KEGG   Tachyglossus aculeatus (Australian echidna): 119920101
Entry
119920101         CDS       T10703                                 
Symbol
AKT1
Name
(RefSeq) RAC-alpha serine/threonine-protein kinase
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
tacu  Tachyglossus aculeatus (Australian echidna)
Pathway
tacu01521  EGFR tyrosine kinase inhibitor resistance
tacu01522  Endocrine resistance
tacu01524  Platinum drug resistance
tacu04010  MAPK signaling pathway
tacu04012  ErbB signaling pathway
tacu04014  Ras signaling pathway
tacu04015  Rap1 signaling pathway
tacu04022  cGMP-PKG signaling pathway
tacu04024  cAMP signaling pathway
tacu04062  Chemokine signaling pathway
tacu04066  HIF-1 signaling pathway
tacu04068  FoxO signaling pathway
tacu04071  Sphingolipid signaling pathway
tacu04072  Phospholipase D signaling pathway
tacu04140  Autophagy - animal
tacu04150  mTOR signaling pathway
tacu04151  PI3K-Akt signaling pathway
tacu04152  AMPK signaling pathway
tacu04210  Apoptosis
tacu04211  Longevity regulating pathway
tacu04213  Longevity regulating pathway - multiple species
tacu04218  Cellular senescence
tacu04261  Adrenergic signaling in cardiomyocytes
tacu04370  VEGF signaling pathway
tacu04371  Apelin signaling pathway
tacu04380  Osteoclast differentiation
tacu04510  Focal adhesion
tacu04517  IgSF CAM signaling
tacu04518  Integrin signaling
tacu04550  Signaling pathways regulating pluripotency of stem cells
tacu04611  Platelet activation
tacu04613  Neutrophil extracellular trap formation
tacu04620  Toll-like receptor signaling pathway
tacu04625  C-type lectin receptor signaling pathway
tacu04630  JAK-STAT signaling pathway
tacu04660  T cell receptor signaling pathway
tacu04662  B cell receptor signaling pathway
tacu04664  Fc epsilon RI signaling pathway
tacu04666  Fc gamma R-mediated phagocytosis
tacu04668  TNF signaling pathway
tacu04722  Neurotrophin signaling pathway
tacu04725  Cholinergic synapse
tacu04728  Dopaminergic synapse
tacu04810  Regulation of actin cytoskeleton
tacu04910  Insulin signaling pathway
tacu04914  Progesterone-mediated oocyte maturation
tacu04915  Estrogen signaling pathway
tacu04917  Prolactin signaling pathway
tacu04919  Thyroid hormone signaling pathway
tacu04920  Adipocytokine signaling pathway
tacu04922  Glucagon signaling pathway
tacu04923  Regulation of lipolysis in adipocytes
tacu04926  Relaxin signaling pathway
tacu04929  GnRH secretion
tacu04931  Insulin resistance
tacu04932  Non-alcoholic fatty liver disease
tacu04933  AGE-RAGE signaling pathway in diabetic complications
tacu04935  Growth hormone synthesis, secretion and action
tacu04936  Alcoholic liver disease
tacu04973  Carbohydrate digestion and absorption
tacu05010  Alzheimer disease
tacu05017  Spinocerebellar ataxia
tacu05132  Salmonella infection
tacu05135  Yersinia infection
tacu05142  Chagas disease
tacu05145  Toxoplasmosis
tacu05152  Tuberculosis
tacu05160  Hepatitis C
tacu05161  Hepatitis B
tacu05162  Measles
tacu05163  Human cytomegalovirus infection
tacu05164  Influenza A
tacu05165  Human papillomavirus infection
tacu05166  Human T-cell leukemia virus 1 infection
tacu05167  Kaposi sarcoma-associated herpesvirus infection
tacu05168  Herpes simplex virus 1 infection
tacu05169  Epstein-Barr virus infection
tacu05170  Human immunodeficiency virus 1 infection
tacu05200  Pathways in cancer
tacu05205  Proteoglycans in cancer
tacu05207  Chemical carcinogenesis - receptor activation
tacu05208  Chemical carcinogenesis - reactive oxygen species
tacu05210  Colorectal cancer
tacu05211  Renal cell carcinoma
tacu05212  Pancreatic cancer
tacu05213  Endometrial cancer
tacu05214  Glioma
tacu05215  Prostate cancer
tacu05218  Melanoma
tacu05220  Chronic myeloid leukemia
tacu05221  Acute myeloid leukemia
tacu05222  Small cell lung cancer
tacu05223  Non-small cell lung cancer
tacu05224  Breast cancer
tacu05225  Hepatocellular carcinoma
tacu05226  Gastric cancer
tacu05230  Central carbon metabolism in cancer
tacu05231  Choline metabolism in cancer
tacu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
tacu05415  Diabetic cardiomyopathy
tacu05417  Lipid and atherosclerosis
tacu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:tacu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    119920101 (AKT1)
   04012 ErbB signaling pathway
    119920101 (AKT1)
   04014 Ras signaling pathway
    119920101 (AKT1)
   04015 Rap1 signaling pathway
    119920101 (AKT1)
   04370 VEGF signaling pathway
    119920101 (AKT1)
   04371 Apelin signaling pathway
    119920101 (AKT1)
   04630 JAK-STAT signaling pathway
    119920101 (AKT1)
   04668 TNF signaling pathway
    119920101 (AKT1)
   04066 HIF-1 signaling pathway
    119920101 (AKT1)
   04068 FoxO signaling pathway
    119920101 (AKT1)
   04072 Phospholipase D signaling pathway
    119920101 (AKT1)
   04071 Sphingolipid signaling pathway
    119920101 (AKT1)
   04024 cAMP signaling pathway
    119920101 (AKT1)
   04022 cGMP-PKG signaling pathway
    119920101 (AKT1)
   04151 PI3K-Akt signaling pathway
    119920101 (AKT1)
   04152 AMPK signaling pathway
    119920101 (AKT1)
   04150 mTOR signaling pathway
    119920101 (AKT1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    119920101 (AKT1)
   04518 Integrin signaling
    119920101 (AKT1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    119920101 (AKT1)
  09143 Cell growth and death
   04210 Apoptosis
    119920101 (AKT1)
   04218 Cellular senescence
    119920101 (AKT1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    119920101 (AKT1)
   04550 Signaling pathways regulating pluripotency of stem cells
    119920101 (AKT1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    119920101 (AKT1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    119920101 (AKT1)
   04613 Neutrophil extracellular trap formation
    119920101 (AKT1)
   04620 Toll-like receptor signaling pathway
    119920101 (AKT1)
   04625 C-type lectin receptor signaling pathway
    119920101 (AKT1)
   04660 T cell receptor signaling pathway
    119920101 (AKT1)
   04662 B cell receptor signaling pathway
    119920101 (AKT1)
   04664 Fc epsilon RI signaling pathway
    119920101 (AKT1)
   04666 Fc gamma R-mediated phagocytosis
    119920101 (AKT1)
   04062 Chemokine signaling pathway
    119920101 (AKT1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    119920101 (AKT1)
   04922 Glucagon signaling pathway
    119920101 (AKT1)
   04923 Regulation of lipolysis in adipocytes
    119920101 (AKT1)
   04920 Adipocytokine signaling pathway
    119920101 (AKT1)
   04929 GnRH secretion
    119920101 (AKT1)
   04915 Estrogen signaling pathway
    119920101 (AKT1)
   04914 Progesterone-mediated oocyte maturation
    119920101 (AKT1)
   04917 Prolactin signaling pathway
    119920101 (AKT1)
   04926 Relaxin signaling pathway
    119920101 (AKT1)
   04935 Growth hormone synthesis, secretion and action
    119920101 (AKT1)
   04919 Thyroid hormone signaling pathway
    119920101 (AKT1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    119920101 (AKT1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    119920101 (AKT1)
  09156 Nervous system
   04725 Cholinergic synapse
    119920101 (AKT1)
   04728 Dopaminergic synapse
    119920101 (AKT1)
   04722 Neurotrophin signaling pathway
    119920101 (AKT1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    119920101 (AKT1)
  09149 Aging
   04211 Longevity regulating pathway
    119920101 (AKT1)
   04213 Longevity regulating pathway - multiple species
    119920101 (AKT1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119920101 (AKT1)
   05205 Proteoglycans in cancer
    119920101 (AKT1)
   05207 Chemical carcinogenesis - receptor activation
    119920101 (AKT1)
   05208 Chemical carcinogenesis - reactive oxygen species
    119920101 (AKT1)
   05230 Central carbon metabolism in cancer
    119920101 (AKT1)
   05231 Choline metabolism in cancer
    119920101 (AKT1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    119920101 (AKT1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    119920101 (AKT1)
   05212 Pancreatic cancer
    119920101 (AKT1)
   05225 Hepatocellular carcinoma
    119920101 (AKT1)
   05226 Gastric cancer
    119920101 (AKT1)
   05214 Glioma
    119920101 (AKT1)
   05221 Acute myeloid leukemia
    119920101 (AKT1)
   05220 Chronic myeloid leukemia
    119920101 (AKT1)
   05218 Melanoma
    119920101 (AKT1)
   05211 Renal cell carcinoma
    119920101 (AKT1)
   05215 Prostate cancer
    119920101 (AKT1)
   05213 Endometrial cancer
    119920101 (AKT1)
   05224 Breast cancer
    119920101 (AKT1)
   05222 Small cell lung cancer
    119920101 (AKT1)
   05223 Non-small cell lung cancer
    119920101 (AKT1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    119920101 (AKT1)
   05170 Human immunodeficiency virus 1 infection
    119920101 (AKT1)
   05161 Hepatitis B
    119920101 (AKT1)
   05160 Hepatitis C
    119920101 (AKT1)
   05164 Influenza A
    119920101 (AKT1)
   05162 Measles
    119920101 (AKT1)
   05168 Herpes simplex virus 1 infection
    119920101 (AKT1)
   05163 Human cytomegalovirus infection
    119920101 (AKT1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    119920101 (AKT1)
   05169 Epstein-Barr virus infection
    119920101 (AKT1)
   05165 Human papillomavirus infection
    119920101 (AKT1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    119920101 (AKT1)
   05135 Yersinia infection
    119920101 (AKT1)
   05152 Tuberculosis
    119920101 (AKT1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    119920101 (AKT1)
   05142 Chagas disease
    119920101 (AKT1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    119920101 (AKT1)
   05017 Spinocerebellar ataxia
    119920101 (AKT1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    119920101 (AKT1)
   05418 Fluid shear stress and atherosclerosis
    119920101 (AKT1)
   05415 Diabetic cardiomyopathy
    119920101 (AKT1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    119920101 (AKT1)
   04932 Non-alcoholic fatty liver disease
    119920101 (AKT1)
   04931 Insulin resistance
    119920101 (AKT1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    119920101 (AKT1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    119920101 (AKT1)
   01524 Platinum drug resistance
    119920101 (AKT1)
   01522 Endocrine resistance
    119920101 (AKT1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tacu01001]
    119920101 (AKT1)
Enzymes [BR:tacu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     119920101 (AKT1)
Protein kinases [BR:tacu01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   119920101 (AKT1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 PH_11 Seadorna_VP7 KELK
Other DBs
NCBI-GeneID: 119920101
NCBI-ProteinID: XP_038596771
LinkDB
Position
1:143331178..143416745
AA seq 480 aa
MNDVTIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRESPLNNFSVAQC
QLMKTERPKPNTFIIRCLQWTTVIERTFHVETPEEREEWTRAIQTVADSLKKQEEELMDF
RSGSPSDNSGAEEMEVSTTKPKHKVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLSPEAKSLLSGLLKKDPKQRLGGGPDDAKEIMQHKFFAGIEWHDVYEKK
LIPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDNMECVDNERRPHFPQFSYSASGTA
NT seq 1443 nt   +upstreamnt  +downstreamnt
atgaacgacgtcacgattgtcaaggaaggctggttgcacaagcgaggagaatacatcaaa
acgtggaggccgagatattttctgctgaagaatgacgggaccttcattggctacaaagag
cggccgcaagacgtggaccagcgagagtctcccttgaacaacttctctgtggcccaatgc
cagctgatgaagacggagcgccccaagcccaacaccttcatcatcagatgtctgcagtgg
accacggtcatcgagagaaccttccatgtggagacccccgaagagagggaagaatggacc
cgggctattcagacggtggcggacagcctcaagaagcaagaggaggaattgatggatttc
aggtccgggtctcccagcgacaattccggggccgaggaaatggaggtgtcgacgacgaag
cctaaacataaagtgaccatgaatgaattcgagtacctgaagctgctggggaaaggcacc
tttggcaaggtcatcctggtgaaggagaaagccaccgggcgctactacgccatgaaaata
ctgaagaaggaggtcatcgtggccaaggatgaggtggcgcacacgttgacggagaatcga
gtcctgcagaactccaggcacccgttcctcaccgctttaaaatattctttccagacccat
gatcgcttgtgctttgtgatggagtatgctaatggtggagagttgtttttccacctatca
agagagcgggtgttttctgaagaccgggctcgattttatggcgccgagattgtatcggcc
ctggattatctccattcagagaagaatgtggtttatagagacttaaagctggaaaacctg
atgctggacaaagacggccacatcaagatcaccgacttcgggctctgcaaggaaggcatc
aaggatggagcgacgatgaagacgttctgcggcacgcccgaatatctggcccccgaggtg
ctggaggacaacgactacggacgtgcggtggactggtggggcctgggcgtggtgatgtac
gagatgatgtgcggccggctgcctttctacaaccaggaccacgagaagctcttcgagctg
atcctcatggaggagatccgcttcccccgcaccctgtcgcccgaggccaaatcgctcctg
tctgggctgctgaagaaagacccgaagcaaaggttagggggcggtccggatgacgccaaa
gagattatgcaacacaagttctttgctggcatcgagtggcatgacgtctatgagaagaag
ctcatccccccgtttaagccgcaagtcacgtcagaaactgacacaaggtattttgatgaa
gaattcacagcccagatgatcacaatcaccccacccgaccaagacgacaacatggaatgt
gtcgacaatgagcgacgcccacattttcctcagttctcctactcggccagtggaaccgct
taa

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