KEGG   Sciurus vulgaris (Eurasian red squirrel): 306641190
Entry
306641190         CDS       T11892                                 
Symbol
AKT3, ACX6B4_003622
Name
(RefSeq) RAC-gamma serine/threonine-protein kinase isoform 1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
svul  Sciurus vulgaris (Eurasian red squirrel)
Pathway
svul01521  EGFR tyrosine kinase inhibitor resistance
svul01522  Endocrine resistance
svul01524  Platinum drug resistance
svul04010  MAPK signaling pathway
svul04012  ErbB signaling pathway
svul04014  Ras signaling pathway
svul04015  Rap1 signaling pathway
svul04022  cGMP-PKG signaling pathway
svul04024  cAMP signaling pathway
svul04062  Chemokine signaling pathway
svul04066  HIF-1 signaling pathway
svul04068  FoxO signaling pathway
svul04071  Sphingolipid signaling pathway
svul04072  Phospholipase D signaling pathway
svul04140  Autophagy - animal
svul04150  mTOR signaling pathway
svul04151  PI3K-Akt signaling pathway
svul04152  AMPK signaling pathway
svul04210  Apoptosis
svul04211  Longevity regulating pathway
svul04213  Longevity regulating pathway - multiple species
svul04218  Cellular senescence
svul04261  Adrenergic signaling in cardiomyocytes
svul04370  VEGF signaling pathway
svul04371  Apelin signaling pathway
svul04380  Osteoclast differentiation
svul04510  Focal adhesion
svul04517  IgSF CAM signaling
svul04518  Integrin signaling
svul04550  Signaling pathways regulating pluripotency of stem cells
svul04611  Platelet activation
svul04613  Neutrophil extracellular trap formation
svul04620  Toll-like receptor signaling pathway
svul04625  C-type lectin receptor signaling pathway
svul04630  JAK-STAT signaling pathway
svul04660  T cell receptor signaling pathway
svul04662  B cell receptor signaling pathway
svul04664  Fc epsilon RI signaling pathway
svul04666  Fc gamma R-mediated phagosome formation
svul04668  TNF signaling pathway
svul04722  Neurotrophin signaling pathway
svul04725  Cholinergic synapse
svul04728  Dopaminergic synapse
svul04810  Regulation of actin cytoskeleton
svul04910  Insulin signaling pathway
svul04914  Progesterone-mediated oocyte maturation
svul04915  Estrogen signaling pathway
svul04917  Prolactin signaling pathway
svul04919  Thyroid hormone signaling pathway
svul04920  Adipocytokine signaling pathway
svul04922  Glucagon signaling pathway
svul04923  Regulation of lipolysis in adipocytes
svul04926  Relaxin signaling pathway
svul04929  GnRH secretion
svul04931  Insulin resistance
svul04932  Non-alcoholic fatty liver disease
svul04933  AGE-RAGE signaling pathway in diabetic complications
svul04935  Growth hormone synthesis, secretion and action
svul04936  Alcoholic liver disease
svul04973  Carbohydrate digestion and absorption
svul05010  Alzheimer disease
svul05017  Spinocerebellar ataxia
svul05132  Salmonella infection
svul05135  Yersinia infection
svul05142  Chagas disease
svul05145  Toxoplasmosis
svul05152  Tuberculosis
svul05160  Hepatitis C
svul05161  Hepatitis B
svul05162  Measles
svul05163  Human cytomegalovirus infection
svul05164  Influenza A
svul05165  Human papillomavirus infection
svul05166  Human T-cell leukemia virus 1 infection
svul05167  Kaposi sarcoma-associated herpesvirus infection
svul05168  Herpes simplex virus 1 infection
svul05169  Epstein-Barr virus infection
svul05170  Human immunodeficiency virus 1 infection
svul05200  Pathways in cancer
svul05205  Proteoglycans in cancer
svul05207  Chemical carcinogenesis - receptor activation
svul05208  Chemical carcinogenesis - reactive oxygen species
svul05210  Colorectal cancer
svul05211  Renal cell carcinoma
svul05212  Pancreatic cancer
svul05213  Endometrial cancer
svul05214  Glioma
svul05215  Prostate cancer
svul05218  Melanoma
svul05220  Chronic myeloid leukemia
svul05221  Acute myeloid leukemia
svul05222  Small cell lung cancer
svul05223  Non-small cell lung cancer
svul05224  Breast cancer
svul05225  Hepatocellular carcinoma
svul05226  Gastric cancer
svul05230  Central carbon metabolism in cancer
svul05231  Choline metabolism in cancer
svul05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
svul05415  Diabetic cardiomyopathy
svul05417  Lipid and atherosclerosis
svul05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:svul00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    306641190 (AKT3)
   04012 ErbB signaling pathway
    306641190 (AKT3)
   04014 Ras signaling pathway
    306641190 (AKT3)
   04015 Rap1 signaling pathway
    306641190 (AKT3)
   04370 VEGF signaling pathway
    306641190 (AKT3)
   04371 Apelin signaling pathway
    306641190 (AKT3)
   04630 JAK-STAT signaling pathway
    306641190 (AKT3)
   04668 TNF signaling pathway
    306641190 (AKT3)
   04066 HIF-1 signaling pathway
    306641190 (AKT3)
   04068 FoxO signaling pathway
    306641190 (AKT3)
   04072 Phospholipase D signaling pathway
    306641190 (AKT3)
   04071 Sphingolipid signaling pathway
    306641190 (AKT3)
   04024 cAMP signaling pathway
    306641190 (AKT3)
   04022 cGMP-PKG signaling pathway
    306641190 (AKT3)
   04151 PI3K-Akt signaling pathway
    306641190 (AKT3)
   04152 AMPK signaling pathway
    306641190 (AKT3)
   04150 mTOR signaling pathway
    306641190 (AKT3)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    306641190 (AKT3)
   04518 Integrin signaling
    306641190 (AKT3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    306641190 (AKT3)
  09143 Cell growth and death
   04210 Apoptosis
    306641190 (AKT3)
   04218 Cellular senescence
    306641190 (AKT3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    306641190 (AKT3)
   04550 Signaling pathways regulating pluripotency of stem cells
    306641190 (AKT3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    306641190 (AKT3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    306641190 (AKT3)
   04613 Neutrophil extracellular trap formation
    306641190 (AKT3)
   04620 Toll-like receptor signaling pathway
    306641190 (AKT3)
   04625 C-type lectin receptor signaling pathway
    306641190 (AKT3)
   04660 T cell receptor signaling pathway
    306641190 (AKT3)
   04662 B cell receptor signaling pathway
    306641190 (AKT3)
   04664 Fc epsilon RI signaling pathway
    306641190 (AKT3)
   04666 Fc gamma R-mediated phagosome formation
    306641190 (AKT3)
   04062 Chemokine signaling pathway
    306641190 (AKT3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    306641190 (AKT3)
   04922 Glucagon signaling pathway
    306641190 (AKT3)
   04923 Regulation of lipolysis in adipocytes
    306641190 (AKT3)
   04920 Adipocytokine signaling pathway
    306641190 (AKT3)
   04929 GnRH secretion
    306641190 (AKT3)
   04915 Estrogen signaling pathway
    306641190 (AKT3)
   04914 Progesterone-mediated oocyte maturation
    306641190 (AKT3)
   04917 Prolactin signaling pathway
    306641190 (AKT3)
   04926 Relaxin signaling pathway
    306641190 (AKT3)
   04935 Growth hormone synthesis, secretion and action
    306641190 (AKT3)
   04919 Thyroid hormone signaling pathway
    306641190 (AKT3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    306641190 (AKT3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    306641190 (AKT3)
  09156 Nervous system
   04725 Cholinergic synapse
    306641190 (AKT3)
   04728 Dopaminergic synapse
    306641190 (AKT3)
   04722 Neurotrophin signaling pathway
    306641190 (AKT3)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    306641190 (AKT3)
  09149 Aging
   04211 Longevity regulating pathway
    306641190 (AKT3)
   04213 Longevity regulating pathway - multiple species
    306641190 (AKT3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    306641190 (AKT3)
   05205 Proteoglycans in cancer
    306641190 (AKT3)
   05207 Chemical carcinogenesis - receptor activation
    306641190 (AKT3)
   05208 Chemical carcinogenesis - reactive oxygen species
    306641190 (AKT3)
   05230 Central carbon metabolism in cancer
    306641190 (AKT3)
   05231 Choline metabolism in cancer
    306641190 (AKT3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    306641190 (AKT3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    306641190 (AKT3)
   05212 Pancreatic cancer
    306641190 (AKT3)
   05225 Hepatocellular carcinoma
    306641190 (AKT3)
   05226 Gastric cancer
    306641190 (AKT3)
   05214 Glioma
    306641190 (AKT3)
   05221 Acute myeloid leukemia
    306641190 (AKT3)
   05220 Chronic myeloid leukemia
    306641190 (AKT3)
   05218 Melanoma
    306641190 (AKT3)
   05211 Renal cell carcinoma
    306641190 (AKT3)
   05215 Prostate cancer
    306641190 (AKT3)
   05213 Endometrial cancer
    306641190 (AKT3)
   05224 Breast cancer
    306641190 (AKT3)
   05222 Small cell lung cancer
    306641190 (AKT3)
   05223 Non-small cell lung cancer
    306641190 (AKT3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    306641190 (AKT3)
   05170 Human immunodeficiency virus 1 infection
    306641190 (AKT3)
   05161 Hepatitis B
    306641190 (AKT3)
   05160 Hepatitis C
    306641190 (AKT3)
   05164 Influenza A
    306641190 (AKT3)
   05162 Measles
    306641190 (AKT3)
   05168 Herpes simplex virus 1 infection
    306641190 (AKT3)
   05163 Human cytomegalovirus infection
    306641190 (AKT3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    306641190 (AKT3)
   05169 Epstein-Barr virus infection
    306641190 (AKT3)
   05165 Human papillomavirus infection
    306641190 (AKT3)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    306641190 (AKT3)
   05135 Yersinia infection
    306641190 (AKT3)
   05152 Tuberculosis
    306641190 (AKT3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    306641190 (AKT3)
   05142 Chagas disease
    306641190 (AKT3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    306641190 (AKT3)
   05017 Spinocerebellar ataxia
    306641190 (AKT3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    306641190 (AKT3)
   05418 Fluid shear stress and atherosclerosis
    306641190 (AKT3)
   05415 Diabetic cardiomyopathy
    306641190 (AKT3)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    306641190 (AKT3)
   04932 Non-alcoholic fatty liver disease
    306641190 (AKT3)
   04931 Insulin resistance
    306641190 (AKT3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    306641190 (AKT3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    306641190 (AKT3)
   01524 Platinum drug resistance
    306641190 (AKT3)
   01522 Endocrine resistance
    306641190 (AKT3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    306641190 (AKT3)
Enzymes [BR:svul01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     306641190 (AKT3)
Protein kinases [BR:svul01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   306641190 (AKT3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 ABC1
Other DBs
NCBI-GeneID: 306641190
NCBI-ProteinID: XP_078962263
LinkDB
Position
12:complement(53748639..54060575)
AA seq 479 aa
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
NT seq 1440 nt   +upstreamnt  +downstreamnt
atgagcgatgttaccattgtgaaagaaggttgggttcagaagaggggagaatatataaaa
aactggaggccaagatatttccttttgaagacagatggctcattcataggatataaagag
aaacctcaagatgtggatttaccttatcccctcaacaacttttcagtggcaaaatgccag
ttaatgaaaacagaacgaccaaagccaaacacatttattatcagatgtctccagtggacc
accgttatagagagaacatttcatgtagatactccagaggaaagggaagaatggacagag
gctattcaggctgttgcagacagactacagaggcaagaagaagagagaatgaattgtagt
ccaacttcacaaattgataatataggagaagaagaaatggatgcttctacaacccatcat
aaaagaaagacaatgaatgattttgactatttgaaactactaggaaaaggcacttttggg
aaagttattttggttcgtgagaaggcaagtgggaaatactatgctatgaagattctgaag
aaagaagtcattattgcaaaggatgaagtagcacacactctaactgaaagcagagtatta
aagaacactagacatccatttttaacatccttgaaatattccttccagacaaaagaccgt
ttgtgttttgtgatggaatatgttaatgggggagagctgtttttccatttgtcgagagag
cgggtgttctctgaggaccgcacacgtttctatggtgcagaaattgtctctgctttggac
tatctacattccgggaagattgtgtaccgtgatctcaagttggagaatttgatgttggac
aaagatggacacataaaaattacagatttcggcctttgcaaagaagggatcacagatgca
gctactatgaagacattctgtggtactccagaatatctggcaccagaggtgttagaagat
aatgactacggccgagcagtagactggtggggcctaggagttgtcatgtatgaaatgatg
tgtggaaggttacctttctacaaccaggatcatgaaaaactctttgaactaatactaatg
gaggatattaagtttcctagaactctttcttcagatgcaaaatcattgctttcagggctc
ttgataaaggatccaaataaacgccttggtggaggaccagatgatgcaaaagaaattatg
agacacagcttcttttctggagtaaactggcaagatgtgtatgataaaaagcttgtacct
ccttttaagcctcaagtaacatctgagacagataccagatattttgatgaagaattcaca
gctcagactattacaataacaccacctgaaaaatatgacgaggatggtatggactgcatg
gacaatgagcggcggccgcatttccctcagttctcctactctgcaagtggacgagaataa

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