Tachysurus fulvidraco (yellow catfish): 113647419 Help Entry 113647419         CDS       T08119                                  Symbol obscna Name (RefSeq) obscurin   KO K17531   obscurin-RhoGEF [EC:2.7.11.1] Organism tfd  Tachysurus fulvidraco (yellow catfish) Pathway tfd04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:tfd00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     113647419 (obscna)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:tfd01001]     113647419 (obscna)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:tfd04131]     113647419 (obscna) Enzymes [BR:tfd01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      113647419 (obscna) Protein kinases [BR:tfd01001]  Serine/threonine kinases: CAMK group   Trio family [OT]    113647419 (obscna) Membrane trafficking [BR:tfd04131]  Others   Rho GTPase associated proteins    Rho guanine nucleotide exchange factors (GEFs)     113647419 (obscna) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  I-set Ig_3 ig Ig_2 Pkinase V-set PK_Tyr_Ser-Thr Ig_5 Ig_4 Izumo-Ig SOS1_NGEF_PH RhoGEF Receptor_2B4 IQ PH Kdo IQ_SEC7_PH fn3 RHG20_PH APH Motif Other DBs NCBI-GeneID:  113647419 NCBI-ProteinID:  XP_047655884 LinkDB All DBs Position 14:complement(1603605..1669536) Genome browser AA seq 6481 aa AA seqDB search MATLNKIQVIKGLEDVTLCEKEAWTFEVILSHAYVQGTWTRNGLRFKSKPTCRMAMQGKR HTLTLTRVSLLDMGLISFQADGAETSANLTVTARDIQILTHLQDVSVTERESVTFVCEVN LEDVDGKWFKKSSRIKSGDNVRIRQDGKIHTLTFKAIKPEDAGEITFTAERVSSSAMLRV KELPVQIVKPLRVKIAMYRHRAMLECQVSRANAEVTWYKCNREITPNGKYRFISDSLYRQ LTIEEVGSSDEDTFICDAGDDKTSCRLFVEEQAISIVRGLSSVEVMEPKEARFRVETNIK AERAPKWTLNGELLSPGPEVRIEKEGTTHRLTFTNTNSSMCGTIQFSSGKSRSTAQLTVT ERPLVVTQPISDVEVKENCSVALKCEFCPSPRVVRWFKGRTPLLASSKYNMRQEKNRVEM IIMNAKAVDTGEYRCLAGGAESRARVNVEVKRLKITRHLEHVEVEEEGTAVFFCELNHEA PGIQWLLNERVIHASHINKIQNSGKVYTLVLKRLAPQESRVTFKTVSISESTVLRVKERP AVFLRPLEDVVAEERAKVCLQCEVSKQAVTPVWSKDGTVLNASEKHEILQLGKLLSLIIH KLRKDDAGEYSCDVGTSQTKAKVVVRDLHITIVKRLRTISVLEGEYCSFECILSHDIIDE PSWTLNGQLIISNARIQIANQGSKYTMNIQEVIITDAGEVVFTIKDLSCRTMLFVREKPI RVFRDMLNVKAVPGEDPELSCEITKPGVTIKWLKNGRSIRSNSKYEMIQKGFLVTLVIHN ATVKDSGEYCCEADGTSTRARLEVRDFQHTFATELRDVNAEEKTMVVLECETKRPATKVS WLKGMVVLISGQKYLMMKKGVFLSLTIFNLDKSDSDLYTCDVGTMQSRALLTVQGQKVLI LDELEDVECLEGDSAVFKCRICPSDFTEVKWYLDETLLYTNDLNEIQMIHGGYHSLTIKQ LARKDTGTISFEAGDKRSYASLLVRERRPTIIKPLKDIEAIEGGSLNLSCKASKPCHILW YKDGCLMWNSSSYFMTRSGNEARLTIREVKDTDAGVYECNAGSVSTKATVTVKAVPAEFT RQLHSQEADEGSSVTLFCEFSVPGVRYLWRKGAETLRSGEKYLTKQRKNYLSLTIHNLKL EDSGTYTCICRNQRSTATVTVHAIPITFIKELKNQESEEDMAMTLRCELSKAGVPVEWMR NEEVLSPGLKFQMRQIVSIQELVIRNPVPEDSGTYSCVCTGQRTEAIITIKAQPITFKKK LKSQVVEEGNSVTLHCEVSKPGLPVEWRRGQELLKSGEKYRMRQRNCLLELKIFNLICED SEIYSCSCGNVQTSARVTVSKRPVSFTEKLTNLVAEEGKTLTLHCELSKPGVPVEWWNGE DLLQPGQKYQMRERDATHELIICDTVPEDSGVYRCICGNQKTKAMIKIVGVAATFKHNLK NQEALEGGDVVLRCELSKAGVPVEWWKGEERLAPSGRYQIRQEGKVAEMEITNVLLNDAG IYSCDAGNHKSSAEVKIKALPITFKQELQDQVCKEGDKAVFVCELSKPGAPVEWRKGRVL LKPGEKYKMRLEGRLTKLEINNLEEDDSGSYICKTKDAQSTAELTVQALPATFKNVLKNH EAQEGSSISLQCELSKAGTHVEWWKGAEMLRTGERYQLRKKGATAELLIRKAQPEDSGVY RCVCGEQSTEAQIKVNALPIMFKQELKNQEAEEGNNVTLRCELSKSEALVEWWRGEQLLK PGEKYQMRQMATKMELVIRKVVPEDSGVYTCVCPDQKSSASVKIKAIPVIFKQNLRNQET VEGKNITLRCELSKSGALVKWWKGQRELAGGEKYHMKTEGKTAELVIKNVSCEDAGVYGC TIGEQKTTSEIKVRAQPVTFKRELQNEVSKEGETAVFSCELSKPGAPVDWRKGRVILKAG DKYEIKQDGKMTTLVIRNVEGSDAGYYSCKTKDSESTAELTVQVPPIIFKVKLKNQEVEE ESDVRLHCELSKAGLPVQWKKGKEVIKSGLKYQIIQRDTTVELIVKKATSEDSGVYSCIC GDQDTKANIKVFASPVTFRQNLMNQEAPEGGIIVLHCEISKPGVPVQWWKDEEELCNGSK YKMKQDGLVAELHIRNVLPMDVGEYSCVVGDQKTTAEVNVRAAASVFFEKELQDQEVMEG NSVVFSCLLSSPNAPVAWKKDSLQITQGGRFTVHQKGSTQELEIRKLRSEDAGVYTCSTR GKTTSAHLRVIDRVRIVRELQDLTIVAGEDAHFVCELSHSDITDGVWWLDSTVLQANEMN QMTCHGREHHLTLTMTTPEESGIVAFVVGEEWTSARLQVKSKPKVLIEEKVKDLVVLEGE TATLSCVTSADCTPITWKKNNVTLLAGEKYEPRKEGKHNMLLIHTVEKDDTGVYMCDTGD MQSMAVLTVRERPLFFREELQSQQVEEGETAFLHCELSKPGVVVQWKKGGTLIKPGNKYQ IKQDGCEAQLQISELVVQDSGIYRCCVDGIETKASLSVKDQPLFFREKLQSMEAEEGETA FLCCELSKPGVQAQWRKGTVLLRPGIKYQMKQNSCELELQINDLKCEDSGVYRCRVGSLE TTANILVKEQPLFFSEELQNQQVEEGETAFLCCELSKPGVSVQWKKGTVLLRPGDKYELN QDGCKLQLKIHDVIGLDSGNYKCCAGGLVTTASVAVKEQPLFFHEELQNLESVEGETASM CCKVSKSGVSVQWRKGAVVLKPGNKYEMKQNDCEFQLKIHDLTNHDSGIYRCCTGVVVTT ASLEVKEQPPFFLEELQSMQAIEGETASLICELSKPGVPVVWKKGATRLRPGGKYEIRQK GCKLQLKVRNLTHQDSGFYKCCAGDLETMASLEVKEVPVFFHEELQNLELEEGGTALLSC KLSKPGVAVQWKKGSVLLRPCEKYKLTVNVCDLQLQIHDLTCEDSGTYRCSAENTETTAV VLVKEQPLFFYKELKNQEAEEGETSSLCCELSKPRASVQWKRDSMLLKTGEKYEIKQDGC KLQLKIHDLNSSDCGSYKCCAGSLVTTACLLVKEKPLFFCKELQNLEVEEGKTALLCCEL SKPGISVVWKKGVLLLKPGEKYGMKQDGCELQLMIHDLRSSDSDSYKCCAGSLVTTASIV VKEKPLFFCKELQNLEVEEGKTAFFCCELSKPGISVVWKKGVLLLKPGEKYEMKQDGCKL QLKIHDLKSSDSGAYKCCAGSLVTTASIAVKEKPLLFCKELQKLEVEEGTIALLCCELTK PGVAVQWKKGAIPLKPGEKYEMKQNGCELQLYIHDLRQSDSGFYKCCAGSMVSTASIVVK EKPLFFCKELKDLDVEEGTIALLCCELTKPGVAVQWKKGAIPLKPGEKYEMKQNGCELQL RIDDLRSSDNGSYKCCAGTTSTTASIVVKEKPLFFCKDLQNLEVEEGKTALLCCELSKPG ISVVWKKGVLLLKPGEKYGMKQDGCKLQLMIHDLRSSDSDSYKCCAGSLVTTASIVVKEK PLFFCKELQNLEVEEGKTAELYCELSKPGISVQWYTETMLLRPGSKYEIKQDGYKHHLKI YGLENQDTGSYKCCAGGLVTTASITVKEHPVFFSKELESQEVEEGSNVILCCELSKPGAT VQWKKDTVLLHPGNKYEMKQNGCEVQLNVYNLNTEDCGVYKCCASKVETAATVGVKGSAF PAKLKDIPRVPPRTKGKRSQQSPLLYRQSNTVDQCQDDLLDHSEKRTEEQVSEKTLMEER VKENERFSVKDEVMVDIKKSTFSPDSCVTAMQRKSAEKIEVPTTVSKQNRDNMKHVPVSS DTDERKSETRGKVVQLATPLHKEKLTQPQIVLQAQDVLEPKTRVSVMELFEEPNFRISSD TESQSLDFGAKITKEKHTAKETSVREEIKEKKPHVHSETSVDPEKIESSSEVKEHLTEKA LRHHIMDQEYKKQHVSAGKTAELSIKPAHVVDMGFTDQTNVKQRDEAPEHSTHGPVAAQT RREGLVGGAVKPKPWEKITKACEVAELTKDTKPLEQQRDKAPEHSTHGPVAAQTKREGPV GGAVKPKPWEKITKACEVAELTKDTKPLDQHHQDLSGLDIPVSHEDETEMLDAAVKIQAA FKGYKARKDMRPNFKAVFKTQNVELSNAFCLECIVDGKPSIVRWLKDGVEIQSGKRHNIS HHDDGRCLLVVANASYKDAGIYTCEVANKFGTISYNGNVTVSHPKKPIKKTAQKTAAEPT PGKEVWQMSNKEEDKLKLIYDLPTDNTYRKIQEKRKSLISVSPSSCPSDHDITPDVDTGN LSKEKEAEKTKSDMKPSKIFEEEKNISPQPQNISGLKVKEGKPISKTPSPKYPQSLKALS NVESLSESDEDDEREETFDIYVVKVDCHPIGGNKETFILKEGQFVDVLDSVHPVKWLIRT KPSKNTPSRQGWLSPAYLEKKTKELLSMVQETETKDASKKGRKTASEEAYEATSSRLIKS LLDGEIEFVREMNFFVEHHLHHVETSSKVPLTIQSQKEYIFCNIKDIASFHECCILPKLS QCTTDDDVAQCFVNHAPDFEMYLQYIAGRSQAQACISDKNTQHFFKQYADTALAHLDTQV FSISTYLESPLEKLQMYKSLFKELIRNKAKSGQSCCLLEDAFSMVSSLPWRAENVQHVSL IENYPAPLTGLGEPVRQGSFAVWEEAPGTKVSLRGHRRHVFLFKDCIVFCKTKRDLSTQT ILYVFRNKMKLTDVDLKDTVEGDDRSWGIWHEHRGTIRKVRIQAHSVLTRLSWLKDLRDL QQRNKHPWSGPYFKLILSDSVVKLRQTTKLVCNVTGIPKPVVTWYKDGIVLKDNQHRIIS EGNSGACSLVLTCVSVDDSGQYLCYAANPMGNASTLAKVFVDVPPSFTSRLQNTPLVIGQ DVKLQCKAGCIPVPPVRWLKDGTQLEKSKRYEIDSDTQTGNLLLVIKKAEEKDVGQYECE ITNQMGSAKCKAQVYYTPPPETDSTKNQPQDTTAPVPEQETKDPIRAILIRRFRRLVQCF GEEPLPDVLSVWIFQPEISIPIKSLHQIFFRSAQSTRESQDTPKVNEEQSDIPEEQYEET RVSREMGKNDTDPPMVQVDMEDLCVQPGQPATFSVVITGQPIPEISWFKDGVELVAGEHI AMKQNGARFSLNLPNVYFSDRGTYACTAKNSSGYVSCHANLTLDTGPVEFEEEEEEEEEK EEDRGLKVGRRRKLHAVYEVHEEIGRGTFGVVKRVVHRASAEFFAAKFIPLKSSTRNRAI QERDLLSRLTHRSVACLLDFFSTRRTLVLITEICSSQGLVEHMLLKGSVSEREVQVYIQQ ILEGVGYIHSMNILHLDIKTDNILMVSPDGEDLKICDFGFCQEIDPSRHQYSIYGTPEFV APEIIRQEPVTTATDMWSVGVVAFLCLTGHCPFLGENDRATLLKVAEGLLYWNLPEITSL SEQAQDLLHGVLQPDPKTRPSALECLDYEWFQGPCEEKQCDTIDTKSLKSFISRRKWQRS LTCLGSVLTLRSIPDLLDAPACEVAITTLRDPRNTSSNSMSTGSSSEYDEADGWGFFQNP SQEEDDDLEEDGMEYYSYAYLPKRSLALRDEEDVMLGQVRERRGALMIPINKESREMPSA SSELINRDRKEDDKVSSATPIPRGSLIESTFYNSDEQLSPMSARHMMLREKLQARKQDRV RRTLRSSLSGRLNEPLIEYVEDSPDAESCLRHRRGSTLLSKSCSLDRGVRSIHPSSHSHW RSRSLDESRGISGASIEHRTLRNNEDLEFSHNNEFTDEEKEEASEVPVNRVSQSQLESHK VTMEELPIIMGCHVDDSQSHPGEEGSAAMGEEEEKVEGSLAESYERDSDASSRTSTYTEQ QSPSHLLISQRQHRAYDESEEHLVAPSSGKASELSLTQDSEDEDMERVLRNLRQAPLQQH PHSTTMNKNNVTLRRSSSSVPTHPTSATSVSREVLQRHSSAPALELNPPSGKSKYGLMKI FRRKSWTPGPSDSQTQGSDKKVDNGSSQQQKTPLLALRKKMRASASSITKLFSRQSSKEI TALHRRPIVRNPVPPEKATVTSEVYPSPPFSGSLQKKSKLFSLKMPSFKKSKGIPARPSK PDVIQLGSGGALVMWKPVRCVDPVTYCIQYSLKGEEWTNLSENVTDSCYIANTQPIGPSY VYRVACVTKTGPGPFSDPSPPALTTMPAEDSYIPLNLTESTGSEITVVGELGSERSYTFL SEINRGRFSVVTHCKDSRSLRPLAAKLTPYSPEQRQLVLMEYQVLRRLCHPNLVQLHAAI LMPSCLALIEELCSGREVLYSLAERDMYSEMHVCELLRQLLRGVDYLHGRRIVHLDLRSD NVLVTDNNVVKIVDLGSAQHFTPGHALNIEHIKEMTESKVYIVLPKAPEILQGQGVGPAT DIWALGVLAFIMLSADRPFHTDLYWERDHNIRKGKIQFGRCYPGLSEGAINFLRSTLNSK AWGRPSAAECLQNPWLQEERGEPSKHTASMFCFSTEKLQAFLKEREAKRDRTRTKITLPL S NT seq 19446 nt NT seq  +upstreamnt  +downstreamnt atggcgactttgaacaagattcaggtgatcaaaggtcttgaggatgtgacactgtgtgaa aaagaagcctggaccttcgaggtgattctgagtcacgcttatgtccaaggcacgtggacg aggaacgggctgcggttcaaatcgaagcccacatgtcgcatggcgatgcaggggaagaga cacactctcactctgacacgtgtctcgctattagacatgggcctgatcagctttcaggct gatggagcagagacctccgctaatctcaccgtcacagccagagacatacagattctaacc catcttcaggatgtcagcgtgactgaaagggagagtgtgacgtttgtgtgtgaagtgaac ctcgaggacgtggatggaaaatggttcaaaaagagcagcaggataaaaagcggggacaat gttagaattagacaagatggtaaaattcacacactgaccttcaaagccataaagccagaa gatgccggtgaaatcaccttcactgcggagcgagtctcatcatcggccatgctaagagtc aaagagcttccggttcagatcgtgaaacccctgcgggtgaagattgccatgtacagacac cgggccatgctggagtgccaggtctctcgcgctaatgctgaggtcacatggtacaaatgt aacagagaaattacacccaatgggaagtaccggtttattagtgacagtctttacaggcaa ctgaccatcgaagaagtaggttcgtcagacgaggacaccttcatctgtgacgctggtgat gacaagacttcttgccgactgtttgtagaggagcaggctatcagcatcgtccgtggactg agctcggtcgaagtgatggagcctaaggaggctcgtttcagagtggagacaaacattaaa gctgaacgagcccctaaatggactttgaatggagagctgctaagtcctggccctgaagtg agaattgagaaggaaggaacgacacatcgactgactttcaccaacaccaacagcagcatg tgtggcaccatccagttcagctcggggaaaagcaggtcaactgcccagcttactgttaca gagcgccccttggtggtcacccagcctatttctgatgtggaggttaaagagaactgctca gtggctctcaaatgtgagttctgtccttcaccaagagtagtgcgctggttcaagggtaga acaccattattggcctcaagcaaatataacatgaggcaggagaagaacagagtcgagatg atcatcatgaacgcgaaggctgtagatacaggggaatatcgctgcctggctggaggagct gagagcagagctcgagtcaatgtagaagtgaaacggctgaagatcacaagacatctggaa catgtagaggttgaagaagaaggaacagcagtgtttttctgtgagctaaaccacgaggca ccaggcatccagtggcttctcaatgaaagggtgattcatgccagtcacataaacaagatc cagaactcaggcaaagtttacactctggtcctgaaaaggcttgcaccacaggagagcagg gtgactttcaagaccgtcagcatcagcgagtccaccgttctcagagtcaaagaaaggcca gcagtgtttcttagacctctggaagatgttgtggctgaagaacgtgccaaagtttgctta cagtgcgaagtctccaagcaagcagtaacccctgtatggagcaaagatggtacggtccta aatgccagtgagaaacatgaaatacttcaattgggaaagttattatctctgatcattcac aagctcaggaaagatgatgctggggaatattcttgtgatgttgggactagccaaacaaaa gccaaggttgttgttcgtgatctgcacatcaccattgtcaagcgcttgcggacaatttcg gttcttgagggggagtactgcagttttgaatgtattctgtcacatgacatcatcgacgaa ccctcatggacactaaatggccagctgatcataagcaatgcccgaatccaaattgctaac caggggagcaaatacaccatgaacatccaagaggttataattaccgatgctggggaagtg gtcttcactattaaggatctcagttgcaggaccatgctgtttgtcagagaaaagcctata cgtgtgttcagagacatgctaaatgttaaggcggtacctggagaagatccagagcttagc tgtgagattaccaaaccgggggtgaccatcaagtggttgaaaaatggccggtcgatcaga tctaattctaaatatgaaatgatccaaaagggcttcttggttacgctagtaatccataat gcaactgtgaaggactctggggagtactgctgtgaggctgatggaacctccactagggca aggttagaggtaagagatttccagcacacatttgctacagagctaagagatgtaaatgca gaagaaaagactatggtagtgctggaatgtgagaccaaaagacctgccactaaggtgagc tggttaaaaggcatggttgtgcttatatcaggtcagaagtacctgatgatgaagaaaggg gtcttcctctcacttaccattttcaaccttgacaagagtgacagtgatttgtacacatgt gatgttgggacaatgcaaagcagggccttacttacagtacaaggtcagaaagtacttatc ttggatgaactggaggatgttgaatgtctggaaggggacagcgccgtattcaagtgtcgt atctgtccaagtgacttcaccgaggtcaaatggtatctcgatgagactctgctctatact aatgatctaaatgagatccaaatgatacatggtggctaccactctcttaccatcaaacag cttgcacgcaaagacacaggaacgatatctttcgaagctggagacaagagatcttatgcc tcactgctagtaagagaaagacgcccaacgattatcaaaccgttaaaggacatcgaagct atcgagggaggaagtttaaatctgtcatgcaaggcctcaaaaccatgtcatatcctgtgg tataaggatggctgcttaatgtggaattcctccagctatttcatgactcgctctggaaat gaggccaggttgaccatccgagaggttaaggacaccgacgcaggagtgtatgaatgtaac gcaggatctgtcagtaccaaggctacagtgactgttaaagctgtgcctgctgaatttaca aggcagcttcatagtcaagaagctgacgaaggaagtagtgtgacactgttctgtgaattc tccgtacccggcgttcggtacttgtggcgtaaaggagccgagactctcaggtcaggagaa aaatacttaacgaagcaaagaaaaaattatctttctcttacaatccacaatttgaaactt gaggactcagggacatacacatgcatatgcagaaaccagcggtccacggccacggtgacg gtccacgctattcccataactttcatcaaagaacttaaaaatcaagaatcagaggaggac atggccatgacgttacgctgtgagctctccaaagctggagtaccagtggagtggatgagg aatgaggaagtgctcagcccagggctgaagtttcagatgcgacaaatagtatcgatacag gaactggtcattaggaatccagtgccagaggacagtggaacctacagctgtgtgtgtact ggccaaaggaccgaagccataattacgataaaagcacaacctatcaccttcaaaaagaag cttaaatctcaagtggtggaagaaggaaacagtgtcactttgcactgtgaggtatcaaaa cctggacttcctgtagaatggaggaggggccaagagttgctcaagtctggagaaaagtac cggatgagacaaagaaattgtctgttagagctaaagatattcaacttgatatgcgaggac agtgagatatacagctgctcatgtggaaatgtccagacatcagctagagtcactgttagc aagcgaccggtcagtttcacagagaagctaacaaacttggttgctgaggagggcaagact ctgacgttgcactgtgaactgtccaaacctggtgttccagtggaatggtggaatggagaa gatcttctccaacctggacagaagtatcagatgagagaaagggatgcgacacatgagctt atcatctgtgacactgtgcctgaagacagtggagtctacaggtgcatatgtggaaaccag aagaccaaagcaatgataaaaatcgtcggtgtggctgctactttcaagcataatttaaag aaccaagaagctttagaaggaggagatgttgtactaaggtgtgagctttctaaagctgga gtacctgttgaatggtggaaaggtgaagaacgcttagcaccaagtgggaggtatcagatc agacaagaaggcaaggtagccgagatggaaatcacaaatgtacttcttaatgatgccggg atatacagttgtgatgcgggaaatcacaaaagctctgcagaggtgaaaatcaaagctctt ccaattaccttcaaacaagagctccaggatcaggtttgtaaagaaggggacaaagctgtg tttgtctgtgaactatccaaacctggggctccagtagagtggagaaaaggaagagttctt ttgaaaccaggagagaagtacaagatgaggctggaaggaaggctgaccaaactggaaata aacaacctggaggaagatgattccggaagctatatctgtaaaacaaaagatgcacaatca acagctgaactgactgtacaagcacttcctgctaccttcaaaaatgttctgaagaaccat gaagctcaagagggaagcagcatcagtttgcagtgtgaactttccaaagctggcacacat gtggagtggtggaagggagccgaaatgttaaggaccggggagaggtatcagttgagaaaa aagggtgcgacagcagaactgctaataagaaaagcacaaccagaagatagtggagtgtac cgctgtgtttgtggagaacagagcactgaggcacagatcaaagtcaatgctctgccaata atgttcaagcaagaactaaaaaaccaagaagctgaagaagggaacaatgtcacactgcgt tgtgaactctcaaagtctgaagctctggtagagtggtggagaggagaacaacttctcaag cctggggagaaatatcagatgagacaaatggccacaaaaatggagcttgtcatcagaaaa gttgtacctgaagatagcggtgtctatacttgtgtgtgtccagatcagaaatccagtgca tcagttaaaataaaagctataccagtgatttttaaacagaacctgagaaaccaagaaaca gtggaaggcaagaacatcacattacgttgtgaactttctaaatcgggagctctagtgaaa tggtggaaaggtcaacgagagctggctgggggtgaaaaataccacatgaagactgaggga aagaccgctgagctggttattaagaacgtttcatgtgaggacgctggtgtatacggctgc acgataggagagcaaaagactacctcagaaataaaagttcgggctcaaccagtcacattc aaacgagagctccaaaacgaagtttccaaagaaggcgaaactgcagtgtttagttgtgag ctctcaaaacctggagctccggtggactggaggaaaggaagagttattctgaaagcagga gataaatatgagatcaagcaagacggaaaaatgaccacacttgtcatacgtaatgttgag ggaagtgacgctggctattattcatgtaaaactaaggattctgagtcaaccgctgagctt actgttcaggtcccacccattatttttaaagtcaaactaaaaaaccaagaagttgaagag gagagcgatgtacgcctgcattgtgagctctccaaagctgggcttcctgttcaatggaaa aaagggaaggaggtgatcaagtctgggctcaaatatcaaattatacagcgagatactaca gtggagctgatcgttaagaaagcgacgtctgaagatagtggagtgtatagttgtatttgt ggagatcaggatactaaagccaacatcaaagtttttgcctctccggttacattcagacaa aatctaatgaaccaggaggctccagaaggagggatcatagtccttcactgtgagatctct aaacctggggtacctgtgcagtggtggaaagatgaagaggagctttgtaatggatcaaag tacaagatgaagcaagatgggttagtcgccgagttacacatccgcaacgtgctccctatg gatgttggggagtatagctgtgttgtcggagatcagaagactacagctgaagttaacgtc agggctgcagcctctgtgttctttgagaaagagctacaggaccaggaggtgatggaagga aactctgtggtgttcagttgcttgctgtcaagtcctaatgcaccagtggcttggaaaaaa gactcattgcagatcacacaaggtggccgatttactgtacaccaaaagggctcgacacag gagcttgagatccggaaactcaggtctgaggatgctggtgtgtacacgtgtagcacaagg ggaaagacaacatcagcacaccttcgagtgatcgatcgtgtgagaattgtgcgagagcta caggacctgaccatcgtcgcaggagaagatgcccattttgtgtgtgagctttcgcatagc gacattaccgacggagtgtggtggcttgactccaccgttctgcaggcaaacgaaatgaac caaatgacatgtcacggccgtgagcatcacctgacgcttaccatgacaacacctgaggag tcaggtattgtggcctttgtggtaggagaagagtggacttcggctcgtctacaggtgaaa agtaaacccaaagtattgatagaagaaaaagtgaaagacctggtagtcttggagggcgaa 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aatcttttactggttataaagaaagcagaagagaaagatgttggacaatatgagtgtgag ataacgaatcagatgggcagtgctaagtgcaaagcgcaggtgtactacacaccaccccct gagacagacagcaccaaaaaccaacctcaagacaccacagctccagtcccagagcaggag actaaagatccaatccgagccatcctcataagaagattcaggaggttggtccagtgcttt ggtgaagaacctcttccagatgttctttcagtctggatcttccaaccagaaatttcaata ccaataaaatcactgcatcaaatattcttcagatctgcacaaagtaccagagagtctcag gatacaccgaaggtaaatgaggaacaatcagacatcccagaggaacagtacgaggagacg cgagtgtcaagagaaatgggcaaaaatgacacagatcctccgatggtgcaggtggatatg gaagatctgtgtgtacaacctggacaacctgcaactttttctgtggttatcaccgggcag ccaattccagagattagttggttcaaggatggcgtcgagctcgtcgctggtgaacacata gcgatgaagcagaatggcgcgcgtttctctctaaatttaccgaacgtctacttttctgat cgcggcacttacgcctgtacagccaagaacagctcgggctatgtttcctgccacgcaaac ctcaccttggatacaggtccagtggagtttgaggaagaggaggaggaggaggaggagaaa gaggaggacagagggttgaaggtgggcagaaggagaaaactccatgctgtttatgaagtc catgaggagattggcagaggcacatttggggtggtgaagcgagttgtacacagggctagc gctgagttttttgctgctaagttcatcccactgaagagcagcactcgtaaccgagccatt caggagagagacctactgtcccggctcacgcaccgcagcgtcgcctgcctgctcgacttc ttcagcacacgccgtacgctcgtcctcatcaccgagatctgctcctctcagggattagtg gagcacatgttattaaaaggatccgtcagtgaaagagaggtccaggtttacattcagcag atactggaaggggttggatatatccacagcatgaacatcttgcatctcgacattaaaaca gacaacatcctgatggtgtccccagatggagaggacttaaaaatctgtgactttggcttc tgtcaggaaatcgacccgtccaggcatcagtacagcatctatgggactcctgaattcgtg gcaccggaaatcattcgccaagagccggtgacgacggcaactgatatgtggtctgttgga gttgttgcttttttatgtctgactggacactgtccatttttgggggaaaatgaccgtgcc acgctgctgaaagtggctgaagggcttctgtactggaacctcccagagatcaccagcttg agtgaacaagcccaggatttactccatggagttctacagccagacccaaagacgagacca tcagcattggaatgcctggattacgagtggtttcagggtccatgtgaagagaagcagtgt gacacgattgatacgaagagtttaaagtccttcatttctagaagaaagtggcagcgctct ctaacatgtcttggctcagtcctgaccctgaggtcgatcccggacctgctcgatgctcca gcgtgtgaggtcgccatcactaccctgagagaccctcgaaataccagcagcaactccatg agcactggttcctcctctgagtatgatgaagctgatgggtggggctttttccagaaccct agccaggaggaagatgatgacctagaggaagatggtatggaatattattcatacgcctat cttcctaaacgatccttggctctgcgagacgaggaggatgtaatgttgggtcaagtgcga gaacggaggggtgcattgatgattcctataaacaaggaatccagagagatgccttcagct tcttctgagctgattaacagggacagaaaagaagatgataaagtgtctagtgcaacacca atcccgcgtggtagcttgatcgaaagcaccttctacaatagcgatgagcagctctcaccc atgtctgctcgccacatgatgcttcgggagaaactccaggccaggaaacaagacagagta cgcaggacgctacgctccagcctgtctggaaggttaaatgaaccgcttatagagtatgtc gaggattctccagatgcggaatcttgcctcagacataggagagggtccacacttttgtcc aagtcttgttcattggacagaggggtgagatccatccatccaagctcccactctcattgg aggagtaggtcactggatgaatcaagaggaatctcaggagcttctatagagcacaggaca ctgagaaataatgaagatctagagttcagccataataatgagttcacagatgaggagaaa gaggaagcctcagaggttcctgtgaatagggtatcacaaagtcaattagaatctcacaag gttaccatggaggagctgccaataatcatggggtgtcacgtagatgacagccagtcacac cctggagaggaggggtcagcagcaatgggggaagaagaagaaaaggtagaaggttctctt gcagagtcctatgaacgtgactcagatgcttcaagcagaaccagcacctacactgaacag cagtctcccagccacctcttaatttcacagagacaacatagagcatatgatgaatcagag gagcacttggttgcaccatcatcaggaaaagcatcagagctgtctctcactcaggattct gaggatgaggacatggagagagttttgaggaaccttcgccaagcaccactgcaacagcac ccacacagcacaacaatgaacaaaaacaatgttacattgaggagaagttcctcgtcagtt cccacacacccaacatcagcgacctctgtgagccgagaggtgcttcagaggcattcatca gctccagcactggagctcaacccccccagtgggaagtccaaatacggactcatgaaaatt ttccgtaggaagtcctggactccaggaccctctgattcccagacacagggatctgacaag aaggtggataatggctcaagtcaacagcagaagacccctctcttggccttaaggaagaaa atgagggcttcagcatccagcatcaccaagctgtttagcaggcagtccagtaaagagatc acggcattacacaggaggccgatcgtgaggaatcccgttcctccagagaaagcaactgtc acctcagaagtttatccatcacctcccttctcaggaagccttcagaaaaagtccaagctc ttctctctcaaaatgccatcctttaaaaagagcaaaggaatcccggcccgcccgtccaaa ccggatgtgatacagctcggtagcggtggagctctggttatgtggaagccagtgcgatgc gttgatcctgtcacatactgcatacagtacagcctgaaaggtgaagagtggacaaatttg tctgagaatgttacagatagttgctacattgctaatacacaacctataggacccagctat gtgtatcgtgtagcttgcgttaccaaaactggacccggacctttcagtgatccttcacct cctgctcttacgacgatgccagctgaagactcttacattcctctgaacctcacggaatcg accggatccgagatcacagtggtgggagagctcggctcagagaggtcctacacattcctg tctgagatcaacaggggccggtttagtgtggtgacgcactgtaaggacagcaggagcttg cggcctctggcagctaagctgactccgtatagccccgagcagaggcagctagtgctgatg gagtatcaggtgctgcgcaggctgtgccacccgaatcttgttcagctccatgccgccatc cttatgccctcctgcctagcactcattgaggaactctgctccggacgagaagtcttgtac agcctggctgaaagggacatgtattcggagatgcatgtgtgtgagctgttgaggcagctc ttgagaggagtggattacttgcatggacgccgtatagtccacctcgacctccgctctgat aacgtgctagtgaccgacaacaacgtggtgaagattgtggacctgggctctgcgcagcac ttcactccaggccatgccctcaacattgagcacatcaaggagatgacagaaagcaaagtt tacattgtacttcctaaagctcctgagatcttgcaaggtcaaggtgtcggtcctgccacg gatatctgggctctcggagttctggcgttcatcatgctgagtgctgacaggccgttccac acagatctctactgggaaagagatcacaacatcaggaaggggaagatccagttcggccgc tgctatcccggcctttctgagggagccatcaacttcctgaggagcacgctgaacagcaag gcctggggaagaccgtcggctgcagaatgtctccagaacccatggttacaggaagaacga ggagaaccgtccaagcacacagcctcaatgttttgcttttccactgaaaaactgcaggcc ttcctgaaagagcgcgaggcgaaacgtgaccgcactcgcaccaaaatcacactgccactc agctaa

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