ctcgtcgtctccgccacgctggagaccgtgtcggcggccgccgccgagctggtgagcgcc
gggcgcaagcccgacaccccgctcaccgtgaccgtggccggcaccacgacccgccagcgg
acgtggagcgcgaccctgggcaccatcgcccaggtgttcaagcagggcaagatcctcccc
tcgcccgagggatcacggcccgtcatagccgtggtcggggagcacggcgccgccgcgcgc
cgcgaggagctgtcctggttcgagtcgaagccgctgttcggctggcgcgtgctcgtaccg
cggaccaaggagcaggcagcctcgctctccgaccagctgcgctcgtacggcgccgtcccg
cacgaggtgcccaccatcgccgtggagcccccgcgcaccccgcagcagatggagcgggcc
gtcaagggactcgtcaccggccgctacgagtggatcgccttcacctcggtgaacgcggtg
aaggccgtgcgcgagaagttcgaggagtacgggctcgacgcccgtgccttcgccggcatc
aaggtcgccgccgtgggcgagcagaccgccgccgcgctggtcgaattcggcgtcaagccc
gacctggtgcccagcggcgagcagtccgccgccggactgctcgaggactggccgccgtac
gacccggtcttcgacccgatcgaccgcgtcttcctgccgcgcgccgacatcgccaccgag
accctggtcgccgggctgatcgagctcgggtgggaggtcgacgacgtcaccgcctaccgg
accgtgcgcgcgtccccgccgccgcaggacacccgcgaggcgatcaagggcggcggcttc
gacgccgtgctcttcacctcctcctcgaccgtgcgcaacctcgtcggcatcgccggcaag
ccgcacaacgtcaccgtcatcgcctgtatcggaccggcgacggccaagacggccgaggag
cacggcctgcgggtcgacgtcctctcgccggagccgagcgtcggcaagctggcggaggcc
ctcgccgaatacggcgcggcgcgccgcgaggccgcgaaggaggccggggagaacgtctac
cggccgagcgagcggcgcccgggcgcgcgcaggcgccgtacgacgtag
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