Streptomyces sp. 4F: ASR50_10190
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Entry
ASR50_10190 CDS
T04265
Name
(GenBank) UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
strf
Streptomyces sp. 4F
Pathway
strf00300
Lysine biosynthesis
strf00550
Peptidoglycan biosynthesis
strf01100
Metabolic pathways
strf01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
strf00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
ASR50_10190
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
ASR50_10190
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
ASR50_10190
Enzymes [BR:
strf01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
ASR50_10190
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
RPAP1_N
Motif
Other DBs
NCBI-ProteinID:
ALV49744
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Position
complement(2294489..2295904)
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AA seq
471 aa
AA seq
DB search
MIALSLAEIAEVVGGQTHDIPDPSVLVTGEVVRDSREAGPGSLFVAFVGERVDGHDFAAQ
VVEAGAVAVLASRPVGVPAIVVEDVQAALGALARHVVARLGATLVALTGSAGKTSTKDLV
AQVLGNKAPTVFTPGSLNNEIGLPLTALTATEDTRFLVLEMGARGIGHIRYLTGLTPPRI
GLVLNVGSAHIGEFGGREQIAQAKGELVESLPPAEEGGVAILNADDPYVRAMASRTKAKV
ILFGESGEADVSAENVRLTDSGQPSFRLHTPSGASDVTMRLYGEHHVSNALAAAAVAHEL
GMSADEIARALSEAGSLSRWRMEVTERPDGVTVVNDAYNANPESMKAALRALAAMGKGRR
TWAVLGRMAELGDEALAEHDAVGRLAVRLNVSKLVAVGGREAAWLQLGAYNEGSWGEESV
HVSDAQAAVDLLRSELRPGDVVLVKASRSVGLESVAQALLETGAEGEVAAR
NT seq
1416 nt
NT seq
+upstream
nt +downstream
nt
gtgatcgccctctccctcgccgagatcgcagaagtcgtcggcgggcagacgcacgacata
ccggacccctccgtcctggtcaccggcgaggtggtccgggactcgcgggaggcgggtccg
ggaagcctcttcgtcgccttcgtcggcgagcgcgtggacggccacgacttcgcggcccag
gtcgtcgaggcgggcgcggtcgccgtgctcgcctcccggccggtcggggtgcccgcgatc
gtcgtcgaggacgtccaggcggccctcggggctctcgcccggcacgtcgtcgcccggctc
ggcgccaccctcgtcgccctcaccgggtcggccggcaagaccagcaccaaggacctggtc
gcccaggtgctgggcaacaaggcccccaccgtcttcacgcccggctccctcaacaacgag
atcgggctgccgctgaccgcgctcaccgccaccgaggacaccaggttcctcgtgctggag
atgggggcgcggggcatcggccacatccgctacctcaccggactgaccccgcccaggatc
ggcctggtgctgaacgtcggctccgcgcacatcggcgagttcggcggccgggagcagatc
gcccaggccaagggcgagctcgtcgagtcgctgccgccggccgaggaggggggcgtcgcg
atcctcaacgcggacgacccctacgtccgcgccatggcctcccgaacgaaggcgaaggtg
atccttttcggagagtccggcgaagcggacgtctccgccgagaacgtgcgactcacggac
agcggacagccttccttcaggcttcacacaccctccggtgcaagcgatgtgaccatgcgc
ctgtacggtgagcatcacgtgtcgaacgcgctcgccgcggccgccgtcgcccacgagttg
ggcatgtccgcagacgagatcgcccgcgcgctctccgaggcgggctccctctcccgctgg
cgcatggaggtcaccgagcgaccggacggcgtgacggtcgtcaacgacgcctacaacgcg
aaccccgagtccatgaaggccgcgctgcgtgcgctggcggccatgggcaaggggcgccgt
acgtgggcggtgctcggcaggatggccgagctcggggacgaggcgctcgccgagcacgac
gcggtcggacggctcgccgtccggctcaacgtcagcaagctcgtcgcggtcgggggcagg
gaagccgcctggctgcaactgggcgcatataacgagggttcgtggggtgaggagtcggtg
cacgtgtccgacgcacaggcggcggtcgacctgttgcgcagcgaattgcgcccgggggat
gtcgtactcgtgaaggcgtcccgttcggtcgggctcgagagcgtggcgcaggcgctgctc
gagaccggtgccgagggtgaggtcgccgcccgatga
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