Sturnus vulgaris (common starling): 106852145 Help Entry 106852145         CDS       T08833                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism svg  Sturnus vulgaris (common starling) Pathway svg04020   Calcium signaling pathway svg04260   Cardiac muscle contraction svg04261   Adrenergic signaling in cardiomyocytes svg04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:svg00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     106852145 (RYR2)    04020 Calcium signaling pathway     106852145 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     106852145 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     106852145 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:svg04040]     106852145 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:svg04990]     106852145 (RYR2) Ion channels [BR:svg04040]  Voltage-gated cation channels   Ryanodine receptor    106852145 (RYR2) Domain-containing proteins not elsewhere classified [BR:svg04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    106852145 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  106852145 NCBI-ProteinID:  XP_014730064 LinkDB All DBs Position Unknown AA seq 4991 aa AA seqDB search MAEGGEGEDEIQFLRTNYSLTIGTTSRAWEAHFVVDDEVVLQCTATVHKEQQKLCLAAEG FGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWKFM MKSAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSMDKLAFDVGLQEDTTGEACWWT IHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGS EVAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLR VAWSGSHIRWGQPFRLRHITTGKYLSLLDDKSLLLTDKEKADVKSTAFCFRSSKEKLDIG TRKEVDGMGAPEIKYGDSICFIQHVDTGLWLTYQSADAKSVRMGSLQRKAIMHHEGHMDD GLTLSRSQNEESRTARVIRSTVFLFNRFIRGLDSLNKKVKSSIIDLPIESVSLSLQDLIG YFHPPDEHLEHENKQNRLRALKNRQNLFQEEGMINLVLECIDRLNVYSSAAHFADVAGKE AGEAWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVE SPEALNIIKEGHIKSIICLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRD LLLQTRLVNHVSSMRPNIFLGISEGSAQYRKWYYELMVDHLEPFVTAESTHLRVGWASTE GYSPYPGGGAEWGGNGVGDDLYSYGFDGLHLWSGCVARTVNSPNQHLLRTDDVISCCLDL SAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAP CFEAVLPKEKLKVEHSREYKQDRSYTRDLLGPTVSLSQAAFTPVPVDTSQIVLPPHLERI REKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLK TLLALGCHVGIADERAEEKVKKMKLPKNYQLLSGYKPAPMDLSFIKLTPSQEAMVDKLAE NAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYG YNLEAPDQDHATRLDMCSGIMEKFRIFRTEKTYAVKAGKWYFEFEAVTAGDMRVGWTRPG CLPDQELGSDEEAFVFDGFKAQRWHQGNEHFGRSWLAGDVVGCMVDMNEHTMMFTLNGEI LLDDSGSELAFKDFEVADGFLPVCSLGPSQVGRMNFGKDVSTLKYFTICGLQEGYEPFAV NTNRDITIWLSKRLPQFLPVPQNHEHIEVMRIDGTIDSCPCLKVTQKSFGSQNSKTDVMF FRLSMPIECAEVFSRSAAGGLPGSGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRTER EKDATKPELNNHKDYVQEKPSRLKQRFMLRRTKPDYSTSHSARLTEDVLADDRDDYDYLM QTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTSFDLDRVRTVTVTLGDEKGKVHESIK RSNCYMVCAGESLSPGQGRNNNGLEIGCLVDAASGLLTFTANGKELGTYYQVEPSTKLFP AVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVSQCPPRLHVQFLTHVLWSRVPN HFLKVDVSRISERQGWMIQCLNPLQFMALHIPEENRTIDILELTEQEELLKFHYHTLRLY SAVCALGNNRVAHALCSHVDESQLLYAIENKYMPGLLRAGYYDLLIDIHLNTYATARLMM NNEFIVPMTDETKSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSISSECFQFSPE FPLEILKAKTIEMLTEAVQEGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNEDLKH ILQLIEPRVFKEAMSQEDEVDFSEKEFSSDEFKSEEGEEETRGEQMPKEGLLQMKLPEPV KLQMCHLLQYLCDCQVRHRIEAIVAFSDDFVAKLQENQRFRYNEVMQALNMSAALTARKT KEFRSPPQEQINMLLNFKDDKNDCPCPEEIRDQLLDFHEDLMTHCGIELDEDGTLDGNSD STIRGRLLYLMEKVTYLKKKQAEKTVDDDDKTSSTLQQLISETMVRWAQESVIEDPELVR AMFVLLHRQYDGIGGLVRALPKTYTINSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLM IRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCY FCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDL EKVVRYLAGCGLQSCPLLICKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVR LLIRRPECFGPALRGEGGNGLLAAMEEAIQISEDRTRDGPSPSNGSSKTLEIEEQEDDTI HMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLEDLVGVISIAFHM PTIAKDGTVVEPDMSAGFCPDHKAAMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASL DTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLT KAQRDSIEECLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYC LPSGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYME SNYVNMMEKQSSMDSDGNFNPQPVDTSNITIPEKLEYFINKYAEHAHDKWSMEKFANGWT YGETFSESAKVQPLMKQYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYN RTRRISQTSQISVDTAHGYTPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELEA KVGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYVVSRGLKDLELDTPSIEKRF AYSFLQQLIRYVDEAHQYILEFDGGSRGKGEQFPYEQEIKFFAKVVLPLIDQYFKNHRLY FLSSASRPLSSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLD ARTVMKTGLESVRMALRAFLDNAAEDLEKTMENLKQGQFTHSRNQPKGVTQIINYTTVAL LPVLSSLFEHIGQHQFGEDLILEDVQVSCYRILDSLYALGTSKSIYVERQRSALGECLAA FSGAFPVAFLETHLNKHNIYSIYNTKNARDRAVLNLPTSVEEVCPNIPSLVKLMEEIVEL AESGIRYTQMPHIMEVILPMLCSYMSHWWEHGPENNPDRAEMCCTALTSEHMNTLLGNIL KIIYNNLGIDEGAWMKRLAVFSQPIISKAKPQLLKTHFLPLMDKLKKKAAVVVSDEEHLR AEGRGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAE VFIYWSKSHNFKREEQNFVVQNEINNMSFLISDTKSKMSKAAVSDQERKKMKRKGDRYSM QTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSMKDTEDEVRDVIRSNLHLQGKLED PAIRWQMALYKDLPNRTEDSSDPEKTVERVLDIANVLFHLEQKSACVGRGYFFWENLVEH PQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYDKSWIETEEHYFED KLIEDLAKPGEEPPEEDESIKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKS CHDEEDDDGEEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVAAT LKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLG MVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYL LRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHS RLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQ MVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGIISKRDFHRAMESHKHY TQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTF LELSESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVN EGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEENEKDNPEEEDPRMGFFSL VTMKSALVALKYNLMTLMKMLSMKSLKKQMKKVKKMTMKDMVMALFSSYWSILVGLLHFA CSVVRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGEEEEGERKPTEAAL PAEDLTDLQTLTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLLSTPSLAPMPEVQ EKIQEKVKEDEKEEKEETKSEPEKAEGEDGEKEEKTKEDKGKQKLRQLHTHRYGEPEVQE SVFWKNIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSAVTEEKELPVVS DGESTKLNILESDDDERVIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVP LVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDK YGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSFSAVLNSIDVKYQMWKLGVVFTD NSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAV VVYLYTVVAFNFFRKFYNKSEDGDMPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAG DEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGND YFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGD CFRKQYEDQLN NT seq 14976 nt NT seq  +upstreamnt  +downstreamnt atggccgaggggggcgagggcgaggacgagatccagttcctgcgaactaattacagtttg acaattggaaccacatctagagcttgggaagcgcactttgttgtagatgatgaggtggtt ctgcagtgcactgcaaccgttcacaaggagcaacagaaattgtgtcttgctgcagaagga tttggcaacaggctttgctttttggaatccacgtcgaattctaagaatgttccacctgat ttgtccatctgcacctttgtgctggagcagtcactgtcagtgcgggccctccaagaaatg ctggctaacacagaagaaaaggcagaagggctagttgatgtggaaaaatggaaatttatg atgaagtctgctcaaggtggtggacatcgaacactgctctacggacatgcaatcttgctg cgccattcctacagtggcatgtacctgtgctgtctctctacgtctcgatcatcaatggat aagctggcatttgatgtaggattgcaagaggacacaacaggtgaggcttgctggtggact atacatcctgcttccaaacaacgatcagaaggagaaaaagtgcgtgttggagatgatctg attttagtcagtgtctcttcagaaagatatttgcatctctcttatggcaatggtagctta catgttgatgcagccttccagcagacactctggagtgtggcaccaatcagttcaggaagt gaagttgcccaaggatacctgatagggggggatgttctgaggttattgcatggtcacatg gatgaatgtttgacagtcccttcgggtgaacatggagaagaacaaagaaggactgtccat tatgaaggtggtgctgtgtccattcatgctcgttccctttggcgactagagactctaaga gttgcgtggagtggcagccacattagatggggacagccattcagactaagacatataaca acaggaaaatatttaagtctcctggatgacaagagtcttcttcttacagacaaagagaag gcagatgtaaaatctacagcattctgttttcggtcttccaaggaaaaattggacataggg acaagaaaagaggtggatggaatgggagcacctgaaataaagtatggggattcaatatgc ttcatacaacatgtagatacaggcttatggctcacataccagtcagctgatgcaaagtct gtaaggatgggttctctgcagcgaaaggcaataatgcaccatgaagggcacatggatgat ggtttaacactgtccagatctcagaatgaagaatcccgtacagcacgtgtcatccgtagt acagtcttccttttcaacaggttcataaggggccttgattctctcaacaagaaagtgaag tcttccatcatcgatttgcctatcgagtcagtcagtctgagccttcaggacttgattggc tactttcacccccctgatgaacatttggagcatgaaaacaaacaaaacaggctccgagca ctgaagaatcgccagaacctcttccaagaagagggtatgatcaaccttgttcttgaatgt attgatcgcttgaatgtatacagcagtgcagctcactttgcagatgtagctgggaaggag gctggagaagcatggaaatctattctgaattctttgtatgaattactagcggctctgatt cgaggaaatcgtaaaaactgtgctcaattttctggatctcttgattggttgataagcaga ttagaaagactggaagcctcttctggaattctagaagttttacattgtgtgttggtagaa agtccagaagctctaaacattattaaggaaggacatattaaatcaattatctgtcttttg gacaagcatggaagaaaccataaggttttggatgttttgtgttctctctgtgtttgtcat ggagtagctgtgcggtctaatcaacatctaatctgtgataatctcctgccaggaagagat ctgctcttacagacacgccttgtcaaccatgtgagcagcatgcgacccaacatcttcttg gggattagtgaaggctcggcccaatacaggaaatggtactatgaactgatggtggaccat ctagagccctttgtgactgcagaatcaactcatctacgagtgggctgggcttcaacagaa ggctactcaccctacccagggggaggagcagaatggggaggaaatggtgttggtgatgat ttatattcctatggctttgatggtctacatctgtggtcaggctgtgtagcacgaacagta aattctcccaaccaacatctgttacgaactgatgatgttattagctgctgtttggacctg agtgcccccagcatctctttccgaataaatggtcagccagttcaaggaatgtttgaaaac ttcaacatagatggcctcttcttcccagttgtcagcttctctgcaggaataaaggttcgt ttcttgcttggaggtcgccatggagagttcaagttccttcctccacctggatatgctcca tgctttgaagctgtcctgccaaaggagaagctgaaagtggagcacagccgagagtacaaa caagatcgtagctacacaagagacctactgggtcccactgtgtctctgtcacaagcagct ttcactccagttcctgtagatactagtcagattgttttgcctccccacctggaaaggatt agagaaaaattagcagagaacatccatgaactttgggttatgaataagattgaacttggc tggcagtatggaccagttagagacgacaacaaaagacaacacccgtgcttagtggagttc tcgaaattgccagagcaggaaagaaattataacttgcaaatgtcacttgaaacactgaaa accctgttggcattaggttgccatgtaggaattgctgatgaacgtgctgaagaaaaagtg aaaaaaatgaaacttccaaagaactatcagttgttgagtggatataagccagcacccatg gatctgagttttatcaagctgaccccctctcaagaagctatggtggataaactagcagag aacgctcacaatgtctgggcaagggaccgtataaggcaaggctggacatacggcatccag caggatgtgaaaaatcgacgaaatcctcgccttgtaccgtacgctcttttggatgatcgg acaaagaagtccaacaaggacagtcttcgggaggcagtccgcacccttctaggctatggt tacaatctggaagctcctgatcaagatcatgcaacaagacttgacatgtgcagtgggata atggaaaagttcaggatctttcgcacagaaaagacttatgcagtgaaggctgggaagtgg tactttgagtttgaggcagttactgcaggagacatgagagttggctggaccaggcctggt tgtctgccagatcaggaacttggctcagatgaagaagcttttgtttttgatggctttaag gcacagcggtggcatcaaggtaatgagcattttggccgctcttggttggcaggagatgtt gttggatgtatggtggacatgaatgagcacactatgatgttcaccttaaatggtgaaatc ctgcttgatgactcaggctcagaacttgcatttaaggactttgaggttgctgatggattt ctacctgtgtgcagcctcggcccatctcaagtgggaagaatgaactttggaaaagatgtc agcactctaaaatatttcactatatgtggcttacaagaagggtatgaaccctttgctgtt aatacaaacagagacatcaccatttggctgagtaaaaggcttcctcagtttctaccagtg ccacaaaaccatgaacatattgaggtgatgagaattgatggcaccatagacagctgcccc tgtctgaaggtcacacagaagtcttttggttcccagaacagtaaaacagatgtcatgttt tttcgattaagcatgcccattgaatgtgctgaggtgttctccagatcagctgcaggaggg ttaccaggctctggtctttttggcccaaaaaatgacttggaggattatgatgctgattct gattttgaggttctaatgaaaactgctcatggtcatctagttcctgaccggacagaaaga gaaaaagatgccacaaaaccagagttgaataaccataaagattatgttcaagaaaagccc tcacgtcttaaacaaagatttatgctcaggaggacaaagccagattacagcacaagtcat tctgcacggcttactgaggatgtgctagcagatgatagggatgactacgattatttgatg caaacttccacgtactattactctgtgagaatatttcctggtcaagaacctgccaatgtc tgggtgggctggattacatcagactttcaccagtatgacacaagctttgacttggacaga gtgcgtactgtcacagttacactgggagacgaaaaagggaaggttcatgagagtataaaa cgcagcaactgctatatggtgtgcgcaggagagagcctgagcccagggcaaggacggaat aataatggtctggagattgggtgcttggttgatgctgccagtggcctgctgaccttcaca gctaatggcaaggagctaggcacctactatcaggttgaaccaagtacaaagttgtttcct gctgtatttgctcaagctacaagccccaatgttttccagtttgaattgggaagaataaag aatgtaatgccattatctgctggattattcaaaagtgaacacaaaaatccagtctctcaa tgtcctccacgtctccatgtccagtttctgactcatgtgctttggagcagagtgccaaac cacttcctgaaggtggatgtgtctcggatcagtgaacgtcaaggctggatgatacagtgc ctgaatcctttgcagttcatggcccttcatattcctgaggaaaacagaacgattgatatt ttagagctgacagaacaagaagaattgctgaaatttcactaccacaccctccgattgtat tcagctgtttgtgctttaggcaacaaccgagtggcccacgctctgtgtagccatgtggat gaatctcagctcctctatgctattgagaataaatacatgccaggattattacgtgcagga tattatgacttactcattgacatccatcttaatacctatgcaactgccaggctgatgatg aataatgaatttatagttccaatgacagatgagaccaagagtattactttgtttcctgat gaaaacaaaaaacacggccttcctggtataggacttagcacttccttaaggccaagaatg cagttttcctctccgagttttgtaagcattagcagtgaatgctttcagttcagtcctgaa ttccctctggaaattttgaaggccaaaaccatagagatgctgactgaagctgtccaggag ggaagcctccatgtcagagatccagttggaggttctacagaatttctgtttgtccctctc atcaagctcttttatacccttctaattatgggaatcttccacaatgaggatctgaaacac atcttgcagttgattgaaccccgagttttcaaagaagcaatgagccaggaggatgaagtt gatttctcagagaaggagttcagttcagatgagttcaagtcagaagaaggagaggaagaa accagaggggaacagatgccaaaggaaggactccttcagatgaaacttccagaacctgtt aaattacagatgtgtcatctgctccagtacctgtgtgattgccaagtacgacaccgaata gaagccattgtagcattttccgatgattttgtggccaagctccaagagaatcaacgcttc cggtacaatgaagtgatgcaggccttgaacatgtctgctgccctcacagctagaaaaaca aaagaatttcgatcccctcctcaagaacagattaacatgctgctgaactttaaagatgat aaaaatgattgtccttgccctgaagaaattcgggatcaactcttggatttccatgaagac ctaatgacacactgtggaattgaactagatgaagatggaaccttggatggcaacagtgat tcaaccattaggggtcgcctcctataccttatggaaaaagttacatatctgaagaagaaa caagctgagaagacagttgatgatgatgataagacatcctctactctccagcagttgatt tcggagacgatggtgcgttgggcccaggagtcagtgatagaggacccggagttagtgagg gccatgtttgtgttgctgcatcgccagtatgatggtattggtggcctggtgcgagccctg ccaaagacctacaccattaatagcgtgtctgtggaagacaccatcaatcttctggcatcc cttggccaaatccgttccttgcttagtgtcagaatggggaaggaagaggagaagcttatg attcgtggattaggagacatcatgaataataaagtattttaccaacatccaaatctcatg agagctttaggcatgcatgaaactgtcatggaagtgatggtgaatgtgcttggtggaggg gagtccaaggaaatcactttcccaaagatggtggcaaactgctgtcgttttctatgttat ttttgccgcatcagcaggcagaatcaaaaagctatgtttgatcatcttagctatttattg gaaaacagcagtgttggccttgcctccccttctatgcgagggtcaactcctttagatgtt gccgcagcgtctgtaatggataacaatgaacttgctctggctttaagggagcctgatctg gagaaggtggttcgctacttggctggatgtgggttgcagagttgtcctttgttgatttgt aaaggctacccggacattggatggaatccagttgaaggagaacgatatttggattttctt cgttttgctgttttttgcaatggagagagtgtggaggagaatgctaatgttgtggtcagg ctgcttattcgccggcctgaatgttttggtcctgctctaagaggagaaggaggcaatggg ctgcttgctgccatggaggaggcaatacaaatatcagaagaccgaacaagagatggacct tccccaagtaatggatctagtaaaacccttgaaatagaagaacaagaagatgacactatt cacatgggaaatgcaataatgaccttttatgctgccttgattgatctcttaggacgttgt gcccctgaaatgcatctaatccatgctggtaaaggggaagccattagaatcagatcaatt ctacgatctttgattccacttgaagatttggtgggagtaatcagtattgctttccatatg ccaaccatagcaaaagatggtactgtggtggaacctgacatgtctgcggggttttgccca gatcacaaggcagccatggttttgttccttgacagggtctatggaattgaggaccaggat tttcttctacaccttcttgaagttggctttctgccagacctccgtgctgctgcctcatta gatacggctgctttaagtgctacagatatggctttggctctgaatcgatacctttgcaca gcagtcttgcctctcctgaccagatgtgctcctctgtttgctggcacggagcaccacgct tccctcatcgattccttattacacactgtgtacagactctcaaagggatgctctcttacc aaagctcagcgagattctattgaagagtgtttgctctctatctgtgggcagttgcgccct tccatgatgcagcatttgctgaggagattagtatttgatgtacctctgttaaatgaacat gcaaagatgcctctcaagttgctgacaaatcattatgaaagatgctggaagtattattgt ttgccaagtggatggggtaactttggtgctgcctcagaagaagagcttcatttatccaga aagttgttctggggtatttttgatgctttatctcaaaagaagtatgaacaagaactgttc aaattggctttgccttgtctgagtgcggttgcaggagccttacctccagattatatggaa tcaaattatgtcaatatgatggaaaaacagtcttcaatggattcagatgggaactttaat cctcaacctgttgatacctcaaacattacgatccctgaaaagctagaatatttcattaac aaatatgcagagcatgctcatgacaaatggtcaatggaaaagtttgccaatggatggacc tatggtgaaacattttctgaatctgcaaaagtgcaaccattgatgaaacaatataagtta ctgtctgaaaaggagaaagaaatttatcgatggccaatcaaagaatcactaaaaaccatg ctggcatggggatggcgaattgaaagaacacgggaaggagattccatggcactgtataat cggacacgccgcatctctcaaaccagtcaaatctctgtagatacagcccatggttacact cctcgtgcaattgacatgagcaatgtcaccctctccagagacttacatgctatggctgag atgatggctgaaaactatcataacatatgggcaaagaaaaagaaactggagcttgaagca aaagtaggaggaggcaaccatccccttcttgttccttatgatacattaacagccaaagaa aaagccaaggacagagaaaaagcacaagatattctgaaatttctacagattaatggatat gttgtctccaggggacttaaggacctggaattagacacgccttccattgagaaacgcttt gcctacagtttccttcagcaacttataagatatgtggatgaagcccatcagtacattttg gagtttgatggtggcagcagaggcaaaggagagcaattcccgtatgaacaagaaatcaag ttttttgccaaagttgtgctccctttgattgatcagtattttaaaaatcatcgcctgtat ttcttatcttcagcaagtaggcctctcagcagtggaggccatgcctctaataaagagaaa gaaatggtgacaagcctgttctgcaaacttggagttcttgtcaggcataggatttcactg tttggaaatgatgcaacatcaatagtcaactgtcttcacatactgggacagaccttggat gcaaggactgtgatgaaaactggtctggagtctgttaggatggcattgagagcatttttg gacaatgctgctgaggatctggagaaaacaatggaaaatcttaagcaaggccagtttaca cacagcagaaaccagccaaaaggagttacacagatcattaattacaccacagttgctctt ctgccagtgctatcttcattatttgagcatattggacagcatcaatttggggaagatttg atattggaagatgttcaggtctcttgttacagaatattggacagtttatatgctctggga accagcaagagtatctatgtagagaggcaacgatcagcactgggagagtgcttggctgct ttctcaggggcctttcccgtggcttttttggaaactcacttgaacaaacataatatctac tcaatctacaataccaagaacgcgagagatagagcagttctcaatttgccaactagtgta gaagaggtttgcccaaatattccttccttggtgaagctaatggaagaaatagtggaactg gcagaatccggtattcgttacacacaaatgccacacatcatggaagtcatactgcctatg ctgtgcagttacatgtcccactggtgggagcatgggccagagaacaatcctgacagggct gaaatgtgttgcacagccttgacatcagagcacatgaacactctgttgggtaacatattg aaaatcatctataacaacctcggtattgatgaaggagcctggatgaagagattagcagtg ttttcccagcccatcataagtaaagcgaagccacagctcttaaagacacacttcctccca ctgatggataaactaaagaaaaaggcagcagtggttgtatcggatgaagaacatctaaga gcagaaggcagaggtgacatgtcggaggctgaactgctcatcctagatgagttcaccact ttggcacgggacctctatgccttctaccctttgttgattagatttgtggactataacaga gcaaaatggctgaaagagcccaatcctgaagcagaagaattgttccgcatggtggctgag gtcttcatttactggtcaaagtctcataatttcaaaagggaagaacagaattttgtagta cagaatgaaatcaacaacatgtctttccttatcagtgacaccaaatctaagatgtctaag gcagcagtttctgaccaggaaaggaagaagatgaagcgaaaaggtgaccgctactctatg cagacctctctcattgtggcagcactgaagagattgcttccaataggcctcaacatttgt gctcctggagaccaagagctaattgcactggccaaaaatcgatttagcatgaaagacact gaagatgaagtacgagatgtcatccgcagtaatcttcaccttcagggcaagcttgaggat cctgccattagatggcagatggcactttacaaagatttgccaaacaggactgaagattcc tcagatccagagaagactgtggaaagggtccttgatatagctaatgtgctgtttcacctg gaacagaaatctgcttgcgtaggccgaggctatttcttttgggaaaatttagttgagcat cctcagcggtccaaaaaagcagtgtggcataagctgctgtctaaacagaggaaacgagca gtagttgcctgctttagaatggcaccgttgtataatctgccaagacaccgagccgtcaat ctctttcttcaaggctatgataaatcttggattgaaacagaagaacactattttgaagac aaactgatagaagacttagcaaaacctggagaggaaccaccagaagaagatgaaagcatt aaaagagttgatcctttacatcaacttattctgctattcagtcgaacagccttgactgaa aaatgcaaattggaagaagatttcctgtatatggcttatgctgacattatggcaaagagc tgccatgatgaagaagatgatgatggtgaagaagaagtgaagagttttgaggaaaaagaa atggaaaagcaaaagcttctgtatcaacaagccagactgcatgatcggggtgctgctgag atggttctgcagacaatcagtgcaagtaaaggtgagatggggccaatggttgctgctacc ctaaagctaggaattgccatcttaaatgggggaaattctactgttcaacagaaaatgctt gactacctcaaggataaaaaggatgtgggattctttcagagccttgctggtcttatgcag tcctgtagtgttcttgacctaaatgcgtttgaacgtcagaacaaagcagaaggccttggc atggtgactgaagagggatcaggagaaaaggtgatgcaggatgatgagttcacctgtgac ctcttccgcttccttcagttgctttgtgaaggacacaattcagattttcagaattacctg agaactcaaactggtaacaacacaactgttaatattatcatttctactgtggattactta ttgagagttcaggaatccatcagtgatttctattggtattattctgggaaggatgttatt gatgaacaaggacaacgaaatttttccaaagccatccaggttgcaaaacaagttttcaat actctcacagagtatatccaggggccatgtactgggaatcagcaaagtctggcacacagc aggctgtgggatgctgtagttggtttccttcatgtgtttgcccacatgcagatgaagctg tctcaggattccagtcaaattgaactattgaaggaattaatggatcttcagaaagatatg gttgtcatgttgctgtcaatgctggaaggtaatgttgtgaatggaactattggaaagcag atggtcgatatgcttgtggaatcatcgaacaatgtggagatgattctgaagttttttgat atgttcttaaaattgaaagatttgacttcctctgatgcattcaaagaatatgaccctgat ggtaaagggataatttcgaaaagggattttcacagggcaatggaaagccataagcactac actcagtctgaaactgagtttctgctgtcatgtgctgaaacagatgagaatgagactttg gactacgaggagtttgtgaaacgatttcatgagccggcaaaagacattggtttcaatgtc gctgttctcctgaccaacctgtcagaacacatgccccatgacacgcgcttgcagactttc cttgagctctcagagagtgtgctgaactactttcagcctttcctcggacgtatagaaatc atgggcagcgcaaagcgcattgagcgagtttattttgaaataagtgagtcaagtcggact cagtgggaaaaacctcaggtaaaagagtcaaagagacagtttatatttgatgttgtaaat gaaggtggggagaaagaaaagatggagctttttgttaacttctgtgaggataccatcttt gaaatgcaactggctgcccagatttctgagtcagatctgaacgaaaggtcagctaataag gaggagaatgagaaagataatcctgaggaagaagatcctagaatgggtttcttctctctc gtgaccatgaagtcagctttagtagctctcaagtataatttaatgactcttatgaaaatg ctcagcatgaagagtctaaagaaacaaatgaaaaaagtgaagaaaatgaccatgaaggac atggtcatggctttgttttcttcctactggagcatattggtgggcttactacattttgct tgcagtgttgtccggggcttttttcgcatcatatgcagtttgctgcttggaggaagcctt gtagaaggagccaagaaaatcaaggtggctgaactgttggctaacatgccagatcccact caggatgaggtgcgtggggaagaagaagaaggggagaggaaaccaacagaagctgcattg cctgcggaagacttgacggatctgcagactttaacagaagagagtgatctgctctcagat atatttggtttggatttgaaacgagaaggtggacagtataaattgatccctcacaatcca aatgctggtttgagtgatttactaagcactccttccttagccccaatgcccgaagtacag gaaaaaatccaggagaaggttaaagaagatgaaaaggaagagaaagaagaaacaaaatca gaacctgaaaaagctgaaggagaagatggagaaaaagaagagaaaaccaaggaagacaaa gggaaacagaaattaagacaactgcatacgcacagatacggagaaccagaagttcaagaa tcagttttctggaagaatatcattgcataccagcagaagcttcttaattattttgcacga aacttttacaacatgaggatgttggcattatttgttgcttttgccatcaactttatcctt cttttctataaggtctccacatctgctgtgacagaagaaaaggagcttcctgtggtatct gatggtgaaagtaccaagttgaacatcctggaaagcgatgatgatgagagggtcattgca gtgcattatgtcttggaagaaagcagtggctacatggagcccacactgaggattttggcc atcctacacacagtcatctcattcttttgcatcatagggtattattgtttgaaagttcca ctggttatttttaagagagaaaaggaagtggcaaggaaattggaattcgatgggctatat ataactgagcagccatcagaagatgatattaagggacagtgggatagacttgtaatcaac acacagtcttttccaaataactattgggacaagtttgtgaaaagaaaggttatggataaa tatggtgagttctatggccgtgacaggatcagtgaattattaggaatggacaaagctgct cttgattttagtgatgctcgagaaaagaagaaaccaaagaaggatagctccttttctgct gtgctaaattccattgatgttaagtatcagatgtggaaattaggagttgttttcactgat aattctttcctttacctagcctggtacatgaccatgtcagtccttggccattacaacaat tttttcttcgctgctcacctccttgacattgcaatgggattcaagacattacgaactatc ctgtcatcagttacccacaatggcaaacagcttgtcctaacagtggggttattggcagta gtggtgtacttgtatacagtagtggcattcaattttttccgcaagttctacaacaagagt gaagacggtgatatgccagacatgaaatgtgatgatatgctaacatgctacatgtttcat atgtacgttggagtacgtgcaggaggaggcattggtgatgaaatagaagatccagcagga gatgaatatgaaatctatcggattatctttgacatcactttcttcttctttgtaattgtc atcctgcttgcaattatccaaggtttaattattgatgcttttggtgagttaagagatcag caagagcaagttaaggaagacatggagacaaagtgctttatctgtggaataggaaatgac tactttgatacagtgcctcatggctttgaaacacacacactacaggagcacaacttggcc aattatttgttttttctgatgtatcttattaacaaagatgaaaccgagcatacaggacag gaatcatatgtatggaaaatgtatcaagaacggtgctgggagtttttccctgctggtgat tgcttccgaaaacaatatgaagaccagctcaactaa

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