Tachyglossus aculeatus (Australian echidna): 119926580
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Entry
119926580 CDS
T10703
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X1
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
tacu Tachyglossus aculeatus (Australian echidna)
Pathway
tacu00790
Folate biosynthesis
tacu01100
Metabolic pathways
tacu01240
Biosynthesis of cofactors
tacu01523
Antifolate resistance
tacu04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
tacu00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
119926580 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
119926580 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
119926580 (FPGS)
Enzymes [BR:
tacu01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
119926580 (FPGS)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_C
Histone_HNS_N
Motif
Other DBs
NCBI-GeneID:
119926580
NCBI-ProteinID:
XP_038600608
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Position
4:117410606..117437393
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AA seq
586 aa
AA seq
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MKVLEPQLAPGRWLQSRSIRFEGTMHGRRLNPQPRRSEAASFEDAVRTLNTLQTNAGYLE
QMKRERGDPQAQLEAMKQYLVRSGLQVEDLDQLNIIHVTGTKGKGSTCAFTERILRNYGL
KTGFYSSPHLVQVRERIRIDGQPLSPELFTKYFWRLYHRLEETKDASCASMPPYFRFLTI
LAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGISSLGIDHTSILGDTIEKIAWQK
GGIFKPGVPAFTVSQPERPLQVLKDRARCLPCPLYLCPNLDVLEEEEQVLGLGLAGDHQR
DNAALALQLARSWLQQHGHKGIGELRAPQQGPRRILPSAPVFRPTLLMQQGLRDTEWLGR
TQVLQHGPLTWYLDGAHTTSSIQAGVRWFRQAALNQEKPSNGSEVRVLLFNASGDRDTAA
LLKLLQPCQFDYAVFCPNFAEVSTVGNADQQNFTVTLDNMLTRCLENQKQWNRLVEEKTG
LDPWLPGRPDPEGGPLHGSLRLVPSSPRPLNSNSLVFSCISHALQWISQGRDPHFQPPAP
RGLHTHPVASSGAVLLKEATAIRVLVTGSLHLVGGVLKLLDRSLSQ
NT seq
1761 nt
NT seq
+upstream
nt +downstream
nt
atgaaggtcttagaacctcagttggctccgggtaggtggcttcagtcccggagcatcagg
tttgaagggacgatgcacggtagaaggttgaatccccagccccgcaggagcgaggctgct
tcttttgaggatgcggtccggaccctcaacactctgcagaccaatgcaggctacctggag
cagatgaaacgggagcggggggatccccaggcccaactggaggccatgaagcagtacctg
gtgcgaagcgggctgcaggtggaagacttggaccagctgaatatcatccatgtaactggg
accaaaggcaagggctccacgtgtgccttcactgagcgcatcctgcgcaactacggtcta
aagacgggattctacagctccccccacctggtgcaggtgcgggagcggatccgcatcgac
gggcagcccctaagccccgagctgttcaccaaatacttctggcggctctaccaccggctg
gaggagaccaaggatgcaagctgtgccagcatgcccccctacttccgcttcctcaccatc
ctcgccttccacgtattccttcaggagaaggtggatctggctgtggtggaggtgggcatc
gggggagcttatgattgtaccaacattatcaggaagccggtggtctgtggaatctcctct
ctgggcatcgatcacaccagcatcctgggggataccatcgagaagatcgcttggcagaag
gggggcatatttaagcctggagttcccgccttcaccgtgtcccaaccggagaggcctctg
caagtactaaaggaccgagcccgctgcctcccgtgccccctctacctgtgccctaacctc
gatgtcctggaggaagaggagcaggtgctgggtctggggctggcgggggaccaccagcga
gacaatgccgccctggccctgcagctggcacggagctggctgcagcagcatggacacaag
gggattggagagctgagggccccccagcagggccccaggcgaatcctgccctcggcgccc
gtgttccggcccaccctcttaatgcagcaggggttgcgcgacacagagtggctgggccgg
acccaagtgctgcagcacgggcccctcacctggtacctggacggggctcacaccaccagc
agcatccaggctggggttcgctggttccgccaggccgccctcaatcaggagaagccgagc
aacggctcagaggtgcgggtgctactgtttaacgcttcaggggaccgagacacggctgca
ctgctgaaattgctacagccctgccagtttgactatgctgttttctgccccaactttgcc
gaggtgtcaactgtgggaaatgcagaccagcagaacttcaccgtgaccctggacaacatg
ctgacccgctgcttggagaaccagaaacagtggaaccggctggtggaggagaaaaccggg
ctggacccctggctgcctggacgtcccgaccccgagggcggcccccttcacgggtccctg
agactggtgccctcctccccccgcccgctcaactccaactccctggtgttcagctgcatc
tcccacgctctgcagtggatcagccagggccgggacccacatttccagcctcccgctccc
cgggggctccacacccaccctgtggccagcagcggggccgtcctcctcaaggaggccacc
gccatccgcgtgctggtgaccggcagcctgcacctggtgggcggggtcctgaagctgttg
gaccgatcgctgtcgcagtag
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