Streptomyces sp. 769: GZL_06432
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Entry
GZL_06432 CDS
T03587
Name
(GenBank) UDP-N-acetylmuramoylalanyl-D-glutamyl-2 C 6-diaminopimelate/D-alanyl-D-alanyl ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
stre
Streptomyces sp. 769
Pathway
stre00300
Lysine biosynthesis
stre00550
Peptidoglycan biosynthesis
stre01100
Metabolic pathways
stre01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
stre00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
GZL_06432
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
GZL_06432
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
GZL_06432
Enzymes [BR:
stre01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
GZL_06432
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Gene cluster
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
Motif
Other DBs
NCBI-ProteinID:
AJC59002
UniProt:
A0A0A8EU93
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Position
6926374..6927864
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AA seq
496 aa
AA seq
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MISLSLAEIASIVGGQQHDIPDPDREVTGPVVSDSRAVRPGGLFVAFAGERVDGHDFAVG
AVEAGAVAVLAARPVGVPAIVVDDVVAALGALARAVVNKSGATVIGLTGSAGKTSTKDLI
AQLLQRHGPTVWPEGNLNNEIGLPLTALRAEDTTRHLVLEMGARGIGHIRYLAGLTPPRI
GVVLNVGTAHLGEFGGREQIAQAKGELVESLPVADEEGLEGLPAEGGGGRRAGGVAVLNA
DDPYVRAMASRTKARTVFFGESADAAIRAENVRLNGLGQPSFTLHTPSGCSDVTMRLYGE
HHVSNALAAAAVAHELGMPVDEIAAALSEAGTLSRWRMEVTERADGVTVVNDAYNANPES
MRAALRALVAMGAAGRARGGRTWAVLGEMAELGEESLAEHDAVGRLVVRLNVSKLVAVGG
REAAWLDMGAKNEGSWGEESVHVSDARAAIDLLRRELRPGDVVLVKASRSVGLERVAAAL
LDGEDGSAATGGAASR
NT seq
1491 nt
NT seq
+upstream
nt +downstream
nt
gtgatctccctgtccctcgccgagatcgcgagcatcgtcggcgggcagcagcacgacata
ccggacccggaccgcgaggtcaccgggccggtcgtctcggactcccgggcggtccgcccg
ggtggcctgttcgtcgcgttcgccggtgagcgcgtcgacggccacgacttcgccgtcggc
gccgtggaagccggtgcggtggccgtcctcgcggcccgcccggtcggtgtcccggcgatc
gtcgtcgacgacgtcgtcgcagctctcggcgcactcgcccgggccgtcgtgaacaagtcg
ggcgccaccgtcatcggtctgaccggctcggccggcaagaccagcaccaaggacctgatc
gcccagctcctccagcggcacggtccgacggtgtggccggaaggcaacctcaacaacgag
atcgggctgccgctcaccgcgctgcgcgccgaggacaccacccggcacctcgtgctggag
atgggcgcccgcggcatcggccacatccgctacctcgccgggctgaccccgccccggatc
ggggtggtcctcaacgtcggcaccgcgcacctcggcgagttcggcgggcgcgagcagatc
gcccaggccaagggcgagctggtcgagtcgctgcccgtggccgacgaggaagggctcgaa
gggcttccggcggagggcggtggcgggcgacgggcgggcggcgtggcggtgctcaacgcg
gacgatccgtacgtccgggccatggcgtcccgcacgaaggcccgtacggtcttcttcggc
gagtccgcggacgccgcgatccgtgccgagaatgtccggctcaacggcctcggacagccc
tccttcacgcttcacacaccctccgggtgcagcgatgtgaccatgcggctgtacggtgag
caccacgtgtcgaacgcgctcgccgcggccgccgtcgcccatgagttgggcatgcccgtg
gacgagatcgccgccgcgctctccgaagccggcacgctctcccgctggcggatggaggtc
accgagcgcgcggacggcgtgacggtcgtcaacgacgcctacaacgcgaaccccgagtcc
atgcgagcggcgctgcgtgcgctggtcgccatgggcgccgccggcagggcgcgggggggc
cggacgtgggcggtgctcggtgagatggccgagctgggcgaggagtcactcgccgaacac
gacgcggtcgggcggctggtcgtccggctcaacgtcagcaagctcgtggcggtcggcggc
agggaagcggcctggctcgacatgggcgccaagaacgagggttcgtggggtgaggagtcg
gtgcacgtgtccgacgcgcgggcggcgatcgacctgttgcgcagggagctgcgaccggga
gacgtcgtgctggtgaaggcgtccaggtcggtgggcctggagcgggtggccgcggcattg
ctggacggcgaggacggttccgctgcgacgggcggagccgcgtcccgatga
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