Streptomyces sp. Mg1: M444_19960
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Entry
M444_19960 CDS
T03958
Name
(GenBank) uroporphyrin-III methyltransferase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
strm
Streptomyces sp. Mg1
Pathway
strm00860
Porphyrin metabolism
strm01100
Metabolic pathways
strm01110
Biosynthesis of secondary metabolites
strm01120
Microbial metabolism in diverse environments
strm01240
Biosynthesis of cofactors
Module
strm_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
strm_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
strm00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
M444_19960
Enzymes [BR:
strm01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
M444_19960
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
M444_19960
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Motif
Pfam:
HEM4
TP_methylase
B12-binding
Motif
Other DBs
NCBI-ProteinID:
AKL67284
UniProt:
B4V346
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Position
1:4620128..4621795
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AA seq
555 aa
AA seq
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MNPSRPTTSALPAVAAQGHVTFLGAGPGDPGLLTLRAVEALTAADVLIAEPEVLDVVRTH
ARAGVDTPQLTIADEASAAAGIPAIRDAANLVMEAARSGRRVVRAVTGDPGLDGNAAQEM
LACATAGIPFEVVPGVATAVGVPAYAGVPLRGEQGADVRFVDARTASARCWSEVGASDGV
LVVSATLETVSAAAAELVSAGRKPDTQLTVTVGGTTTRQRTWSATLGTIATVFKQGKVLP
SPEGARPVIAVVGEHGATARREELAWFESKPLFGWRVLVPRTKEQAASLSDQLRSYGAVP
HEVPTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKFEEYGLDARAFAGI
KVAAVGEQTAAALVEFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPIDRVFLPRADIATE
TLVAGLIELGWEVDDVTAYRTVRASPPPADTREAIKGGGFDAVLFTSSSTVRNLVGIAGK
PHNVTVIACIGPATAKTAEEHGLRVDVLSPEPSVGKLAEALAEYGAARREAAKEAGETVF
RPSERRPGARRRRTT
NT seq
1668 nt
NT seq
+upstream
nt +downstream
nt
ttgaacccctcacgtccgaccacctccgcccttccggccgtcgccgcccagggacacgtc
accttcctcggtgccggccccggcgacccgggtctgctcacgctgcgcgccgtcgaggcg
ctcacggccgcggacgtactgatcgcggagcccgaggtgctcgatgtcgtacgtacgcat
gcgcgcgcgggtgtcgacacgccgcagctgacgatcgctgacgaagcgtcagcggccgcc
ggtatcccggcgatccgggacgcggccaatcttgtcatggaggccgcgcgctccggcagg
cgggtcgtgcgtgccgtcaccggagaccccggactcgacggcaacgcggcccaggagatg
ctcgcctgcgccaccgcgggcatccccttcgaggtggtccccggcgtcgcgaccgccgtc
ggcgtgcccgcctacgcgggcgtcccgctccgcggcgaacagggcgcggacgtccgcttc
gtcgacgcccgcaccgcctcggcgcgctgctggagcgaggtcggcgccagcgacggcgtc
ctcgtcgtctccgcgacgctggagacggtgtcggcggccgccgccgagctggtcagcgcc
gggcgcaagcccgacacccagctgacggtgaccgtgggcggcaccacgacccgccagcgc
acctggagcgcgaccctcggcaccatcgccacggtgttcaagcagggcaaggtcctcccc
tcgcccgagggcgcccgcccggtcatagccgtggtcggtgagcacggcgccaccgcgcgc
cgcgaggagctggcctggttcgagtcgaagccgctgttcggctggcgggtgctcgtaccg
cgcaccaaggagcaggccgcttcgctctccgaccagctccgttcgtacggcgcggtgccg
cacgaggtgccgaccatcgccgtggagccgccgcgcaccccgcagcagatggagcgggcc
gtcaaggggctcgtcaccggacgctacgagtggatcgccttcacctcggtcaacgccgtg
aaggccgtccgcgagaagttcgaggagtacgggctcgacgcccgcgccttcgccgggatc
aaggtcgccgccgtgggcgagcagaccgccgccgcgctcgtcgagttcggcgtcaagccg
gacctggtgccgagcggcgagcagtccgccgccgggctgctggaggactggccgccctac
gacccggtcttcgacccgatcgaccgcgtcttcctgccgcgcgccgacatcgcgaccgag
acgctggtcgcgggcctgatagagctcggctgggaggtcgacgacgtcacggcctaccgc
accgtgcgcgcctctccgccgccggcggacacccgcgaggccatcaagggcggcggcttc
gacgccgttctcttcacctcgtcctccaccgtgcgcaacctcgtcggcatcgccggcaag
ccgcacaacgtcaccgtgatcgcctgcatcggcccggcgaccgcgaagacggcggaggag
cacggcctgcgcgtcgacgtcctgtcgcccgagccgagcgtcggcaagctggccgaggcc
ctggccgagtacggcgcggcccgccgcgaggcggccaaggaggccggcgagacggtgttc
cggccgagcgagcgccgccccggcgcccgccggcgccgcaccacctga
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