Tachysurus fulvidraco (yellow catfish): 113655587 Help Entry 113655587         CDS       T08119                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism tfd  Tachysurus fulvidraco (yellow catfish) Pathway tfd04020   Calcium signaling pathway tfd04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:tfd00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     113655587 (ryr3)    04020 Calcium signaling pathway     113655587 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:tfd04040]     113655587 (ryr3) Ion channels [BR:tfd04040]  Voltage-gated cation channels   Ryanodine receptor    113655587 (ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 DUF2207_C EF-hand_6 Motif Other DBs NCBI-GeneID:  113655587 NCBI-ProteinID:  XP_047657472 LinkDB All DBs Position 16:complement(10545451..10621387) Genome browser AA seq 4889 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVAAIQKENRKFCLSAEGLGNRLCYLEPTSEAKYVPP DLCICNFVLEQSLSVRALQEMLANTDQNGEGTPDHERWAGQGGGHRTLLYGHAILLRHSF SGMYLACLKTSRSLTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVS VSSERFLHLSISNGNIQVDASFMQTLWNVQPTCSGSNVAVGFVLGGHVMRLFHGHDESLT IPGADQSAEQQRLVNYETGKTGSRARSLWRLEPLRISWSGSHIRWGQPFRLRHLSTGHYL GQTEDRGLVLLEREKSDTSATSFCFRPSKEKVDSGSKRDVEGMGVAEIKYGDSVCFIMHV ASGLWLSYMAPDAKSSRLGPLKRRAFLYPEGHMDDGLILQLCQHEESRAARIIRNTTLLF TQFIRGLDELKGEKASGVNLPVGEVLQTLNDLITYFQQPDSELEHEEKQRQLRSLIKRQD LFKEEGMLTLVSICIDRLNMYHSAAEFEEFAGEEAGEAWKDVLNLLYELLAALIRGNRPN CTQFSRKLDWLISKLERLESSSGILEALHCILTESPEALNIIQRDHIKSIISLLYKHGRN HKILDILCSLCVCNGVAVRANQNIICDYLLPRRDLLLQTRLVNDVQSMRPNIFLGISEGS AQYKKWYYELMIDQVDHFVTSESTHLRVGWASTKGYAPYPGGGEGWGGNGVGDDLYSYAF DGLHLWSGRIQRAVASINQHLLTSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNIDGF FFPVVSFSAGVKVRFLLGGRHGEFKFLPPAGYAPCYEALLPKEKMRVEPVKEYKRDMEGV RDLLGTTQFLSQASFIPVPVNTSQTVLPPHLENVRNKLAENIHELWGMNKIELGWTYGKV RDDNKRQHPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCHVVQINVNAEDDLKKIKLP KDYVMSNGYKPAPLELSEVKLTPGQEFLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSR RNPRLVPYSLLDERTKKSNRDSLREAIRTLIGYGYNIEPPDQEVAHVMEKHGVENIRFFR VGKCYAVQSGKWYFEFEAVTGGEMCVGWARPSCRPDVELGMDDKAYVFDGYRGRRVHMGS HFFGRTWNKGDVVGCMINMEDKSMIFTLNGEIVITNKGSELCFTDFETEDGFIPVCSLGL SQIGRMNLGKDASTFKYYTMCGLQEGFEPFAVNMNREITMWFSKRLPTFVNVPVEHEHIE VTRIDGTVDSPPCLKVSHKTFGTQASNNDMIYCRLSMPVEFYSSPRKITNMNEVSSDGQK SKKDDSWKTDYSSITKYFYSVRVFAGQDPASIWVGWVTPDYHYYSKNFNLSKVRTVTVTL GDERGRVHESVRRSNCYMVCAGEITSSSSGRSNADLVIGCHIDLASGLVSFTANNKELPI AYQVEPNTKLFPAVFVQPTSPNLFQFEFPKIKDAMPLSSAIFKSLHNNPEPQCPPRLDVQ TIVAVLWSRMPNIFLSVETARVSERHGWVVQCLEPLQMMAVHIPEENRCIDIMELSEDEV LRQFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLTGQLREGFYDVLISI HLETAKEAKLMMKNEFIIPITDETRSIRLFSDDSKRHTLPGVGLSTSLSPRFNFTPPCFI TTKRESFIYSPQIPLGILKEKAISMLTEAVQGGGAHIRDPVGGSVEYQFVPILKLIATLL IMGSLSSEEVRIILLLIEPNVFGEIKEEETQLLAVEEPAEKEEASSNEEKAVEAGEEESK EHKQPPKGLLEKSLPESVKHQMCELLHYFCDCELKQRIESIVAFSDMFVAKLQFNQKFRY NELMQALNMSAAVTAKKTKEFRSPPQEQINMLLDFSAGEDCPCPEDIQDELHAFHDDLRL HCGIPMEEEEEEPDTSIKGRLLSLLYKIKGRPQKTEEQPSEEEQAAPTNLKELISQTMVS WAQECKIQNPQLVRSMFSLLRRQYDGIGELLRAMRKSYTISEKSVQDAINLLASLGQIRS LLSVRMGEEEGQLMIDGLGDIMNNKVFYQHPNLMRIMGMHETVMEVMVNVLGGDKSKEIA FPKMVASCCRFLCYFCRISRENQKAMFEHLSYLLENSSVGLACPAMRGSTPLDVAASSVM DNNSLALALEEPDLEKVVMYLAGCGLQSCPMLVAKGYPDIGWNPIEGERYLSFLRFAVFV NGESVEENANVVVKLLIRRPECFGPALRGEGGQGLLAAMLEAIKISEDPALDLPNLPGGR APVPGEDGEEEEVAHMGNSIMSFYSALIDLLGRCAPEMHLINTGKGEALRIRAILRSLVP TKDLVGIISIPLKVPVINKDGSVTEPDMNSSFCPEHKSPMVLFLDRVYGIEDQSFLLNLL EVGFLPDFRVSASLDTEVLSTTETALALNRYIGSAVLPLLTRCASLFAHTEHYTTLMDST LQTIYRLSKGRSLTKAQRDSIEECLLAICKHLRPSMLQQLLRRLVFDVPQLTEYCKMPIK LLSNHYEQNWKYYCLPSGLGSYGMASEEELHLTTKLFWGLFDALSQKKYDAELFKMAMMC LSAIGGAIPPDYVYMSPATTLVKQVSVDSQGNFDPKPINTANISLPEKLDYIANKYAEHC HEKWSSEKFALGWTAGEKVDDQAKTHPLLKPYKALSEKERETYRYPVKESLKCMLAMGWT IERTKEGDAMFQQREAEKQIKTSEPSQVGRLKIQGIKKTQLFNRDDLCSSFVLLKGDGFH PAPVELENVTLSRELQSMVETVAENYHNIWANKKKMELSSKGGGTHPLLVPYDTLTAKEK FRDREKSQELFKFLQLNGYAISRGLKDLEHDSSSMEKRIAYKFLKRLLSYVDSAQEFIAH LEAMATSGKTDKSPHEQEIKFFAKVLLPLLDQYFKNHCLYFLSSPSINLSSSGYASNKEK EMITSLFCKLASLVRHRISLFGSDSATMVSCLLILAHSLDFRTVMKSGSELVKAGVRTFF ENAAEDLEKTMENLKLGKMGQSRTQMKGVAQIINYTSVALLPILTALFQHITEHQFGADL LLDDVQLSCYRILTSLYSLGTGKNIYVEKQLPVLGECLATLVGAMPVAFLEPHLNMHNPR SVFNTKTPRERAILSMPDTVEEMCPEMPRVDGLLKDIHDISESGARYTEMPHVIEVILPM LCNYLSYWWEKGPENSPNHESCCTTVTSEHLSLILGDILKILNNNLGIDEASWMKRLAVY TQPIISKAGADLLRTHFLPTLEKLKKKTVKIVAEEEMIRAESKADTQEAELQILDEFAVL CRDLYAFYPMLIRYVDNNRSKWLKKPSTDSTELFNMVAEIFILWCKSHNFKREEQNFVVQ NEINNLAFLTGDNKTKMSKSGGQDQERRGKKRRGELYSIQTSLIVAAHKKLLPIGLNMCT AGDQELISLAKIRYSLKDTDDEVKDHLRQNLHLQQKTEDPAVQWQLNLYKDVEVKGEEPL NTDHIIAKIQGISAAVFHLDQVEQPLRCKKLVWQKHLSKQRKRAVVACFRMAPLYNLPRH RSINLFLTGYQKLWIVAEKYSFEEKLVQDLAKTPMAVEKEEEEAEAEVQPDPLNQLILHF SHNALTERSVQEVDPLYIAYADMMAKSCAEDEEAEEEEEKEKTFEEKEMEKQKILYQQAR LHARGAAEMVLQMISASKGHLGPMVRYTLKLGISILNGGNVVVQQKMLDYLKEKRDAGFF KSLSGLMLSCSVLDLNAFERQKKAESLGMVTEEGSINASERGSKVLQNDEFTKDLFRFLQ LLCEGHNNDFQNFLRTQSGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDIIDEHGQL NFSKAMEVAKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQ IELLKELMDLQKDMVVMMLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLN NLTTSDNFKEYDPEGKGIISKKEFQKSMESQKQYTQSEIDYLLSCAEADENDMFNYMEFV ERFHEPAKDIGFNVAVLLTNLSEHMPHDSRLSTFLDLAESVLSYFEPYLGRIEIMGGAKR IERIYFEISESSREQWEKPQVKESKRQFIFDMVNEGSESEKMELFVNFCEDTIFEMQLAS QISESGTVERPEEEEEQHSMLEDLSEEEDQSLESASAFTVACASVKKKVSNFRQTLTIKN MRKQFKKFKKLTIKEMITGFFSFFWMLFTGFFKGIFSLIFGFFHIIWSSMFGGGLVEGAK NMKVTDILGNMPDPTQFGIHGDITELEKAENGEIVVSTEMVQMAGTVDKLEPDAIIDLIS PPTKREGKHGHEPGLGDVSEITTEASPRVEKKKCQKAAPEEPEPEKADTETHEKEDKAKE EKPEEPVAEEMLAPRKHHGPAKDEPPELMATFFAGLEVYKTKMLNYLARNFYNLRMLALF VAFAINFILLFYKVTAETEDEDEEESWGGSDDDEEEDSDMEFYVLQEGTGYMAPTLTFLA ILHTVISLLCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSDDDIKGQWDRLVIA TPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKSALDFDPTEEAVVKEASLLSWL SSIDTKYHIWKMGVVLTDNSYLYLIWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILS SVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDQPDMKCDDMMTCYLFHMY VGVRAGGGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQE QVKEDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQES YVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14670 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggagaaggggaagatgaaatccagttcttgcgaactgatgatgaagtg gtgctccagtgtgttgctgctattcagaaggagaatcgtaaattctgcttgtctgcagag ggacttggaaatcgactgtgttacctcgagcccacctcagaagctaagtatgttcctcct gacctgtgcatctgtaactttgtactggagcagtctctctctgtgcgagccctgcaggag atgctggccaacacagaccaaaatggggaaggtactcctgatcatgagcgatgggcggga caggggggtggacatcggacactgctgtatggtcacgccatcctactaaggcattcattc agtggaatgtatctagcctgtctaaagacgtcaaggtctctgacagacaagctgtcattt gatgtaggattacaggaggattcgacaggcgaggcctgttggtggaccattcatccagca tccaaacaaaggtctgagggtgaaaaggttcgcattggtgatgatctcattttggtcagt gtgtcctcagagagattcctgcatctatcaatctccaatggaaacatacaagtggatgcg tctttcatgcaaacactgtggaatgtgcagcctacctgctctggcagcaatgtggcagtg ggttttgtactggggggacatgtgatgcgcctgttccatggacatgatgagagccttact ataccaggagcagaccagtctgccgagcagcagcggctggtgaactatgagactgggaaa acagggtccagggccaggtccctgtggagattagagccacttcggattagctggagtggg agccatattcggtggggtcaacctttccgcctgcgccatctctccactggtcactacctg ggtcagacagaggaccgtggcctggtactgctggaaagagagaagtctgacacttctgcc acatcattctgcttcaggccaagcaaggagaaagtggactctggctcaaagcgagacgtt gaaggcatgggggtggcagagatcaagtacggtgattcggtctgcttcatcatgcatgtg gcatcagggctgtggttgtcctatatggcaccagatgcaaaatcctcccgccttgggcca ctcaagagaagggctttcctgtatccagagggccacatggatgatgggctgattctgcag ctctgccagcatgaagagtccagagcggctcgcatcatccgcaacaccactcttctcttc acccagttcatcagagggctggatgaactgaagggtgagaaagcatcaggggtgaatctg ccagtgggagaagtactacaaactctgaacgacctcatcacctacttccaacaacctgac tcagagttggagcacgaggagaagcagaggcagttacgttcgcttatcaaacgccaggac cttttcaaagaggagggaatgcttacactggtctctatctgcattgaccgactcaacatg taccacagtgctgctgagtttgaggagtttgcaggagaggaagcaggagaggcctggaag gacgtcctcaacctcctctatgagctgcttgctgccctgatccgaggaaacagacccaac tgtacgcagttctcccgcaaactggactggctgataagcaagctggagcggctggagtcc tcctcaggtattctggaggctttgcactgcatcctaacagagagtccagaggcccttaac ataatccagagagaccacattaaatccatcatttcccttctctataaacatggacgcaac cacaagatcctggatattctctgctctctttgtgtctgcaatggagtggcagtccgagcc aatcagaacatcatctgtgactacctacttcccagacgagacctgctgctgcaaacacga ttggtcaatgatgtgcaaagcatgagacccaacatcttcctaggcataagtgaaggatcg gctcagtataagaagtggtactatgagctgatgattgatcaggtggatcattttgtcaca agtgaatccactcatcttcgtgtaggctgggccagcactaaaggctatgccccctaccct ggtggcggagagggctgggggggcaacggagttggtgatgatctctactcctatgccttt gatggacttcatctgtggtcagggcgaatccaacgggccgtggcctccattaaccagcac ttgctgacctcggatgacgtggtgagctgctgcctggacctcggtgcgcccagcatgtcc ttccgcattaacggccagcctgtgcagggaatgttcgaggacttcaacatcgacggtttc ttcttccctgttgtcagcttctcagcaggggtcaaggttcgtttcttgttgggcggtcgc catggtgaattcaagtttctaccccctgctggctatgcaccttgttatgaagcccttctc cccaaagaaaagatgcgggtggagcctgtgaaggagtataagagggatatggagggagtg agggacttgctgggaaccactcaattcctttctcaagcatccttcattcccgttcctgtc aataccagccagactgttctgcctccacaccttgaaaatgtacgcaataagctagctgag aacatccatgaactctggggtatgaacaaaatcgagcttggctggacctatggcaaggta cgtgatgacaacaagaggcagcatccttgcctggttgacttttccaagctgcctgaaact gaaaaaaattataacctgcaaatgtcaacagaaactttaaagaccttactggctttggga tgtcatgttgtacaaattaatgtcaatgctgaagatgacctgaagaagatcaaacttccc aaagactatgtgatgtcaaatggttataagcctgcgccactagaactttctgaagtgaaa ctgacacctggtcaggaatttctggttgataaactagctgaaaacgctcataatgtttgg gctaaagatcgcattaagcaaggatggacctatggtattcagcaggatttaaagagtaga cgcaatcctcgtctggtgccatattctttgttagatgaacgcacaaagaagtctaacaga gacagccttcgagaggccatccgaacactaattggttacggatacaacattgagcctcca gatcaagaggtggcccatgtgatggagaagcatggtgttgaaaacattcgtttcttccgg gtggggaaatgctatgcagtgcaatcagggaaatggtattttgagtttgaggctgttact ggaggagaaatgtgcgtaggctgggctcggcccagctgtagacctgatgttgaattgggc atggatgacaaagcctatgtttttgatggctaccgtggtcgacgggtacacatgggcagc cacttctttgggagaacatggaacaagggtgacgtggtgggatgcatgattaacatggaa gataagtccatgatctttactctcaatggagagatagtcatcaccaacaagggctctgag ctctgcttcactgactttgagactgaagatggcttcatcccagtttgcagtcttgggctc tcgcagattggccgtatgaacctgggcaaagacgccagcacctttaagtactacaccatg tgtggccttcaggagggttttgagcctttcgcggtcaacatgaatagagagatcactatg tggttcagcaaacgccttcctacgtttgtcaatgtgccagtggaacatgagcacattgag gtcaccagaattgatgggactgtggactcaccaccatgtctgaaggtgagccataagacc tttggaactcaagctagcaacaacgacatgatctactgccgcttgagcatgcctgtcgag ttttattctagtccccggaaaatcactaatatgaacgaggtgagcagtgatggacaaaaa tctaagaaggatgacagctggaagactgactatagcagcattacaaagtatttctactca gtgagggtgtttgcaggtcaggaccctgcctcgatatgggtaggctgggtaacaccagac taccactactacagcaagaattttaacctgagcaaagtccgtacagttactgtgactctc ggggacgagcgtggccgcgttcatgagagtgtgaggaggagtaattgctacatggtgtgt gctggtgaaattacaagcagctcttctggacgaagcaatgctgacctcgtaattggatgt catattgatcttgcctctggccttgtttcattcactgccaacaacaaagagctgcctatt gcatatcaggttgagcccaacacaaaactgttccccgctgtgtttgttcagcccacaagc cccaacctgtttcagtttgaatttccaaagatcaaagatgccatgccattgtcttcagcc atttttaaaagtcttcacaataacccagagccacagtgtcctccacggctggatgtacag accattgtagctgttctgtggagcaggatgcccaacattttcctctcagtggagacagca cgggtcagcgagaggcatggctgggtggttcagtgtctggagcccctgcagatgatggca gtgcacattcctgaggaaaacaggtgcatagacatcatggaactctcagaggacgaggtc ttgcgacagtttcactaccacactctgaagctctactgtgctctctgtgctctgggaaac actcgtgtggcccatgctctctgtagccacctagaccaatcacagctcctttacaccatt gacaaccaatacctgacaggacagctgcgcgagggcttctatgatgttcttatcagcatc cacctggagacagcaaaagaagcaaaactcatgatgaagaatgagtttatcatacctatc acagatgagacacgtagcatccgcctcttctctgatgactccaaacgccacactttgcca ggcgtgggactgagcacatcactgagccctcggtttaacttcacacctccatgcttcata accactaagcgtgagtccttcatctacagtccacagattccgctaggtattctaaaggag aaggccatcagcatgctgacagaggcagtgcaaggtggaggtgctcatattcgtgaccct gtagggggcagcgtagagtaccaatttgtgcctatactcaagttgattgcgactctattg attatgggctctctgagtagtgaggaggtgagaatcatcctcctgcttattgaacccaat gttttcggagaaatcaaggaggaggagacacaacttttagctgtagaggagccagcagaa aaagaagaggcaagcagcaatgaagaaaaagccgtggaggctggggaggaagaaagcaaa gaacacaagcagccacctaaaggccttttggagaagagtctgcctgagtcagttaaacac cagatgtgtgaactcctgcactatttctgtgattgtgagctgaagcagcgcatcgagtct attgtggcattctcggatatgttcgtggccaaactgcagttcaaccagaagttccgctac aatgaactcatgcaggccctcaacatgtccgctgctgttactgctaagaagacgaaggaa ttccgctctcctccccaagagcagattaacatgcttctggacttcagtgctggagaggat tgtccctgtcctgaggacattcaagatgagcttcatgccttccatgatgatctgagactc cactgtggtattcccatggaagaagaagaggaggaaccggatacatctataaaaggccgc ctgctttccttgttatataaaatcaaaggtcgcccacagaaaactgaggaacaaccatca gaggaagagcaagcagctccaacaaacctgaaggagctgatctctcagacaatggtgagc tgggcccaggaatgcaaaattcagaacccacagttggtacgaagcatgttcagcctactc cgaaggcaatatgatggcattggtgagctgctgcgtgccatgagaaaaagctacactatc agtgagaaatctgttcaggatgccattaacctactggcctcactgggccagatccgttct ctgctcagcgtcagaatgggtgaagaggagggccagctcatgatcgatggcctgggggat ataatgaacaacaaagtgttttatcagcatccaaatctgatgcggataatgggcatgcat gagacagtcatggaggtcatggtcaacgtgctaggaggcgacaaatctaaggagattgct ttccccaaaatggtggccagttgctgccgtttcctttgctacttctgtcgcatcagccgt gagaatcagaaagccatgtttgaacacttgagctacctactggagaatagcagtgtgggg ctggcttgccctgccatgagaggctccactcctttggatgtggctgcatcctcagtgatg gacaacaacagcctggccctggctttagaggaaccagacctggaaaaggtggtgatgtac ttggctggttgtggtctacagagctgccctatgctggtagctaagggataccctgacatc ggctggaatcctatagaaggggaacgttatctgtctttcctccgatttgctgtgtttgtt aatggtgagagtgtagaggagaatgctaatgtggtggtaaagttgttgatcaggcgtcct gagtgttttggccctgcactgagaggagaggggggacaaggtctgttggctgctatgctg gaggccatcaagatctctgaggaccctgctctcgacctgcccaacctgcctggaggaaga gcacccgtgcctggggaggatggggaggaggaagaggtggcacacatgggcaactctatc atgtccttctactcagctcttattgacctgctgggacgctgtgcacctgagatgcattta atcaatacaggcaagggtgaagctctgcgtatccgtgccatcctgcgttctctagtgcct accaaagacttagtgggcatcatcagcataccactcaaagtgccagtaatcaacaaagat ggcagtgtcacagagccagacatgaactctagtttctgtccggagcacaagtcaccaatg gtgctcttcctggaccgtgtgtacggtattgaggaccaaagcttcttgctaaacctgttg gaggtgggcttcctgcctgacttcagggtctctgcatctttggacacagaggtgctgagc actacagagacagcactggccttgaacaggtatattggttcagctgtgctgcctttgctg acacgatgtgcgtctctctttgctcatactgagcactacactacgctcatggactccaca ctacaaaccatttacagactgtccaagggccgctctctcaccaaggctcagagagactct atcgaggagtgccttcttgccatctgcaaacacctgcggccttctatgctgcaacagctt ctgcgccgtctggtgttcgatgtgccacaacttacagaatactgcaagatgcccataaag cttttgtccaatcactatgaacagaactggaaatactactgcctgccttcgggcctgggc agttatggcatggcatcagaagaggagcttcacctcaccaccaaactcttctggggtctt tttgatgctctctctcaaaagaaatatgatgcagagcttttcaaaatggctatgatgtgt ctgagtgccataggtggagccatcccacctgattatgtatacatgagcccggccaccact cttgtaaagcaggtctctgtggattcgcaaggaaactttgatcccaagcctatcaacact gccaacatctcactgcctgaaaaactagattacattgccaacaagtatgctgaacattgc catgagaaatggtcttctgaaaagtttgctctaggctggactgcaggtgaaaaagtagat gaccaagccaaaacccaccctttactgaagccatataaagcactgagtgaaaaggagagg gaaacctaccgctacccagtaaaggaatctctgaagtgcatgctggcaatgggctggacc atcgaaaggaccaaagaaggcgatgccatgttccaacagcgtgaagcagagaaacagatt aagacttcagagccttctcaggtaggaagacttaagatacaaggaatcaaaaaaacacag ctgtttaacagagatgatctttgttcatcatttgttcttttaaagggagacggatttcat ccagcacctgtagaattggagaatgtaactttatctagagaactacagagtatggtagag actgtagcagagaattaccacaatatctgggcaaataaaaagaaaatggaactaagcagc aaaggaggagggactcacccactgctggtaccttatgacacactgacagcaaaggagaag ttcagagacagagaaaagtctcaggagctcttcaaattcctgcagcttaacggctatgca ataagcagaggtttgaaggacttggagcatgattcttcctctatggaaaaaaggattgct tacaagttcctgaagaggctgctgagttacgtagactcagcgcaggaatttatagcccat ctagaggctatggccaccagtggaaaaactgacaaatcacctcatgagcaggagataaag ttctttgcaaaggtcctgctgccgttgcttgaccagtactttaagaatcattgcctttac ttcctgtcttctcccagcatcaacctgagcagcagtggttatgcttctaacaaagagaag gagatgatcaccagtctcttctgtaagctggcgtctctggttagacataggatttctttg tttggaagtgactctgctacgatggtgagctgtctgcttatccttgcacattcactggac tttaggacagtgatgaagtctggttcagaattggtgaaggctggagtcaggacgttcttt gagaatgctgcagaagacttggagaagactatggagaacctaaaactgggcaagatgggc cagtctcgcacccaaatgaagggagtggctcagatcatcaactacacttcagtggcactg ctgcctattcttactgctctatttcagcacatcactgagcaccagtttggggcagacttg ctgttggatgatgttcaactttcctgctaccgaattctgaccagcctatactccctggga actggcaaaaacatctatgttgaaaagcagcttccagtgctgggagaatgcttggctact ctggtgggagctatgcctgtagctttcctagagcctcatctgaacatgcacaacccacgc tctgtcttcaatacaaagacaccacgggagagagcaattctgagcatgcctgacactgtg gaggagatgtgtcctgagatgccacgtgtggacggcctgttgaaagatatccacgatatc tcggagtctggggctcgctacacagagatgccacatgtcatcgaggtcatcttgcccatg ctgtgtaactatctttcttactggtgggaaaagggtcctgagaactctccgaatcatgag agctgctgtaccactgtcacttctgagcacctcagcctcatcctgggtgacatcctcaag atcctcaacaacaacctgggtatagatgaagcatcctggatgaagaggcttgcagtgtac acacagccaatcattagcaaagcaggagcagacctgttacgtactcacttcctgcccacc ctggagaagctgaagaagaagacagtgaagattgtggctgaggaggagatgatcagggct gaaagcaaagctgacactcaggaggccgagctgcagatcctggatgagtttgctgtcctc tgcagagacctgtacgctttttaccccatgctcatccgctacgtggacaacaacaggtct aaatggctgaagaaaccaagtacagattcaacagaactcttcaacatggtggcagagatt ttcatactctggtgtaaatctcataatttcaaaagagaagagcaaaactttgtggtgcaa aatgaaatcaacaaccttgccttcctcactggagacaacaagaccaagatgtcaaagtca ggaggtcaggaccaggagaggagagggaagaagagaagaggagaattgtactctattcaa acatccttaattgtggcagctcacaagaaactgctgccaatcggcctcaacatgtgcacg gctggagaccaggagctcatctctctggccaagatccgctacagtctgaaagacacagat gacgaggtgaaggatcatcttagacagaacctacatcttcaacagaagacagaggatccg gcagtgcagtggcagctaaacctctataaggatgtggaggtgaagggcgaggagcctcta aatactgaccacattatcgcgaagatccaaggcatctcagccgccgtcttccatcttgat caggtggagcagcctctcaggtgtaaaaaattggtatggcagaagcatctgtccaaacag cgcaagcgtgctgtggttgcctgtttccgcatggcccctttgtacaacctccctaggcat cgctctattaacctcttcctcacgggctatcagaaactttggatagtagcagagaagtac tcctttgaggagaagctagtgcaggacctggcaaaaacccccatggctgtggaaaaggaa gaggaggaagcagaggctgaggtccagccagatcctcttaaccagctcatcctccacttc agtcataatgccctgactgagagaagtgtccaagaagtagatcccttgtatattgcgtat gcagatatgatggcaaagagctgtgctgaggatgaagaagcagaggaggaagaagaaaaa gaaaagacatttgaggagaaggagatggagaagcagaaaattttgtatcagcaggccagg cttcatgctcgaggtgcggctgagatggtactccagatgattagtgcaagcaagggccat cttggccctatggtgaggtatactctgaaactgggtatctctattctcaatggaggcaat gtagttgttcagcagaaaatgctggactacctgaaagaaaaaagagatgctggctttttt aaaagtctgtctggactgatgctgtcctgcagtgtgctggatctgaacgcatttgagaga cagaagaaggcagagagccttggaatggtgactgaagaaggttcaatcaacgcgagtgag cggggttccaaagtactacaaaatgatgaatttacaaaggatttatttcggtttttgcag ctgttatgtgagggccacaataatgatttccaaaatttcctgcgaactcaaagtggaaat acaaccacggtcaacatcattattagcacagtggactacctcctacgtttgcaggaatcc ataagtgatttctactggtattactctggaaaagacatcattgatgagcatggacagcta aacttctccaaagccatggaagtagcgaaacagatcttcaactcactcactgagtacatt cagggtccatgtattggtaaccagcagagtctggcacacagtaggctgtgggatgccgtg gttggattcctgcatgtttttgccaacatgcaaatgaaactatcacaggactctagccag attgagctgttaaaggaattaatggatttgcagaaggatatggtggtcatgatgttatct cttttggagggtaacgtggtgaatggcacaattgggaagcagatggtcgacacattagtg gagtcctcaagtaatgttgaaatgatcctcaaattctttgatatgtttctcaagttaaac aatcttactacctctgataactttaaagagtatgaccctgaagggaaaggaattatttct aaaaaggagttccagaagtcaatggagagccaaaagcagtacacacaatctgagatcgat tatcttctctcttgtgctgaggctgatgaaaacgacatgtttaactacatggaatttgtg gaacgcttccacgagccggcaaaggatattggcttcaatgtggccgtgctgctcaccaat ctgtctgagcatatgccccacgattcacgcctcagcaccttcctggacctggcagagagt gtactgagttactttgagccctatttgggccgtatcgagatcatgggcggtgcaaagcgg atcgagcggatctactttgaaatcagtgaatctagcagagagcagtgggagaagcctcag gtgaaggagtccaagaggcagtttatctttgacatggtcaatgagggcagtgaaagtgag aagatggagctgtttgtaaacttctgtgaagacacaatttttgagatgcagctggcttcc cagatatccgagtcaggtactgtagaacgccctgaagaggaagaagaacagcatagtatg ttggaggatctgtcagaagaggaagatcagtcccttgagtctgcttcagccttcactgtt gcctgtgcttctgtgaagaaaaaagtatccaacttccgtcaaacgctgaccatcaagaac atgcgtaaacagttcaagaagtttaaaaagctgactattaaggaaatgatcacagggttc ttttcattcttttggatgcttttcacagggttctttaaaggcatttttagcctgatcttt ggattctttcatataatctggtcctcgatgtttggaggaggccttgttgaaggagctaaa aacatgaaggtaacagacatcttaggcaacatgccagatcctactcagtttggaatccat ggtgatattacggagttggagaaagcagagaatggtgaaatagtggtgtctacagaaatg gtacagatggctggaacagtggacaaactggaacctgatgccatcatagatctcattagt ccaccaactaaacgagagggaaagcatggacatgagcctggacttggggatgtctcagag attacaacagaagccagtcctcgtgttgaaaagaaaaagtgccagaaagctgcaccagag gagcctgaacctgagaaagctgatacagagactcatgaaaaagaagataaggccaaagag gaaaagcctgaagagccagtagcagaggagatgctagctccaagaaaacaccatggccca gccaaggacgaacctcctgaattaatggccaccttctttgctggccttgaagtgtacaag accaagatgctaaactacttggctcgtaatttttacaaccttcggatgttggcgcttttt gtggcattcgcaattaacttcatcctgctcttctacaaggtgactgctgaaacagaggat gaggatgaggaggagtcatggggtggcagtgatgatgatgaagaagaagacagtgatatg gaattctatgtactccaggagggcactggctatatggctcccactctgactttcttggct atactgcatacagttatttctctcctttgtgtggttggatattattgcctcaaggtcccc ttggtggtgtttaagcgagagaaggagatcgcaaggaagctcgagtttgatggattgtac atcaccgaacagccatctgatgatgatatcaagggtcaatgggatcgtttggttattgcc actccgtctttccccaataattactgggacaaatttgtcaagaggaaggtcatcaacaaa tacggagatttgtatggagctgagcgtattgctgaactcctcggactggataagagtgca ctcgactttgatcctacagaggaagctgtggtgaaagaggcttctctgttatcctggttg agctctatagacacgaagtaccacatttggaaaatgggagttgtcctaactgacaattct tacctctacctgatctggtacaccaccatgtctgttttgggccattacaacaacttcttc tttgctgctcatttgctggatattgccatgggcttcaagactttgagaacaatcctgtct tctgtaactcacaacggcaaacagttggtgttgactgtgggcctgcttgcagttgtggtt tatctgtacactgttgtggcgttcaacttcttccgcaagttctacaacaagagcgaggat gaggatcaacctgacatgaaatgtgatgatatgatgacttgctacctattccacatgtac gttggtgtgagagctggtggaggcattggtgatgagattgaagacccagctggtgaccct tatgagctttaccgcatcctctttgacattaccttcttcttctttgtcattgtcatcctg ttggccatcattcagggtttaatcatcgatgcatttggcgagttgagagatcagcaggaa caggtgaaggaggacatggagacaaagtgttttatatgtgggattggaaatgactacttt gacaccacaccgcatggctttgagactcatactctacaagagcacaacctggccaactat ctattcttcctgatgtatctcattaataaagatgaaactgaacatactggtcaggagtcc tatgtatggaagatgtatcaggagaggtgctgggacttcttccctgccggagactgcttc cgcaaacaatacgaggaccagttgggctag

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