KEGG   Tachyglossus aculeatus (Australian echidna): 119934245
Entry
119934245         CDS       T10703                                 
Symbol
ERBB2
Name
(RefSeq) LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2
  KO
K05083  receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Organism
tacu  Tachyglossus aculeatus (Australian echidna)
Pathway
tacu01521  EGFR tyrosine kinase inhibitor resistance
tacu01522  Endocrine resistance
tacu01524  Platinum drug resistance
tacu04010  MAPK signaling pathway
tacu04012  ErbB signaling pathway
tacu04020  Calcium signaling pathway
tacu04066  HIF-1 signaling pathway
tacu04151  PI3K-Akt signaling pathway
tacu04510  Focal adhesion
tacu04520  Adherens junction
tacu04530  Tight junction
tacu05200  Pathways in cancer
tacu05205  Proteoglycans in cancer
tacu05206  MicroRNAs in cancer
tacu05212  Pancreatic cancer
tacu05213  Endometrial cancer
tacu05215  Prostate cancer
tacu05219  Bladder cancer
tacu05223  Non-small cell lung cancer
tacu05224  Breast cancer
tacu05226  Gastric cancer
tacu05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:tacu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    119934245 (ERBB2)
   04012 ErbB signaling pathway
    119934245 (ERBB2)
   04066 HIF-1 signaling pathway
    119934245 (ERBB2)
   04020 Calcium signaling pathway
    119934245 (ERBB2)
   04151 PI3K-Akt signaling pathway
    119934245 (ERBB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    119934245 (ERBB2)
   04520 Adherens junction
    119934245 (ERBB2)
   04530 Tight junction
    119934245 (ERBB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119934245 (ERBB2)
   05206 MicroRNAs in cancer
    119934245 (ERBB2)
   05205 Proteoglycans in cancer
    119934245 (ERBB2)
   05230 Central carbon metabolism in cancer
    119934245 (ERBB2)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    119934245 (ERBB2)
   05226 Gastric cancer
    119934245 (ERBB2)
   05219 Bladder cancer
    119934245 (ERBB2)
   05215 Prostate cancer
    119934245 (ERBB2)
   05213 Endometrial cancer
    119934245 (ERBB2)
   05224 Breast cancer
    119934245 (ERBB2)
   05223 Non-small cell lung cancer
    119934245 (ERBB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    119934245 (ERBB2)
   01524 Platinum drug resistance
    119934245 (ERBB2)
   01522 Endocrine resistance
    119934245 (ERBB2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tacu01001]
    119934245 (ERBB2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:tacu04147]
    119934245 (ERBB2)
   04090 CD molecules [BR:tacu04090]
    119934245 (ERBB2)
Enzymes [BR:tacu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     119934245 (ERBB2)
Protein kinases [BR:tacu01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   119934245 (ERBB2)
Exosome [BR:tacu04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   119934245 (ERBB2)
CD molecules [BR:tacu04090]
 Proteins
  119934245 (ERBB2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 ABC1 Stevor Haspin_kinase DUF4381 APH Kinase-like
Other DBs
NCBI-GeneID: 119934245
NCBI-ProteinID: XP_038609605
LinkDB
Position
11:15311389..15350011
AA seq 1264 aa
MDLPGGGGLCRRCCYFWGLLLTLLTPAVGCTQVCTGTDMKLQAPASPETHVEMLRQLYQH
CHVVQGNLEITYLPAHTDLSFLQTIEEVHGYVLIAHSLVSFVPLQRLRVVRGTQLYEERY
ALAVLENGPRGLPGAPDHAGLRELQLRSLTEILKGGVLIQGNPQLCHQDTVLWEDVIHRH
NEPAVFDIDNNRSRICGPCSSSCKFRKCWGEGAQDCQSLTSTICTSGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLNFNHSGTCELHCPPLVIYNSDMFESIPNPGGRYTFGASCV
TACPYNYLATEVGSCTLVCPLDNHEVTTEDGTQRCEKCNKPCPKVCYGLGREDLRGVRAV
TAKNIESFKGCRKLFGSLAFLTESFAGDPLTNTPPLKPDQLKVFEDLEEITGYLFISAWP
ESLSDLSVFQNLRLIRGRVLYNGAYSLTLQHLGIRWLGLRSLREVSSGLALIHHNARLCF
IDTVPWDLLFRNPHQALLSSANRPKNECVSEAQSCNQLCAQGKCWGPGPSQCVSCSQFLR
GQECVEECRVHHGSPREYVRERRCLQCHHECQPQNGTETCFGSDADECVACAHYKDPPFC
VETCPSGLKPEFSLVPVWKFPDEDGVCQICPTNCTHSCAVLDAHGCPAEQKPSPVPSIIA
GAVGVLLAVVLILATGIWIKRRRQQERKHTMRRLLQETELVEPLTPSGALPNQAQMRILK
ETELKKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAG
VGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDYVRENKERLGSQDLLNWCVQIAKGMSYL
EEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILR
RRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMV
KCWMIDSECRPRFRELVAEFSRMARDPQRFVVIQNEELSGPSAPMDSTFYGSLLDEDEMQ
DLVDAEEYLVPHQGFFSPGPPAPTSGRRRPSSITSGGELTVEGEGPEEPPRGSPSDWSQG
AGSEGLRRGGRDGGGXKGQQGPPTRENSLLQRYSEDPTSLPAPEADGYSAPHAGGPPARC
EYVNQLDPRPPPPSPLECPPASRARXRPATSTLERPKGPAPGRNGLVKTRFGGGPFAVGR
GRNPEYLGPPARSPSRAFDNLYYWDQGPPEPGAPPNGFAATPTAENPEYLGLAESVSHPK
DLAV
NT seq 3795 nt   +upstreamnt  +downstreamnt
atggatctgcccggcggtggtggtctctgccgccgctgctgctacttttgggggctcctc
ctgaccctgctgaccccggccgtgggctgcacgcaagtctgcacaggaactgacatgaag
ctgcaggctccggccagcccggagactcacgtggagatgctccgacaactgtaccagcac
tgccacgtggtacagggcaacctggagatcacgtacctccctgcccacactgatctctcc
ttccttcagaccatcgaggaggtgcatggctacgtgctgatcgcccacagcctggtgagc
tttgtgccgctgcagcggcttcgggtggtgcggggcacacaactgtacgaggaacgctac
gctctggccgtgctggagaacggcccccgcggcctccctggggcccccgaccacgccggc
ctccgcgaactgcagctccgcagcctcacggagatcctgaaaggaggggtcctgatccag
gggaacccccagctgtgccaccaggacacggtgctgtgggaagacgtgatccaccggcac
aatgagccagccgtcttcgacattgataataaccgcagccgcatctgcggtccctgctcc
tcatcctgtaagttccggaagtgctggggagaaggtgcccaggattgccagagtttgacc
agtaccatctgcaccagtggctgtgcccgctgcaagggacccctgccaaccgactgctgt
catgagcagtgtgcggcaggctgcaccggtcccaaacactccgactgcttggcttgcctc
aacttcaaccacagcggcacctgcgagctgcactgcccgcctctggtcatctacaactcg
gacatgtttgagtcgatccccaatcccggcggccgctacaccttcggggccagctgtgtc
accgcatgcccctacaactacctggctacagaagtgggctcctgcaccctagtgtgtccc
ctggacaaccacgaagtcaccaccgaggatgggactcagcggtgtgaaaagtgtaacaag
ccctgtcccaaagtgtgctacggattggggagggaagacctgcgaggagtccgggctgtc
accgccaaaaacattgagagcttcaaggggtgcaggaagctcttcgggagcctggccttc
ctgactgagagcttcgctggggaccccctgaccaacacccccccgctgaagcccgaccag
ctcaaggtcttcgaggacctggaggagatcacaggttacctgttcatctcagcctggccg
gagagcttatcagacctcagcgtcttccagaacctgcggctcatccgggggagagtgctg
tataatggtgcctactccctgactctgcagcacctgggcatccgatggctagggctgcgc
tcgctccgtgaggtgagcagtgggctggcgctgatccatcacaacgcccgcctctgcttc
atcgataccgtgccctgggaccttctcttccgcaatccccatcaggccctgctgtccagc
gccaatcggcccaagaacgagtgtgtgagcgaagcgcagtcttgcaaccagctgtgtgcc
cagggcaagtgctggggccctggcccttcccagtgtgtcagctgcagccagttcctcagg
ggtcaggagtgtgtggaggaatgccgtgtccaccatggctcccctcgagagtatgtgagg
gagaggcgctgcctgcagtgccaccacgaatgccagccacagaacggcacagagacctgc
ttcggatcggacgcggatgagtgcgtggcttgtgcccactataaggatccgcctttctgc
gtggagacctgccccagcggcctgaaacccgaattctccttggtgcccgtctggaagttc
ccagacgaggacggcgtctgccagatctgccccaccaactgcacccactcctgcgccgtg
ctggatgcccacggatgcccggcggagcagaagcccagcccagtgccgtccatcatcgcg
ggggcggtgggcgtgctgctcgcggtggtcctcattctggccacgggcatttggatcaag
cggcggaggcagcaggagcggaaacacaccatgcggcggctgctgcaggagaccgagcta
gtggagccactgacgcccagcggggcgctgcccaaccaggcccagatgcgcattctgaaa
gagacggagctcaagaaagtgaaggtcctgggctcaggtgcctttgggacggtctacaag
ggcatctggatcccagacggggaaaatgtgaagatcccggtggctattaaggtgttacgg
gaaaacacatctcccaaggccaacaaggagatcctggacgaagcgtacgtgatggccggg
gtgggcagcccctatgtctcccgactcctgggcatctgcctgacgtccacggtgcagctg
gtgacccagctcatgccctacggttgcctcctggactacgtgagagagaacaaggagcgc
ctgggttcccaggacctgctcaactggtgtgtgcagatcgccaaggggatgagctacctg
gaggaggtgcgactagtccaccgggatctggccgcccgcaatgtcctggtcaagagcccc
aaccacgtcaagatcactgactttggcttggcccggttgctggacatcgatgagacggag
taccacgcggatgggggcaaggttcccatcaagtggatggccctggagtccattctccgc
cggcgcttcacccatcagagcgacgtctggagctacggcgtgacggtatgggagctgatg
acgtttggggcgaagccgtacgacgggatcccggcccgagagatccccgacctgctggag
aagggagagcgcctgccccagccccccatctgcaccatcgacgtctacatgatcatggtc
aagtgctggatgatcgactcagagtgccgcccacgattccgggaactggtggccgagttc
tcccgcatggctcgtgatccccagcgtttcgtcgtcatccagaacgaggagctgtcaggg
cccagcgcccccatggacagcaccttctacggctcgttgctggacgaagacgagatgcag
gacctggtggacgcggaggagtacctggtcccccaccagggcttcttcagtcccgggccc
ccggcccccacctctggccgccgtcgcccctcgtccatcacgagcggtggggagctgacg
gtggagggagaggggccggaggagcccccccgcgggtccccgtcggactggtcgcagggc
gccggctccgagggtcttcgacgtggaggccgtgacgggggggggnccaaggggcagcag
ggtccccccacccgggaaaacagcctcctgcagcgctacagcgaggatcccaccagcctc
cctgcccccgaggccgacggctacagtgcccctcacgccgggggaccccctgccaggtgc
gagtacgtgaaccagctggacccccggcccccacccccctcgcccctggaatgccccccg
gcgtcccgggcccgctgacggccggcgacctccaccctggagcggcccaagggcccggcc
cccgggaggaacgggctggtcaagacgcgtttcggcggaggccccttcgcggtgggccgt
gggagaaaccccgagtacctgggccccccggcccgctccccctcccgggccttcgacaac
ctctactactgggaccaggggccccccgagcccggggcacccccaaatggctttgcggcg
acgccaacggccgagaaccccgagtacctaggcctggccgagtctgtgagccaccccaag
gacctggcagtatga

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