Strix uralensis (Ural owl): 141941091 Help Entry 141941091         CDS       T11361                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism sura  Strix uralensis (Ural owl) Pathway sura04020   Calcium signaling pathway sura04260   Cardiac muscle contraction sura04261   Adrenergic signaling in cardiomyocytes sura04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:sura00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     141941091 (RYR2)    04020 Calcium signaling pathway     141941091 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     141941091 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     141941091 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:sura04040]     141941091 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:sura04990]     141941091 (RYR2) Ion channels [BR:sura04040]  Voltage-gated cation channels   Ryanodine receptor    141941091 (RYR2) Domain-containing proteins not elsewhere classified [BR:sura04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    141941091 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  141941091 NCBI-ProteinID:  XP_074719310 LinkDB All DBs Position 3:85762408..86203487 Genome browser AA seq 4995 aa AA seqDB search MAEGGEGEDEIQFLRTNYSLTIGTTSRAWEAHFVVDDEVVLQCTATVHKEQQKLCLAAEG FGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWKFM MKSAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSMDKLAFDVGLQEDTTGEACWWT IHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGS EVAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLR VAWSGSHIRWGQPFRLRHITTGKYLSLLDDKSLLLTDKEKADVKSTAFCFRSSKEKLDIG TRKEVDGMGAPEIKYGDSICFIQHVDTGLWLTYQSADAKSVRMGSVQRKAIMHHEGHMDD GLTLSRSQNEESRTARVIRSTVFLFNRFIRGLDALNKKVKSSAVDLPIESVSLSLQDLIG YFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLNVYSSAAHFADVAGKE AGEAWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVE SPEALNIIKEGHIKSIICLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRD LLLQTRLVNHVSSMRPNIFLGISEGSAQYRKWYYELMVDHLEPFVTAESTHLRVGWASTE GYSPYPGGGAEWGGNGVGDDLYSYGFDGLHLWSGCVARTVNSPNQHLLRTDDVISCCLDL SAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAP CFEAVLPKEKLKVEHSREYKQDRSYTRDLLGPTISLSQAAFTPVPVDTSQIVLPPHLERI REKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLK TLLALGCHVGIADERAEEKVKKMKLPKNYQLLSGYKPAPMDLSFIKLTPSQEAMVDKLAE NAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYG YNLEAPDQDHAMRLDVCSGIMEKFRIFRTEKTYAVKAGKWYFEFEAVTAGDMRVGWTRPG CLPDQELGSDEEAFVFDGFKAQRWHQGNEHFGRSWLAGDVVGCMVDMNEHTMMFTLNGEI LLDDSGSELAFKDFEVGDGFLPVCSLGPSQVGRMNFGKDVSTLKYFTICGLQEGYEPFAV NTNRDITIWLSKRLPQFLPVPQNHEHIEVMRIDGTIDSCPCLKVTQKSFGSQNSKTDVMF FRLSMPIECAEVFSRSAAGGLPGSGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRTER EKDATKTELNNHKDYVQEKPSRLKQRFMLRRTKPDYSTSHSARLTEDVLADDRDDYDYLM QTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTSFDLDRVRTVTVTLGDEKGKVHESIK RSNCYMVCAGESMSPGQGRNNNGLEIGCLVDAASGLLTFTANGKELGTYYQVEPSTKLFP AVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVSQCPPRLHVQFLTHVLWSRVPN HFLKVDVSRISERQGWMIQCLNPLQFMALHIPEENRTIDILELTEQEELLKFHYHTLRLY SAVCALGNNRVAHAMCSHVDESQLLYAIENKYMPGLLRAGYYDLLIDIHLNTYATARLMM NNEFIVPMTDETKSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSISSECFQFSPE FPLEILKAKTIEMLTEAVQEGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNGDLKH ILQLIEPRVFKEAMNQEDEIDFSEKELSSDELKSEEGEEETRGEQVPKEGLLQMKLPEPV KLQMCHLLQYLCDCQVRHRIEAIVAFSDDFVAKLQENQRFRYNEVMQALNMSAALTARKT KEFRSPPQEQINMLLNFKDDKNDCPCPEEIRDQLLDFHEDLMTHCGIELDEDGTLDGNSD LTIRGRLLYLMEKVTYLKKKQTEKPVDDDAKTSSTLQQLISDTMVRWAQESVIEDPELVR AMFVLLHRQYDGIGGLVRALPKTYTINSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLM IRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCY FCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDL EKVVRYLAGCGLQSCPLLISKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVR LLIRRPECFGPALRGEGGNGLLAAMEEAIQISEDPTRDGPSPSNGSSKTLEMEEQEDDTI HMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLEDLVGVISIPFHM PTIAKDGTVVEPDMSAGFCPDHKAAMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASL DTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLT KAQRDSIEECLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYC LPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYME SNYVNMMEKQSSMDSDGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMEKFANGWT YGETYSESSKVQPLMKQYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYN RTRRISQTSQISVDTAHGYTPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELEA KVGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYVVSRGFKDLELDTPSIEKRF AYSFLQQLIRYVDEAHQYILEFDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLY FLSAASRPLSSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLD ARTVMKTGLESVKMALRAFLDNAAEDLEKTMENLKQGQFTHSRNQPKGVTQIINYTTVAL LPVLSSLFEHIGQHQFGEDLILEDVQVSCYRILASLYALGTSKSIYVERQRSALGECLAA FSGAFPVAFLETHLNKHNIYSIYNTKNARDRAVLNLPTSVEEVCPNIPSLVKLMEEIVEL AESGIRYTQMPHIMEVILPMLCSYMSHWWEHGPENNPDKAEMCCTALTSEHMNTLLGNIL KIIYNNLGIDEGAWMKRLAVFSQPIISKAKPQLLKTHFLPLMDKLKKKAAVVVSDEEHLR AEGRGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAE VFIYWSKSHNFKREEQNFVVQNEINNMSFLISDTKSKMSKAAVSDQERKKMKRKGDRYSM QTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSMKDTEDEVRDIIRSNLHLQGKLED PAIRWQMALYKDLPNRTEDSSDPEKTVERVLDIANVLFHLEQRSACVGRGYFFWVEHPQR SKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYDKSWIETEEHYFEDKLI EDLAKPGEEPPEEDESLKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHD EEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGP MVAATLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNK AEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIIS TVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQ SLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNG TIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGIISKRDFHKAME SHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPHDT RLQTFLELSESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFI FDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEENEKDKPEEQDPRM GFFSLVTMKSALVALKYNLMTLMKMLSMKSLKKQMKKVKKMTMKDMVMALFSSYWSILMG LLHFACSVVRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGEGEEGERKP TEAALPTEDLTDLRTLSDESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLLSTPSLAP MPEVQEKIQEQVKEDEKEEKEETKSEPEKAEGEDGEKEEKAKEEKGKQKLRQLHIHRYGE PEVQESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSAVTEEKE VPVVSSGESTKLNSLESDNQKVIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYC LKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRK VMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGV VFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVG LLAVVVYLYTVVAFNFFRKFYNKSEDGDMPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIE DPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICG IGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFF PAGDCFRKQYEDQLN NT seq 14988 nt NT seq  +upstreamnt  +downstreamnt atggccgaggggggcgagggcgaggacgagatccagttcctgcgaactaattacagtttg acaattggaaccacatctagagcttgggaagcgcactttgttgtagacgatgaagtggtt ctgcagtgcacggcaactgttcacaaggagcaacagaaattgtgtcttgctgcagaagga tttggcaacaggctttgttttttggaatccacatcaaattctaagaatgttccacctgat ttgtccatctgcacctttgtgctggagcagtctctgtcagtacgagccctccaggagatg ctggctaacacagaagagaaggcagaagggctagttgatgtggaaaaatggaaatttatg atgaagtctgcacaaggtggtggtcatcgaacgctactctatgggcatgcaatcttgctg cgccattcctacagtggcatgtatctatgttgcctctctacgtctcgatcttcaatggat aagctggcatttgatgtaggattacaagaggacacaacaggtgaggcatgctggtggacc atccatcctgcttccaagcaacgatcagaaggagaaaaagtgcgtgttggagatgatctt attttagtcagtgtctcttcagaaagatatttgcatctctcttatggcaatggtagctta catgttgatgcagccttccagcagacgctctggagtgtagcaccaatcagttcaggaagt gaagttgcccaaggatatctgataggaggggatgttctgaggttattgcatggtcacatg gatgaatgtttgacagtcccttcgggtgaacacggagaagaacaaagaagaactgtccat tatgaaggtggtgccgtgtcaattcatgctcgttccctttggcgactagagactctaaga gttgcgtggagtggcagccacattagatggggacagccattcagactaagacatataaca acaggaaaatatttaagtctcctggatgacaagagtcttcttcttacagacaaagagaaa gcagatgtaaaatctacggcattctgttttcggtcttccaaggaaaagttggacataggg acaagaaaagaggtggatggaatgggagcaccagaaataaaatatggggattcaatatgc ttcatacaacatgtagatacaggcttatggctcacgtaccagtctgctgatgcaaagtct gtaagaatgggttctgtgcagcggaaggcaataatgcaccatgaaggtcacatggatgat ggtttaacattgtccagatctcagaatgaagaatcccgtacagcacgtgtcatccgtagt acggtcttccttttcaacaggtttataaggggccttgatgctctcaacaagaaagtgaag tcttccgccgtcgatttgcctattgagtcagtcagtctgagccttcaggacttgattggc tactttcacccccctgatgaacatttggagcatgaagacaaacaaaacaggctccgagca ctgaagaatcgccagaacctcttccaggaagagggtatgatcaaccttgttcttgaatgt attgatcgcttgaatgtatacagcagtgcagctcattttgcagacgtagctgggaaggaa gctggagaagcatggaaatctattctgaattctttgtatgaattactagcggctctgatt cgagggaatcgtaaaaactgtgctcaattttctggatctcttgactggttgatcagcaga ttagaaagactggaagcctcttctggaattctagaggttttacactgtgtgttggtggaa agcccagaagctctaaacattattaaggaaggacatattaaatcaatcatctgtcttttg gacaaacatggaagaaaccataaggttttggatgttttgtgttctctctgtgtttgtcat ggagtagctgtgcggtctaatcaacatctaatctgcgataatctcctgccaggaagagat ctgctcttacagacacgccttgtcaaccatgtgagcagcatgcgacccaacatcttcttg gggattagtgaaggctctgcccaatacagaaaatggtactatgaacttatggtggaccat ctagagccctttgtgactgcagaatcaactcatctacgagtgggctgggcttcaacagag ggctactcaccatatccagggggaggagcagaatggggaggaaatggtgttggtgatgac ttgtattcctatggcttcgatggtctgcatctgtggtcaggttgtgtagcacgaacagta aattctcccaaccaacacctgttaagaactgatgatgttattagctgctgtttggacttg agtgcccccagcatctctttccggataaatggtcagccagttcaaggaatgtttgagaat ttcaacatagatggcctcttcttcccagttgtcagcttttctgcaggaataaaggtacgc ttcttgcttggaggtcgccatggagagttcaagttccttcctccacctggatatgctcct tgctttgaggctgttctaccgaaagagaagctgaaagtggagcatagccgagagtacaag caggatcgtagctatacaagagacctactgggtccaactatctctctgtcacaagcagct ttcactccggttcctgtagatactagccagattgttttgcctccccacctggaaaggatt agagaaaaattagcagagaacatccatgaactttgggttatgaataagattgaacttggc tggcagtatggaccagttagagatgacaacaaaagacaacacccatgcttagtggagttc tcaaaattgccggagcaggagagaaattataacttgcaaatgtcacttgaaacactgaaa accctcctggcattaggctgccatgttggaattgctgatgaacgtgctgaagaaaaagtg aaaaaaatgaaacttccaaagaactaccagttgttgagtggatataagcctgctcccatg gatctgagtttcatcaaactgaccccctctcaagaagctatggtggataaactagcagag aatgctcacaacgtgtgggcaagggaccgtataaggcaaggctggacatacggtatccag caggatgtgaaaaatcgacgaaatcctcgccttgtaccttatgctcttttggatgatcgg acaaagaagtcaaataaagacagtcttcgggaagcagtccgcacccttctaggctatggt tacaacctggaagctcctgatcaagatcatgcgatgagactggacgtgtgcagtgggata atggaaaaattcaggatcttccgcacagaaaaaacttacgcagtgaaggctgggaagtgg tactttgagtttgaggcagttactgcaggagacatgagagttggctggaccaggccgggt tgtctgccagatcaggaacttggctcagatgaagaagcttttgtttttgatggctttaag gcacagcggtggcatcaaggtaatgagcattttggccgctcttggttggcaggagatgtt gttggatgtatggttgacatgaatgagcacactatgatgttcaccttaaatggtgaaatc ctgcttgatgactcaggttcagaacttgcattcaaggactttgaggttggtgatggattt ctacctgtgtgcagcctcggcccatctcaagtgggaagaatgaactttggaaaagatgtc agcactctaaaatatttcactatctgtggcttacaggaagggtatgaaccctttgctgtt aatacaaacagagacatcaccatttggctgagtaaaaggctccctcagtttctaccagtg ccacaaaatcatgaacatattgaggtgatgagaattgatggcaccatagacagctgcccc tgcctgaaggtcacacagaagtcatttggttcacagaacagtaaaacagacgtcatgttt tttcgattaagcatgcctattgaatgtgctgaggtgttctccagatcagctgcaggaggg ttaccaggctctggtctttttggcccgaagaatgacttggaggattatgatgctgattct gattttgaggttctaatgaaaactgctcacggtcatctagttcccgaccggacagaaaga gaaaaagatgccacaaaaacagagttaaacaaccataaagattatgttcaagaaaagcct tcacgtcttaaacaaagatttatgctcaggaggacaaagccagattatagcacaagtcac tctgcacggcttactgaggacgtgctagcagatgatagggatgactatgattatttgatg caaacttccacgtactattattcagtgaggatatttcccggtcaagaacctgctaatgtc tgggtgggctggattacatctgacttccatcagtatgacacaagctttgacttggacaga gtgcgtactgtcacagttacactgggagatgaaaaagggaaggttcatgagagtataaaa cgcagcaactgctatatggtgtgcgcaggagagagcatgagccctggacaaggacgtaat aataatggtctggagattggttgcttggttgatgctgccagtggcctgctgaccttcaca gctaatggcaaggaactaggcacgtactatcaggttgaaccgagtacaaagttatttcct gctgtatttgctcaagctacaagccccaatgttttccagttcgagttaggaagaataaag aatgtaatgccattatctgctggcttattcaaaagcgaacacaaaaacccggtctctcaa tgtcctccacgtctccatgtccagtttctgactcatgtgctttggagcagagtgccaaac cacttcttgaaggttgatgtctctcggatcagtgaacgtcaaggctggatgatacagtgc ctgaatcctttgcagttcatggcccttcatattcctgaagaaaacagaacaattgatatt ttagagctgacagaacaagaagaattgctgaaatttcactaccataccctccgattatat tcagctgtttgtgctttaggcaataaccgagtggcccatgctatgtgtagccacgtggat gaatctcagctcctgtatgctattgagaacaaatatatgccaggattattacgtgcagga tattatgacttactcattgacatccatctcaatacctatgcaactgccaggttaatgatg aataatgaatttatagtaccaatgactgatgagactaaaagtattactttgtttcctgat gaaaacaagaaacatggcctccctggtataggactcagcacttcattaaggccaagaatg cagttctcctctccaagttttgtaagcattagcagtgaatgctttcagttcagtcctgaa ttccctctggaaattttaaaggccaaaaccatagagatgctgactgaagctgttcaggag ggcagcctccatgtcagagatccagttggaggttctacagaatttctgtttgtccctctc atcaagctcttttataccctgctaattatgggaatcttccacaatggggatctgaaacac atcttgcagctgattgagccccgggtttttaaagaagcaatgaaccaggaggatgaaatt gatttctcagagaaggagctgagttcagatgagctcaagtcagaagaaggagaggaagaa accagaggggagcaagtgccaaaggaaggactccttcagatgaaacttccagagcctgtt aaattacagatgtgccatctacttcagtacctgtgtgattgccaagtacgacaccgaata gaagccattgtagcattttcggatgattttgtggccaagcttcaggagaatcaacgcttc cggtacaatgaagtgatgcaggccttgaacatgtctgctgccctgacagctagaaaaaca aaagaatttcgatccccacctcaggagcagattaacatgctgctgaactttaaagatgac aaaaatgattgtccttgccctgaagaaattcgggatcagctcttggatttccatgaagac ctaatgacacactgtggaattgaactagatgaagacggaaccttggatggaaacagtgat ttaaccattaggggtcgactcctataccttatggaaaaagttacatatctgaagaagaag caaactgagaagccagttgatgatgacgctaagacatcatctactcttcagcagttgatt tcagacacaatggtacgctgggcccaggaatcagtgatagaagacccggagttagtgagg gccatgtttgtattgctgcaccgccaatacgatggtattggtggcctggttcgagcccta ccaaagacctacaccataaatagcgtgtctgtggaagacacaatcaatcttctggcatcc cttggccaaatccgttccttgcttagtgtcagaatggggaaggaggaagagaaacttatg attcgtggattaggagacatcatgaataataaagtattttaccaacatccaaatctcatg agagctttaggaatgcatgaaactgtcatggaagtgatggtaaatgtgcttggtggagga gaatccaaggaaatcactttcccaaagatggtggcaaactgttgtcgttttctgtgttat ttttgccgcatcagcagacagaatcaaaaagctatgtttgatcatcttagctatttattg gaaaacagcagtgttggccttgcctctccttctatgcgaggatcaactcctttagatgtt gcagcagcctctgtgatggataacaatgaacttgcactagctttaagggagcctgatctg gagaaggtggttcgctacttggctggatgtggattgcagagttgtcctttgctgatttct aaagggtacccagacattggatggaatccagttgaaggagagcgatatttggattttctt cgttttgctgttttttgcaatggagagagtgtggaggagaatgctaatgttgtagtcaga ctgcttatccgacgacctgaatgttttggtccagctctgagaggagaaggaggcaatggg ttacttgctgccatggaggaagcaatacaaatatcagaagatccaacaagagatggacct tccccaagtaatggatctagtaaaacccttgaaatggaagaacaagaagatgacactatt cacatgggaaatgcaatcatgaccttttatgctgctttgattgatctcttaggacgttgt gccccggaaatgcatctaatccatgctggtaaaggggaagccattagaatcagatcaatt ctacggtctttgattccactggaagatttggtgggagtcattagtattcctttccacatg ccgactatagctaaagatggtactgtggtggaacctgacatgtctgcggggttttgccca gatcacaaggcagccatggttttgttccttgacagggtctatggaattgaggaccaggat tttcttctacaccttcttgaagttggctttctgccagatcttcgtgcagctgcttcttta gatacggctgctttaagtgctacggatatggctttggctctgaatcgatacctttgcaca gcagtcttgcctctgttgaccaggtgtgctcctctttttgctggcacagagcaccatgct tcactcatcgattccttattacatactgtgtacagactctcaaagggatgctctcttacc aaagctcagcgagattctattgaagagtgtttgctgtctatctgtgggcagttgcggcct tccatgatgcagcatttgctgagaagattagtatttgatgttcctctattaaatgaacat gcaaagatgcctctcaagttgctgacaaatcattatgaaagatgctggaagtattattgt ttgccaggtggatggggtaactttggtgctgcttcggaagaagaacttcatttatccaga aagttgttctggggtatttttgatgctttgtctcaaaagaagtatgaacaagaactgttc aaattggctttgccttgtttgagcgcagttgcaggggccttacctccagactatatggaa tcaaattatgtcaatatgatggaaaaacagtcttcaatggattcagatgggaactttaat cctcaacctgttgatacctcaaacattacaatccctgaaaagctagaatatttcattaac aaatatgcagaacactctcatgacaaatggtcgatggaaaagtttgccaatggatggaca tatggtgaaacatattctgaatcttcaaaagtgcaaccattaatgaaacaatataaatta ctatctgaaaaggagaaagaaatttatcgatggccaatcaaagaatcactaaaaactatg ctggcatggggatggcgaattgaaagaacacgtgagggagattccatggccctgtataat cggacacgtcgcatatctcaaaccagtcaaatctctgtagatacagcccatggttacact cctcgagcaattgacatgagcaatgtcaccctctccagagacttacacgctatggctgag atgatggccgaaaactaccataacatatgggcaaagaaaaagaaaatggagcttgaagca aaagtaggaggaggcaaccatcctcttcttgttccttatgatacactcacagccaaagaa aaagccaaggacagagaaaaagcacaggatattctgaaatttctacagattaatggatat gttgtctccagaggatttaaggacctggaattagacacaccttccattgagaaacgcttt gcctacagttttcttcagcaacttataagatatgtggatgaagcccatcagtacattctg gagtttgatggtggcagcagaggcaaaggagagcatttcccatacgaacaagaaatcaag ttttttgctaaagttgtgcttcctttgattgatcagtattttaaaaatcatcgcctgtat ttcttatctgcagcaagtaggcctctcagcagtggaggccatgcctctaataaagagaaa gaaatggtgacaagcctgttctgcaaacttggagttcttgtcaggcataggatttcactg tttggaaatgatgcaacatcaatagtcaactgtcttcacatactgggccagactttggat gcaaggactgtgatgaaaactggtctggaatctgttaagatggcattgagagcatttttg gacaatgctgctgaggatctggagaaaacaatggaaaatcttaagcaaggccagtttaca cacagcagaaaccagccaaagggagttacacaaatcattaattataccacagttgctctc ctgccagtgttatcttcattatttgagcatattggacagcaccagtttggggaagatttg atattggaagatgttcaggtctcctgttacagaatactggccagtttatatgctttggga accagcaagagtatctatgtagagaggcaacgatcagcactaggagaatgcttggctgct ttctcaggtgcctttccagtggcttttttggaaactcacttgaacaaacataatatctac tcaatttacaataccaagaatgcgagagacagagcagttctcaatttgcctactagtgta gaagaggtttgcccaaatattccttccttggtgaagctaatggaagaaattgtggaactg gcagagtctggtattcgttacacacaaatgccacatatcatggaagtaatactgcctatg ttgtgtagttacatgtcacactggtgggagcatgggccagaaaacaaccctgacaaggct gaaatgtgttgcacagccttgacgtcagagcacatgaacactctgttgggtaacatattg aaaatcatctataacaaccttggtattgatgaaggagcctggatgaaaagattagcagtg ttttcccagcccatcataagcaaagcgaagccacagctcttaaagacacacttcctgcca ctgatggataagctaaagaaaaaagcagcagtggttgtatcggatgaagaacatctaaga gcagaaggcagaggtgacatgtcggaggctgaactgctcatcctagatgagttcaccact ttggcacgggacctctatgccttctaccctttgttgattagatttgtggactataacagg gcaaaatggctgaaagagcccaaccctgaagcagaagaattgttccgcatggtggctgag gtcttcatttactggtcaaagtctcataatttcaaaagggaagagcagaactttgtggta caaaatgaaatcaacaacatgtctttccttatcagtgacaccaaatctaagatgtccaag gcagcagtttctgaccaggagaggaagaagatgaagcggaaaggtgaccggtactctatg cagacctctctcattgtggcagcactgaagagattgcttcccattggcctaaacatttgt gctcctggagaccaagagctaattgcactggcaaaaaatcgattcagtatgaaagatact gaagatgaagtacgagatatcatccgcagtaatcttcatctccagggcaagcttgaggat cccgccattaggtggcagatggcactttacaaagatttaccaaacaggactgaagattcc tcagatccagaaaagactgtcgaaagggtccttgatatagctaatgtactgtttcacctg gaacagagatctgcttgcgtaggccgaggctatttcttttgggttgagcatcctcagcgg tccaaaaaagcagtgtggcataaattgctgtctaaacagaggaaaagagcagtagttgct tgctttagaatggcaccattgtataatctgccaaggcaccgagccgtcaatctctttctt caaggctatgataaatcttggattgaaacagaagaacattattttgaagacaaactgata gaagacttagcaaaacctggggaggaaccaccggaagaagatgaaagccttaaaagagtt gatcctttacatcaacttattctgctattcagtagaacagccttgactgaaaaatgcaaa ttggaagaagattttctgtatatggcttatgctgacattatggcaaagagctgccatgat gaagaagatgatgatggtgaagaagaagtgaagagttttgaagtgacaggatcacaacgc agcaaggaaaaagaaatggaaaagcaaaaacttctgtatcaacaagccagactgcatgac cgaggtgctgctgagatggttctgcagacaatcagtgctagtaaaggtgagatgggacca atggttgcagctaccctaaagctaggaattgccatcttaaatggaggaaattccactgtt caacagaaaatgcttgactacctcaaggataaaaaggatgtgggattctttcagagcctt gctggtcttatgcagtcctgtagtgttcttgacctaaatgcatttgaacgtcagaacaaa gcagaaggccttggcatggtgactgaagagggatcaggagaaaaggtgatgcaggatgat gagttcacctgtgacctcttccgcttccttcaattgctttgtgaaggacataattcagac ttccagaattacctgagaactcagactggtaacaacacaactgttaatattatcatttcc actgtggattacttattaagagttcaggaatccattagtgatttctattggtattattct gggaaggatgttattgatgagcaaggacaacgaaatttttccaaagccatccaggttgca aaacaagttttcaatactcttacggagtatatccaggggccatgtactgggaatcagcaa agtctggcacacagcaggctatgggatgctgtagttggttttcttcatgtgtttgcccac atgcagatgaagctgtctcaggattccagtcaaattgaattactgaaggaattaatggat cttcagaaggatatggttgtcatgttgctgtctatgctggaaggtaatgttgtgaatgga actattggcaagcagatggtcgatatgcttgtggaatcgtccaacaatgtggagatgatt ctgaagttttttgatatgttcttaaaattgaaggatttgacttcctctgatgcattcaaa gaatatgaccctgatggtaaagggataatttcaaagagggattttcacaaggcaatggaa agccataagcattacacccagtctgaaactgagtttctgctatcatgtgctgaaacagat gagaatgagactctggactatgaggagtttgtgaaacgattccatgaacctgccaaagat attggtttcaatgttgctgttctcctgaccaacctgtcagaacacatgccccatgatacc cgcttgcaaacttttcttgaactttcagagagtgtgctgaattactttcagcctttcctt ggacgcatagaaatcatgggcagtgcgaagcgcattgaacgagtttattttgaaataagt gagtcaagtcggactcagtgggagaaacctcaggtaaaagagtcaaagaggcagtttata tttgatgttgtaaatgaaggcggagagaaggaaaagatggagctttttgttaatttctgc gaggataccatctttgaaatgcaactggctgcccagatctctgaatcagatctgaatgaa aggtcagcaaataaagaggagaatgagaaagataagcccgaggaacaggatcctagaatg ggtttcttctctctcgtgaccatgaagtcagcattagtagctctcaagtataatttaatg actcttatgaaaatgctcagcatgaagagcctaaagaaacagatgaaaaaagtgaagaaa atgaccatgaaggacatggtcatggctttattttcttcctattggagcattttgatgggc ttactacattttgcttgtagtgttgtccggggcttctttcgcatcatatgcagtttgctg cttggaggaagcctagtagaaggagcaaagaaaatcaaggtggctgaactcttagctaat atgccagatcccactcaggatgaggtgcgtggggaaggagaggagggggagaggaagcca acagaagctgcattgcctacggaagacttgacagatctgagaactttatcagatgagagt gatctactctcagatatatttggtttggatttgaaacgagaaggtggacagtataaatta atccctcacaatccaaatgctggtttgagtgatttactgagcactccctccttagctcca atgcctgaggtgcaggaaaaaatccaggagcaggtgaaagaagatgaaaaggaagagaag gaggaaacaaaatctgaacctgaaaaagcagaaggagaagatggagaaaaagaagagaaa gccaaggaagagaaagggaaacaaaaattaagacaacttcatattcacagatatggagaa ccagaagttcaggaatcagctttctggaagaaaataattgcataccaacagaagcttctt aattattttgcacgaaacttttacaacatgaggatgttggcattgtttgttgcttttgcc atcaacttcatcctgcttttctataaggtctccacctctgctgtgacagaagaaaaggaa gttcccgtggtatcttctggtgaaagtaccaagttgaacagcctggaaagtgacaaccag aaggtcattgcagtgcattatgtcctggaagaaagcagtggctacatggagcccacactg cggattttggccatcctacacacagtcatctcattcttctgcatcatagggtattactgt ttgaaagttccactggttatttttaagagagaaaaggaagtggcaaggaaattggaattt gatgggctgtatataactgaacagccatcagaagatgatattaagggacaatgggataga cttgtaatcaacacacagtcttttccaaataattattgggacaaatttgtgaaaagaaag gtcatggataaatatggtgagttctatggccgtgacaggatcagtgagttactaggaatg gacaaagctgctctcgattttagtgatgctcgagaaaagaagaaaccaaagaaggatagc tccttatctgctgtgctaaattccattgatgttaagtatcagatgtggaaattaggagtt gttttcactgataattctttcctttacctagcatggtacatgaccatgtcagtccttggc cattacaacaattttttctttgctgctcatctccttgacattgcaatgggattcaagaca ttacgaactatcctgtcatcagtgacccacaatggcaaacagcttgtcctgacagtggga ttactggcagtagtagtatatttatatacagtagtggcgttcaattttttccgcaagttc tataacaagagtgaagatggtgatatgccagacatgaaatgtgatgatatgctaacatgc tacatgtttcacatgtatgttggagtacgtgcaggtggaggcattggtgacgaaatagag gatccagcaggagatgaatatgaaatctatcggattatctttgacatcactttcttcttc ttcgtgattgttatcctgcttgcaattattcaaggtttaattattgatgcttttggtgag ttaagagatcagcaagagcaagttaaggaagacatggagacgaagtgctttatctgtgga ataggaaatgactactttgatacagtgccccatggctttgaaacacacacactacaggag cacaatttggccaattatttgttttttctgatgtatcttattaacaaagatgaaacagag catacaggacaggaatcctatgtatggaaaatgtatcaagaacggtgctgggaatttttc cctgctggcgattgcttccgaaaacaatatgaagaccagctcaactga

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