KEGG   Tachyglossus aculeatus (Australian echidna): 119946061
Entry
119946061         CDS       T10703                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
tacu  Tachyglossus aculeatus (Australian echidna)
Pathway
tacu01521  EGFR tyrosine kinase inhibitor resistance
tacu01522  Endocrine resistance
tacu04010  MAPK signaling pathway
tacu04012  ErbB signaling pathway
tacu04014  Ras signaling pathway
tacu04015  Rap1 signaling pathway
tacu04022  cGMP-PKG signaling pathway
tacu04024  cAMP signaling pathway
tacu04062  Chemokine signaling pathway
tacu04066  HIF-1 signaling pathway
tacu04068  FoxO signaling pathway
tacu04071  Sphingolipid signaling pathway
tacu04072  Phospholipase D signaling pathway
tacu04114  Oocyte meiosis
tacu04140  Autophagy - animal
tacu04148  Efferocytosis
tacu04150  mTOR signaling pathway
tacu04151  PI3K-Akt signaling pathway
tacu04210  Apoptosis
tacu04218  Cellular senescence
tacu04270  Vascular smooth muscle contraction
tacu04370  VEGF signaling pathway
tacu04371  Apelin signaling pathway
tacu04380  Osteoclast differentiation
tacu04510  Focal adhesion
tacu04517  IgSF CAM signaling
tacu04540  Gap junction
tacu04550  Signaling pathways regulating pluripotency of stem cells
tacu04613  Neutrophil extracellular trap formation
tacu04620  Toll-like receptor signaling pathway
tacu04650  Natural killer cell mediated cytotoxicity
tacu04660  T cell receptor signaling pathway
tacu04662  B cell receptor signaling pathway
tacu04664  Fc epsilon RI signaling pathway
tacu04666  Fc gamma R-mediated phagocytosis
tacu04668  TNF signaling pathway
tacu04720  Long-term potentiation
tacu04722  Neurotrophin signaling pathway
tacu04725  Cholinergic synapse
tacu04726  Serotonergic synapse
tacu04730  Long-term depression
tacu04810  Regulation of actin cytoskeleton
tacu04910  Insulin signaling pathway
tacu04912  GnRH signaling pathway
tacu04914  Progesterone-mediated oocyte maturation
tacu04915  Estrogen signaling pathway
tacu04916  Melanogenesis
tacu04917  Prolactin signaling pathway
tacu04919  Thyroid hormone signaling pathway
tacu04921  Oxytocin signaling pathway
tacu04926  Relaxin signaling pathway
tacu04928  Parathyroid hormone synthesis, secretion and action
tacu04929  GnRH secretion
tacu04934  Cushing syndrome
tacu04935  Growth hormone synthesis, secretion and action
tacu05010  Alzheimer disease
tacu05022  Pathways of neurodegeneration - multiple diseases
tacu05034  Alcoholism
tacu05132  Salmonella infection
tacu05135  Yersinia infection
tacu05160  Hepatitis C
tacu05161  Hepatitis B
tacu05163  Human cytomegalovirus infection
tacu05164  Influenza A
tacu05165  Human papillomavirus infection
tacu05166  Human T-cell leukemia virus 1 infection
tacu05167  Kaposi sarcoma-associated herpesvirus infection
tacu05170  Human immunodeficiency virus 1 infection
tacu05200  Pathways in cancer
tacu05205  Proteoglycans in cancer
tacu05206  MicroRNAs in cancer
tacu05207  Chemical carcinogenesis - receptor activation
tacu05208  Chemical carcinogenesis - reactive oxygen species
tacu05210  Colorectal cancer
tacu05211  Renal cell carcinoma
tacu05212  Pancreatic cancer
tacu05213  Endometrial cancer
tacu05214  Glioma
tacu05215  Prostate cancer
tacu05216  Thyroid cancer
tacu05218  Melanoma
tacu05219  Bladder cancer
tacu05220  Chronic myeloid leukemia
tacu05221  Acute myeloid leukemia
tacu05223  Non-small cell lung cancer
tacu05224  Breast cancer
tacu05225  Hepatocellular carcinoma
tacu05226  Gastric cancer
tacu05230  Central carbon metabolism in cancer
tacu05231  Choline metabolism in cancer
tacu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:tacu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    119946061 (MAP2K1)
   04012 ErbB signaling pathway
    119946061 (MAP2K1)
   04014 Ras signaling pathway
    119946061 (MAP2K1)
   04015 Rap1 signaling pathway
    119946061 (MAP2K1)
   04370 VEGF signaling pathway
    119946061 (MAP2K1)
   04371 Apelin signaling pathway
    119946061 (MAP2K1)
   04668 TNF signaling pathway
    119946061 (MAP2K1)
   04066 HIF-1 signaling pathway
    119946061 (MAP2K1)
   04068 FoxO signaling pathway
    119946061 (MAP2K1)
   04072 Phospholipase D signaling pathway
    119946061 (MAP2K1)
   04071 Sphingolipid signaling pathway
    119946061 (MAP2K1)
   04024 cAMP signaling pathway
    119946061 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    119946061 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    119946061 (MAP2K1)
   04150 mTOR signaling pathway
    119946061 (MAP2K1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    119946061 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    119946061 (MAP2K1)
   04148 Efferocytosis
    119946061 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    119946061 (MAP2K1)
   04210 Apoptosis
    119946061 (MAP2K1)
   04218 Cellular senescence
    119946061 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    119946061 (MAP2K1)
   04540 Gap junction
    119946061 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    119946061 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    119946061 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    119946061 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    119946061 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    119946061 (MAP2K1)
   04660 T cell receptor signaling pathway
    119946061 (MAP2K1)
   04662 B cell receptor signaling pathway
    119946061 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    119946061 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    119946061 (MAP2K1)
   04062 Chemokine signaling pathway
    119946061 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    119946061 (MAP2K1)
   04929 GnRH secretion
    119946061 (MAP2K1)
   04912 GnRH signaling pathway
    119946061 (MAP2K1)
   04915 Estrogen signaling pathway
    119946061 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    119946061 (MAP2K1)
   04917 Prolactin signaling pathway
    119946061 (MAP2K1)
   04921 Oxytocin signaling pathway
    119946061 (MAP2K1)
   04926 Relaxin signaling pathway
    119946061 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    119946061 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    119946061 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    119946061 (MAP2K1)
   04916 Melanogenesis
    119946061 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    119946061 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    119946061 (MAP2K1)
   04726 Serotonergic synapse
    119946061 (MAP2K1)
   04720 Long-term potentiation
    119946061 (MAP2K1)
   04730 Long-term depression
    119946061 (MAP2K1)
   04722 Neurotrophin signaling pathway
    119946061 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    119946061 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119946061 (MAP2K1)
   05206 MicroRNAs in cancer
    119946061 (MAP2K1)
   05205 Proteoglycans in cancer
    119946061 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    119946061 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    119946061 (MAP2K1)
   05230 Central carbon metabolism in cancer
    119946061 (MAP2K1)
   05231 Choline metabolism in cancer
    119946061 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    119946061 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    119946061 (MAP2K1)
   05212 Pancreatic cancer
    119946061 (MAP2K1)
   05225 Hepatocellular carcinoma
    119946061 (MAP2K1)
   05226 Gastric cancer
    119946061 (MAP2K1)
   05214 Glioma
    119946061 (MAP2K1)
   05216 Thyroid cancer
    119946061 (MAP2K1)
   05221 Acute myeloid leukemia
    119946061 (MAP2K1)
   05220 Chronic myeloid leukemia
    119946061 (MAP2K1)
   05218 Melanoma
    119946061 (MAP2K1)
   05211 Renal cell carcinoma
    119946061 (MAP2K1)
   05219 Bladder cancer
    119946061 (MAP2K1)
   05215 Prostate cancer
    119946061 (MAP2K1)
   05213 Endometrial cancer
    119946061 (MAP2K1)
   05224 Breast cancer
    119946061 (MAP2K1)
   05223 Non-small cell lung cancer
    119946061 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    119946061 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    119946061 (MAP2K1)
   05161 Hepatitis B
    119946061 (MAP2K1)
   05160 Hepatitis C
    119946061 (MAP2K1)
   05164 Influenza A
    119946061 (MAP2K1)
   05163 Human cytomegalovirus infection
    119946061 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    119946061 (MAP2K1)
   05165 Human papillomavirus infection
    119946061 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    119946061 (MAP2K1)
   05135 Yersinia infection
    119946061 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    119946061 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    119946061 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    119946061 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    119946061 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    119946061 (MAP2K1)
   01522 Endocrine resistance
    119946061 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tacu01001]
    119946061 (MAP2K1)
Enzymes [BR:tacu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     119946061 (MAP2K1)
Protein kinases [BR:tacu01001]
 Serine/threonine kinases: STE group
  STE7 family
   119946061 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 119946061
NCBI-ProteinID: XP_038623369
LinkDB
Position
26:8280117..8358739
AA seq 395 aa
MPMPRKKPDPIQLNPTPDGAAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQ
KVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLIMARKLIHLEIKPAIRNQIIRELQVL
HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT
YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGT
HYSVQSDIWSMGLSLVEMAIGRYPIPPPDSKELELMFGCTVEGDASETSPRQRTPGRPIS
SYGLDNRPPMAIFELLDYIVNEPPPKLPNGVFSLEFQDFVNKCLIKNPAERADLKQLMVH
TFIKRAEAEDVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1188 nt   +upstreamnt  +downstreamnt
atgcccatgcccaggaagaagcccgaccccatccagctcaaccccaccccggacggggcc
gccgtcaacgggaccagctccgccgagaccaacctggaagcgctccagaagaagctggaa
gaactggagctggacgagcagcagcgcaaacgactggaggctttcctcacccagaaacag
aaagtcggggaactcaaggatgacgacttcgagaaaatcagcgagctgggagccgggaac
ggcggggtggtgttcaaagtctcccacaagccctctgggctcatcatggcccgaaagctc
atccacctagagatcaagccggccatccggaaccagatcatccgggagctgcaggtgctc
catgaatgcaactccccgtacatcgtcggcttctacggggccttctacagtgacggcgag
atcagcatctgcatggagcatatggatggtgggtccttggatcaggtcctgaagaaagcc
ggtagaattccagagcagattctgggcaaagttagcatcgctgtaataaaaggtctaacg
tatctgagggagaaacataaaattatgcacagagacgtgaagccgtccaacatcttggtg
aactcccgcggtgagatcaagctctgcgatttcggggtcagcgggcaactgatcgactcc
atggccaactcctttgtgggcacgaggtcctacatgtcgccggagagactacaaggtact
cattattcagtgcagtctgacatctggagcatgggcttatctttggtggagatggctatt
ggtaggtacccgatccctcctcccgattccaaggagctggaactgatgttcggatgcacg
gtggagggagacgcttcggagacgtcgcctcgacagcggaccccagggaggcccattagc
tcttacggcctggacaacagaccccccatggccatctttgaactgctggactacatcgtc
aacgagccgccacccaaactgcccaatggagtcttcagtcttgagtttcaagactttgtg
aataaatgcctcatcaaaaacccggctgagagagccgacctgaagcaactcatggttcac
actttcatcaagagagccgaggcggaggacgtggactttgcgggctggctctgctccacg
ataggcctgaaccagcccagcacgcccacccacgccgccggagtctaa

DBGET integrated database retrieval system