Salmo trutta (river trout): 115190128 Help Entry 115190128         CDS       T08542                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism stru  Salmo trutta (river trout) Pathway stru04020   Calcium signaling pathway stru04260   Cardiac muscle contraction stru04261   Adrenergic signaling in cardiomyocytes stru04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:stru00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     115190128 (ryr2a)    04020 Calcium signaling pathway     115190128 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     115190128 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     115190128 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:stru04040]     115190128 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:stru04990]     115190128 (ryr2a) Ion channels [BR:stru04040]  Voltage-gated cation channels   Ryanodine receptor    115190128 (ryr2a) Domain-containing proteins not elsewhere classified [BR:stru04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    115190128 (ryr2a) SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  115190128 NCBI-ProteinID:  XP_029604479 LinkDB All DBs Position Unknown AA seq 4984 aa AA seqDB search MADAGEAGEDEIQFLRTDDEVVLQCSATVQKEQQKLCLAAEGFGNRLCFLESTSNSKNVP PDLSICTFVLEQSLSVRALQEMLANTEEKAEGKFMMKTAQGGGHRTLLYGHAVLLRHSYS GMYLCCLGTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSV SSERYLHLSYGNDSLHVDAAFQQTLWSVATVCSGSEVAQGFMIGGDVLRLLHGHMDECLT VPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHTRWGQPFRLRHVTTGKYL SIMEDKGLLLMDKEKADVKSTAFCFRPSKEKLDSVPKKEVDGMGVPDIKYGDSVCYIQHV DTCLWLTYQAVDAKSARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLF NRFIRGLDTLSKKGKTSTLDLPIESVSLSLQDLIGYFQPPDEHLEHEDKQNRLRALKNRQ NLFQEEGMINLVLDCIDRLHVYSSGAHFAEVAGREAGDAWRSTLNSLYELLAALIRGNRK NCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGR NHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEG SAQYRKWYYELMVDEVLPFVTAEATHLRVGWATTDGYQPYPGGGEGWGGNGLGDDLYSYG FDGLHLWSGCISRTVSSPNQHLLRVDDVVSCCLDLSAPSISFRINGQPVQGMFENFNSDG LFFPVASFSAGVKVRFLLGGRQGEFKFLPPPGYAPCFEAVLPREKLRVEHSQEYKEDHSE TRDLLGPTITLSQAAFTPTPVDTSQVVLPPHLERIREKLAENIHELWVMNKIDLGWTYGA VRDDNKRQHPCLVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGLADEHAVEKVKNLKL SATYELSSGYKPAPMDLGHIKLASTQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKN RRNPRLVPYTLLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARADISNMSAERFR IFRAEKTYSVNAGKWYFEFEVLTSGEMRVGWARPGCLPDQELGSDQHAFVFDGFKAQLWH QGNEHFGRSWAPGDVVGCMVDLNEHTMMFTHNGEVLLDHSGSELAFKDFEVWEGFIPVCS LGVCQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDLTMWLSKRLSQFIPVPPQHE HIEVTRMDGTVETFPCLKVTQRSFGSQNSNPDITFYRLSMPIECNEALAKSPGGTLQSGG GFSFSSKKDLDDFETVSDFEFVFPSPQVLTKSAHCTLGSGLDKEKDQFNNHKDYNQEKPS KLKQRFMLKRTKPEFTSSNSSARLSEEVLADRDDCDVFMQTSTYYYSVRIFPGQEPSSVW VGWVTSDFHQYDMAFDLEKVRTVTVTLGDEKGKVHESIKRSNCYMVWAGECTSPGQGRNN TGLEIGCLVDTVNGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPSIFQFELGRIKN VMPLSAGLFKSERTNACPQCPPRLHVQFLTPVLWSRVPNHFLKVDVSRVNDRHGWLVTCS EPLQFMSLHIPEENRSVDILELTEQKDLLKFHYHTLRLYSAVCALGNNRVAHALCSHADE AQLLYAIENKYMPGLLRTGYYDLLIDIHLSTYATARLMMNNEYIVPMTDETKSITLFPDE KKKHGLPGIGLSTSLRPRMHFSSPSFICSGADCFQFSPEFPLDTLKTKTIEMLTEAVSEG SLHVRDPIGGSTEFLFVPLIKLFYTLLIMGVFHNGDLKNILRLIEPSVFSEGGDAPADAP ADTPESDVTKGGRGEEGSGGEERTGKVPKGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRI EAVVGFSDDFVARLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLSFKDE KVDCPCPEHIRQQLVDFHEDLMTHCGIEIDEDKLNEADSDFTIRGRLMSLVEKVVYLKKK MSFMPKNKKKDKKPSTLQQLISETMVRWAQESIMEDPELVRAMFVLLHRQYDGIGGQVRA LPKAYTINSVSVEDTIKLLASLGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNL MRALGMHETVMEVMVNVLSGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYL LENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCSMLV SKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGN GLLAAMMEAIKISEDPCRDGPSPTSEAGRTLSEVLLEDEEDDTIHMGNAIMTFYAALIDL LGRCAPEMHLIHAGKGEAIRIRAILRSLIPIEDLEGVISIPFPMPTLAKDGSVVEPDMSA GFCPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNR YLCTAVLPLLTKCAPLFAGTEPYASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLATCG QLRPSMMQHLLRRLVFDVPLLNEHTKMPLKLLTNHYERCWKYYCLTGGWGSFGASSDEEL HLSRKLFWGVFDALSRKSYDQELFKLALPCLSAVAGALPPDYMESNHVAVMEKQSSMDAE GNFNPQPADTTNVNVPEKLDYFVNKYAEHSHEKWSMDKFSNGWVHGDKVCETSKAHPLLK PYKGLSEKDKESYRWPIKESLKTMVVWCWSIERTREGDPASLHNRARRISQISQQHSVEG APGFSPRPIDMSNVTLSRDLHSMAELLAENYHNIWAKKKKVELEAKGGGNHPLLVPYDTL TAREKYKDRGKAQDILKFFQINGYTVSRAMKEQELDTPSIEKRFAYTFLQQLITYVDQAH EHMLESDVGTPPKGASIPHEQQIKFFGKVVLPLVDQYFKNHRLYFLSTAIRPISSGGHAS NKEKEMVTSLFCKLGLLVRHRISLFGSHATSIVNCLHILGQTLDARTVMKTGLETVKAAL RAFFDNAAEDLEKTLENLKQGQFTHSHSQPKGVTQIINYTSVALLPVLSSLFEHIGQNLF GEDLILDDVQVSCYRILNSLYSLGTNNSIYVERQRPALGECLAAFSGAFPVAFLEPELNK FNNYSIYITKGSRDRTALDLPSQVGEMCPVIPSLEKSLEEIMDLAESGLHYTQMPHVMEV VLPMLCSYMSHWWEHGPENNPPETADSCCTHLTSDHMNSLLGNILKIIYNNLGIDEGAWM KRLAVFSQPIIGKAKGGLLKSHFLPLMEKLRKKAATVLMDEEQMKAEGRGEMSEAELLIL DEFTILIRDLYAFYPLLIRFVDYNRAKWLKESNPEAEELFRMVAEVFIFWSKSHNFKREE QNFVVQNEINNMSFLITDTKSKMSKGAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPV GLNICAPGDQELIALAKIRFSQKDTEDEVREIIRNNLHLQGKLEDPAIRWQMALYKDLPN RSEDTSDPEKTVERVLDIAHVLFYLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPL YNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLARPGGEEPPEEDEGAKRIDPLHQL IQLFSRTALTEKCKLEEDILYMAYADIMAKSCHDEEDEDGEEVKSFEEKEMEKQKLLYQQ ARLHDRGAAEMVLQTISASKGEMGPMVASTLKLGIAVLNGGNSTVQQKMLDYLKDKKDVG FFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSVITHERGEKVMQDDVFTCDLFRF LQLLCEGHNSDFQNYLRTQTGNNTTVNVIISTVDYLLRVQESISDFYWYYSGKDVIDEQG QRNFSKAINVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDS SQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLK LKDLTSSDAFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAEPDENELLDYEE FVERFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELAESVLNYFQPYLGRIEIMGSA KRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQL AAQMSDIGERSAVKEESEKEKPEEESPEMGFFSVTTVRTALMALRYNVMFLMNVLSMKSL KKQIKRMKKMTVKDMVMTLVSFYWSVIMGLFHFTFSVSRGFCRIMYNTFLGGSLVEGAKT MKVSDLLANMPDPTQDEVREEGEKALSARPSAEEELADLALPVDGTEVLSDIFGLDLRRG EGGQYKITAHNPNASLTDLLNSPVPSSPVPATSPSPELRRRHQAKSPSEEERTGTEETKE AKSEPEKAEGVDGEKQEEEERRKEEKPKAKVRQHHTSKSDEHDMQESAFWKKIIAYQRKL LNYFARNFYNMRMLALFVAFAINFILLFYKVSSSSAVMPESRRPRAGSSVRWDPVMEGSS PQEPQNPQQGPVFVHFVLEESTGYMEPTLRILAILHTVISFCCIIGYYCLKVPLVIFKRE KEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTGSFPNNYWDKFVKRKVMDKYGEFYGH DRISELLGMDKAALDFSDAQEKKKPKKDSSLAAVLNSVDVKYQIWKLGVVFTDNSFLYLA WYMTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTV VAFNFFRKFYNRGEEGETPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYR IIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPH GFETHTLQEHNLANYLFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYE DQLN NT seq 14484 nt NT seq  +upstreamnt  +downstreamnt atggctgatgcgggagaagccggcgaggatgaaatccagttcttacgaaccgatgacgag gttgtcctgcagtgttctgccacagtccagaaggagcaacagaagctgtgtctggcagcc gagggcttcggaaacagactctgcttcctcgagtcaacatccaactctaagaatgtccct ccagacctgtccatctgtacgtttgtcctcgaacagtccctctcagtacgggccctgcag gagatgctggccaacaccgaggagaaggcagaagggaagttcatgatgaagacggcccag ggagggggccaccgcaccttactgtacggacacgctgtcctgctacgacactcctacagc ggcatgtacctctgttgcctaggtacctcccgatcctcaaccgacaaactggcgtttgat gtcggactgcaggaagacacaacaggagaagcatgctggtggaccatccaccctgcctcc aagcagaggtcagagggagagaaggtgcgagtcggggatgacctcatcctagttagcgtg tcatcagaacgatacctgcacctatcgtacggtaacgacagcctgcatgtggacgcagcc ttccagcagaccctctggagcgtggccaccgtctgctctggcagcgaggtggcccaaggg ttcatgatcggcggggacgtgctgaggctgctccatggtcacatggatgaatgtctgacg gtgccgtcgggggaacatggggaggagcagcgcaggacggtgcactacgaggggggagct gtgtccatccatgcccgctccctctggaggctggagacgctacgagtggcgtggagcggc agccacacccgctggggtcaacccttccgtctccgtcatgtgaccacggggaagtacctc agtatcatggaggataagggcctgctgctgatggacaaggagaaggctgacgtcaagtct actgctttctgcttccgcccctccaaggaaaagctggactcggtgccaaagaaggaagtg gatggcatgggtgttcctgacatcaagtacggggactcagtgtgttatatccaacacgtg gacacctgtctgtggctcacgtaccaggccgtggacgctaagtctgcacgcatgggcggc gtgcagagaaaggccatcatgcaccacgagggtcacatggacgatgggctgaccctgtcc cgctcgcagcacgaggagtcccgcaccgcgcgggtcatacgcagtactgtcttcctgttc aaccgattcatcaggggtctggacaccctcagtaaaaaaggaaagacctcgacactcgac ctgccgatcgagtcggtcagtttgagtctgcaggatctgattggctacttccagcctcct gacgagcacctggagcacgaggacaaacagaaccgcctccgagccctgaagaaccgacag aacctcttccaggaagagggtatgataaacctggtgttggattgtattgaccgtctccac gtgtacagcagcggggctcattttgctgaggtggctgggagggaggctggcgatgcctgg agatccacactaaactcattatatgagctcctggctgcgttgataaggggcaacaggaag aattgtgcccagttctccggctcgttggattggttgatcagccggctggagagactggag gcctcgtctggtatcttggaggtgcttcactgtgtcctggtggagagtcctgaagctctg aacatcatcaaggagggacacatcaagtcaatcatctctctgctagacaaacatggacga aaccacaaggttctggacgtgctctgttctctgtgtgtctgtcatggtgtggcggtccgg tccaaccagcacctgatctgtgacaacctgctacctggcagagacctgctgctacagaca cgacttgtcaaccatgtcagcagcatgaggcctaacatcttcctgggtgtgagtgaaggc tccgcccagtacaggaagtggtattacgagctgatggtggacgaggtgttacccttcgtt acggccgaggcgacacatctaagagtgggctgggccaccacggacggctaccaaccctac ccaggtggaggagagggctgggggggaaacgggctcggtgatgacctgtactcctacggc ttcgacggcttgcacctgtggtcaggctgcatctccaggacagtgagctcacccaatcaa catctcctccgtgtggacgacgtggtcagctgttgtctggacctcagcgctcccagtata tccttccgtatcaacggtcagcccgtccaggggatgttcgagaacttcaactctgacgga ctgttcttccctgtagccagcttctccgccggggtcaaagtgcgtttcctgctgggtggt cgtcaaggagagtttaagttcctgcccccgccgggctacgctccgtgtttcgaggctgtt ctacccagggagaagctgagagtggaacacagccaggagtacaaggaggaccacagtgag accagggatctcctggggcccaccatcaccctgtcccaggctgccttcacccctacacct gttgacaccagccaggttgttctgcctcctcacctggagagaatcagggagaagctggca gagaacatccatgagctgtgggtgatgaacaagattgacctgggctggacctacggagct gtacgggacgataacaagcggcagcatccttgtctggtggagttctccaagctgcctgag caggagaggagctacaacctacagatgtctctggagactctcaagactctcttggccctg ggttgccacgtggggttggctgatgagcacgccgtggagaaggtgaagaacctcaagctc tccgccacttatgagctgtctagtggctacaagcctgctcctatggacctgggccacatc aagctggcctctacccaggaggccatggtggacaagctggcggagaacgctcacaatgtg tgggctagggatcgcatacgccagggctggacctacggcatccagcaggatgtgaagaat cgtaggaacccacgcttggttccgtacactctgctggacgagaggaccaagaagtccaac aaggacagtctgagggaggctgtccgcactctgctggggtacggatacaacctggaggct ccggatcaggaccacgcagccagagcagacatcagtaacatgtctgctgagcggttccgt atcttccgagcagagaagacgtacagcgtgaacgccgggaagtggtactttgagtttgag gtgctgacgtcaggggagatgagggtgggctgggcgcggcccggctgtctacctgaccag gagctgggctctgaccaacacgctttcgtcttcgacggattcaaggcccagctgtggcac caaggtaacgagcacttcggcaggtcatgggctccaggtgacgtggtgggctgtatggtt gatctgaacgaacacaccatgatgtttacccacaatggagaggtgctcctggaccactca gggtctgaattggccttcaaggactttgaggtttgggaaggtttcatcccggtctgcagc ctgggcgtatgccaggttgggaggatgaacttcggtaaagacgtaagcacgctgaagtac ttcaccatctgcggcctgcaggaaggctacgagcccttcgccgtcaacatgaacagagac ctcaccatgtggctcagcaagagactgtctcagttcatccctgtgcctccgcagcatgaa cacattgaggtgacgaggatggacggcaccgtggagactttcccgtgtctcaaggtcacc cagaggtcgttcggctcccagaacagtaacccggacatcaccttctatcgcctcagcatg cctatagagtgtaacgaggcgctggccaagtcgcctggcgggacgctacagtctggcggg ggtttctccttctcctctaagaaagacctggacgactttgagaccgtgtccgacttcgag tttgttttcccttctcctcaggtgttgacgaagtctgcccactgcaccctgggctccggt ctggacaaggagaaggaccaattcaacaaccacaaagactacaaccaggagaaaccctcc aagttaaagcagagattcatgttgaagaggaccaagccagagtttaccagcagtaactct tcagcccgtctatcagaggaggtgttagctgatagggatgactgtgacgtcttcatgcag acctccacttactactactcagtgaggatcttcccaggtcaggagcccagcagtgtgtgg gttggctgggtgacctctgacttccaccagtacgacatggccttcgacctcgaaaaggtc cgcaccgtcaccgttaccctgggagacgagaagggcaaagttcacgagagcatcaagcgt agtaactgctacatggtgtgggctggagagtgtacgagtcctggtcagggccggaacaac accgggttggagattggatgtctggtggacacggttaacggactgctaaccttcactgcc aacgggaaggagctcagcacgtactaccaggttgagcccagtaccaagctgtttcctgct gtgttcgctcaggccaccagccccagcatctttcagtttgaactagggcgcattaagaac gtcatgcccctgtcagcgggactgtttaagagcgagaggacgaacgcctgtccccagtgt cctcccaggctgcatgtccagttcctgaccccggtgctgtggagcagggtacccaaccac ttcctgaaggtggacgtctcccgggtcaacgaccgccacggctggctggtcacctgctct gaaccgctccagttcatgtccctgcacatacctgaggagaacaggtcagttgatatcctg gagttgactgagcagaaggatctgttgaagtttcactaccatactctgaggttgtactct gccgtgtgcgctctggggaacaaccgtgtggcccacgccctctgttcccacgccgacgag gcacagctgctctacgccatagagaacaagtacatgcctggtctcctcaggactggatac tacgacctgctcatagacatccacctcagtacctatgctacggcacgtctcatgatgaac aatgaatacatcgtccccatgacggacgagaccaagtccatcactctgttccctgacgag aagaagaagcacggcctgccaggtatcggcctgagcacctctctccgtccccgtatgcac ttctcctccccgtccttcatctgcagcggagccgactgcttccagttcagccctgagttc cccctggataccctgaagaccaagaccatagagatgctaacggaggcggtgagcgaaggg agtttacacgtcagagatcctatagggggcagcactgaattcctgttcgtacctctcatt aagttgttctatactctactgatcatgggagtgttccacaacggagacctgaagaatatt ctacggctgatagaacccagcgtgttctcggagggaggggacgcgcccgcggacgcgcca gcggacacgcccgagagtgatgtcactaagggagggagaggcgaggaggggtctggagga gaggagaggacagggaaggtgcctaaaggactactccagatgaaactaccagagcctgtc aagctgcagatgtgccacctgctccagtacctgtgtgactgccaggtgcgccaccgtatc gaggcggtggtgggcttcagcgatgacttcgtggctcgtctccaggacaaccagaggttc cgttataacgaggtcatgcaggcgcttaacatgtcggctgccctgactgccaggaaaacc aaagagttcagatctcctcctcaggaacagatcaacatgctgctgagctttaaggacgag aaggtggactgtccgtgtccagaacacatcagacaacaacttgtggacttccacgaggac ctgatgacacactgcggcatagagatagacgaggacaagctgaacgaggcagacagtgac ttcaccatccgaggaagactcatgtccctggtggagaaggtggtctacctaaagaaaaag atgagcttcatgccgaagaacaagaagaaagataagaaacccagcacgttgcagcagctg atcagtgagaccatggtacgctgggcccaggagagcatcatggaggacccagagttggtc agagccatgttcgtcctactccaccgtcagtacgatggcatcgggggccaggtccgggcc ctgcccaaggcctacaccatcaactcagtctctgtggaggacaccatcaaactgctggca tcactgggccagatcagatcgctgttgtctgtacgcatgggacgcgaggaggaaaaactg atgatccgaggactgggagacatcatgaacaacaaggtcttctaccagcaccctaacctg atgagagctctgggaatgcatgaaactgtcatggaggtgatggttaacgtcctgagtgga ggggaatccaaggaaatcacctttcctaagatggtggccaactgctgccgtttcctgtgt tacttctgccgcatcagcagacagaaccagaaagccatgttcgatcacctcagctacctg ctggaaaacagcagcgtcggacttgcgtctccctcgatgcgaggctctactccactagat gtggctgctgcctctgtgatggacaacaacgagctggctctggccctgagggaaccagac ctggagaaagtggtgcagtacttggctggctgtggtctccagagctgctccatgctagtg tctaaagggtaccctgatatcggctggaaccccgtcgaaggagagagatacctcgacttc ctccgcttcgcggtgttctgcaacggtgagagtgtggaggagaacgccaacgtggtggtg aggctgctgattcgtcggccggagtgctttggccccgccctgcgcggagaaggggggaat ggtctcctggcagccatgatggaagccatcaagatatcagaggacccctgtagagacggg ccctcccctacctcagaggccggcaggacactcagtgaggtgttattggaggatgaggag gatgacactattcacatgggaaacgctataatgaccttctacgccgccctcatagacctg ctggggcgctgcgcacctgagatgcacctgatccatgcagggaagggagaggccataagg ataagagccatcctacgttccctgatccctatagaggacctggaaggagtgatcagcata ccctttcccatgccaactctggccaaagatggatcagtggttgaacctgatatgtcagct gggttctgtccggaccacaaggcagccatggtgctgttcctggaccgggtctacgggata gaggaccagaacttcctacttcatctgctggaggtcggattcctgcccgaccttagggct gctgcctcgctcgacacagctgctctgagcgctacagacatggccctggccctcaacagg tacctgtgtacagcggtcctgcctctgctcactaagtgtgccccgctgttcgctgggacg gagccctacgcctcgctcatagactctctacttcacaccgtctaccgtctctctaaggga tgctgcctcacgaaggcacagagagacgccatcgaggagtgtctgcttgccacctgtggt caactgaggccgtccatgatgcagcacctgctgagacgcttggtgtttgatgttcctctc ctcaacgaacacaccaagatgcctctcaagctgttgaccaatcactacgagcgttgttgg aagtactactgtttgacgggcggttgggggagcttcggcgcatcgtcggacgaagagctc catctctccaggaagctgttctggggcgtctttgatgctctgtctcgcaagagctatgat caggagctgtttaagctggctctgccgtgtctgagtgctgttgccggggcgctgcctcct gactacatggagagtaaccacgtggccgtgatggagaaacaatcctctatggacgccgag ggaaacttcaacccacagccagccgacaccaccaatgtgaacgtcccggagaaactggat tactttgtcaataaatatgccgagcattcccatgagaagtggtccatggacaagttttcc aacggctgggttcacggggacaaggtctgtgagacctctaaagcccaccctctcctcaag ccctataaagggttgtcagagaaggataaagagtcgtaccgctggcctatcaaggagtct ctgaagacgatggtagtgtggtgctggagcatcgagaggaccagggagggagacccagcc agcctgcacaacagagcacgtaggatctctcagatcagccagcaacactctgtcgaagga gctccaggtttcagccccagacccatcgacatgagcaatgtgacactgtcccgggacctg cactctatggcagaactgcttgcagagaactatcataatatttgggcgaagaagaagaaa gttgaactagaagccaaaggaggggggaaccatccattactggtgccctatgacacgctc actgccagagagaaatacaaagacagaggaaaagcacaagacattctcaagttctttcag ataaatggctacactgtgtccagggccatgaaagagcaggagctggatactccctccata gagaagcgttttgcctacaccttcctgcagcagctcatcacttatgtagaccaggcccac gaacacatgctggagtctgacgttgggacaccaccgaaaggagcgagcattcctcacgag cagcagattaagtttttcggaaaggtggtcctgccattggtcgaccagtacttcaagaat caccgcctctacttcctgtccacggccatccgaccaatcagcagcgggggccacgcctcc aataaggagaaggagatggtgacaagtctgttctgcaaactgggacttcttgtcagacat aggatatcattgtttggaagccatgctacctccatagtcaactgtcttcacattctgggc cagacactggacgccaggacggtgatgaagacgggtctggagacggtgaaggcggcgttg agggcgttcttcgacaacgctgccgaggacttggagaagactttagagaacctgaaacag ggccagttcactcacagtcactcccagcctaaaggagtaactcagatcatcaactacacc agcgtagccctgctccctgtcctctcctccctgttcgaacacatcggacagaacctcttc ggggaagacctcatattggatgatgtccaggtgtcgtgttacaggatactcaacagcctg tatagtcttggtaccaacaacagcatctacgtagaaaggcagcgtccagccctaggtgaa tgtcttgcagcgttctcgggggcgttccctgtggccttcctggaacctgagctcaacaag ttcaacaactactccatctacattaccaagggctcccgggacagaaccgctctagacctg ccctcccaggtaggagagatgtgtccagtcatcccgtccctggagaagtctctggaagag atcatggatctggctgagtccggcctgcactacacacagatgcctcacgttatggaggtg gtgctgcccatgctatgcagctacatgtctcactggtgggaacacggcccagagaacaac cctccagagaccgcggacagctgctgtactcacctcacctcagaccacatgaacagtctc ctgggtaacatcctgaagatcatctataataacctggggatcgacgagggggcctggatg aaacgacttgcagtgttctctcagccaatcattggtaaggcgaagggggggctgttgaag agccacttcctgccgctgatggagaagttgaggaagaaggctgccaccgtgctgatggat gaggaacaaatgaaggccgagggacgaggggagatgtctgaggctgaactactcatcctg gatgagttcaccatcctgatcagagacctctatgccttttatccgctactcatccgcttt gtagactacaacagggccaaatggctgaaagaatcaaaccctgaggctgaggagctcttc cgcatggtagcagaggtcttcatattctggtccaagtctcataattttaaacgggaggag caaaactttgtggttcagaatgagatcaacaatatgtccttcctcatcacagacaccaag tcaaagatgtccaagggagccgtgtccgaccaggagaggaagaagatgaagaggaagggt gatcgctactccatgcagaccagcctcatcgtagcagcgttgaagagactacttcctgta ggactgaatatctgcgctccgggagaccaggaactgatcgctctggccaagatccgcttc agtcagaaagatacagaggacgaggtgcgggagatcatcagaaacaacctgcacctgcag ggaaagctggaggaccctgctatccgctggcagatggctctgtataaagaccttcccaac aggagtgaggacacgtcagacccagagaagactgtagagagagtcctggacatcgctcac gtcctcttctatctagaccaggtggaacatccacaaaggagtaagaaggctgtgtggcac aagctgctctctaaacagaggaagagggctgtggtggcctgtttcagaatggctccgttg tataacttacccaggcaccgggcggtcaacctgtttctacagggatatgagaagtcctgg attgagactgaggagcactactttgaggataagctcatagaggacctggctagaccggga ggagaggagcctcctgaagaagatgagggagccaagaggatcgaccctcttcatcagctc atacagttattcagtaggacggccctgactgagaagtgtaaactggaagaggatattctc tacatggcctatgctgacattatggctaagagctgtcatgatgaagaggatgaggatgga gaggaggtgaagagttttgaagagaaagagatggagaaacagaagctgttatatcagcag gccaggttacacgaccgaggtgctgcggagatggtgctgcagactatcagcgccagcaaa ggtgagatgggtcccatggtggcctctactctgaagctggggatcgctgtcctcaatgga ggcaactctactgttcagcagaaaatgctggactacctgaaagacaagaaggatgtgggc ttcttccagagtctggctggtctgatgcagtcatgcagtgttctagacctgaatgcgttt gagcggcagaataaagcagagggactgggcatggtgacagaggagggatcagtcatcact catgagcgtggagagaaggtgatgcaggatgacgtcttcacctgtgacctgttccgtttc ctccagctgctctgcgaaggtcacaactcagactttcagaattacctgagaacacagaca gggaacaacactacagtcaacgtcatcatctctaccgtggactaccttcttagagttcag gaatcaatcagtgatttctactggtactattcgggaaaggacgtcattgatgaacaagga cagaggaatttctccaaggcaattaacgtcgcgaaacaggtcttcaatacactcacagag tacatacagggaccgtgtactgggaaccagcagagtttagctcacagccgtctgtgggac gctgtcgttggcttcctccatgtcttcgctcacatgcagatgaagctatcacaggactcg agccagatagagttgttgaaagagttgatggatctgcagaaagacatggttgtgatgctg ctgtccatgctggaaggcaacgtggtcaacggaaccatcgggaagcagatggtagacatg ttagtagagtcctccaacaacgtggagatgatcctcaagttcttcgacatgttccttaaa ctcaaagacctaacgtcgtccgacgccttcaaggagtacgacccggatggtaaaggggtc atctccaagagagacttccacaaagccatggagagccacaagcactatacccagtctgag acggagttcctgctctcctgtgccgagcctgatgagaatgagctattggactacgaggag tttgtggagcgtttccacgaaccggccaaagacatcggcttcaacgtggccgtccttctg accaacctgtctgaacacatgccccacgacacgcgcctgcagaccttcctggagctggct gagagtgtgctgaattacttccagccgtacctgggccgtatcgagatcatgggcagtgcc aagcgtatcgagagggtctacttcgagatcagtgaatccagtcgtacgcagtgggagaag cctcaggtcaaagagtccaaacgccagttcatcttcgacgtagtcaacgagggcggggag aaagagaagatggagctgttcgttaacttctgcgaggacaccatctttgagatgcagctg gccgcccagatgtccgacatcggggaacggtcggccgtgaaggaggagagcgagaaagag aaaccggaagaggagagccctgagatgggcttcttctctgtgaccacggtccggaccgcc ctgatggctctacgctacaacgtcatgttcctgatgaacgttctgtccatgaagagtctg aagaagcagataaagaggatgaaaaagatgacagtgaaggacatggtgatgacgctggtc tccttctattggtccgtcatcatgggcctgtttcactttaccttcagcgtctccagaggg ttctgcagaatcatgtacaacaccttcctaggaggcagtctggtggagggagccaagact atgaaggtgtctgacctgttggccaacatgcctgacccaacccaggacgaggttcgagag gagggggagaaggcgctctcagctagaccctcagctgaggaggagctagcggatctggcc ctgcccgtggacgggaccgaagtcctctcagacatctttggattagatctgaggagagga gaaggaggacagtataagataactgctcacaaccccaacgccagtctgactgatctgctt aactctccagtcccttcctctcctgtccctgctacctcaccgtccccggaactgagaaga aggcaccaggctaagagtccttcagaggaagagaggacagggactgaggaaaccaaggag gccaagtcagagccggagaaagcagagggagtggatggagagaagcaggaggaggaggag aggaggaaggaggagaagccgaaagctaaagtgagacagcaccacacctccaagtctgat gagcatgacatgcaggagtctgccttctggaagaaaatcatcgcctatcagaggaagctg ctgaactattttgctcggaacttctacaacatgagaatgctggcgttgtttgtggccttc gcgattaacttcatcctcctcttctacaaggtgtcgtcctcctcagcagtgatgcctgaa agcagaaggccccgggcaggcagcagtgtgcggtgggaccctgtgatggagggtagtagc ccccaggagcctcaaaacccccagcagggccctgtgtttgtccactttgtgctggaggag agcaccggatacatggagcccaccctgcgtatcctggccatcctacacactgtcatctcc ttctgctgcatcataggatactactgcctcaaggtcccgttggtgatcttcaagcgtgag aaggaggtggcgaggaagctggagttcgacggtctctacatcacggagcagccgtcggag gacgacattaaaggccagtgggacagactggtgattaacactggatcgtttccaaacaac tactgggataagtttgtgaagaggaaggtgatggataagtatggagagttctacggccat gaccgcatcagtgagctgctgggcatggacaaggctgctctggacttcagcgacgcccaa gagaagaagaaacccaagaaggacagctcgttagccgcagtattaaactctgttgatgtg aagtaccagatctggaaactaggagtcgtcttcacagacaattcgttcctgtacctggct tggtatatgaccatgtccatcctgggtcactataacaacttcttcttcgccgctcatctc ctggacatcgccatgggcttcaagaccctccgtaccatcctgtcttctgtcacgcacaac ggcaaacagctggttctgacagtaggactgctggctgtggtggtgtacctctacacggtg gttgcgttcaacttcttcaggaagttctacaatagaggggaagagggagagaccccggac atgaagtgtgatgacatgctcaca

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