Tachyglossus aculeatus (Australian echidna): 119947924
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Entry
119947924 CDS
T10703
Symbol
JAK2
Name
(RefSeq) tyrosine-protein kinase JAK2 isoform X1
KO
K04447
Janus kinase 2 [EC:
2.7.10.2
]
Organism
tacu Tachyglossus aculeatus (Australian echidna)
Pathway
tacu01521
EGFR tyrosine kinase inhibitor resistance
tacu04062
Chemokine signaling pathway
tacu04081
Hormone signaling
tacu04148
Efferocytosis
tacu04151
PI3K-Akt signaling pathway
tacu04217
Necroptosis
tacu04550
Signaling pathways regulating pluripotency of stem cells
tacu04630
JAK-STAT signaling pathway
tacu04658
Th1 and Th2 cell differentiation
tacu04659
Th17 cell differentiation
tacu04725
Cholinergic synapse
tacu04917
Prolactin signaling pathway
tacu04920
Adipocytokine signaling pathway
tacu04933
AGE-RAGE signaling pathway in diabetic complications
tacu04935
Growth hormone synthesis, secretion and action
tacu05140
Leishmaniasis
tacu05145
Toxoplasmosis
tacu05152
Tuberculosis
tacu05161
Hepatitis B
tacu05164
Influenza A
tacu05167
Kaposi sarcoma-associated herpesvirus infection
tacu05168
Herpes simplex virus 1 infection
tacu05200
Pathways in cancer
tacu05207
Chemical carcinogenesis - receptor activation
tacu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
tacu05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
tacu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
119947924 (JAK2)
04151 PI3K-Akt signaling pathway
119947924 (JAK2)
09133 Signaling molecules and interaction
04081 Hormone signaling
119947924 (JAK2)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
119947924 (JAK2)
09143 Cell growth and death
04217 Necroptosis
119947924 (JAK2)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
119947924 (JAK2)
09150 Organismal Systems
09151 Immune system
04658 Th1 and Th2 cell differentiation
119947924 (JAK2)
04659 Th17 cell differentiation
119947924 (JAK2)
04062 Chemokine signaling pathway
119947924 (JAK2)
09152 Endocrine system
04920 Adipocytokine signaling pathway
119947924 (JAK2)
04917 Prolactin signaling pathway
119947924 (JAK2)
04935 Growth hormone synthesis, secretion and action
119947924 (JAK2)
09156 Nervous system
04725 Cholinergic synapse
119947924 (JAK2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
119947924 (JAK2)
05207 Chemical carcinogenesis - receptor activation
119947924 (JAK2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
119947924 (JAK2)
09172 Infectious disease: viral
05161 Hepatitis B
119947924 (JAK2)
05164 Influenza A
119947924 (JAK2)
05168 Herpes simplex virus 1 infection
119947924 (JAK2)
05167 Kaposi sarcoma-associated herpesvirus infection
119947924 (JAK2)
09171 Infectious disease: bacterial
05152 Tuberculosis
119947924 (JAK2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
119947924 (JAK2)
05140 Leishmaniasis
119947924 (JAK2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
119947924 (JAK2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
119947924 (JAK2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
119947924 (JAK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
tacu01001
]
119947924 (JAK2)
Enzymes [BR:
tacu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
119947924 (JAK2)
Protein kinases [BR:
tacu01001
]
Non-receptor tyrosine kinases
JAK family [OT]
119947924 (JAK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
FERM_F2
FERM_F1
SH2_1
Jak1_Phl
ABC1
FERM_C_FAK1
RIO1
Kinase-like
FERM_M
Motif
Other DBs
NCBI-GeneID:
119947924
NCBI-ProteinID:
XP_038625503
LinkDB
All DBs
Position
X4:18341042..18528752
Genome browser
AA seq
1129 aa
AA seq
DB search
MACLTLTEMEGTATSTAHQNGDVPGNDNAVKQIEPFLQVYLYHSLGKAEGDYLQFPAGEH
IAEEICVAACKACGVTPVYHNMFALMCETERTWYPPNHVFHIDESTKHTILYRIRFYFPH
WYCNGDKRAYRHGISRGAEAPLLDDFVMSYLFAQWRDDFVHGWIKVPVTHETQEECLGMA
VLDMMRIAKEKNQTPLAIYNSISYKTFLPKCVRAKIQGYHILTRKRIRYRFRRFIQQFSQ
CKATARNLKLKYLINLETLQSAFYSEKFEVKEPGRGPSGEEIFATIIITGNGGIQWSRGK
HKESETLAEQDLQTYCDFPDIIDVSIKQANQEDSTESRVVTIHKQDSKNLEIEFLSLKEA
LSFISLIDGYYRLTADAHHYLCKEVAPPTVLKNIQSNCHGPVSMEFAISKLKKAGNQTGL
YVLRCSPKDFNKYFLTFAVEREHVMDYKHCLITKNENNEYNLSGTKKSFGNLKDLLNCYQ
METVRSDSIIFQFTKCCPPKPKDKSNLLVFRSNGISDVPTSPTLQRHNNVNQMVFHKIRN
EDLTFNESLGQGTFTKIFKGVRKEIGDYGLHQTEVLLKVLDKAHRNYSESFFEAASMMSQ
LSYKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWAMHF
LEEKNLIHGNVCSKNILLIREEDRKSGNPPFIKLSDPGISITVLPKDILLERIPWVPPEC
IENPKNLSLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTELANL
INNCMEFEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQ
FEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILK
SLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERLDHKKLLQYTSQICKG
MEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAP
ESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLK
NNGRLPRPEGCPDEIYSIMTECWNNNVSQRPSFRELAVRVDRIRDSMGG
NT seq
3390 nt
NT seq
+upstream
nt +downstream
nt
atggcttgcctcaccttgacagagatggagggaactgccacatctactgctcatcagaat
ggtgatgtccctgggaacgataatgctgtgaagcaaatagagccgtttcttcaggtctat
ctttaccactccctgggaaaggctgagggagattacttacagtttccagccggggagcat
attgctgaagagatttgtgtggctgcttgtaaagcttgtggtgtcacacctgtgtatcat
aacatgtttgctctaatgtgtgagacagagaggacctggtatcctcccaaccatgtcttc
catatagatgagtcaaccaagcacaccatcctgtaccgaataaggttttactttcctcac
tggtattgtaatggagataagcgagcctaccgacatgggatttctcgaggtgctgaggcc
cctcttcttgatgattttgtcatgtcttacctctttgctcagtggagagatgactttgtt
cacggttggataaaggtgcctgtaactcatgaaacacaggaagaatgtcttgggatggcg
gtcctggatatgatgagaatagctaaggaaaaaaaccaaacccccttggccatctataac
tctatcagctacaagacattcttaccaaaatgtgttcgagcaaagattcaaggctatcac
attttgacgcgaaagcgaataaggtacaggttccgcagatttattcagcaattcagccag
tgcaaagctactgccagaaacttgaaacttaagtatcttataaatctggaaactcttcag
tctgccttctactcagaaaaatttgaagtaaaagagcctggcagaggtccttcaggtgag
gagatttttgcaaccattataataactggaaacggtggaattcagtggtcaagagggaaa
cataaagaaagtgagacactggcagaacaggatttacaaacatattgtgactttcctgat
attatcgacgtgagcattaagcaagcgaaccaagaagactctactgagagtagggtggta
actattcataagcaagacagcaagaatttggaaattgaatttctctccttaaaagaagct
ctgtcttttatatcactgattgatgggtattacagattgactgcagatgcacaccattac
ctctgtaaagaagtcgcacccccaacagtgcttaaaaatatccaaagcaattgtcacggg
cctgtttcgatggaatttgccatcagtaaactgaagaaagcaggtaaccaaactggcctc
tatgtccttcgctgcagtcctaaagactttaataaatacttcctcacctttgctgttgag
cgggaacatgtcatggattacaagcattgcttgattactaaaaatgagaacaacgaatac
aatctcagtggaactaagaagagctttggtaaccttaaagatcttctgaactgctatcaa
atggaaactgttcgctcagacagcatcattttccagtttaccaaatgttgcccacctaag
cccaaagataaatctaatctcttagtcttcaggagcaatggcatttcagatgtgcctaca
tcacccactttgcagagacacaataatgtaaaccagatggtttttcacaaaatcagaaat
gaagatttgacatttaacgaaagtctgggacaaggtacctttaccaagattttcaagggt
gtaaggaaagaaataggagactacggtctccatcaaacagaagtccttttaaaagttctg
gataaagcacacagaaactattcagagtctttttttgaagcagccagcatgatgagccaa
ctttcgtacaagcaccttgtattaaattatggagtctgtgtctgtggagaggaaaatatc
ctggttcaagagtttgtcaaatttggatcactggacacttatctgaaaaaaaacaagaat
tctatcaatattttgtggaagttggaagtggccaaacagttggcatgggccatgcatttt
ctagaggaaaaaaatctcattcatgggaatgtatgttcaaaaaatattttacttatcagg
gaagaggacaggaaatcaggaaaccctcctttcatcaagctcagcgatcctggcattagt
attacagttttgccaaaagacatccttctagagagaataccatgggttccacctgaatgc
attgaaaaccccaaaaatctaagcttggcaacagataaatggagttttggaaccactctg
tgggaaatctgcagtggaggagacaaaccactgagtgcacttgattctcaaagaaagcta
cagttttacgaagacaggcaccaacttcctgcaccaaaatggacagaattagcgaatctt
atcaacaactgtatggaatttgaaccagatttcagaccttctttcagagccatcatacgg
gatctcaacagtttgttcactccagattatgaacttttaacagaaaatgacatgttaccc
aacatgagaattggtgccctcggattttctggtgcgtttgaagacagggaccccacacag
tttgaagagagacaccttaaattcctacaacagctcggcaagggtaattttggcagtgtg
gagatgtgccggtacgaccccctgcaagacaatactggtgaggtggtagctgtgaagaag
cttcagcacagcactgaagaacacttgcgagattttgaaagagaaattgaaattctgaaa
tccctgcagcatgataacattgtcaaatacaagggagtctgctatagtgccggtcgtcgt
aatctgagattgatcatggaatatttgccctatggaagtttacgtgattatctccaaaaa
cataaggaaaggctggatcataagaagctattacagtacacatctcagatatgcaagggc
atggagtatcttggaacaaagagatacatccatagggatctggccacaagaaatatctta
gtggagaatgagaacagagttaaaattggagattttggattgactaaagtcctgccacaa
gataaggaatattacaaagtgaaagaacctggagaaagtcccatattctggtatgctccg
gaatctctgacggagagcaagttttccgtagcctcggatgtctggagttttggagtggtt
ctgtatgaactgttcacatatatcgagaaaagcaaaagcccaccagcggaattcatgcga
atgattggcaatgacaaacaaggacagatgattgtattccatttgatagaacttttgaag
aataatggacggcttccaagaccagagggctgtcctgatgagatttattctataatgaca
gagtgctggaacaacaatgtaagccagcgcccctccttcagggagctcgctgttcgagtg
gatcgcatcagggacagcatgggtggatga
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