Triplophysa dalaica: 130439264 Help Entry 130439264         CDS       T09616                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism tdw  Triplophysa dalaica Pathway tdw04020   Calcium signaling pathway tdw04260   Cardiac muscle contraction tdw04261   Adrenergic signaling in cardiomyocytes tdw04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:tdw00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     130439264 (ryr2a)    04020 Calcium signaling pathway     130439264 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     130439264 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     130439264 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:tdw04040]     130439264 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:tdw04990]     130439264 (ryr2a) Ion channels [BR:tdw04040]  Voltage-gated cation channels   Ryanodine receptor    130439264 (ryr2a) Domain-containing proteins not elsewhere classified [BR:tdw04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    130439264 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  130439264 NCBI-ProteinID:  XP_056627767 LinkDB All DBs Position 17:22278647..22366115 Genome browser AA seq 5009 aa AA seqDB search MTDGGEAEDEIQFLRTDDEVVLQCSAMVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEERAEGHIDMERWKFMMKTAQGGGHRTLLYGHAVL LRHSYSGMYLCCLSTARSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRAVHYEGGAVSIHARSLWRLETLRVAWSGSHTRWGQPFRLRHV TTGKYLSMMDDQGLLLMDKEKADVKSTAFCFRSSKEKLDFGLRKEVDGMGVPDIKYGDSV CYIQHVDSALWLTYQSVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESHTARVIR STVFLFNRFIRGLDTLSKKGKTSTLDLPIESVSLSLQDLIGYFQPPDEHLEHENKQNRLR SLKSRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGKEAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQNLICDNLLPGRDLLLQTRLVNHVNSMRPNIF LGVSEGSAQYRKWYYELIVDHVEPFVTAEATHLRVGWASTQGYWPYPGGGEGWGGNGVGD DLYSYGFDGLHLWAGCVARSVSSPNQHLLRAEDVISCCLDLSAPSISFRINGQPVQGMFE NFNSDGLFFPAVSFSAGVKVRFLLGGRHGEFKFLPPSGYAPCFEAVLPREKLRVEHSQDY KHDHGNMRDLLGPTVTLTQAAFTPTPVDTSQIVLPPQIERIREKLAENIHELWVMNKIDL GWTYGAVRDDNKRQHPCLVEFSRLPEQERSYNLQMSQETLKTLLALGCHVGVADERAAEK VNNLKLSAKYELSSGYKPAPMDLSHIKLASAQEAMVDKLAENAHNVWARDRTRQGWTYGI QQDIKNRRNPRLVPYMLLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARSDVNNL SMERFRIFRAEKTCSVNAGKWYFEFDVVTAGEMRVGWAQPGCLPDQELGSDEQAFVFDGL KAQRWHQGNEHFGRTWQSGDVVGCMVDMNEGTMMFTLNGEVLLDDSGSELAFKDFEVCEG FIPVCSLGVSQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDTTMWISKRLPQFIP VPANHEHIEVNRIDGTVESPPCLKVTQRSFGSQNSNTDIMFYRLSMPVECSETFGRSPGG MLSANGSFFSPKRDLDDFETVSDFEVLMKTPHSHVSSNGPDRERDEFNNHKDHNQEKPSK IKQRFLLKRSKPDVSSSHSNTRLSEDVIADERDDTENLLQTSTYFYSVRIFPGQEPSSVW VGWVTSDFHQYDPAFDLNMVRTVTVTLGDEKGKVHESIKRSNCFMVWGGECSNPSQGRNN NGLEIGCLVDTANGFLTFTSNGKELCTFYQVEPRTKLFPAVFAQATSPNVFQFELGRIKN VMPLSAGLFKSERKNKVPQCPPRLHVQHLTPVSWSRVPNQFLRSEVSRVNERLGWMIQCS DPLQFMTLHIPEENRSLDILELTEQRDLLKFHHHTLRLYSAICALGNNRVAHALCSHVDE AQLLYAIQNKYMPGLLRTGYYDLLIDIHLSGYATARLMMNSEYIVPMTSETKSITLFPDE KKKHGLPGIGLSTSLQPRMRFSSPNFVGSIPGNHGNGAAAAAGDCFQYSPEFPLETLKSR TMEMLTEAVREGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGVFHNGDLKTILQLIEPSV FSQDSGLEGGVDGPEADESCGRGRLEGGGAEEHGLRGKMPKGGLLQMKLPEPVKLQMCHL LQYLCDCQVRHRIEAVVAFSDDFVAHLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPP QEQINMLLNFKDEKQDCPCPEGIREQLLEFHEDLMTHCGIEIDDDKSGDGDGDFTIRGRL MSLVEKVTYLKKRMTEIPKKKKSKKPSTLQQLISETMVRWAQESVIEDPELVRAMFVLLH RQYDGIGGQVRALPKTYTINAVSVEDTISLLASLGQIRSLLSVRMGREEEKLMIHGLSDI MNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQ NQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYL AGCGLQSCVMLMSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPE CFGPALRGEGGNGLLAAMEEAIKISEDPSRDGPSPTTEEKRTLNDVIEEEEDETIHMGNA IMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRAILRSLIPIEDLVGVISIPFLMPTLAK DGSVIEPDMSAGFCPDHKAAMVLFLDRVYGIEDQIFLLHLLEVGFLPDLRAAASLDTVAL SATDMALALNRYLCTAVLPLLTKCAPLFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRD AIEECLLAVCGKLRPSMMQHLLRRLVFDVPVLNEHTKMPLKLLTNHYERCWKYYCLSGGW GSFGAASDEELHLSRKLFWGIFDALARKKYDVELFKLALPCLSAVGGALPPDYMESNYVA MMEKQSSMDAEGNFNPQPADTSSVVVPEKLDHFINKYAENSHEKWSMEKFAMGWVHGDSF CESSKVHPLLKPYKCLSEKDKEVYRWPIRESLKTMLSWGWSIERTKDSDASTLHNRTRRI SLSSQRSIEGAHGFCPQPVDMSNVTLSRDLHSMAELLAENYHNIWARKKKLELESKGGGS HPLLVPYDTLTAKEKCRDREKAQDILKFFQINGYTVSRAMKEQDLDTPSIEKRFAYTFLK QLITYVDEAHEHMLEFDVGVRCKGDKIPHEQQVKFFGKVVLPLVDQYFKNHRLYFLSTAV RPISSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDAASIVNCLHILGQTLDARTVMK TGQDSVKAALRGFFENAAEDLEKTMENLRQGQFTHTRAQPKGVTQIINYTTVALLPVLSS LFEHIGQNVFGEDVILDDVQVSCYRVLNSLYSLGTSKSIYVERHRPALGECLAAFSGAFP VAFLEPGLNRHNTHSIYNSKASRERAALGLASQVEEACAQVPSLERALQEIMELAESGLR YTQMPHVMEVLLPMLCSYMSHWWESGPENNPEPSDSCCTSLTSEHMNTLLGNILKIIYNN LGIDEGAWMKRLAVFSQPIIGKAKSQLLKSHFLPLMEKLKKKAATVLQDEDQMKAEGRGE LSESELLILDEFTVLVRDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIFWA KSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKGAVSDPERKKMKKRGDRYSLQTSLIV AALKRLLPVGLNICVPGDQELIALAKNRFTQKDTEHEVREIIRNNLHLQGKSEDPAIRWQ MALYKEVPNRSEDTSDPEKTVERVLNIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAV VACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGVEEPSEEDEMI KRIDPLHQLIQLFSRTALTEKCKLEEDHLYMAYADIMAKSCHDGEEDEEEEVKSFEEKEM EKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVASTLKLGIAVLNGGNSTVQQKMLD YLKDKRDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSVLTHERGEKVMQDD EFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWFYS GKDVIDEQGQRNFSKAINVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAH MQMKLSQVHPQSKQIQSNMEKTMLSERVVFILKDSSQIELLKELMDLQKDMVVMLLSMLE GNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGVISKRD FHKAMESHKHYTQSETEFLLSCAETDENELLDYEEFVERFHEPAKDIGFNVAVLLTNLSE HMPHDSRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKE SKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAARMSDAGERSASKEDSEREKPEEE SPEMGFFSMATVRTALFALRYNVMMLMKVLSMKSIKKQVKRAKKMTVKDMVTALASFYWG VLLGLLHFTFSVARGFFRIVYSSFLGGSLVEGAKTMKVSELLANMPDPTQDEVRGETEEG EKKPADRTPPEEDLADLAVKADDTDLLSDIFGLDLKREGGQYKLMPHNPNASLTDLLNAP VPPPAAPSPGVRRRQQTKSSSSSAENNEITEDTKSVPEKVQGENGKKTQKKKEVDEEEVK RKVRLHYSRSDEPDLQESAFWKKIIAYQRKLLNYFARNFYNMRMLALFVAFAINFILLFY KVSTSSAVSEGKDVLFSGTSDTSVQWDPLGSSSSPPVTVHFVLEESSGYMEPTLRILAIL HTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQ SFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMDKAALDFSDAHKKKKPKRDGSLSAVL NSIDVKYQIWKLGVVFTDNSFLYLAWYMSMSILGHYNNFFFAAHLLDIAMGFKTLRTILS SVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGESPDMKCDDMLTCYMFHMY VGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQE QVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFFMYLINKDETEHTGQES FVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 15030 nt NT seq  +upstreamnt  +downstreamnt atgacggacggcggagaagctgaggatgagatccagttcttacggaccgatgatgaggtg gtcctacagtgttcagcgatggtccataaggagcagcagaagctctgtctcgctgctgag ggcttcggaaacagactctgttttctggagtccacctccaactcaaagaacgtacctccg gatctctccatctgtacctttgtcctggagcagtctctgtctgtacgagcgctgcaggag atgctggccaacactgaggaacgggctgaagggcacatagacatggagagatggaaattc atgatgaagacggctcagggcggaggtcaccggacgctgttgtacggtcatgcggtttta ctgcgacactcttacagcgggatgtatctgtgctgcctctcgacggctcgctcatctaca gacaaactggcttttgatgttgggcttcaggaagacacgacaggtgaggcctgttggtgg accattcaccctgcgtccaaacagaggtcagaaggtgagaaagtgagagtgggtgacgat ctcattctggtcagcgtgtcgtctgaacgctatctgcacttgtcttatggtaatggaagt ttacatgtggacgcggcgttccagcaaaccctgtggagcgtagcacccatctgctcgggg agtgaagtggctcagggctttctgattggtggagatgttcttcggctgcttcatggtcac atggatgaatgtttgacggtcccgtctggagaacacggagaagagcagcgcagggcggta cattatgaaggtggagccgtgtccattcacgccagatcactgtggagactggagacgctc cgggtggcgtggagcggcagtcacactcgctggggtcagccgtttcggttgcgtcacgtg accaccggcaaatatctcagcatgatggacgatcaagggctcctgctgatggacaaagag aaagcagatgtcaagtccacagccttctgcttccgctcctcaaaggagaagctggacttt ggcctgaggaaggaggtggatgggatgggggttcctgacatcaaatacggcgactccgtc tgctacatccagcacgtggactccgccctctggctcacctaccaatcggtggacgccaag tgtgctcgcatgggcggagttcagagaaaggccatcatgcatcatgaaggtcacatggat gatggtttgacgctctcacggtcacaacacgaagagtctcatacagccagagtcatacgc agtactgtattcctcttcaaccgcttcatcaggggtcttgatactctgagtaagaaagga aagacgtccacgctggatctaccaatagaatcagtcagtctgagtctgcaggatctgatt ggctacttccagccacctgatgagcacctggagcacgagaacaaacagaatcgactgcga tcgctcaagagccgacagaacctctttcaggaggagggcatgataaacctggtgctggag tgtatcgatcgtttacatgtctacagcagtgcggctcattttgcagacgtggctggaaaa gaagcaggagaatcctggaaatccatcctgaactctctctacgagctcttggctgctctt atcagaggaaataggaagaattgtgcacagttttctggctctttggattggttgatcagt cgcctggagaggttggaagcctcgtccgggatcctggaggttcttcactgtgttctggtg gagagtcctgaagctctgaacatcattaaagagggacacattaaatccatcatctctctg ctggacaaacatggacgcaaccacaaggttctggatgtgttgtgttctctgtgtgtgtgt cacggcgtggcggttcgctctaatcagaatctgatctgtgataatctgctgcccggcaga gatctgctgctacagacacgactggtcaatcacgtcaacagcatgagacccaatatcttc ctcggggtgagcgaaggctccgcccagtacaggaagtggtattatgagctcatcgtggac cacgtggagccgttcgtgacggccgaagccacacacctgcgggtgggctgggcatccaca cagggttactggccgtacccgggcggtggagagggctggggcgggaacggagtcggagac gatctgtactcgtacgggtttgatgggctgcacctgtgggcaggttgcgtggcgcggtcc gtgagctcacccaatcagcatctgctgcgggcggaggacgtgatcagctgctgtctggac ctcagcgctcccagcatctcattccgaatcaacggtcagccggtccagggaatgtttgag aactttaactcagacggactctttttccctgcggtgtctttctcggcaggggtcaaagtg cgcttcctgttgggcggtcgtcatggagaattcaagttcctgcctccgtctggatacgct ccgtgttttgaggctgttttaccacgagagaagctgagagtggagcacagtcaggactat aaacatgatcatgggaacatgagagacctccttggacccacagtcacactcacacaagct gccttcacaccgacacctgtggacaccagtcagattgtgctgccgcctcaaatcgagcga atccgtgagaaactggcagagaacattcatgagctgtgggtgatgaacaagatcgatctg ggatggacctacggagcggtgcgagatgataataaacgtcaacatccctgtctggtggag ttcagcagactgcctgaacaagagagaagctacaacctccagatgtctcaagagacgctc aagactcttctggctctaggttgtcatgtcggtgtggcagacgagcgggcggcagagaaa gtcaacaatctcaaactgtcagccaagtatgagctctccagcggttataaacccgctcct atggacctgagtcacatcaaactggcctcagcacaggaagctatggtggacaaactggca gagaacgcacacaacgtctgggccagagaccgcacacgacagggatggacctacggtata caacaggacattaagaaccgaagaaaccctcgtctggttccttacatgctcctcgatgaa agaaccaagaaatcaaacaaggacagtctgagagaagccgtcaggacgttactgggttac ggctataacctggaggctccggaccaggatcatgcagcgagatctgatgtcaataatctg tcgatggagcgcttccggattttccgagcggagaagacgtgcagtgtgaacgcggggaag tggtattttgagtttgatgtggtgacggcgggtgagatgcgggtgggctgggctcaaccc gggtgtctgccggatcaggagctgggctcagatgagcaggcctttgtgtttgatggactc aaggcccagcgctggcatcagggtaacgagcactttggccggacgtggcagtcgggtgat gtggtgggttgtatggtggatatgaatgaagggacgatgatgttcactctgaacggtgag gttctgctggacgactccggctctgaactcgcattcaaagactttgaggtttgtgaaggc ttcattcccgtctgcagtctgggcgtctctcaggtcggccggatgaatttcgggaaggac gtgagcacgctgaagtacttcaccatctgtggcctgcaggagggctatgaaccctttgcc gtcaacatgaacagagatacgaccatgtggatcagcaaacgactgcctcagttcatcccc gtcccagccaaccatgagcacatagaggttaacagaatcgacgggacagtggagagccca ccgtgtctgaaggtcacgcagaggtcattcggctcacagaacagtaacacagacatcatg ttctatcgtctgagcatgcccgtcgagtgctcggagacgttcggaaggtcgcccggcggg atgctgtcggccaacggaagcttcttctctccaaagagagatctggatgattttgagacg gtgtccgattttgaggttctgatgaagaccccacacagtcacgtcagctccaacgggccg gacagagaacgagatgaattcaacaaccataaagatcacaatcaagagaaaccctccaaa atcaaacagaggtttttgttgaagagatcgaagccggacgtcagcagcagtcattctaac actcgactgtcagaggacgttatagcagacgagagagacgacacagagaatctcctgcaa acatccacgtatttttactcggtgaggatcttccccggtcaggagccgtccagtgtttgg gtcggttgggtgacgtcagattttcatcagtatgatccggcctttgacctcaatatggtc cgaacggtcacggttaccctgggagacgagaagggtaaagttcacgagagtattaaacgc agtaactgcttcatggtttgggggggtgaatgcagtaaccccagtcagggtcgtaataat aacggtctggagatcggatgtctggtggacacggccaacggcttcctcaccttcacatcc aacgggaaagaactctgcaccttttaccaggtggagccgagaactaaactctttcctgca gtgtttgcgcaggcgaccagtccaaatgtcttccagtttgaactgggacgcattaagaat gtgatgcctctctctgcaggcctgtttaaaagtgaacggaagaacaaagtaccccagtgt ccaccgcgcttacacgtgcagcacctcacacccgtctcatggagtcgtgtgcccaaccag ttcctgaggtcagaggtcagcagggtgaatgagagattgggctggatgatccaatgttca gatccactgcagttcatgactctacatatacctgaagagaataggtcgttggatatccta gagttgacagagcagagagatctattgaagtttcaccatcacacactgcgtttatattct gccatctgcgctctggggaacaatcgtgtagctcatgcgctctgtagtcacgtggacgag gctcagctcctgtacgccatccagaacaagtacatgccaggcctcctgcgcaccggatac tacgacctgctcatagacatccacctgagcggctacgccaccgcccgtctcatgatgaac tccgagtacatcgttcccatgacgtccgagaccaagagcatcactctcttccccgacgag aagaagaaacatggcctgcccggcatcggactgagcacctcgctgcagccgcgcatgcgc ttctcctcgcccaacttcgtagggtccatccccggtaaccacggtaacggcgcggcggcc gctgccggtgactgtttccagtacagcccagagtttcccttggagacgctgaagagtcgg acgatggagatgctgacggaggcggtgcgggagggcagtttacacgtgcgggatcctgta gggggcagtactgagttcctcttcgttcctctcatcaaactcttctacacgctcctcatc atgggtgtctttcacaacggagacctgaagaccatcctgcaactgatcgaacccagcgtc ttctcacaggactctgggctggagggcggcgtcgatggcccggaggcggacgagagctgt gggcggggccggcttgagggaggcggggccgaggagcacggtttgagaggaaagatgccc aaaggaggacttttgcagatgaaacttcctgaacctgtcaaactccagatgtgtcacctg ctgcagtatctgtgcgactgtcaggtccggcatcgcattgaggcagtggtcgcattctcc gatgactttgtagcacatcttcaggataaccagcgcttccgttataatgaagtcatgcag gcgctgaacatgtccgctgctctgaccgcacgaaaaaccaaagagttccgctcgcctcca caggaacagatcaacatgctgctgaattttaaagatgagaagcaggattgtccgtgtccg gagggcatcagagaacagctgctggagtttcacgaggacctcatgacacactgcggcatt gagatagacgatgacaaatctggagatggtgacggtgatttcaccatcagaggtcgtctg atgtctctggtggagaaggtcacctacctgaagaagagaatgaccgaaataccaaagaag aagaaatcaaagaagcccagcactcttcagcagttgatctcagagacgatggtgcgctgg gctcaggagtctgtcatcgaggatccagagctggtccgggccatgtttgtgttactccac aggcagtatgacggcatcggcgggcaggtgcgagcgctgcccaaaacctacaccatcaac gccgtctctgtggaggacaccatcagcctgctggcgtctctggggcagatcagatctctg ctcagcgtccgcatgggtcgtgaagaagagaagctcatgattcacggcctcagtgacatc atgaataataaagtgttttatcagcatccaaacctgatgagagcgctcggcatgcatgag accgtgatggaggtgatggtaaatgttctgggaggaggagaatctaaggagatcacgttt cctaagatggtggcgaactgctgtcgttttctgtgttacttctgtcgaatcagccgtcag aatcagaaggccatgtttgatcatttgagttatctgctggagaacagcagcgtgggactc gcgtctccgtccatgcgaggttccactcctctggatgttgctgcagcgtcagtgatggat aacaatgaactggctctggcgctgagagaaccagacctggagaaagttgttcggtatctg gccggctgtggattgcagagttgtgtcatgttgatgtctaaaggatatcctgacatcggc tggaacccggttgagggtgaacgatatctggactttctcagatttgctgtcttctgtaat ggtgagagtgtggaggaaaacgctaacgtggtggtccggctcctgattcgtcggccagag tgttttggccccgccctgcgtggagaaggtgggaacgggctgctggcagcgatggaggaa gccattaagatttcagaagatcccagcagagacggaccatcacccaccacagaagagaaa agaacacttaatgatgtcatagaggaagaggaagatgagaccattcacatgggaaatgcc atcatgaccttctatgcggctctcatcgatctgttgggccgctgtgctccagagatgcat ctgattcacgcagggaagggtgaggccatccgcatccgggccatcctcagatctctcatt cccatcgaggacctggtgggtgtgatcagcatcccgttcctgatgcccactctggccaaa gacggttctgtgatcgagccggacatgtcagcaggcttctgtcccgatcacaaagcggcc atggttctgtttctggaccgtgtgtatggcattgaggaccagatctttctcctgcacctg ctggaggtgggattcctgcctgacctccgagccgccgcctcattggacaccgttgctctg agcgccacagacatggcgttagctctgaaccggtacctgtgcacggccgtactgccgctc ctcaccaaatgtgctcctctgtttgccggcaccgagccattcgcctctctcatcgactct ctgctgcacaccgtctacagactctccaaaggctgctgtctcactaaagcacagagagac gccatcgaggagtgcctgctggccgtctgcggtaaactgcggccctctatgatgcagcat ctcttgagacgtctggtgtttgatgttcctgtactcaatgaacacaccaagatgcccttg aagctcttgaccaatcactacgagcgctgttggaagtattactgtctgtcaggaggatgg ggaagtttcggggcggcgtcagacgaggagctgcatctgtccagaaaactcttctgggga atctttgatgctctggccagaaagaaatatgacgtggagttgtttaagttagctctgccg tgtctgagcgcggtgggcggagctttacctcctgattacatggagtcaaactatgtggcc atgatggagaaacagtcgtctatggatgctgaaggaaactttaacccacagccggcggac accagcagcgttgttgttccggagaagctcgatcatttcatcaataaatatgccgaaaat tctcatgagaaatggtcgatggagaagtttgcgatgggctgggttcatggagactcgttc tgtgaatcatctaaagttcatcctctgctgaagccttacaagtgtctctctgagaaggat aaagaggtttaccgctggccaatcagagagagtctgaagacgatgctgtcgtgggggtgg agcatcgagcggacgaaagatagcgacgcgtccacgctacacaaccgcacacgcagaata tctctgtccagtcagcggtctatagagggcgctcatgggttctgtcctcagccggtggac atgagtaacgtcaccctgtccagagatctacattcgatggcagaactgctggcggagaac tatcacaacatctgggctcggaagaaaaaactggagctggagtctaaaggtggaggcagt catccgttgctggttccttacgacactttaactgccaaagagaagtgcagagaccgagaa aaagcacaagacatcctgaagttctttcagatcaacggatacacagtttcaagggctatg aaagaacaggatctggacacaccgtctatagagaagcgtttcgcgtacacattcctcaaa cagttgatcacgtatgtggatgaagctcatgaacacatgctggagtttgatgttggcgtc agatgtaaaggtgataaaattccccatgagcagcaggtgaagttttttggaaaggttgtg ttgccgttggttgatcagtacttcaaaaaccatcgcctttacttcctgtccactgccgtc cgtccaataagcagcggcggtcacgcctccaataaagaaaaagagatggtgaccagcctt ttctgcaaactgggagttctggtcagacaccggatttctctgtttggaaatgatgcagcg tcaatagtgaactgcctgcacatactgggacaaactctagacgccaggacggtgatgaaa acaggtcaggattcggtaaaagcggctctgagagggttcttcgagaacgcagcagaagat ctggagaagacgatggaaaacctgcgacagggtcagttcactcacacccgcgcacaaccc aaaggtgtgacgcagatcatcaactacaccaccgtggcgttactgcccgtcctctcgtcg ctgttcgaacacatcggacagaacgtgtttggagaggatgtgatactggatgatgtccag gtgtcctgctatcgtgttttaaacagtttgtactcactcggaaccagtaaaagtatttat gtcgagagacaccggccggctctgggtgaatgtctggctgcgttctcaggcgcgttccct gtggccttcctggaacccggtctgaaccgacacaacacacactccatctacaacagcaaa gcatcccgagaacgagcagctctcggtcttgcgtcgcaggtggaggaggcgtgtgctcag gtgccgtctctggagcgagcgctgcaggagatcatggagctggcggagtcgggcttgcgc tacacgcagatgccacacgtgatggaggttcttctgcccatgctctgcagctacatgtct cactggtgggagagcggacccgagaacaatccagagccgtctgacagctgctgcacgtct ctcacctctgaacatatgaacacactgctgggaaacatcctgaagatcatctacaacaac ttgggcatcgacgagggagcctggatgaagagactcgctgtgttttctcagcccatcatt ggtaaagctaaatctcagctgttgaagtctcactttctgccgctgatggagaagctgaag aagaaggcggcgacagttcttcaggatgaagatcaaatgaaagctgagggtcgaggcgag ttgtctgaatccgagctgcttatcctcgatgagttcaccgtcctcgtgcgagatctgtac gccttctacccgctgcttatacgattcgtcgactacaacagagccaaatggctgaaagaa ccgaatccagaggcagaagaattattccggatggtggcagaagtctttatcttctgggct aaatcacacaactttaagagagaggagcagaactttgtggttcagaatgaaatcaataac atgtccttcctcatcacagacaccaaatccaaaatgtccaagggtgcggtgtcagacccg gagaggaagaagatgaagaagcgcggtgaccgctactcactgcagacgtctctgatcgtg gcggctctcaagagattactgcctgtgggtctgaacatctgtgtgccgggagatcaggag ctcatcgcgctcgccaagaaccgcttcacacagaaagacacggaacatgaagtgagagag atcatcaggaacaacctccatctgcaggggaagtcagaggatcctgcgatccgctggcag atggctctgtataaagaggtgcccaaccgcagcgaggacacgtctgaccctgagaagacg gtggagagagttctgaacatcgctcacgtcctctttcatctcgatcaggttgaacatcca cagagaagcaagaaggcggtttggcacaagctgttgtccaaacagagaaagagagccgtg gtggcgtgtttcaggatggcgccgctctataatctgcccagacacagagccgtcaatctg ttccttcagggttatgagaagtcctggatcgagaccgaggaacattatttcgaagacaag ttgatcgaggatttggccaaacccggtgttgaagaaccgtcagaagaagatgagatgatc aaacgcattgatccgttacatcagctcattcagctcttcagcagaactgcactgactgag aaatgtaaacttgaggaggatcatctctacatggcttatgctgatataatggcaaagagc tgtcatgatggagaggaagatgaagaggaggaggtgaagagttttgaggagaaggagatg gagaaacagaagctgttatatcagcaggccagacttcatgatcgaggagctgcagagatg gtcctgcaaaccatcagcgccagcaaaggagagatggggccgatggttgcttctacactc aaactgggtatcgccgtactcaacggaggaaactcaaccgtacaacagaaaatgttggat tacctgaaagacaagcgggatgtgggcttcttccagagtttggccggactgatgcagtcg tgcagtgttttggatctgaatgcgtttgagcgtcagaataaagctgagggtctggggatg gtgacagaagaaggttcagtcctcactcatgagcgtggtgaaaaggtcatgcaggatgat gaattcacctgtgacctcttccgcttcctgcagctgctctgtgagggacacaactcagat tttcagaactacctgcgaacacagacgggtaacaacacaacggtcaacatcatcatctct acagtagattatctgctgagagtacaggagtccatcagtgatttctactggttttattct gggaaagacgtcatcgatgaacaaggccagaggaatttctctaaagccatcaatgtagcc aaacaggtgttcaacacactgacagagtatattcagggtccctgcacagggaatcaacag agtctggctcacagtcgtctgtgggacgctgtcgttggatttctacacgttttcgcacac atgcagatgaagctgtcacaggtacatccacaatccaaacaaatccaatcaaacatggag aaaacaatgttgagtgaacgtgtcgttttcattctgaaggattcaagtcaaatcgagctg ttgaaggagctgatggatcttcagaaggatatggttgtcatgctcttgtccatgttagaa ggaaatgttgtgaacgggaccattggaaagcagatggtggatatgttagtggagtcgtcc aacaacgtggagatgatcctgaagttcttcgatatgtttctcaaactgaaagatctgaca tcatcagacgccttcaaagagtacgaccccgacggcaaaggggtcatctccaagagagat tttcataaagccatggagagccacaaacattacacccaatctgagaccgagttcctcctg tcgtgtgcagaaacggacgaaaacgaacttttggactatgaagagttcgtcgagcgcttc catgaaccggccaaagacatcggcttcaacgtggccgtccttctcaccaacctctctgaa cacatgccacatgactctcgcctccagaccttcctggaactggccgagagcgtgctgaac tatttccagccatatctgggccggatcgagatcatgggcagtgctaagcgcatcgagcgt gtgtacttcgagatcagcgagtccagccgcacgcagtgggagaagccgcaggtcaaagag tccaaacgtcagtttatctttgacgtggtcaacgagggaggcgagaaagagaaaatggag ctcttcgtgaacttctgcgaggacaccatctttgagatgcagctggccgctcggatgtcg gacgctggcgaacgctcggccagcaaagaggacagcgagagagagaaaccggaggaggag agtcccgaaatgggtttcttctccatggccaccgtgaggacggctctgttcgctctgcga tacaacgtcatgatgctcatgaaggttctgtccatgaagagcatcaagaaacaggtgaag agagcaaagaagatgacggtgaaggacatggtcacggcgctggcgtctttctactggggc gtcctgctgggtctcctgcacttcaccttcagcgtcgctcgagggttcttccgcatcgtg tacagcagtttcctcggaggcagtctagtggagggcgccaagaccatgaaggtgtccgaa ctcctggccaatatgcccgatccaacgcaagatgaagtgagaggagagacggaggagggc gagaagaaacctgcggacagaaccccgcccgaagaagacctggctgatctggcggtgaag gcggatgacaccgatcttctgtctgatatattcggtttggatctgaagagagaaggcgga cagtataaactcatgcctcacaatcccaatgccagcctcaccgatctgctcaacgccccc gttccacctccggccgcaccgtcgcctggagtacgccggagacagcagaccaagagctcc tcatcttcagcggagaacaacgagattacggaagacaccaaatctgtgcccgagaaagtc caaggtgaaaatggaaagaagactcagaagaagaaggaggtggatgaggaggaggtgaag cgtaaagtacgacttcactacagcagatcagacgagccggaccttcaggagtctgcattc tggaagaagatcattgcttatcaacgcaaacttctgaattattttgcacggaatttttac aacatgagaatgttggctctgttcgtggcgtttgccatcaacttcattctgctgttttac aaggtgtcgacgtcttcagcggtctctgaggggaaggacgtgttgttcagcggtacatca gacaccagcgttcagtgggatcctctggggtcctccagcagtccacccgtcacggttcac ttcgtcctggaggagagcagcgggtacatggagcccaccctcaggattctggccattcta cacaccgtcatctctttcttctgtatcatcggctactattgtttaaaggttcctctggtg atatttaagcgtgagaaggaggtggccagaaagctggagtttgatggtctgtatatcacc gaacagccgtcagaagatgatattaaaggtcaatgggacagactggtcattaacactcag tccttcccgaacaactactgggataaatttgtgaagaggaaggtgatggataagtatgga gagttttatggtcatgatcgaatcagtgagctgctcgggatggataaagccgctctggac ttcagtgacgcccacaagaagaagaaaccaaagcgagacggatccctgtcagcagtactg aactccatcgatgtgaagtatcagatttggaagttaggagtggtcttcacagataattct tttctgtatctggcctggtacatgagcatgtctattctgggacactacaataatttcttc ttcgctgctcatctgttggacatcgccatgggcttcaagaccctgaggaccatcctgtcg tctgtcacacacaacggcaaacagttggtcctgaccgtaggtctgctggcggttgtggtt tatctctacactgtggtggctttcaacttcttccgtaagttctacaacaagagtgaagat ggagaatctccagacatgaagtgtgatgacatgctgacgtgttatatgttccacatgtat gttggcgttcgggctggcggtgggatcggtgatcagatcgaggatccggccggggacgag tatgagatctatcgcatcatctttgacatcaccttcttcttcttcgtcatagtcatcctg ctggccattatacaaggtcttattattgatgcatttggtgagttaagagaccaacaagag caggtgaaagaagacatggagactaaatgtttcatctgtggaattggaaatgattatttt gacaccgttccacacggctttgaaacccacacgctacaggaacacaacctggccaactat ctatttttctttatgtatctcatcaacaaagatgaaacagagcacacaggccaggagtca ttcgtttggaaaatgtaccaggaacgctgctgggaattctttcctgctggcgactgtttc cggaaacaatacgaggaccagctgaattaa

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