Thermomonospora curvata: Tcur_0328
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Entry
Tcur_0328 CDS
T01127
Name
(GenBank) pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit
KO
K00166
2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:
1.2.4.4
]
Organism
tcu
Thermomonospora curvata
Pathway
tcu00280
Valine, leucine and isoleucine degradation
tcu00640
Propanoate metabolism
tcu00785
Lipoic acid metabolism
tcu01100
Metabolic pathways
tcu01110
Biosynthesis of secondary metabolites
tcu01210
2-Oxocarboxylic acid metabolism
Module
tcu_M00036
Leucine degradation, leucine => acetoacetate + acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
tcu00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00640 Propanoate metabolism
Tcur_0328
09105 Amino acid metabolism
00280 Valine, leucine and isoleucine degradation
Tcur_0328
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
Tcur_0328
Enzymes [BR:
tcu01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
Tcur_0328
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Motif
Pfam:
E1_dh
TPP_enzyme_C
Motif
Other DBs
NCBI-ProteinID:
ACY95930
UniProt:
D1A1K8
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Position
358584..359726
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AA seq
380 aa
AA seq
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MTIDSARGAPASGLQQAPPPELIQLLTPEGVRVEHPDYPLELTPEEVRALYRDLVMVRRI
DMEAVALTRQGELGLWASLLGQEAAQVGSGRALGERDMVFPTYREHGVAWCRGVDPIRLL
SLFRGLSNGGWDPAEHNFHLYTIVIGSQTLHATGYAMGIQRDGVLGTDKAAAAIAYFGDG
ATSQGDVNESFVFASVFNAPIVFFCQNNQWAISEPLEKQTRIPLYRRAQGFGFPGLRVDG
NDVFACLAVTRRALEAARSGQGPTLIEAYTYRMGAHTTTDDPTRYRLEAELEAWKLKDPI
ERVKAYLIKNEQADAEFLAGVEEEAKQYAADLRRRCLQLPDPEPGAIFEHVYAEPHPLIT
EEQREYAAYLESFEDEGERS
NT seq
1143 nt
NT seq
+upstream
nt +downstream
nt
gtgaccatcgactccgcacgcggtgcgccggccagcggcctgcaacaggccccgccgccc
gagctcatccagttgctgactcccgagggcgtccgggtcgagcaccccgactaccccctg
gagctgacccccgaagaagtccgcgccctctaccgcgatctggtgatggtccgccgcatc
gacatggaggcggtggcgctgacccgccagggcgagctcggcctgtgggcgtccctgctg
gggcaggaggcggcgcaggtcgggtcgggacgggcgctgggcgaacgcgacatggtgttc
ccgacctaccgggagcacggcgtggcctggtgccggggcgtggacccgatccggctgctg
tcgctgttccgggggctgagcaacggcggctgggacccggccgagcacaacttccacctg
tacacgatcgtcatcggcagccagaccctgcacgccacgggctacgccatgggcatccag
cgggacggcgtgctgggcaccgacaaggccgccgccgccatcgcctacttcggggatggg
gcgacctcccagggcgatgtcaacgagtcgttcgtgttcgcctcggtgttcaacgccccg
atcgtgttcttctgccagaacaaccagtgggccatctccgagccgctggagaagcagacc
cgcatccccctgtaccgccgggcccagggcttcggcttccccggcctgcgggtggacggc
aacgacgtgttcgcctgcctggcggtcacgcgccgggccctggaggccgcccgcagcggc
cagggccccacgctgatcgaggcctacacctaccggatgggcgcgcacaccaccaccgac
gaccccacccgctaccggctggaggccgagctggaggcctggaagctcaaagaccccatc
gaacgcgtcaaggcgtacctgatcaaaaacgagcaggccgacgccgagttcctcgccggg
gtcgaggaggaggccaagcagtacgcggccgacctgcgccgccgctgcctgcagctgccc
gaccccgagcccggggcgatcttcgagcacgtctacgccgagccccacccgctgatcacc
gaggagcagcgcgagtacgccgcctatctggagtcgttcgaggacgagggggagcggtca
tga
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