Salmo trutta (river trout): 115162368 Help Entry 115162368         CDS       T08542                                  Name (RefSeq) ryanodine receptor 3-like   KO K04963   ryanodine receptor 3 Organism stru  Salmo trutta (river trout) Pathway stru04020   Calcium signaling pathway stru04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:stru00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     115162368    04020 Calcium signaling pathway     115162368  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:stru04040]     115162368 Ion channels [BR:stru04040]  Voltage-gated cation channels   Ryanodine receptor    115162368 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 Motif Other DBs NCBI-GeneID:  115162368 NCBI-ProteinID:  XP_029569460 Ensembl:  ENSSTUG00000030486 LinkDB All DBs Position 25:complement(29831323..29994765) Genome browser AA seq 4906 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVACIHKENRKFCLTAEGLGNRLCYLEPTSEAKYVPP DLCICNFVLEQSLSVRALQEMLAKTGQNSEGPRVKDRWAAQGGGHRTLLYGHAILLRHSF SAMYLTCLKTSRSQTDKLSFDVGLQQDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVS VSSERYLHLSISNGNIQVDASFMQTLWNVHPTCSGSNVEEGYLLGGHVLRLFHGHDEVLT IPGSDQSDEQQRIVNYETGNAGAKARSLWRLEPLRISWSGSHIRWGQPFRLRHLTTGHYL SLTEERGVVLQDREKSDTSSTAFCFRASKEKLESSPKRDIEGMGMAEIKYGDSICFVMHV ATGLWLSYQAPDVKSSRLGPLKRRACLHSEGHMDDGLTLQRCQHEESRAARIIRNTTRLF SHFIRDLDCLGGKNRASVALPIEEVLQTLNDLITYFQVPNAELEHEEKQIMLRSLKNRQN LFKQEGMLTLVSCCIDRLNVYNSAAHFGECAGAEAGASWKDILNLLYELLAALIRGNRNN CTQFSNNLDWLVSKLERLESSSGILEVLHCILIESPEALNIIQRGHIKSIISLLYKHGRN HKILDVLCSLCVCNGVAVRANQNLICDHLLPKRDLLLQTRLVNDVQSMRPNIYLGMSEGS AQYKKWYYELMIDQVDHFLTSDPSHLRVGWATNKGYAPYPGGGEGWGGNGVGDDLYSYGF DGLHLWSGRISRAVASINQHILTSEDVVSCCLDLGAPSISFRINGQPVQGMFENFNIDGL FFPVVSFSAGVKVRFLMGGRHGDFKFLPPSGYAPCYEALLPKEKMKVEPVKEYKRDMEGV RDLLGTTQFISQASFIPTPVETSQIVMPPYLEKVRDRLAENIHELWAMNKIELGWSYGKI RDDNKRQHPCLVDFPRLPETEKNYNLQMSTETLKTLLALSCHVVQVNANAEEDLKKIKLP KNYMMSNGYKPTPLELSDVKLTPGQELLVDKLAENAHNVWAKDRIKQGWTYGIQQDVKSK RNPRLVPYSLLDERTKKSNRDSLREAIRTLIGYGYNIEPPDQEGAGHAVDRLSIDKIRFF RVERTYAVMTGKWYFEFDVVTGGDMRVGWARPGCRPDVELGTDELAFVFDGYKGQRLNMG SRFFGRCWHAGDVVGCMINMEDKSMIFTLNGEILITNKGSELCFADFETEDGFIPVCSLG LSQVGRMNLGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPKNHNHI MVTRIDGTIDSPPCLKVSHRTFGTQNSNGDMVYCRLSMPVEFHSFFKTSPVMDMNGVHED HESLKLKHRHPLKSMRHSHDGIRGTDYSNISTYHYSVRVFAGQDPSCVWVGWVTPDYHYY SNHFNLSKNRTVTVTLGDQRGRVHESVRRSNCYMVWGGDVTSSGHSSSRSNVDLEIGCLI DLATGLVTFTGNGKELATSYQVEPNTKLFPAVFVRPTSPNLFQFELSKIKNAMPLSAAIF KSEHKNPVPQCPPRLDIQTINSVLWSRMPNTFLKVETARVSERHGWVVQCLEPLQMLAVH IPEENRCVDIMELSEQEDLRKFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDN QYLSGMLREGFYNILISIHLETAKEARLMMNNEFIIPITTETRSIRLFSDASKHHSPPGV GLSTSLKPRLSFYPPCFISTRREQHLYSPQIPLDALKEKAITMLTEAVQGGGHHIRDPVG GSVEYQFVPILRLIGTLLTMGVLGSQDVHKILLLIDPNVFVEHSEEAVAVVMEATEKEGL TGSEEKAVEAGEEDAAKEAKLPMKGLLEKRLPEPVKRQMCELLHYFCDCELKHRIEAIVS FSDSFVSKLQYNQKFRYNELMLALNMSAAVTAKKTKEFRSPPQEQINMLLNFSTGEDCPC PEDIQEELYAFHNELRLHCGIPMEEEEDEQDTSIKGRLLALVYKIKGQPLKTEEEPTEQE QQAPSNLKELISQTMVSWAQECHVEDPELVRVMFSLLRRQYDSIGELLRAMRKSYTISAA SIQDTINLLASLGQIRSLLSVRMGKEEEKLMIDGLGDIMNNKIFYQHPNLMRVLGMHETV MEVMVNVLGGGKSQEIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLAS PAMRGSTPLDVAASSVMDNNGLALALEEPDLDKVVTYLAGCGLQSCPMLLDKGYPDIGWN PIEGERYLSFLRFAVFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAI KISEDPALDLPSSAQGVSSDVSAEDDEEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLIN KGKGEALRIRAILRSLVPTEDLVGIISIALKMPVIHKDGTVTEPDMAASFCPDHKAPMVL FLDRVYGIEDQSFLLHLLEVGFLPDLRASASLDTEVLSTTETALAMNRYIGSAMLPLLTR CAPHFAGTEHYATLIDSTLHTIYRLSKGRSLTKAQRDAIEECLLAVCRYLRPSMLQQLLR RLVFDVPLLTEYCKMPLRLLTNHYEQSWKYYCLPSGWGSYGMASDEELLLTKKIFWGVLD SLSQRKYDADLFKMAMPCLSAISGALPPDYIDSTISTTLEKPASVDAQGNFDPKPISTAN ISLPEKLENVANKYAEHSHDKWSAEKVMLGWKYGDCIDEKAKTHPQLRTYKGLTEKEKEI HRLPVRETLKSMLAMGWNIDRTKDGETMSLRESEKMRKISQSSSQGNSFNPTPIDTSNVV LSRELQGMMEVVAENYHNIWAKKKKNDLGIRGGATHPLLVPYDTLTAKEKARDKEKAQDM FRFLQINGYAITRGLKDMEQDSSSMEKRFAYKFLKKLLKYVNSAQEFIAHLEAMATSGKT DKSPHEQEIKFFAKVLLPLIDQYFKNHCLYFLSSPSKNLSSSGYASNKEKEMVTSLFCKL AALVRHRISLFGSDSTTMVSCLHILAHTLDTRTVMKSGSELVKAGLRTFFENAAEDLEKT LENLKLGKFTHSRSQMKGVSQNINYTTVALLPILTALFEHITQHHFGVDLLLDDVQVSCY RILTSLYALGTGKNIYVERQLPALGECLATLAGAMPVAFLEPLLNKHNPCSVFNTKTARE RAILGMPDAVEEMCPEMPRLDVLMKDINDMSESGARYTEMPHVIEVVLPMLCNYLSYWWE KGPENQASPHSGGSVCSTTVTSEHLSLILGNILKILNSNLGIDEASWMKRIAVYAQPIIS KARAVLLKSHFLPTLEKLKKKTVKVVTEEELLKADSKGDTQEAELLILDEFAVLCRDLYA FYPMLIHYVDNNRSRWLKEPDADSNELFRMVAEIFILWCKSHNFKREEQNFVVQNEINNL SFLTGDSKTKMSKSGGQDQERKHKRKRGEFYSIQTSLIVAALKKMLPMGLNMCTPGDQEL ISLAKTRYLLKDTDDEVKEHVRQNLHLQEKSDDPAVRWQLNLYKDVMVKNEGPPDPERTV FRVQSISAAVFHLEQVEQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLF LLGYQRIWIETEMYSFEEKLVQDLAKTQLKVEEEEEEEAEMQPDPLHQLILHFSHNALTE RSSLEEDPLYIAYADMMAKSCAEDEEEEDEEGKEKTFEEKEMEKQKTLYQQARLHDRGAA EMVLQMISASKGTLGPMVTFTLKLGISILNGGNILVQQKMLDYLKEKGDAGFFKSLSGLM QSCSVLDLNAFERQNKAEGLGMVTEEGSINVSERGSKVLQNDEFTKDLFRFLQLLCEGHN NDFQNFLRTQTGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDIMDEAGQRNFSKALA VAKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKEL LDLQKDMIVMMLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDN FKEYDPESKGVISKKEFQKSMENQKQYSQSEIEFLLSCAEADENDMFNYEEFVKRFHEPA KDIGFNVAVLLTNLSEHMPHDARLATFLDLAESVISYFEPYLGRIEIMGGAKRIERVYFE ISESSRTQWEKPQVKESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASQISEPDA VERPEEDDEDSQSVTEEPEEEEEESMMESHSAFTNSCVSMRKNLSSFRQLLTFKSMRRQY RRFRKMSVREMVQGFFSFFWMIIMGLFRFLYNLVWGFFHILWSSMFGGGLVEGAKNMKVT DILGNMPDPTQFGIHGDVLETEKMEASEASSVAEMGHMGQGNKAEADLMAELLNIQTKSQ GGKHAPEPGLGDMGEVVGVDAPSLASAVKQKKAKDSMCFLKEAATKEPTNGDHKAEPEKA DPEDGEKKDQDKVKEEAPPEPLPEEKKAPKKRPGLKKESPEEFMASFFSSLDIYQTKMLN YLARNFYNLRFLALFVAFAINFILLFYKVTGDDRDDDDPDPWNGGGATDEEEDEGGMEYF VLQESTGYMAPTLRFLAILHTVISFLCVVGYYYLKVPLVVFKREKEIARKLEFDGLYITE QPSDDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKSALDF NPTEETVVKEASLVSWLSSIDTKYQCWKMGVVFTDNSFLYLVWYTTMSILGHYNNFFFAA HLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDNQ PDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAI IQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFF LMYLINKDETEHTGQESYVWKMYQERLWDFFPAGDCFRKQYEDQLG NT seq 14721 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggtggtgaaggggaagatgaaattcagttcttgagaactgatgatgaagtg gtgctccagtgtgtcgcctgcatccacaaggagaatcgcaagttctgcctgacagcagag gggctcggcaatcgactgtgctaccttgaacccacatcagaggcaaagtatgtccctcca gacctatgcatctgcaactttgtgctggagcagtctctttctgtgcgggccctgcaggag atgctggctaagactggccagaacagtgaagggcctcgagtaaaggaccgatgggcggct cagggcggtggacacagaacacttctttatggacacgccatcctcctgaggcactccttt agcgctatgtatctgacctgtttgaagacttcaaggtcacagacggataagttgtcattt gatgtggggctgcagcaggactcaacaggtgaagcctgttggtggaccatccatcctgct tccaaacagaggtcagagggcgagaaggtacgcatcggagatgacctcatccttgtcagc gtgtcatcagaacgataccttcacctgtccatctccaatggcaacatccaggtggacgcg tccttcatgcagactctgtggaacgtccaccccacctgttccggcagcaacgtggaggag ggttacctgctgggtggccatgtgttgcgtctgttccacggtcatgatgaggttttgacc atcccagggtctgaccagagtgatgagcaacagaggatagtgaactatgagacggggaat gcaggagccaaggccaggtctctgtggaggctggagcctctcagaatcagctggagcggg agtcacattcgctggggtcagcccttccgtctccgccacctcaccacggggcactacctg tccctgacggaggagaggggggtggtgctgcaggaccgggagaagtctgacacttcctcc accgccttctgcttcagagcctccaaggaaaagctggagtcgagtccaaagcgggacatc gagggcatggggatggcagagattaagtatggggactcaatctgcttcgtcatgcatgtg gccacaggactctggctgtcctaccaggcgcctgatgtaaaatcatctcgcctgggccct ctcaagagacgggcctgcctccactctgagggtcatatggatgatgggctgaccttgcag cggtgtcagcacgaagagtcccgtgctgctcgcatcatccgtaacaccacccgcctcttc agtcacttcatcagagacctggactgtctggggggaaagaaccgtgcgtcagtagccctg cccatcgaggaggtcctccagaccctcaatgacctcatcacctacttccaggtgcctaat gctgagctggagcacgaggagaaacagatcatgctgcgctctctcaagaaccgacagaac ctcttcaaacaggaaggcatgctgactctggtgtcctgctgcatcgaccgtctcaacgtg tacaacagtgcagcccactttggggagtgtgccggggcagaggctggggcttcctggaag gacatcctcaacctgctctatgagctgctagcggcgctgatccgaggcaacaggaacaac tgcacccagttctccaacaacctggactggctggtcagcaagctggagagactggagtcc tcctcaggcatactggaggttctccactgcattctaattgagagcccggaggctctaaat atcatccagagaggacatatcaagtccatcatctccctgctctacaaacatggacgcaac cacaagattttggatgtgctctgttccctctgtgtgtgtaatggggtggcagtacgagcc aatcagaacctcatctgcgatcacctgctccccaaaagagatctgcttctccagacccga ttggtcaatgacgtccaaagcatgaggcccaacatttacctgggaatgagtgagggctcg gcccagtataagaagtggtactacgagctgatgattgatcaggtggaccacttcttgacc agcgacccctctcacctgcgtgtgggctgggccaccaacaagggttacgccccttaccca ggtggaggggagggttgggggggcaacggggtgggggatgacctctactcttacggcttt gacggacttcatctctggtcaggtcgtatctcccgggcggtggcttctattaaccaacac atcctgacctctgaggatgtggtgagctgttgtctggacctgggagcccccagcatctcc tttaggatcaatggacagcccgtacagggcatgttcgagaacttcaacatcgatggactc ttcttccctgttgtcagcttttccgctggggtcaaggtgcgtttcctgatgggcggtcgt catggtgacttcaagttccttcctccgtcgggctatgctccgtgttacgaggccctactc cccaaggagaagatgaaggtggagccggtgaaggagtacaaaagggacatggagggggtc cgagacctgctggggaccacacagttcatatctcaggcctccttcatacccacccctgtg gagaccagccagatcgtcatgccgccatacctggagaaggtccgggacagactggctgag aatatccacgagctgtgggccatgaacaagatagaactgggctggtcttatgggaagata agggacgataataagcggcagcacccctgccttgtggattttcccagactgcctgaaact gaaaagaattacaacctacagatgtcaacggaaaccttgaagactctgctggcattaagc tgccatgttgtccaggtcaacgccaacgctgaagaggacctgaagaagatcaaactccca aagaactacatgatgtcgaatggttacaagcccacgccactggagctgtctgacgtgaag ctgaccccaggccaggaacttctggtggataaactggcggagaacgcccacaacgtgtgg gccaaggacaggatcaaacaaggatggacctatggcattcagcaggatgtgaagagcaag cggaaccctcgcctagtgccatattctttattagacgagcgcactaagaagtccaacagg gacagcctccgtgaggccatccgcactctgattggatacggatacaatatcgaacctcca gatcaggagggcgcaggccatgcggtggacagactgagcatcgacaagatccgtttcttc cgtgtggagaggacgtacgcggtgatgacggggaagtggtactttgagtttgacgtggtg acagggggagacatgcgtgtgggctgggccagacctggatgtaggcctgatgtagagctg ggcactgatgagctggcctttgtcttcgacggatacaagggtcaacgtctgaacatgggc agtcgtttctttgggcggtgttggcacgcgggggacgtggtgggctgtatgatcaacatg gaggacaagtctatgatcttcaccctcaacggagagatcctcatcaccaacaagggctct gagctctgctttgccgacttcgagacggaggacggttttatcccagtgtgtagtctgggc ctgtcccaggtgggtcgtatgaacctggggaaggacgccagtacctttaagtactacacc atgtgtggcctgcaggagggcttcgaacccttcgccgtcaacatgaaccgtgaggtcacc atgtggttcagcaaacgcctccccacctttgtcaatgtgccaaagaaccacaaccacata atggtgaccagaatagatggcaccatcgacagccctccatgtctgaaggtgagccacagg acgtttgggacccagaacagtaacggtgacatggtgtactgtcgactgagcatgcccgtg gagttccactccttcttcaagaccagccctgtcatggacatgaacggagtgcatgaagat cacgagtccctcaaactgaaacacagacatccattgaagtctatgagacacagtcatgat ggaataagaggaacagattacagcaacatcagcacgtaccactactctgtcagggtgttc gctggtcaggatccatcctgtgtgtgggtgggctgggtcacccccgactaccattactat agcaaccacttcaacctcagtaagaaccggacggtgacggttaccctgggagaccagcgt gggcgggtccatgagagtgtgaggaggagtaactgctacatggtgtggggtggggacgtc accagctcaggtcactcgtccagtcgcagtaatgtggacctggagataggctgtctcatt gacctggccactggcctggtgactttcactggcaacggcaaggagctggccacctcctac caggtggaaccaaacacaaagctgtttcctgctgtgtttgtgcgaccgaccagccccaac ctcttccagtttgagctgtccaagataaagaatgccatgcccctgtcagctgccatcttt aagagtgagcataagaacccagtgcctcagtgccctccgaggctggacatccagaccatc aactcagtgctgtggagtcgcatgcccaacaccttcctgaaggtggagacagccagggtc agtgagagacacggctgggtggtgcagtgtctggagcccctgcagatgctggctgtgcac atacctgaggagaacaggtgtgttgacatcatggagctgtctgagcaggaggacttgagg aagttccactaccacaccctgaagctgtactgtgccctgtgtgccctgggaaacacccgc gtggcacacgccctctgcagccacctggaccaatcccagctgctctataccatcgacaac cagtacctgtcgggcatgctgcgcgagggcttctacaacatcctgatcagcattcacctg gagacggccaaggaggcccgcctcatgatgaacaacgagtttatcatccccatcaccacc gagacgcgcagcatccgcctgttctccgatgcctccaagcaccactctcctcccggggtg ggcctcagtacctccctgaagccccggctcagcttctaccccccctgcttcatcagcacc aggagggagcagcacctgtacagcccccagatccccctggatgccctgaaggagaaggcc atcaccatgctgactgaggccgtgcagggcggtgggcatcacatcagggaccctgtaggg ggcagcgtggagtaccagtttgtgcccatcctgaggctgattggtacactgctcaccatg ggcgtgctgggcagtcaggatgttcataagattctgctcctcatcgaccccaacgtgttt gtggagcatagcgaggaggccgtcgccgtggtgatggaggccacagagaaggaggggctg acgggctccgaggagaaggcggtggaggccggggaggaggatgcggccaaagaggccaag ctgccaatgaaaggtctgctagagaagaggctgcctgagccagtgaaacgacagatgtgt gagctgctgcactacttctgtgactgtgagctgaagcatcgcatcgaggccatcgtgtcc ttctcagacagctttgtctccaagctgcagtacaaccagaagttcaggtacaacgagctg atgctggccctcaacatgtctgctgccgtcaccgccaagaagaccaaggagttccgctcc ccaccccaagaacagattaacatgctgttgaacttcagtacgggggaggactgcccgtgt ccagaggacattcaggaggagctctatgccttccacaacgagctgcggctgcactgtgga atccctatggaggaagaggaagatgagcaggacacgtctattaaaggtcgtctgctggcc ctggtctacaaaatcaaaggtcaacctctgaagactgaagaggagcccacggagcaggaa cagcaagctccctccaaccttaaagagctgattagccagaccatggtgagctgggctcag gagtgccacgtcgaggaccccgagctggtcagagtgatgttcagcctgctgaggagacag tacgacagcattggagagctgctccgggccatgaggaagagctacactatcagtgctgcc tctatacaggacaccatcaacctactggcctctctgggtcagatcagatcactgctgtct gtacgcatgggcaaggaggaagagaaactcatgatcgacggtctgggtgacatcatgaac aacaagatattctaccagcaccccaacctgatgcgcgtgctgggcatgcatgagacggtg atggaggtgatggtcaacgtgctgggaggaggcaagtcccaggagatagcgttccccaag atggtggccagctgctgtcgcttcctgtgttacttctgcaggatcagtcgtcagaaccag aaggccatgtttgaccacctcagctacctcttggaaaacagcagcgtgggcctggcgtcc ccggccatgaggggctctactcctctagacgtggctgcctcctctgtaatggacaacaac ggcctggccttggccctggaggaacccgacctggataaggtggtgacatacctagcaggc tgtgggctccagagctgtcccatgctgctggacaaaggttaccctgacatcggttggaac cccatagagggcgagcgctacctctccttcctgcgctttgctgtctttgttaatggtgag agtgtggaggagaactccagtgtggttgtgaagctactgatcaggcgtccagagtgtttt ggtccggccctgagaggagaggggggtaacgggctgctagcagccatgaaggaggccatc aagatctctgaggaccctgctctggacctgccctcctctgcccagggggtcagctctgac gtgtctgctgaggatgatgaggaggaagaggtggttcacatgggaaatgccatcatgtcc ttctactctgccctcatcgacctattgggacgctgtgccccagagatgcacttgattaac aaggggaaaggggaagccctgcgtatccgtgccatcctgcgctccctagtgcccactgaa gacctggtgggcatcatcagcatagccctcaagatgcctgtcattcacaaagacggcact gtgacagagcctgatatggcggccagtttctgcccggaccacaaggcccccatggtgcta ttcctggaccgggtctatggtatcgaggaccaaagcttcctacttcacctgctggaagtg ggcttcctgccagacctgcgagcctctgcttctctggacacggaggtactcagcaccaca gagacagctctggccatgaacaggtacattggctccgccatgcttcccctgctcacccgc tgtgccccccacttcgctggcacagagcactacgccacgctaatcgactccacgctacac accatctacaggctgtccaagggccgctcgctcaccaaggcccagagagatgctattgag gagtgtctgctggctgtctgcaggtacctccgcccctccatgctgcagcagctcctgcgc cgcctggtctttgacgtgcccttgctgacagagtactgcaagatgcctctcaggctcttg accaaccactacgagcagagctggaagtactactgtctgccgtcaggctggggcagctac ggcatggcctcagacgaggaactgctcctcacaaagaagatcttctggggtgtcttggat tcgctctcacagaggaagtacgatgcagatctatttaagatggccatgccctgtctgagt gccatatctggggccttaccgcctgactacatagactccaccatcagcaccaccctggag aagcctgcgtctgtggacgcgcagggcaacttcgaccccaaacccatcagcacagccaac atatctcttccagagaaactggaaaatgttgccaacaaatatgctgagcattcccatgac aaatggtcagcagagaaggtgatgttgggatggaagtacggagactgtatagatgagaag gccaagactcaccctcagctcaggacctacaaaggcctcacagagaaggagaaggagatc cacaggttgccagtgagggagactctgaagagcatgctggctatgggctggaacattgac aggaccaaggatggagagaccatgtccctacgggagagtgagaagatgcggaagatctcc cagtcctcctctcagggtaacagtttcaacccaacaccaatagacaccagcaatgtggtt ctgtctagagagttacagggcatgatggaggttgtggctgagaattatcacaacatctgg gctaagaagaagaagaatgaccttggaattagaggtggggcaactcaccctctgctagtg ccctatgataccctgactgccaaagagaaggcccgggacaaagagaaggcccaggacatg ttccgcttcctgcagatcaacggctacgccatcaccagaggtctgaaggatatggagcag gactcttcctccatggagaagaggtttgcctacaagttcctcaagaagctcctcaagtat gtgaactcagcccaggagttcatcgcccaccttgaggccatggctaccagtggtaagaca gacaagtcacctcatgagcaagaaatcaagtttttcgccaaagtcctcctccctctgata gaccagtacttcaagaaccactgtctctacttcctgtcttctcccagtaagaacctgagc agcagcggctatgcatctaataaggagaaggagatggtcaccagcctgttctgtaaactg gcagctcttgtcagacacaggatttccctctttgggagtgactccaccaccatggtgagc tgtctccacatcctggcccacacactggacaccaggacggtgatgaagtctggctcagag ctggtgaaggcggggttaaggacgttcttcgagaacgcagcggaggacctggagaagacc cttgagaacctgaagttggggaagttcacccactcccgctcacagatgaagggcgtgtcc cagaacattaactacaccacggtggcactactgcccatcctcactgccctgtttgaacac atcacccagcaccactttggagtggacctgctcttggatgatgtccaagtgtcatgctat cgtatcttgaccagcctctatgcactcgggactggaaaaaacatctatgtggaaaggcag ctgccggccctgggggagtgtctggccaccctggcaggcgccatgcctgtggccttcctg gagccactgctcaacaaacacaacccctgctctgttttcaacaccaagactgcccgcgaa cgcgccatcctaggcatgccagacgcggtggaggagatgtgtccggagatgcctcgtcta gacgtcctgatgaaggacatcaacgacatgtctgagtctggggcgcgctacacagagatg ccccacgtcatcgaggtggtgctgcccatgctgtgtaactacctgtcctactggtgggag aagggcccagagaaccaggcgtctccgcacagtgggggcagtgtgtgttccaccaccgtc acctcagaacatctcagcctcatcctgggaaacatcctgaagatcctcaacagcaacctg ggcatcgacgaggcctcctggatgaagaggatcgcagtgtacgcccagcccatcatcagt aaggccagggctgttctgttgaagagtcacttcctgcctacgctggagaagctgaagaag aagactgtgaaggtggtgacggaggaggagctattgaaggctgacagtaagggagacacc caggaggctgagctcctcatcctggatgagttcgctgtgctctgcagagacctctacgcc ttctacccgatgctcatccattacgtagacaataacaggtccaggtggctaaaagaacca gacgctgactccaatgaactcttcagaatggtggctgagatcttcatcctctggtgcaaa tcacataacttcaaaagggaagagcagaactttgtggttcagaatgaaatcaacaacctg tctttcctgactggtgatagcaagacgaagatgtcaaagtcagggggtcaggaccaggag aggaagcataagaggaagcgaggagagttctactccatccagacctccctgatcgttgct gccctgaagaagatgctgcccatgggactcaacatgtgcacccccggggaccaggagctc atctccctggccaagacacgttacctcctgaaggacacagatgatgaagtgaaggaacat gtgcggcaaaatttgcaccttcaagaaaagtcagatgaccctgcagtgaggtggcagctg aacctgtataaggatgtgatggtgaagaacgaggggcctccagaccctgagaggacagtg ttcagagtccagagcatatcagctgcagtcttccatctggagcaggtggaacagccgttg aggtctaagaagtgtgtgtggcagaagctgctgtccaagcagagaaagcgtgcggtggtg gcctgcttccgcatggctcctctctacaacctgcccaggcatcgctctattaacctcttc ctcctgggctatcagagaatatggatagaaacagagatgtactcttttgaagagaagcta gtgcaggacctggcaaagacccaactgaaggtggaagaggaggaagaggaggaggcagag atgcagccagaccctcttcatcagctcatcctgcatttcagtcacaatgcgctcactgag cggagttctttggaagaggatcctttgtatattgcgtatgcagacatgatggcaaagagt tgtgcagaagatgaagaagaagaagatgaagaaggaaaagagaaaacgtttgaggaaaaa gagatggagaaacagaagactctgtaccagcaggccaggctgcatgacagaggagctgct gagatggtgttacagatgatcagcgccagcaaaggtacgcttgggcccatggtgaccttt accttgaagctgggcatctctatactcaacggaggcaacatactggttcagcagaaaatg cttgactatctgaaggaaaaaggagatgctggctttttcaagagtttgtcaggactcatg cagtcttgcagtgtcctggatttgaatgcattcgaaaggcaaaacaaagcggaaggtctt gggatggtgactgaggaaggatcaatcaacgtgagtgagcggggttccaaagtactgcaa aacgatgagttcactaaggatctctttaggtttctgcaactgctctgtgagggacacaac aacgacttccaaaacttcctgcggactcaaacagggaacacgaccaccgtaaatatcatc atcagcactgtggactacctgctccgactgcaggaatccatcagtgatttctactggtac tactctgggaaagacatcatggatgaggctggccagcggaacttctccaaagccctggct gtggccaagcagattttcaactctctcactgagtacatacagggcccgtgtattgggaac cagcagagtctggcacacagcaggctatgggatgcagtggtgggattcctgcatgtgttt gccaatatgcagatgaagctgtcacaggattcaagtcagattgagttattgaaggagctg ctggacctgcagaaggacatgatcgtgatgatgctctcccttctggaaggaaacgttgtc aacggaaccatcgggaaacagatggtggacaccctggtggagtcctccagcaatgtggag atgatcctcaagttcttcgacatgttcctcaaactcaaagacctgaccacctcggacaac ttcaaggagtacgacccagagagcaagggagtgatctccaagaaggagttccagaagtcc atggagaatcagaagcagtactcccagtcggagatcgagttcttgctctcctgcgccgag gctgacgagaacgacatgttcaactacgaggagtttgtgaagcgctttcatgagccggcc aaggacattggctttaacgtggcggtcctgctcaccaacctgtcagaacacatgcctcac gatgcccgtctggccaccttcctggacctggctgagagcgtgataagctacttcgagccc tacctgggccgcatagagattatgggcggagccaagcgcatcgagagggtctactttgag atcagcgagtctagtcgtacacagtgggagaagccccaagtcaaagagtctaagagacag tttatctttgacgtggtgaatgagggtggagagagcgagaagatggagctgtttgtcaac ttctgtgaggacaccatatttgagatgcagctggcctcacagatctctgagcctgacgca gtggagcgtcccgaggaggacgacgaggacagccagagtgtgacggaggagccagaggag gaagaggaggagagcatgatggagtctcactccgccttcaccaactcctgcgtctccatg cggaagaacctgtccagcttccgccagctgctgaccttcaaaagcatgaggcggcagtac aggaggttcaggaagatgagtgtgagggagatggtccaaggcttcttctcattcttctgg atgattatcatgggcctcttccgcttcctttacaacctggtgtggggcttcttccatatc ctgtggtcctccatgtttggcgggggcctggtggagggggccaagaacatgaaggtcaca gacatcctggggaacatgcccgaccccacacagtttggtatccatggtgacgtgctggag acagagaagatggaggcgagtgaggcgtcatctgtggcagagatgggccacatgggccag gggaacaaggcagaggcagatctgatggctgagctgcttaacatccaaaccaagagccag gggggaaagcatgcgcccgagccaggtctgggggacatgggtgaggtggtgggggtcgac gccccctctttagccagtgccgtcaagcagaagaaggccaaggattccatgtgtttcttg aaggaggctgcgactaaggagcctaccaacggagatcacaaagccgagccagagaaagca gacccagaggatggggagaagaaggaccaggacaaagtcaaagaggaggctcccccagag cccttaccggaggagaagaaggcccccaagaagagaccgggactgaagaaagagtctcca gaggagttcatggccagcttcttctctagcctggacatctaccagaccaagatgctgaac tatctggccagaaacttctacaacctgcgtttcttggcattgtttgttgcatttgccata aactttattctgctcttctacaaagtgactggagatgacagggatgacgatgatccagat ccctggaatggaggtggagctactgatgaagaggaggatgaaggtgggatggagtatttt gtcctgcaggagagcacaggctacatggcacctacactgcgcttcttggccatactacac acagtcatctctttcctgtgtgtggtgggatactactacctaaaggtacctctggtggtg ttcaagagagaaaaggagatcgccaggaagttggagtttgacggcctgtacatcacagag cagccgtcagacgatgacatcaaaggacagtgggaccgcctcgtcatcaacaccccttcc ttccctaataactactgggacaagtttgtgaaacgcaaggtgatcaataagtacggagat ctgtatggagcagagaggatagcagagctgctggggctggataagagtgctctggacttc aaccccacagaggagacggtggtgaaggaggcatcgctggtgtcctggttgagctctatt gacaccaagtaccaatgctggaaaatgggtgtggtgtttacagacaattcgttcctgtac ctggtgtggtacaccaccatgtccatcctgggtcactacaacaacttcttcttcgctgcc catctgttggacatcgccatgggcttcaagaccctccggaccatcctgtcctcggtcacc cacaatggcaaacagctggttctgactgtaggtctcctggcagtggtggtctatctgtac actgtggtggccttcaacttcttccgcaagttctacaacaagagtgaggatgacaaccag cccgatatgaagtgtgacgacatgatgacttgctacctgttccacatgtacgttggtgtg agggcagggggtggaatcggggatgagatcgaggaccctgcgggcgacccgtacgagctc taccgcatcctcttcgacatcaccttcttcttctttgtcatcgtcatcctgctggccatc atacagggtctgatcattgatgcttttggagagctgagagaccaacaggagcaagtgaaa gaggatatggagaccaaatgtttcatctgtggcatcggtaatgactactttgacacgacg cctcacggctttgaaacacacaccttacaagagcacaacttggccaactacctgtttttc ctgatgtaccttatcaacaaagatgagacggaacacaccggtcaggagtcatacgtgtgg aagatgtaccaggaaaggctctgggactttttccctgctggagactgtttcagaaagcag tatgaggaccagcttggatag

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