Tribolium castaneum (red flour beetle): 655265 Help Entry 655265            CDS       T01046                                  Name (RefSeq) ryanodine receptor   KO K04962   ryanodine receptor 2 Organism tca  Tribolium castaneum (red flour beetle) Brite KEGG Orthology (KO) [BR:tca00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:tca04040]     655265    04990 Domain-containing proteins not elsewhere classified [BR:tca04990]     655265 Ion channels [BR:tca04040]  Voltage-gated cation channels   Ryanodine receptor    655265 Domain-containing proteins not elsewhere classified [BR:tca04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    655265 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 Mo25 DUF996 Motif Other DBs NCBI-GeneID:  655265 NCBI-ProteinID:  NP_001308588 UniProt:  A0A097P7A6 LinkDB All DBs Position LG3:complement(21560859..21659061) Genome browser AA seq 5094 aa AA seqDB search MAEAEGGSEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDLS QCVFVIEQALSVRALQELVTAAGNETGKGTGSGHRTLLYGNAILLRHQNSDMYLACLSTS SSNDKLAFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYLHTTKE NEISIVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSTWSIDAN IVIYEGGSVMSQARSLWRLELARTKWAGGFINWSHPMRIRHITTGRYLAVNENNELYLVS REEANTATTAFCLRQEKDDQKVVLEDKDLEVIGSPIIKYGDSTVIVQHSETGLWLSYKSY ETKKKGVGKVEEKQAILHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFTQFINGLETL QMNRRHSVFFLAVNLNEMVMCLEDLINYFAQPEDDMEHEEKQNRFRALRNRQDLFQEEGI LNLILEAIDKINVITSQGFLAGLAGDQNWEMISGYLYQLLAAIIKGNHTNCAQFANSNRL NWLFSRLGSQASSEGTGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEKHGRDPKVLDV LCSLCVGNGVAVRSSQNNICDYLLPGKNLLLQTQLVDHVASVRPNIFVGRVDGSAIYQKW YFEVTVDHIEQTTHMMPHLRIGWANSKGYVPYPGGGEKWGGNGVGDDLYSYGFDGVYLWS GGRSTQVVTTYTTPFIKKNDVVGCALDLTVPIITFTFNGVPIKGSFRNFNLDGMFFPVIS CSSKLSCRFLLGGDHGRLKYIPPEEFSPLVESLLPQQILNLEPCFYFGNMNKNVIAGPLT VEDDTAFVPNPVDTSMVSLASYVESIRDKLAENIHEMWAMNKIEAGWQWGEYRDDLRHIH PCLVPFDKLPPAEKKYDSQLAVQTLKTIIALGYHITMDKPPSRIKTVRLPNEPFMQSNGY KPAPLDLSAITLTPKLEELVDQLAENTHNLWAKERIQQGWTYGLNEDPDMFRSPHLVPYI KVDDAIKKANRDTASETVRTLLVYGYNLDPPTGEQHEALLAEASRSRQAIFRTYRAEKNY AVSSGKWYFEFEILTAGPMRVGWAKADCAPGCMLGSDENTWAFDGYNEEKVYSNSAESFG KQWQVGDVVGVFLDLIDHTISFSLNGELLMDALGGETTFADVQGDNFVPAFTLGVGQKAR LCFGQDVTQLKYFTMCGLQEGYEPFCVNMKRPVTYWYTKDQPIFENTDDMPDTKIDVTRI LAGSDSPPCLKISHNTFETMEKANWEFLRLSLPVICHSTFISEDEKMRRWQEIKIRQHRL KAEAESNISPAHIEQMMMKSGFSMSDIKGLHRNYSEDAVESDEVMKHHGKSTKSMPARPP RKGSLSRNVNGFEDNMLGANTGRGVNRSTSELNLNRYLDMAPANQEKPDEKKKRGRSPFR FFSRKKAGNSPGGESVKADKSKTPDRERERMGTIKVPTRQAGVSPSRLTRSPTIKQSQSD LMQVPAAASGQQKQLSVPHTSDVEAVGDELFDGECLKLINEYFYGVRIFPGQDPTHVYVG WVTTQYHRHTKDFNQNQVRKSSIVILDDYDRVVDCVDRQSCYMVRADELYNQVTQDASGK GASQGMFIGCFLDAATGVITFTCEGKPTSHVFRMEPETKLFPAIFVEATSKEILQIELGR TPTSLPLSAAVLQNSAKHVIPQFPPRLKVQCLKPHQWARVPNQSLQVHALKLSDIRGWSM LCEDAISMLALHIPEEDRCIDVLELIEMDKLLSFHAHTLTLYAALCYQSNYKAAHVLCKH VNQRQLLYAIKAEYMSGPLRQGFYDLLIAVHIESAATTMEVCQNEYVIPLSQELKEMYED PEMRHSLRALMMESVQPQMKMSDITDTVENIKNLYSPYFPLDIVRDYVMTALAEAVETNQ VHNRDPIGGSNENLFLPLLKLVDRLLLVGMLRDEDIAKLLIMICPETWDPSFVKDGKDEH RKGLLSMKMAEGAKLQMCYLLQHLCDIQLRHRVESIIAFSHDFVGDLQSDQLRRYIEIKQ SDLPSAVAAKKTREFRCPPREQMNAILSFKNLEEEDKENCPLGEELCEKLNDFHGLLMSH VSLQALQAPEEEEGNDVQKPGPFKRLYNFINAVKELEEEPKEEPEPEKKTPEEIFRKVLI STIVQWAEEAQIETPKLVQEMFSLLVRQYDSVGELIRALQKTYVINAKTKQDVAEMWVGL SKIRALLPVQMSQEEEELMRERLWKLVNNHTFFQHPDLIRVLRIHENVMAVMINTLGRRS QAQSDAQAQAQAAEGDTTVKEKDTSHEMVVACCRFLCYFCRTGRQNQKAMFEHFDFLLEN SNILLARPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAIYLSRCGLQSNSELVEKG YPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECLGPALRGEGEGLLR AIVDANKMSERISDRRKMMDEAEGTVNVAPFTHPLPESDDDEDYIDTGAAILNFYCTLVD LLGRCAPDATVIELGKNESLRARAILRSLVPLEDLQGVLSLRFTLQNPAAGEERPKSDMP SGLIPGHKQSVVLFLERVYGIETQELFFRLLEEAFLPDLRCATMLDRNDGSESDMALSMN RYIGNSILPLLIQHSKFYSEAENYASLLDATLHTVYRLSKNRMLTKGQREAVSDFLVALT SALQPSMLLKLLRKLTVDVSNLSEYTTVALRLLTLHYDRCAKYYGSSTGQGLYGAASDEE KRLTMMLFSNIFDSLSKMDYDPELFGKALPCLSAIGCALPPDYSLSKNYDDEWYANKSAK TGPDGPYNPQPINTSSVALNNDLNSIVQQFSEHYHDAWASRKLENGWQYGETWSDSNKTH PRLKPYSMLNDYEKERYKEPVRESLKALLAIGWSVEHSEVDHPSTNRNSVHHQSGEGSSP FNYNPHPVDMTNLTLSREMQNMAERLAENAHDIWAKKKKEELNTCGGGIHPQLVPYDLLT DKEKRKDRERSQEFLKYLQYQGYKLHKPIRGGQGETEQTTAGASIELRFAYSLLEKLIQY ADRATINMKLLKPSSTFSRRPSYKTSSRDIKFFSKVVLPLMEKYFSTHRNYFIAIATATN NVGAASLKEKEMVASLFCKLASLLRSKLTAFGADVRITVRCLQVLVKGIDAKSLVKNCPE FIRTSMLTFFNNTADDLGHTIINLQEGKYSHLRGTHLKTSTSLFYVNTVIIPILTAMFDH LANCEYGSDLLLDEIQVASYKILQALYTLGTDTTLTHDRKYLKTEIEKYKPALGSCLGAF SSTFPVAFLEPHLNKNNQFSFLNRIADHSLEAQDIMAKMEGSMPTLETILSEVDQFVESE KTYSDAPHIIDVIMPMLCSYLPFWWSQGPDNVSPTGGTHVSMVTAEHMNHLLKNVLKLIK KNIGNETAPWMTRIAAYTQQIIINSSEELLRDPFLPLAERVKKRTETMFHKEESLRGFIK SSSDDTSQIETQIQEDWHLLVRDIYAFYPLLIKYVDLQRNHWLRHNIAEAEDLYNHVADI FNIWSKSQYFLREEQNFISANEIDNMVLIMPTATRRPVVTDGTQQTGGKKKKKHRDKKRD KDKEIQASLMVACLKRLLPVGLNLFAGREQEMVQHCKDRFLKKAPEYDIIEFAKTQLTLP DKIDPADEMSWQHYLYSQLGSKKSAAVGMVDNNGKNLLEETVDRIVAMSKVLYGLHMIDH PQQQQKGVYHSVVSTQRKRAVLSCFRQASLHSLPRHRAINIFIRSYYELWLQDENVGQEV MIEDLTQSFEDSELKKKDGEEEESKPDPLTQLVTTFCRGAMTERSGALQEDPLYMSYAEI IAKSCGEEEEEGEEEESGEGEEGGASIHEQEMEKQKLLFNQARLAKRGVAEMVLLHISAC KGVPSEMVMKTLELGISILRGGNFDIQMGMLNHLKEKKDVGFFTSIAGLMNSCSVLDLDA FERNTKAEGLGVGSEGAAGEKNMHDAEFTCALFRFIQLTCEGHNLEWQNYLRTQAGNTTT VNVVICTVDYLLRLQESIMDFYWHYSSKDLIDPAGKANFFKAIGVASQVFNTLTEVIQGP CTLNQQALAHSRLWDAVGGFLFLFSHMQDKLSKHSSQVDLLKELLNLQKDMITMMLSMLE GNVVNGTIGKQMVDTLVESASNVELILKYFDMFLKLKDLTSSPSFQEIDINNDGWVSPKD FKEKMEQQKSYTSEEIDFLLACCEVNHDGKVDYIGFIDRFHEPAKEIGFNLAVLLTNLSE HMPNEPRLARFLETAGSVLNYFEPFLGRIEILGGSKRIERVYFEIKESNIEQWEKPQIEE SKRAFFYSIVTEGGDKEKLEAFINFCEDAIFEMQHASGLMAVEESGGGGPTRAASYSYMN VDDEDRGKDPIRRGYQSIKEGIAYGLSSLSPSNIKHKFAEMQQMTIPELFIGFFRMIIYA FYYSGFGVAIIFKYIFGVLLSLMRGPIEEPAVLEIKEEEEKVGLSRVLPALPSSEEQNTQ MQAFGLDITKEDNGQYKMAAHESPTTSQPSSAEGEGETTPEEDGEHPETETMEAPLSLSD LLGGEQAKRAAQEKVEAQAAQQAVMQAIESESKQPVVTEPSAVSQINFGAYSHRAVSFLA RNFYNLKYVALVLAFCINFMLLFYRVSTLGDDAEGSGSKGIPDILEGSAEGSGAGSGESG EDDDPPELVHVDEDFYYMAHVMRLAAILHSVVSLAMLIAYYNLKVPLAIFKREKEIARRL EFEGLYIAEQPEDGDLKSHWDKLVISAKSFPVNYWDKFIKKKVRQKYSETYDFDSISNLL GMEKTSFQQQESDEGRSFIYFIINIDWRYQIWKSGVAITDNSFLYSLWYFIFSILGNFNN FFFAAHLLDVAVGFKTLRTILQSVTHNGNQLVLTVMLLTIVVYIYTVIAFNFFRKFYVQE EDEEVDKKCHDMLTCFVFHLYKGVRAGGGIGDEIEPPDGDDYEVYRIMFDITFFFFVIVI LLAIIQGLIIDAFGELRDQLESVKEDMESNCFICGMGKEYFDKVPHGFDTHVQQEHNLAN YMFFLMHLINKPDTEYTGQETYVWNMYQQRCWDFFPVGDCFRKQYEEELGGGGG NT seq 15285 nt NT seq  +upstreamnt  +downstreamnt atggcggaggccgaagggggctccgaacaggatgatgtttcattcttgcgaacggaagat atggtgtgtctctcctgcaccgcgacaggggagcgtgtgtgcttggctgcggaggggttc ggtaatcgacactgctttttagaaaatattgcagacaagaatatacctccagatctttcg caatgtgtgttcgttatagaacaggcattgtctgtgcgtgctttacaagagttggtcact gcagctggcaatgaaactggtaaaggtacaggatctggacaccgcacccttttgtatggt aatgccatccttttacgccatcaaaacagtgatatgtacttggcttgtttgtcgacaagt tcaagtaacgataaacttgcttttgatgtcgggttgcaagaacatagccaaggcgaagcc tgctggtggacggttcatcccgccagtaaacagaggtctgaaggtgaaaaggtgcgtgtt ggagacgatttgatcttggtatcagtcgctacagaacgatacttgcacacgacgaaagaa aacgaaatttcgatcgtaaacgccagtttccacgtaacccattggtctgtacaaccatat gggactggaatctcgcgaatgaaatatgtggggtatgttttcggcggagatgttctcaga tttttccacggaggcgacgagtgcctgaccataccgtccacatggagcatagatgcgaat attgtaatttacgaaggcgggagcgtaatgtcgcaagcccgctctttgtggagattagaa ctggcgaggacaaaatgggccggaggttttataaattggtcgcatccaatgcggataaga catattacaactggaagatatcttgctgttaatgaaaataatgagttgtatctggttagt agagaagaggcaaatactgcgaccacagctttctgtcttcggcaagaaaaggacgatcag aaagttgtgcttgaagacaaggatttggaagttattgggtcaccgattatcaagtatggt gactccacggttattgtacaacattcagaaactggactgtggctttcgtacaagtcgtac gagaccaagaaaaaaggagtgggtaaagttgaagaaaaacaggccatactccacgaagaa ggaaaaatggacgatggtttagacttcagtaggagtcaagaagaagaatccagaactgcg agagtcattcgtaaatgcagttccctatttactcaattcataaatggacttgaaacactt caaatgaaccgtcgtcattcggtatttttcctggcagttaatttaaatgaaatggttatg tgtctcgaagatttgatcaattattttgctcaaccagaggatgacatggaacacgaggag aagcaaaacaggtttagggctttgcgaaaccgacaagacctgtttcaggaagaaggaatt ttgaatttaattttagaagcaatagacaagataaatgtgataacgtcgcaaggcttctta gccggacttgctggcgaccaaaattgggaaatgatttcgggttatttgtaccaattgctc gccgctattatcaaaggcaatcacacaaattgtgctcaatttgccaactctaaccgtttg aattggcttttttctcgattgggttcacaagcttccagtgaagggactggaatgttggac gtgctgcactgtgtccttatcgattcaccggaagctttaaatatgatgagggacgaacac attaaagtaataatttctctactggagaaacacggaagagatccgaaagttttggacgtg ctttgctcactttgtgtcggtaatggtgtagcagtgcgtagctctcaaaacaatatctgt gattatcttcttcctggaaaaaatttacttttacaaacgcagttagtagatcacgtagca agcgtaagaccaaatatttttgtgggtagagtcgatggtagcgcaatttatcaaaaatgg tattttgaagttactgtagatcatatagaacaaactactcacatgatgcctcacttgagg attggctgggccaactccaaaggatacgtcccataccctgggggtggtgaaaaatggggc ggcaatggtgtaggagatgatttatattcctacggtttcgatggagtttatctctggtca ggaggacgctcaacacaagttgtgaccacttacactactccatttattaagaaaaacgac gtggttggctgtgccttagatttaactgttccaataattacttttacattcaacggtgtg ccaattaaaggaagtttccgaaactttaacttggatggaatgtttttccctgtgattagt tgctcgtccaaacttagttgtcgatttctattaggtggcgaccatggccgcttaaaatac atccctccggaggaattttcaccactggttgaaagcctcctcccgcaacaaattctaaac ctcgaaccgtgtttctatttcggaaacatgaacaaaaacgtcattgccggtcctctgacc gttgaggatgacaccgcttttgtaccaaaccctgtagacacttccatggttagtttagcg agttacgtcgagtcaattcgggataaattggcggaaaacatccacgaaatgtgggccatg aacaagatcgaagccggctggcaatggggggagtacagggacgatttgaggcatatccat ccctgtttggtgcccttcgacaagttgcccccagccgagaagaaatacgactctcaactg gcagttcaaacactaaaaacaatcattgcgcttggataccacataaccatggacaaaccc ccctcgcgcatcaaaacagtccgtcttccaaacgaacccttcatgcaatcaaacggctac aagccggcccctcttgacctaagtgccataaccctgaccccaaaactggaagaactcgtt gaccaattggccgagaacactcataatctctgggccaaggaaaggatccagcaaggttgg acctacggactcaatgaggatcccgatatgttccgaagtccgcatctggtgccttacatc aaagttgacgatgcgataaagaaagccaatagggatacagcgtctgagacagttcggact ctcttggtatacggatataatttggatccgccaactggtgaacaacatgaagctttgctg gctgaggctagtcggtcgagacaagccatatttaggacttacagggcggagaaaaattat gcggtcagctcggggaagtggtattttgagtttgagattcttacagcgggaccaatgaga gttggatgggccaaggctgattgtgcgcccggatgtatgttggggtcggatgaaaatacg tgggcctttgatggatacaatgaagaaaaagtgtatagcaattcggccgaatcgttcgga aaacagtggcaagttggggacgtagttggcgtattccttgacctaatcgatcatacaatt agtttctcattaaatggtgaattgttaatggatgcgttgggtggcgaaaccactttcgct gacgtacaaggggacaattttgttccggcttttacactgggtgttggtcagaaagcccgt ctttgtttcggccaagacgtaacgcaattaaaatattttacaatgtgtgggttacaagaa ggttacgagcccttctgtgttaacatgaaacgtcctgtcacttattggtacaccaaagat cagccaatttttgaaaatactgacgacatgcccgacactaaaatcgacgttacgaggatt ctggcaggttcagacagtcctccgtgtcttaagatcagtcacaacactttcgagactatg gagaaggcgaattgggagtttttgcgactcagtttgcccgtaatttgccattcaacattt atttctgaggatgagaaaatgaggcgttggcaggaaattaaaattagacagcatagactc aaggctgaagccgagtcgaatatttctcctgcacatattgagcaaatgatgatgaagagc ggattctcgatgagtgacatcaaaggtttacatcgtaattactctgaagatgccgtcgaa tcagacgaagtaatgaaacatcatggcaagtccacgaaaagcatgcctgcaagaccaccc agaaaaggctcactttcccggaacgtcaacggttttgaagataacatgttgggtgcaaac actggcagaggtgttaatcgctccaccagcgaactaaacctcaacagatacctcgacatg gccccagctaaccaggagaaacctgacgaaaagaaaaaacgcggaaggtctccgttcaga tttttctcgcgaaagaaagccgggaattcccccggaggtgagtctgttaaagcagacaaa tccaaaactccagaccgggaaagagaaagaatgggaacgatcaaagtgccgactcgtcaa gctggagtgtcgccgtcgaggctcacaaggagtccaacaattaaacaatcacagagcgat ctaatgcaagttccggccgctgcttcaggacaacagaaacagctttcggtgcctcatact tctgatgttgaggcggtcggtgatgaattgtttgatggagagtgccttaaacttatcaat gaatatttttatggtgttcgaatttttcctggtcaggatcccactcacgtgtatgttggg tgggtcacaacacagtaccatcgacataccaaggattttaatcaaaatcaagtcaggaaa agttctattgttatcctcgatgattatgacagagttgtggactgcgttgacagacaatca tgctacatggtacgcgctgacgagttgtacaaccaagtaactcaagacgcttccggcaaa ggagcatctcaaggcatgttcattggttgtttcctcgacgctgctaccggtgttatcacc ttcacctgcgaaggcaaaccaacttctcacgtattcaggatggagcctgaaaccaaactc ttccctgcaattttcgtcgaagccacaagcaaagaaatcctccaaattgaactaggtcga acacctacaagcctaccactctcggctgctgttctgcaaaacagtgccaaacacgtaatc ccccagttccctccaagactgaaagtgcaatgtcttaaaccacaccaatgggctcgagtg cctaaccagagcttgcaagtccatgcattgaaattatccgacataagaggttggtcgatg ctgtgtgaggacgcaatttcaatgctagctctccacattccggaggaagatcgctgtatt gatgtattggaattgatcgaaatggacaaattgttgagtttccacgcacacactttgact ctttatgccgccttgtgttaccaaagcaattacaaagcggctcatgtgctttgcaaacac gtcaaccagagacagcttttgtatgccatcaaggcggagtatatgagtgggcctttgagg cagggattttacgatttacttatcgccgttcatatcgaatcggctgcaactacgatggag gtttgtcagaatgagtatgttattccactgagtcaagaattgaaggaaatgtatgaggat ccagagatgcggcatagtttgagagctttgatgatggagtcggtgcagccgcaaatgaaa atgtctgacataactgacaccgtggaaaacatcaaaaatttatactcaccttacttcccc ttggacattgtccgcgactacgtgatgacagcgttagccgaagccgttgaaaccaatcaa gtgcacaatcgtgacccgattggaggctcaaacgaaaacctatttctacctttacttaaa ctagtagaccgcctgttgttagtcggcatgttacgcgatgaagacattgccaaactgctg ataatgatttgtcccgaaacttgggacccttcattcgtcaaagacggaaaagacgagcac cgcaaaggcctcctctcgatgaaaatggccgaaggagcgaagctccaaatgtgttacttg ctccagcatttgtgcgacattcaattgaggcacagagtggagtccatcattgccttcagt cacgatttcgtcggtgatttacaatcggatcagttgcgacgttacattgaaatcaaacaa tcagaccttccttctgctgtcgcagccaagaaaacgcgtgagttccggtgtccaccacgc gagcaaatgaacgcgattttatcgttcaaaaacttggaggaggaagataaggaaaactgt ccgcttggtgaagaactctgtgagaaacttaacgattttcacggcttattgatgagccac gtgtcgctacaagccctacaagcgccagaagaagaggaaggcaatgacgtgcaaaaacct gggcctttcaaacgcctgtacaatttcataaacgccgtcaaggaactggaagaggaaccg aaagaggaaccggaacccgagaagaaaactccggaggaaatcttccggaaggttctgatt tcaacaattgtgcaatgggctgaagaagcccagatcgaaacaccgaaactagtccaagaa atgttcagtctgctcgtgcgacagtacgactccgttggtgaattaatccgagccctgcag aaaacttacgtgatcaacgcaaaaaccaaacaagatgttgccgaaatgtgggtcggtttg agcaaaatcagggcgcttttgcccgtgcaaatgtcccaagaggaggaggagctgatgagg gagcgtttgtggaaactggtcaacaaccacacgttcttccagcacccggatttaatccgg gttttgcgaattcacgaaaacgtcatggctgttatgattaacacgcttggtcgccggtcg caggctcagtccgacgcacaagcacaagctcaagccgccgaaggcgatactactgttaag gagaaagacacttcgcatgaaatggtggtggcttgctgtcgctttttgtgttatttctgc cggactgggcgtcaaaatcaaaaagctatgttcgagcattttgacttcttgttggagaat agtaatattttgttggcgaggcctagtttaagagggtcgactccgttagatgtggcgtat tcgtcgctgatggaaaatacggagttggcgttggctttgcgtgaacattatttggagaag atcgcgatttatttgtcaaggtgtggtttgcagtcgaattctgaacttgtggaaaagggg tatcctgatttggggtgggatccggtggaaggggaacgctatcttgatttcctcaggttc tgtgtttgggttaatggtgaaagtgttgaggagaatgcaaatttagttattaggttgctt atcaggaggcctgaatgtttagggccggctttaagaggcgaaggcgagggcttgctgcgt gctatcgtagatgcgaacaaaatgtctgaacgtatttccgacagacgaaaaatgatggac gaagctgaaggcaccgtaaacgtcgctcctttcactcaccctcttccagaaagcgacgac gacgaagactacatagacacgggagccgccatcctgaacttctactgcactttagtagac cttttaggacgatgtgcccccgatgcaacagttatagaacttggcaaaaacgaatcactt cgtgcccgtgccattctcagatctctagttccactcgaagaccttcaaggcgtcctaagt ctcagatttactcttcaaaacccagcggctggcgaagagcgacccaaatctgatatgcca tcaggtctaatccctggccataaacaatccgttgtacttttcttagaaagagtttacgga attgaaactcaagaactcttcttcagattgttggaggaagcgtttctgcctgatttgaga tgcgctactatgctagacaggaacgacggcagcgagtccgacatggcattaagcatgaac cgctacatcggcaactcgattttaccactcctcatccaacacagcaaattctacagcgaa gctgaaaactatgcctctctccttgacgctactttacacacagtctaccgactgtccaag aaccgtatgctcaccaaaggccaacgagaagccgtttctgatttcttggtagccttaaca agtgctctccaaccctcaatgttgctaaaacttctccgcaaactcacagttgacgtttca aacttatcggaatatacaacagttgctttgcgacttttgacgctacactacgaccggtgt gccaaatattacggttccagcaccggccaaggcctctatggagccgctagtgatgaagag aagcggctgacaatgatgctgttctctaacattttcgattctttgagtaaaatggattac gacccggaattgttcggaaaagcgttgccgtgcttgagtgcgattggatgtgctcttcca cctgattattccttgtcgaagaactatgacgatgagtggtatgcgaataaatcggcaaag actggtcctgatggtccctataatccacaacctatcaatacatcatcagtggctcttaat aatgacttaaatagtatcgtgcaacaattttcggaacattatcatgatgcttgggcttcg aggaagttggaaaatgggtggcaatatggagagacttggtctgacagtaacaagacacat ccgaggctaaaaccctactccatgctgaatgattacgagaaggaacggtacaaagaacct gttcgtgagtctttgaaagccttattggccattggttggtcggtcgagcactcagaagtg gatcatccttcaaccaatcgcaactcagtccaccaccaatcaggcgaaggttcatccccc tttaattacaaccctcacccagtcgacatgaccaacttaacactgtcaagagagatgcaa aacatggccgaacgtcttgccgaaaacgctcatgacatttgggccaaaaagaagaaagaa gagttgaacacttgtggtggtggcatccatccacaactagtcccttacgatcttttgacc gataaagaaaaacgcaaagatagagagcgttcgcaagagttcctcaagtatttgcaatac caaggatataaattacacaagcccatacgtggtggtcaaggcgaaacggagcaaacaaca gccggagcttcaatcgagttacgtttcgcttacagtttattagaaaaactgatccaatac gcagacagagctacgattaacatgaaactattgaagccttcatctaccttcagtcgcaga ccttcgtacaaaacctcatcacgcgatattaaattcttctcaaaagttgtcctccctctg atggagaaatatttctccactcatcgcaactacttcattgctattgctacagctacgaat aatgtcggagctgctagtttgaaggagaaggaaatggtggcttccctgttttgcaaattg gcgagtttgctacgttccaaacttactgcttttggggcagatgtcaggattacggtgagg tgtctgcaagttttggttaaagggattgatgcaaaatcgctggtgaaaaactgtcccgag tttattcgcacgtcgatgttgacgttctttaataatactgccgatgatttggggcatacg attattaatctgcaagaagggaagtacagccatttgcgcgggacgcatttgaagacttcg acgtctttgttttatgtcaatacggtcataattcccattttgacggctatgttcgatcat cttgctaattgtgaatatggaagtgatctgctactcgatgaaattcaagttgcctcgtat aaaattttgcaagctttgtatactctgggcactgacacgacccttacccacgacagaaag tatcttaaaactgaaatcgaaaaatacaaaccggctttaggttcctgtttaggcgccttc agctcaactttcccagttgcgttcctagagcctcatctcaataaaaacaaccaattttct ttcttaaaccgcattgcagatcactcattagaagcccaagacattatggcaaaaatggag ggctcaatgcccacacttgagacaattttatcagaagtggaccaatttgtcgaaagtgaa aagacatattctgacgctcctcatattatagatgttataatgcctatgttgtgttcatat ttgcctttttggtggtctcaaggacctgataatgtcagtccaactggaggtacccacgtg tcgatggtaacagcggaacatatgaatcatttattgaagaatgttttaaaattgataaag aaaaacatcggtaatgaaacagctccctggatgacacgcatagctgcatacacccaacaa attatcattaacagcagtgaagaactgcttagggatccattcttgcccttagctgaacgt gtgaagaagcgaactgaaacaatgttccacaaagaagaaagtttgagaggttttattaag agctcttcagatgacacctcacaaattgaaacgcaaattcaggaagactggcaccttcta gttagggatatttatgccttctatccgcttctaatcaagtacgttgatttgcaaagaaat cattggttgaggcataacattgccgaagctgaagatttgtacaatcatgtggccgatatt ttcaacatttggtcgaagtcacaatatttcctgcgagaggaacagaactttatctctgcg aatgagattgataacatggttttgataatgcccacagctaccagaaggccggttgtaact gacggtactcaacagacaggtggcaagaaaaagaagaagcatcgtgacaagaagcgtgat aaagacaaggaaatccaagcttcattaatggtggcttgcttgaaacgtttattgccagta ggtcttaacttatttgctggccgagagcaggaaatggtccaacattgcaaagaccgtttc ttgaagaaagcaccagaatacgacatcatcgagttcgctaaaacccagcttactttgcct gataaaattgacccagctgacgaaatgtcttggcaacattatttgtacagccaactggga agcaaaaagagcgcagctgtaggaatggtcgacaataacggcaaaaatttgctagaagag acagttgatagaattgtcgccatgagtaaagtactctatgggttacatatgatcgatcac ccacaacaacaacaaaaaggtgtttaccatagcgtggtctctactcagaggaaacgtgct gtactgtcttgtttccggcaagcttctttgcacagtttaccaagacatcgggccataaat atcttcatccgttcctactacgagctgtggctgcaagacgaaaatgtgggtcaggaagtt atgattgaagatcttactcaaagtttcgaagactcggaacttaagaagaaagacggtgaa gaggaagaaagcaaaccggatcctcttacccaacttgtgacgactttctgtagaggagct atgactgagcgttcgggggcgttacaggaggatccgttgtatatgtcttatgccgaaatt attgctaagtcatgtggtgaggaagaagaagaaggggaagaagaggaaagtggtgaaggt gaagaaggaggagcatctattcatgagcaagaaatggaaaagcagaagttgcttttcaac caagcaagactggccaaacgaggcgtagcagaaatggtccttctgcacatatcagcatgc aaaggcgtcccctcagaaatggtaatgaaaacactcgaactgggcatttctatcctccgt ggtggtaacttcgacatccaaatgggaatgttaaaccatttgaaagagaaaaaagacgtt ggattcttcaccagcattgctggactaatgaacagttgtagtgttttggacctggacgcg tttgaaagaaacacaaaagcggaaggtcttggcgtcggatcagaaggtgctgctggtgaa aagaacatgcacgatgcggaatttacatgtgcgttattcaggtttatccaactgacttgt gaaggccacaatttagaatggcaaaattatttgcgtactcaagctggtaataccacaacc gtaaatgtggttatttgcacagtagattatctgctacgtctacaggaatcaataatggat ttttactggcattattccagcaaggatttgattgatcctgccggtaaagcaaactttttt aaagctatcggtgttgctagtcaagttttcaacaccctgactgaggtgattcaagggcct tgtaccctcaaccaacaggcattggctcattccagattgtgggacgctgttggaggtttc cttttcctcttctctcacatgcaagacaaactgtcaaaacactcgagtcaagtcgatttg ttgaaagaattattaaacttgcaaaaagacatgattaccatgatgttgtctatgcttgaa ggtaacgttgttaatggtaccattggtaagcagatggtggacaccttggttgaaagtgca tcaaacgtcgaactaatccttaaatatttcgacatgtttttgaaattgaaagatttgact tcatcacctagcttccaagaaattgatattaataatgacggttgggtgtctcccaaagac tttaaggagaagatggagcaacaaaaaagctacacatctgaagaaatcgacttcttgctg gcgtgttgtgaagttaaccatgatggtaaagtggactatataggtttcatcgaccggttc cacgaaccagccaaagaaattggttttaatttagctgttttgctaacaaatctgtcggaa catatgccgaatgaaccgagattggccaggtttttggaaactgccggctctgtgttgaat tactttgaaccgtttttgggccgtattgagattttgggaggcagcaaacgaattgaaagg gtgtactttgagattaaggaatccaacattgaacagtgggaaaaaccacaaattgaggaa tcaaaacgagccttcttctactccatcgtcacggaaggtggcgacaaggagaaactcgaa gcctttatcaacttctgtgaagatgcgatttttgaaatgcaacacgctagtggtctaatg gcagtggaagaatcaggtggtggtggcccaactcgtgccgccagctacagttacatgaac gtcgatgacgaagaccgtggcaaagatccaattcgtcgaggctaccaatccataaaagaa ggcatcgcttacggactttcatcccttagtccttcaaacatcaaacacaaatttgccgaa atgcagcaaatgaccattccggaactgtttatcggtttcttcagaatgatcatttatgcg ttttactattccggctttggagtagcgattattttcaaatatattttcggcgtgttgttg tctttgatgaggggtccgattgaagaaccggctgttctagaaataaaggaagaagaggaa aaggttgggttatcgagagtgttaccggcgttaccatcttcggaggaacaaaacacgcaa atgcaagcatttggattggatataacgaaagaggataacggacaatacaaaatggcagca cacgaatcaccaaccacaagtcaaccgtcatcagcagaaggtgagggagaaacgacaccg gaagaagatggcgaacatccggaaacggaaaccatggaagcgccactgtcactatctgat cttttaggtggagaacaggctaaacgagcagctcaagaaaaagtcgaagctcaagcggcc caacaagcggtaatgcaagcaattgagtccgaatccaaacaacctgttgttactgaacct tctgccgtttcacaaatcaattttggtgcttacagtcatcgtgcagtgtcatttttggcc aggaatttttacaacttaaaatatgtggctttggtactggcgttctgtatcaacttcatg ctcctcttctatagggtttcgactcttggtgatgatgcggaaggtagcggaagcaagggc attccagacatcctcgaaggctctgctgaaggaagcggtgctggttctggagaatcagga gaagatgacgatcctcccgaattggtacatgtcgacgaagatttctactatatggcacac gtgatgcgattagctgcgattttacattctgttgtatctctagcaatgctaatagcgtac tacaatctaaaagtgcctctagctatatttaaacgggaaaaggaaattgcacgtcggctt gaatttgaaggtttatacatcgcagaacagcctgaagatggcgatcttaaatcgcattgg gataaattagtaatttcggcaaaatcattcccggtgaattattgggacaagtttattaaa aagaaagtacggcaaaagtatagtgaaacgtatgattttgattccatcagtaatttgctc ggtatggagaaaacatccttccaacagcaagaatctgatgaaggaaggagtttcatatac tttatcatcaatattgactggcgttaccaaatctggaaatctggagttgccatcaccgac aactcctttttgtactctttgtggtacttcattttttcgattttgggcaacttcaataac ttcttctttgcggcccatttattggatgtcgctgtcggtttcaaaactttacgcactatt ttgcaatcagtaacacacaacggaaaccaacttgtcttgactgtaatgctactcacaatc gtggtatacatctacacggtgattgcgtttaacttcttcagaaagttctacgtgcaagag gaggatgaagaagtcgacaagaaatgtcacgacatgttaacatgtttcgtattccatctg tacaaaggagtgagagctggtggtggtatcggtgatgaaatcgagccaccagatggcgac gactacgaagtctatcgtattatgtttgatatcactttcttcttctttgtcatcgttatt cttctggctatcattcaaggtttgatcattgatgctttcggtgagcttcgtgatcagtta gaaagtgtgaaagaggacatggagtccaactgcttcatatgtgggatgggcaaagaatac ttcgataaagtacctcacggattcgacacccacgtccaacaagagcacaacttagcaaat tacatgttcttccttatgcatctaatcaacaaaccggacacggagtacaccggccaagag acctacgtgtggaacatgtaccagcaaagatgttgggactttttccctgtcggtgattgc ttccgtaagcaatacgaagaagaattgggaggtggaggcggttaa

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