Streptomyces sp. PBH53: QR97_14580 Help Entry QR97_14580        CDS       T10303                                  Name (GenBank) AMP-dependent synthetase   KO K15670   rifamycin polyketide synthase modules 1, 2 and 3 [EC:6.2.1.74] Organism stpb  Streptomyces sp. PBH53 Pathway stpb01051   Biosynthesis of ansamycins stpb01052   Type I polyketide structures Brite KEGG Orthology (KO) [BR:stpb00001]  09100 Metabolism   09109 Metabolism of terpenoids and polyketides    01052 Type I polyketide structures     QR97_14580    01051 Biosynthesis of ansamycins     QR97_14580  09180 Brite Hierarchies   09181 Protein families: metabolism    01008 Polyketide biosynthesis proteins [BR:stpb01008]     QR97_14580 Enzymes [BR:stpb01000]  6. Ligases   6.2  Forming carbon-sulfur bonds    6.2.1  Acid-thiol ligases     6.2.1.74  3-amino-5-hydroxybenzoate---[acyl-carrier protein] ligase      QR97_14580 Polyketide biosynthesis proteins [BR:stpb01008]  Polyketide synthase (PKS)   Modular type I PKS    cis-AT PKS     Rifamycin PKS      QR97_14580 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  ketoacyl-synt Acyl_transf_1 KR Ketoacyl-synt_C PP-binding PKS_DH_N KAsynt_C_assoc adh_short Thiolase_N RhiE-like_linker CurL-like_PKS_C PKS_DE PS-DH Epimerase ACP_syn_III SDR Polysacc_synt_2 GDP_Man_Dehyd DUF7572 NmrA Motif Other DBs NCBI-ProteinID:  AKN75336 UniProt:  A0A0H4CL31 LinkDB All DBs Position 3328254..3339608 Genome browser AA seq 3784 aa AA seqDB search MAEVFVQGVAVDWTGVLPEGADGAQVDLPTYAFDHRHYWLKPAPAADATALGQTGSDHPL LGAVVGRPDSGGFMTTSRWSLRSQPWLAEHVVGADAVLVPNAALVELAIRLGDEAGAPVV AELTVERPVVLPVRGGRAVQTVVGGADGAGRRTVEVYSRADDSAPDDAWTRHAHGTLAPA GPAAGDARPADGPGVEVSLGEPAGDADRYGVHPSLLDAAVRTALPAGTLAVTWRGVGLRA SGATVVTVRSAGAAGEGTRFHLSDPAGRTVLTVDAVLSEPFDPARAGLAEALTHDALFRV AWTELTLPAGDGTPSVVTVRSAEDIGAGAADADVLLYAVDPAVTDPRTALAAALAVLQAW LAEPALERAPLVVVTGADATDLATAAVRGLLRSAQSEHPGRIVLVEYDGPGEAQDADAAV RAALPGLLASGEPVIRVRATGAEVPRLVRAEMAAGEIGVPQPGRALDPDGTVLITGGTGT LGALTARHLVAGHGVRRLLLLSRRGPEADGAATLCAELTALGATVTVAACDITDRDRLAA VLDAVPADHPLTAVLHTAGVLDDGVVTALTPSRVDTVLRPKLDAALLLDELTRECDLAAF VLFSSAANVFGNPGQANYAAANAALDALAARRRAQGLPGVSLAWGYWERASGMTRHLGAA DLHRNRRLGMAALSEAEGMALLDLALRPASGLPAAPVAAKLDLPALRAAARTAPVAPLLR GLAPTPRTPARAAGAGDHGDLRDRLAALDPAAQLALLLDLVRRNAADVLGHGSADAVRAD RAFKDAGFDSLTAVELRNRLATATGLTLPSAVVFDYPKPTALAEHLRVRLGGDTAAPAAA AGPAPAAPAASDEPIAIVAMACRFPAGVHSPEDLWRVVADGVDAVTEFPADRGWDIDRLY DADPDKAGTTYVRHGAFLDDAPGFDAAFFGISPNEALAMDPQQRLLLETSWEAFERAAID PTGLGGRDIGVFVGVNSHDYTVRMHHATDAEGFRLTGGSGSVVSGRVAYHFGFEGPAVTI DTACSSSLVALHLAAQALRNGECSMALAGGVMVMGNVETFIEFSRQRGLAPDGRCKAFAD GADGTGWSEGVGVLLVERLSEAERQGHQVLAVIRGSAVNQDGASNGLTAPNGPSQQRVIR KALANAGLTPADVDAVEAHGTGTVLGDPIEAQALLATYGQDREQPLLIGSVKSNLGHTQA AAGVAGVIKMVMAMRHGLLPRTLHVDRPSTHVDWSAGAVEVLTEARAWPEAGRPRRAGVS AFGIGGTNAHLVLEQAPAAGRTDAADGAGSTDGVDGAGPVTDGRTAPLLFPVSARTAAGL RGQAGRLAGWVADRAGTPLAATAHALGTARAHLDHRAVVLAADREGLVTALRALAEGSAD AGTVTGAPADGKLAFLFTGQGSQWAGMGRELAAAHPVFRDAFDAACAAVERHLDGLAHPL SAVVSAEPGTEQAALLDQTLYTQGALFALETALFRLFTSWGVRPDLLAGHSVGEIAAAHA AGILDLADAGRLVAARGRLMQALPEGGAMIAVEAAEDEVAPLLAQAAGTVGIAAVNGPRA VVLSGAEDAVLAVAARLAQDGHRTRRLIVSHAFHSALMEPMLDELRAVAAGLRYRPGTLP VVSTLTGALAEDGLLATPEYWVDQARHAVRFADAVTALRDQGVTTHLELGPGGVLSAMAL GTLGPDTRGCIGTLRRDTPEDTAVRTALAELHVRGVPVDWTAVLGRPDPAVGTDLPTYAF QHQRYWVEGAAATDAEALGARSAGHPLLGGVVEVPGEHGGTGVVLTGRLSGRSPGLYGGG ERAVPAGVLLELLVRAGDETGGGTVERISVDAPLVVPAHGDLQLRVFVDAPGPDGVRAAT VHSRPAGHEGAPWLRHARATLTPGVPRHAFDLRDWPEAPAEAGAPAGVRGLWRQDGRILA DLVLPDELTDEAEAFTLHPVLLDTALRVAAGAQDTVVSLTGCAALAVYAVGATELRARVS PAADGGHLVELADPDGRPVALLGPLTLTATEATATETGIAETAVPETAVPETAVPETGVP EAAPVATAPARRVIRRGPTADGNELAARLAGLAEAEQRRVLLDLVRESTAVVLGHRDADG FDEGQPFKNLGFDSLTAVKLRNRLHDFTGVALPSSLVFDHPTPALLADHLRGELLGTRPE IPAPARRGTADPDEPIAIIAMSSRLPGGVNSPEDLWQLVMDRRDAISGFPTDRDWDIDRL YHPDPAHPGTSYTRAGGFLHDAARFDAQLFGISPREALAMDPQQRLLLETSWEAMERAGI DPLSTRGQDIGVFTGIVHHDYVTRLRQVPEDVQGYTMTGTAASVASGRVSYVFGFEGPAV TVDTACSSSLVAMHLAAQALRGGECSLALAGGATVMATPDAFLEFSRQRGLSADGRCKAY SSTADGTGWAEGVGVVLLERLSDARRNGHRVLAVLRGSAVNQDGASNGLTAPNGPSQQRV IRSALASAGLRPADVDAVEGHGTGTVLGDPIEVQALLATYGQDRPADAPLWLGSVKSNIG HTQAAAGVAGVIKMVEAMRHGVLPPTLNVAEPTAQVDWSAGAVELLTEAREWTRAGRPRR AAVSSFGASGTNAHVILEEAPDTEPVTRPTVPDGVVPLVVSARSTAALAAQAGRLAAFVT DADAAPAEVASALVTRRALLSERAVVVAGSRDETLAGLGALARGESSPLLVTGTVAGSGG PGRTVLVFPGQGSQWPGMGRELLENSPVFAERIEECARALEPWVDWDLRAVLRGEADLLD RVDVVQPASFAVNIALAAVWASVGVVPDAVVGHSQGEIAAACVAGALSLEDAARIVAVRS QVIAGELAGRGGMASVALSEAEAVVRIAAWDGRVEVAAVNGPSSVVIAGDAEALDEALAA LAADGVRVRRVAVDYASHTRHVEAIEGALEKAFADIRSQAPAVPFRSTVTGEWVREAGVL DGDYWYRNLRSQVRFGQAIAALLTEGHTVFVESSAHPVLVQPVNEIFDEAADDNVRLRAV AAGSLRREEGGPRRLLASMAELFVKGVAVDWTGVLPAEARDARPDLPTYAFDRQHYWLRE AATGSDDAPAAESAETDFWAAVEQADADSLARLLDLAAADQRDALRTVVPVLADWRGRRR ERSAAEKLRYHVTWRPLDQEGTGVPGGTWLAVVPEAPAAADLVRELTAQGLHLVTLDVPL EAAAADAGRARLGQRLSAVLAEHDVTGVLSLLALDGEQGPQDPVPLTAATLALVQALGDA GATQPLWCLTRGAVNTGIQDTVTAPAQAAVWGIGRAAALERGDRWGGLIDLPATLDTRTV RHLLGALGHPGDDDQLAVRRSGVHTRRLLRKAAPDPTAGPGWQPAGTVLVTGGAEGLGRH ASLWLARSGARRLIVTTTAGAPEGALAALTAEVAALGTGTTVVACADTDRTAIEGLLART PEDEPLTAVVHTADIARTSTVDDTGVPDLTEVFAAKVDTARWLAERFADTPLDAFVVFSS IAGIWGGGGQGTSGAANAVLDALVEWRRGHGHPATAIAWGALDEIGVGMDEDTLTQLRRR GVLPMAPQIAVTAFEQAVQAHEKAVTVVDMDWGAFIPAFTSVRPGPLFADLPEAQEALRA TQPDTENGDTTAGLVDSLRDVPEAEQNRILLRLVCGHAATVLGHSGAESIGPLQAFQEVG FDSLAAVNLRNSLHVATGLRLPATLIFDYPTPDALVGYLRSELLRDADDGLDGREDDLRR ALATVPLARFKEAGVLDTLLGLVDTEDAPASGTPDAAAPAEDDETLIDAMDVADLVQRAL GRTS NT seq 11355 nt NT seq  +upstreamnt  +downstreamnt atggccgaggtcttcgtgcagggtgtcgccgtcgactggaccggtgtcctgcccgagggc gccgacggtgcacaggtggatttgccgacgtacgccttcgaccaccgccactactggctg aagcccgcccccgcggcggacgcgaccgccctcgggcagaccggtagcgaccatcccctg ctcggggcggtcgtcgggcggccggactccggtgggttcatgacgacctcgcggtggtcc ctgcggtcgcagccgtggctggccgagcacgtggtcggggccgacgcggtgctggtgccg aacgcggccctggtggagctggcgatccggctcggtgacgaggccggcgcgccggtcgtg gcggagctgaccgtcgagcggcccgtcgtactgccggtgcgcggcgggcgggccgtccag accgtggtgggcggggcggacggcgccggacggcgcacggtcgaggtctactcacgcgcg gacgactccgctccggacgacgcctggacacgccacgcgcacggcaccctcgcgcccgcc ggccccgcggccggcgacgcccggcccgccgacgggccgggcgtcgaggtgagcctcggc gagccggccggggacgccgaccggtacggcgtccaccccagcctgctcgacgcggccgtg cggacggcgctgccggccgggaccctggcggtcacctggcgcggggtcggcctgcgggcg tccggcgcgaccgtcgtcaccgtgcggtcggcgggtgccgcgggcgagggcacccggttc cacctgagcgatccggccgggcggaccgtgctgaccgtggacgcggtgctgtccgaaccg ttcgacccggcgcgcgccggactcgccgaggcgctcacccacgacgcgctgttccgcgtc gcctggacggagctgacgctgccggcgggtgacggcacgccgtccgtcgtcaccgtacgg agcgccgaggacatcggcgccggtgcggcggacgcggacgtcctgctgtacgccgtcgac cccgcggtgaccgatccgcgcacggcgctcgccgccgcgctcgccgtcctccaggcgtgg ctggccgaacccgccctggagcgggccccgctggtcgtggtgaccggcgcggacgccacc gacctcgccacggccgccgtacgggggctgctgcggtccgcgcagtccgagcaccccggc cggatcgtgctggtcgagtacgacggcccgggcgaggctcaggacgccgacgcggcggtc cgtgccgcgctgcccggcctgctcgcctccggtgaaccggtgatccgcgtacgggccacg ggcgccgaggtgccccggctggtccgggccgagatggcggcgggggagatcggggtcccg cagccgggccgggcgctcgatccggacgggaccgtgctgatcaccggcggcaccggcacg ctcggcgcgctcaccgcccggcacctggtcgccgggcacggcgtccgccgtctgctcctg ctcagccggcgcggccccgaggcggacggcgcggccacgctctgcgcggagctgaccgcg ctgggcgccaccgtcaccgtcgccgcctgcgacatcaccgaccgggaccggctcgcggcc gtcctggacgccgtacccgccgaccacccgctgaccgccgtcctgcacaccgccggagtc ctggacgacggcgtggtcaccgcgctcaccccgagccgcgtcgacaccgtcctgcggccc aaactggacgcggcgctgctgctggacgagctgacgcgggagtgcgacctcgcggcgttc gtgctgttctcctcggccgcgaacgtcttcggcaacccgggccaggccaactacgccgcc gccaacgccgccctggacgcgctcgccgcgcgccgccgggcccaggggctgcccggcgtc tcgctcgcctggggctactgggagcgggccagcggcatgacccggcacctcggcgccgcc gacctgcaccgcaaccggcggctcggcatggccgcgctgtccgaggccgagggcatggcg ctgctggacctcgccctgcggcccgcgagcgggctgcccgccgccccggtggccgccaaa ctggacctgcccgccctgcgcgcggcggcccgcaccgcgcccgtggcaccgctgctgcgg ggcctcgcgcccacgccgcgcacgccggcccgcgccgccggcgccggcgaccacggcgac ctgcgggaccgcctggccgcgctggacccggcggcccagctggccctgctgctggacctg gtccggcgcaacgccgccgacgtgctcggccacggcagcgccgacgccgtgcgtgccgac cgggccttcaaggacgccgggttcgactcgctgaccgcggtggagctgcgcaaccggctg gcgaccgccaccgggctcaccctgccctcggccgtcgtcttcgactaccccaagccgacc gcgctcgccgagcacctgcgggtccggctcggcggtgacaccgccgccccggccgcggcg gccggtccggcacccgccgcgcccgccgcgtccgacgagccgatcgcgatcgtcgcgatg gcctgccgcttccccgccggggtgcacagccccgaggacctgtggcgggtcgtggccgac ggggtcgacgccgtcaccgagttccccgccgaccgcggctgggacatcgaccggctctac gacgccgaccccgacaaggccggcacgacctacgtgcggcacggcgcgttcctggacgac gcgcccggcttcgacgccgccttcttcgggatctccccgaacgaggccctcgcgatggac ccgcagcagcggctgctgctggagacgtcctgggaggccttcgaacgcgccgcgatcgac cccaccgggctcggcggccgggacatcggcgtgttcgtcggtgtcaacagccacgactac accgtgcggatgcaccacgcgaccgacgccgagggcttccggctcaccggcggctccggc agcgtcgtctccggccgcgtcgcctaccacttcggtttcgagggcccggccgtcacgatc gacaccgcctgctcctcctccctggtcgccctgcacctggccgcccaggcgctgcgcaac ggggagtgctccatggcgctcgccggcggcgtgatggtgatgggcaacgtggagacgttc atcgagttctcccggcagcgcggcctcgcccccgacggccggtgcaaggcgttcgcggac ggcgcggacggcaccggctggtccgagggcgtgggcgtgctgctggtcgagcggctgtcc gaggccgaacggcagggccaccaggtgctcgccgtgatccggggcagcgcggtcaaccag gacggcgcgtccaacggcctgacggcacccaacggcccgtcccagcagcgcgtgatccgc aaggcgctcgcgaacgccgggctgaccccggcggacgtggacgcggtcgaggcacacggc accggcaccgtcctcggcgacccgatcgaggcgcaggccctgctcgccacctacggccag gaccgtgaacagccgctgttgatcggttcggtgaagtcgaacctcgggcacacccaggcc gcggccggggtcgccggggtcatcaagatggtcatggcgatgcggcacggcctgctgccc cgcaccctgcacgtggaccggccctccacgcacgtggactggtcggcgggcgcggtcgag gtgctcaccgaggcccgcgcctggcccgaggccggccgcccgcgccgggccggcgtctcc gccttcggcatcggcggcaccaacgcccacctggtcctggagcaggcaccggcggccggc aggaccgacgccgcggacggcgcgggcagcacggacggcgtcgacggcgcggggcccgtc accgacggccgcaccgcccccctcctcttccccgtctccgcccgcaccgccgccgggctg cgcgggcaggccggccggctcgccggctgggtggcggaccgggccggtacgccgctcgcg gccacggcccacgcgctcggcaccgcccgcgcccacctcgaccaccgcgcggtcgtcctg gccgccgaccgggaggggctcgtcaccgccctgcgcgcgctcgccgagggcagcgccgac gcgggcaccgtcaccggcgccccggccgacggcaagctcgccttcctgttcaccgggcag ggcagccagtgggccggcatgggccgcgaactcgccgccgcccacccggtgttccgcgac gccttcgacgcggcctgcgccgccgtggaacggcacctggacggcctcgcccaccccctg agcgcggtggtgtccgccgagcccggcaccgaacaggccgccctgctcgaccagaccctc tacacccagggcgcgctgttcgccctggagaccgccctgttccggctgttcacctcctgg ggcgtacggcccgacctcctcgcgggccactcggtcggcgagatcgccgccgcccacgcc gccggcatcctggacctggcggacgccggtcgactggtcgcggcccggggccggctgatg caggccctgcccgagggcggcgcgatgatcgccgtggaggcggccgaggacgaggtggca ccgctgctcgcccaggccgccggcaccgtcgggatcgcggcggtcaacgggccgcgggcc gtggtcctgtccggcgccgaggacgccgtcctcgccgtcgccgcgcgcctcgcccaggac ggccaccgcacccgccggctgatcgtcagccacgccttccactccgcgctgatggagccg atgctcgacgagctgcgcgccgtggccgccgggctccgctaccggccgggcaccctcccc gtcgtctccacgctcaccggcgcactcgccgaggacgggctgctcgccacccccgagtac tgggtggaccaggcccggcacgccgtgcggttcgccgacgccgtcaccgccctgcgcgac cagggcgtcaccacccacctggaactggggcccggcggcgtcctcagcgccatggccctc ggcaccctcggcccggacacccgcggctgcatcggcacgctgcgccgggacacccctgag gacaccgccgtccgcaccgcgctcgccgaactccacgtacggggcgtgccggtcgactgg accgccgtcctcggccgcccggacccggccgtcgggaccgacctgcccacctacgccttc cagcaccagcggtactgggtggagggcgccgccgccaccgacgccgaggcgctcggcgca cggtccgccgggcacccgctgctgggcggcgtcgtggaggtccccggcgagcacggcggc accggtgtcgtcctcaccggccggctctccggacgcagccccggcctgtacggcggcggg gagcgggcggtaccggccggcgtgctgctggagctgctggtccgggccggcgacgagacc ggcggcggcaccgtcgagcggatcagcgtcgacgcgcccctcgtcgtccccgcgcacggc gacctccagctccgcgtcttcgtggacgcgcccggccccgacggggtgcgcgcggccacc gtgcacagccggccggccggacacgagggcgcaccgtggctccggcacgcccgcgccacc ctgacccccggcgtcccgcggcacgccttcgacctgcgcgactggccggaggcgcccgcg gaggccggcgccccggccggggtgcgcgggctgtggcggcaggacggccggatcctcgcc gacctcgtgctgccggacgaactcactgacgaggccgaggcgttcaccctccatccggtg ctcctcgacaccgccctgcgggtcgcggccggggcccaggacacggtcgtctccctgacc gggtgcgccgccctcgccgtgtacgcggtcggtgccaccgagctgcgggcgcgcgtcagc ccggccgccgacggcgggcacctggtggagctggccgaccccgacggccggcccgtcgcc ctgctcggcccgctgacgctcacggccaccgaggccaccgccaccgaaaccggcatagcg gagaccgccgtaccggagaccgccgtaccggaaaccgccgtaccggaaaccggcgtaccg gaggccgcacccgtcgcgaccgcgcccgcccgccgtgtcatccgccgcggaccgaccgcc gacggcaacgaactggccgcccggctggccgggctcgccgaggccgaacagcgccgggtc ctgctggacctggtccgggagagcaccgcggtcgtcctcggccaccgggacgcggacggc ttcgacgaggggcagccgttcaagaacctcggcttcgactcgctcaccgccgtcaaactc cgcaaccggctgcacgacttcaccggcgtcgccctgcccagcagcctcgtcttcgaccac ccgaccccggccctgctcgccgaccacctgcgcggcgaactcctcggcacccgcccggag atccccgcgcccgcccggcgcggcacggccgatccggacgagccgatcgccatcatcgcc atgagcagccggctgcccggcggcgtcaacagccccgaggacctgtggcagctcgtcatg gaccggcgcgacgccatctccggcttccccaccgaccgcgactgggacatcgaccggctc taccaccccgacccggcccaccccggcaccagctacacccgggcgggcggcttcctgcac gacgccgcccggttcgacgcccagctcttcggcatctcgccgcgcgaggccctggccatg gacccgcagcagcggctgctgctggagacctcctgggaggccatggagcgcgcgggcatc gacccgctgtccacccgcggccaggacatcggcgtgttcaccggcatcgtccaccacgac tacgtgacccggctgcgccaggtccccgaggacgtccagggctacaccatgaccggtacg gccgccagcgtggcctcgggccgggtctcgtatgtcttcggcttcgaaggccccgcggtg accgtggacacggcctgctcctcctccctggtcgccatgcacctcgcggcgcaggcgctg cggggcggcgagtgctccctcgccctcgccggcggcgccaccgtcatggccacccccgac gccttcctggagttctcccggcagcgcggactgtccgccgacggccgctgcaaggcgtac tcctccaccgcggacggcaccggctgggccgagggcgtcggcgtggtcctgctggagcgg ctgtcggacgcgcggcgcaacggccaccgggtgctggcggtgctgcgcggcagcgcggtc aaccaggacggcgcgtccaacggcctgaccgcccccaacggtccctcccagcagcgggtg atccgcagcgccctggcctccgccgggctgcggcccgccgacgtggacgcggtggagggc cacggcaccggcaccgtcctcggcgacccgatcgaggtgcaggcgctgctggccacctac ggccaggaccgacccgcggacgcgccgctgtggctcggctcggtgaagtcgaacatcggg cacacgcaggccgccgccggtgtcgccggggtgatcaagatggtggaggcgatgcggcac ggcgtcctgccgcccaccctgaacgtcgccgaacccaccgcgcaggtggactggtcggcg ggcgcggtggaactgctcaccgaggcccgcgaatggacccgcgccggccggccgcgccgg gccgccgtctcctccttcggcgcgagcggcaccaacgcgcacgtcatcctggaggaggcg cccgacaccgagccggtcacccggccgacggtccccgacggcgtcgtaccgctggtggtg tcggcccgcagcacggccgccctcgccgcccaggccggacgcctggcggcgttcgtcacc gacgcggacgccgcaccggccgaggtcgcgagtgccctcgtcacccggcgggccctgctg tccgagcgggccgtggtcgtcgccggttcacgcgacgagaccctcgccgggctcggcgcg ctggcccggggcgagagcagccccctgctcgtgaccggaaccgtcgccggctccggcggc cccggcaggaccgtgctggtcttccccgggcagggttcccagtggccgggcatgggccgg gaactgctggaaaactccccggtgttcgcggagcggatcgaggagtgcgcccgggctctg gagccctgggtggactgggacctgcgggccgtcctgcgcggtgaggccgacctgctggac cgggtggacgtcgtgcagccggcgagcttcgccgtgaacatcgccctggcggccgtctgg gcctccgtgggtgtggtgccggacgcggtggtcggtcactcgcagggcgagatcgccgcc gcctgtgtcgccggtgcgctgtcgctggaggacgcggcgcggatcgtcgccgtccgcagt caggtgatcgccggtgagctggcgggccggggcgggatggcctcggtggcgctgtccgag gccgaggccgtcgtccggatcgccgcctgggacgggcgcgtcgaggtcgccgccgtcaac gggccgtcgtcggtcgtgatcgccggagacgccgaggcgctggacgaggcgctcgccgca ctcgcggccgacggggtccgggtccgccgggtcgccgtggactacgcctcccacacccgc catgtcgaggcgatcgaaggggcgttggagaaggcgttcgccgacatccgcagccaggcc cccgcggtgccgttccgctccaccgtcaccggcgagtgggtccgcgaggccggcgtcctc gacggcgactactggtaccggaacctgcgcagccaggtccgcttcggccaggccatcgcc gccctcctcaccgagggccacacggtgttcgtcgagtccagcgcccaccccgtcctcgtc cagcccgtgaacgagatcttcgacgaggccgccgacgacaacgtccgcctccgcgccgtc gccgccggatcgctgcggcgcgaggaaggcggcccgcggcggctgctcgcctcgatggcc gagctgttcgtcaagggcgtcgccgtggactggacgggcgtcctgcccgccgaggcccgc gacgcccgcccggacctgccgacgtacgccttcgaccgccagcactactggctgcgggaa gcggcgaccggcagcgacgacgcccccgccgccgagagcgccgagaccgacttctgggcc gccgtcgaacaggccgacgccgactccctcgcccggctgctcgacctggccgcggccgac cagcgcgacgccctgcgcaccgtcgtccccgtgctggccgactggcgcggccggcggcgc gagcggtcggcggccgagaagctgcgctaccacgtcacctggcgccccctcgaccaggag ggcaccggtgtccccggcgggacctggctggccgtcgtaccggaggccccggcagcggcc gatctggtccgggaactcaccgcgcagggactccacctggtcaccctcgacgtcccgctg gaggccgcggcggccgacgccggccgcgcccggctcggccagcgcctgtcggccgtcctc gccgaacacgacgtcaccggcgtgctgtcgctgctcgccctcgacggcgaacagggcccg caggaccctgtcccgctgaccgcggccaccctggcgctggtgcaggcgctcggcgacgcc ggggccacccagcccctgtggtgcctcacccggggcgcggtcaacaccggcatccaggac accgtcaccgcgcccgcccaggccgccgtctggggcatcggccgggccgccgccctggaa cgcggcgaccgctggggcggactgatcgacctgcccgccaccctcgacacccgcaccgtc cgccacctgctcggcgccctcgggcaccccggcgacgacgaccagctggccgtccgccgg tccggggtgcacacccgccggctgctgcgcaaggccgcccccgacccgaccgccggcccc ggctggcagccggccggcaccgtcctggtcaccggcggcgccgagggcctcggccggcac gcctccctgtggctcgcccgctccggcgcccgccgcctcatcgtcaccaccacggccggc gcccccgagggcgcgctcgccgcgctcaccgccgaggtggccgcgctcggcaccggcacc accgtcgtggcctgcgccgacaccgaccggaccgcgatcgaggggctgctcgcccggacc cccgaggacgagccgctcaccgccgtcgtgcacaccgccgacatcgcccgcaccagcacc gtggacgacaccggcgtccccgacctcaccgaggtgttcgccgccaaggtcgacaccgcc cgctggctcgccgaacggttcgccgacacccccctcgacgcgttcgtggtgttctcctcg atcgccggcatctggggcggcggcgggcagggcacctccggcgcggccaacgccgtcctc gacgccctcgtcgagtggcgccgcggccacggccacccggcgaccgccatcgcctggggc gccctggacgagatcggcgtcggcatggacgaggacaccctcacccagctccgccggcgc ggtgtgctgccgatggccccgcagatcgccgtcaccgccttcgaacaggccgtccaggcc cacgagaaggccgtcacggtggtcgacatggactggggcgccttcatccccgccttcacc tcggtccggcccggcccgctcttcgccgacctgcccgaagcacaggaggcactgcgggcc acccagccggacaccgagaacggcgacaccaccgccggcctcgtggactccctgcgcgac gtccccgaggccgagcagaaccgcatcctgctccggctggtgtgcggacacgccgccacc gtcctcggccacagcggcgccgagagcatcggccccctccaggccttccaggaggtcggc ttcgactcgctcgccgccgtcaacctgcgcaacagcctgcacgtggcgaccggcctgcgg ctgcccgccaccctcatcttcgactaccccacgccggacgccctcgtcggctatctgcgc tccgagctgctccgggacgcggacgacgggctggacgggcgggaggacgacctcaggcga gccctcgccaccgtccccctcgcccggttcaaggaggccggcgtcctggacaccctgctc ggcctcgtggacaccgaggacgccccggcgtccgggacgcccgacgcggcggccccggcc gaggacgacgagaccctgatcgacgccatggacgttgccgatctcgtgcagcgtgctctg ggcaggacgagctga

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