Tachysurus fulvidraco (yellow catfish): 113660277 Help Entry 113660277         CDS       T08119                                  Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism tfd  Tachysurus fulvidraco (yellow catfish) Pathway tfd04020   Calcium signaling pathway tfd04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:tfd00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     113660277    04020 Calcium signaling pathway     113660277  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:tfd04040]     113660277 Ion channels [BR:tfd04040]  Voltage-gated cation channels   Ryanodine receptor    113660277 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 Ago_Mid Motif Other DBs NCBI-GeneID:  113660277 NCBI-ProteinID:  XP_047677279 LinkDB All DBs Position 12:complement(6164474..6335159) Genome browser AA seq 4895 aa AA seqDB search MAEGGEAEDEIQFLRTDDEVVLQCVACIQKENRKFCLSAEGLGNRLCYLELTSEAKYVPP DLCICNFVLEQSLSVRALQEMLAKSGENNEKLIRKTAHGGGHRTLLYGHAILLRHSFSGM YLTCLKTSRSLTDKLSFDVGLQLDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSS ERYLHLSISNGNIQVDASFMQTLWNVHPTCSGSSVEEGYLLGGHVMRLFHGHDEVLTIPG SDQSEEQQRIVNYETGKVGAKARSLWRLEPLRISWCGSHIRWGQPFRLRHLTTGHYLALT EDKGLVLQDREKSDTASTAFCFRASKEKLEWSPKKDIEGMGVPEIKYGDSLCFIMHMATS LWLSYQAPDVKSTRLGPLKRRACLHAEGHMDDGFTLQRCQHEESRAARIIRNSTRLFSHF IRDLDNLAGKNRTDVVLPVDEVLQTLNDLITYFQLPDAELEHEEKQIKLRSLKNRQNLFK QEGMLTLVSNCIDRLSVYNSAAHFGECVGEEAGAAWKDILNLLYELLAALIRGNRNNCTQ FSQNLDWLVSKLERLESSSGILEVLHCILIESPEALNIIQRGHIKSIISLLYKHGRNHKI LDVLCSLCVCNGVAVRANQNLICDHLLPKRDLLLQTRLVNDVQSMRPNIFLGVREGSAQY KKWYFELMIDQVEHFVTSEPSHLRVGWASSKGYAPYPGGGEGWGGNGVGDDLYSYGFDGL HLWSGRIPRRVASVNQHILTSDDVVSCCLDLGAPSISFRINGQPVQGMFESFNTDGLFFP VVSFSAGVKVRFLLGGRHGEFKFLPPSGYAPCYEALLPKERMRVEPVKEYKRDADGVRDL LGTTQFLSQASFIPTPVDTTQIVMPPHLEKVRDRLAENIHELWAINKIELGWTYGKIRDD NKRQHPCLVDFSKLPETERNYNLQMSTETLKTLLALGCHVVQFNVNAEEELKKVKLPKNY MMSNGYKPMPLELSEVKLSPAQELLVDKLAENAHNVWAKDRVKQGWTYGIQQDLKSKRNP RLVPYALLDERTKKSNRDSLREAIRTLIGYGYNIEPPDQEGGCVVERLSIDKIRFFRLER TYAVKTGKWYFEFEIVTGGDMRVGWARPGVRPDVELGTDDQAFVFDGYKGHRVHQGSRLF GRCWHAGDVVGCMINMEDKSMIFTLNGEILITNKGSELCFADFETEDGFIPVCSLGLSQV GRMNLGKDASTFKYYTMCGLQEGFQPFAVNMNREVTMWFSKRLPTFVNVPKDHSHIAVIR IDGTIDSPPCLKVTHKTFGTQNSNADMVFFRLSMPVEFHSTYKNFPVTEMNGVHEEEPLK LKYRYPVKSMKHVDEGRRTDYSNITTYSHSVRVFAGQDPSCVWVGWVTPDFHYYSNYFNL SKIRTVTVTLGDERGRVHESVKRSNCYIVWGGDVISSSHSSSRSNVDLEIGCLIDLATGL VTFTVNGRELPTSYQVEPNTKLFPAVFVRPTSSNLFQFELTKIKNAMPLSSAIFKSEHKN PIPQCPPRLDIQTIKSVLWSRMPNTFLKVDTARVSERHGWQVQCLEPLQMLAVHIPEENR CVDIMELSEQEDLRTFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYIIDNQYLSGM LRQGFYDVLISIHLETAKAAQLMMNNEFIIPITAETRSIRLFLDSSKRHQPPGVGLSTSL KPRLSFAPPCFITPKRDQYLYSPAIPLDVLREKAISMLTEAVQGGGDHIRDPVGGSVEYQ FVPILRLISTMLTMGVLTSQDVHKILLLIELHVFGEQKADEMGEATEKEGMTGAEEKAVE AGEEEAKDKKQQMKGLLEKKLPESVKLQMCKLLQYFCDCELRHRIEAIVSFSDSFASKLQ FNQKFRYNELMLALNMSAAVTAKKTKEFRSPPQEQINMLLNFSMGEDCPCPEDIREELYE FHSELCLHCGIPMEEEEEDQDTSFKGRLMALVNKIKGQRHKAEEKPKEKEQAIPSNLKEL ISQTMVSWAQESHIQDPELVRAMFSLLRRQYDSIGELLRAMRKSYTISAASVHDTIHLLA SLGQIRSLLSVRMGKEEEQLMIDGLSDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGG GKSQEIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLD VAASSVMDNNSLALALEEPDLNKVVTYLAGCGLQSCPMLLAKGYPDIGWNPIEGERYLSF LRFAVFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLCAMKEAIKISETPALDL PSTTQGRISDTSTEDEEEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKGKGEALRIR AILRSLVPTEDLVGIISIPLRMPVVNKDGSVTEPDMSACFCPDHKAPMVLFLDRVYGIED QSFLLHLLEVGFLPDLREAASLDTEALRTTETALAMNRYIGSAMLPLLTRCAPHFAGTEH HVSLIDSTLHTIYQLSKGSSLTKAQRDAIEECLLAVCKYLRPSMLQQLLRRLVFDVPLLS EYCKMPLKLLTNHYEQNWKYYCLPSGWGSYGMASEEELLLTKKIFWGIFDSLSQKKYEQE LFKMAMPCLSAIAGALPPDYVDSSLSTTLEKPVFVDAQGNFDPRPINTAIISLPEKLEYI THKYAEHSHDKWSAEKVVLGWKYGDNVDEKAKTHPMLRSYKSLTEKEKDIYRFPVKESLK SMLAMGWSIDRTKEGEAMFQQRENEKIRKISQASQGSGFHPSPVDMSNVLLSRELQAMVE LLAENYHNIWAKKKKSDLAVKGGTHSLLVPYDTLTAKEKARDREKAQDLFRFLQINGYAI TRGFKDMEQDSSSMEKRFAYKFLKKLLKYVDCAQEYIAHLEAMASSGKNDRSPHEREIKF FAKVLLPLIDQYFKNHSLYFLSSPSKNLSSSGYASNKEKEMVTSLFCKLAALVRHRISLF GSDSATMVSCLHILAHTLDTRTVMKSGSELVKAALRTFFENAADDLEKTLENLKLGKFTH SRSQMKGVSQNINYTTVALLPILTALFEHITEHQFGADLLLDDVQVSCYRILSSLYSLGT GKNIYVERQLPALGECLATLAGAMPVAFLEPHLNTHNPFSVFNTKTARERAILGMPETVQ QMCPEVPHLDCLMKDINDMSESGARYTEMPHVIEVVLPMLCNYLSYWWERGTENQAKGIT TACSTTVTSEHLSIILGNILKILNSNLGIDEASWMKRIAVYAQPIISKARADLLKTHFLP TLEKLKKKTVKVVAEEELLKADNKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNR SRWQKEPDADSNELFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGDSKTKISK LFLPKAGGQDQERKHKKRRGEVYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKTRY GLKDTDEEVKEHLRRNMHLQERSEDPAVRWQLHLYKDVIVKNEGPPDPERTIDRIQTISA AVFHLEQVEQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLTGYQRIW IETETYSFEEKLVQDLARTQRKVEEEEEEIDEIQPDPLHQLILHFSHNALTERSSLEDDL LYIAYTDMMAKSCAEDENEEEEGREKTFEEKEMEKQKMLYQQARLHDRGAAEMVLQMISA SRGRLGPMVTSTLKLGISILNGGNILVQQKMLDYLKEKRDAGFFKSLSGLMQSCSVLDLN AFERQNKAEGLGMVTEEGSINVRERGSKVLQNDEFTKDLFRFLQLLCEGHNNDFQNFLRT QTGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDVMDEAGQRNFSKALNVAKQIFNSL TEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIKLLKELMDLQKDMIV MMLSLLEGNVVNGTIGKQMVDTLVESSNNVEMILKFFDMFLKLKDLTTSDSFKEHDCDGK GVISKREFQKSMENQKQYSQSEIEFLLSCVEADENDMFNYVEFVKRFHEPAKDIGFNVAV LLTNLSEHMPHDSRLATFLNLAESVLNYFEAFLGRIEIMGGAKRIERVYFEISESSRTQW EKPQVKESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASLISEPDTVERGEEDED EMHNVIKDLEVEEEENTLESSSAFTMACVSMKKNLCSLGRLLTLKSLRKHYKKFRKMSLR EMISGFFSFFWMIFTGLLRFFYNLVWCFFHILWSTLFGGGLVEGAKNIKVTDILGNMPDP TQFGIHGDVMETEKMEVSEASLVADVDQMAQGDKTEMDLMSELLSIQPKKEGGKHGAEPG LGDVSEVVGVDSPSLVTAVQQKKAQEAASKQSDENELNAESEKADKVYVFVRFNSTEEGE KNDQVKSKELLMEPSSEEERKPSKRRCGRKKEQPEVIMASFFAGLEIYQTKILNYLARNF YNLRFLALFVAFAINFILLFYKVTGEESEEVDSWTGRNEDEDESAIEYFILQENTGYMAP TLRFLAVLHTIISFLCVVGYYYLKVPLVVFKREKEIARKLEFDGLYITEQPSDDDIKGQW DRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKSALDFNPTEETIAKEA SLVFWLNFIDTKYHIWKMGVVFTDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFKT LRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSENEDEPDMKCDDMMTC YLFHMYVGVRAGGGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGE LRDQQEQVKEDMETKCFICGIGNEYFDTTPHGFETHTLQEHNLANYLFFLMYLVNKDETE HTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14688 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggcggagaagcggaagacgagatccagttcttacggacggatgatgaggtg gtgttgcagtgtgtggcctgcatccagaaggagaatcgcaagttctgtctgtctgctgag ggacttggcaatcggctttgctacttggaactcacttctgaggccaagtatgtccctcca gatctgtgcatctgtaactttgtgctggaacagtcactgtctgttcgggccctgcaggag atgctggccaaaagcggggagaataatgaaaagctcattagaaagacggcacatggaggt ggacacagaacactactgtatggacacgccatcctcctgcggcactctttcagtggaatg tatctgacatgtttaaagacatccaggtccctgacagataagttgtccttcgatgttggt cttcagttggactcgacaggtgaagcttgttggtggactatccatcctgcttctaagcag agatcagagggggagaaagttcgtattggtgatgacctcattcttgtcagtgtatcatct gagcgctatctacacctatccatctccaatggtaacatccaggtggatgcatctttcatg cagactctgtggaatgtccatcccacctgttctggcagcagtgtagaggaaggatatctc cttggtggtcatgtgatgcgtttgtttcatggacatgatgaggttttgacgatcccgggc tcagatcagagtgaggaacagcagagaatagttaactatgaaacaggcaaagtaggggct aaggccagatctctgtggagattggaacctctacggatcagttggtgtggcagtcatatc cgctggggacagccatttcgcctgcgccacctcaccacaggtcattatctggccctgact gaagacaaaggccttgtgctgcaggatcgggagaaatcagacacagcctccaccgccttc tgcttccgagcatccaaggagaagctggagtggagtccaaagaaagatattgagggcatg ggggtgcctgagattaagtatggggactcgctctgtttcatcatgcacatggccactagc ctgtggctctcgtaccaggcaccggatgtaaaatcaacacgactggggcctctcaagagg cgggcatgtctccatgcagaaggacacatggatgacggcttcacgcttcagcgctgtcag cacgaagaatcgcgtgcagcacgcatcatccgcaacagcaccagactcttcagccatttc atcagagacctggacaatctggctggaaagaatcgaacagatgtcgtccttcccgtcgat gaggttctccagaccctaaacgacctcattacatattttcaactccctgatgctgaactg gagcatgaagagaagcagatcaaactacgctcactcaagaaccgtcaaaatctcttcaaa caggaggggatgctgacattggtgtctaactgcatcgatcgtttgagtgtctataacagt gcagcacactttggggaatgtgttggagaggaagctggtgcagcttggaaagacattctc aacctgctctatgagctccttgccgctttgatccgaggaaacagaaataactgcacacaa ttctctcaaaacctggactggctggtcagcaagctagagagactggagtcctcctcaggg atcctggaggtccttcactgcatcttaattgaaagcccagaggcgcttaacatcattcag agaggacatatcaaatccatcatctcactgctatacaaacatggacgcaaccacaagatc ctagatgttctgtgctcactctgcgtttgtaacggagtagctgtaagagccaatcagaac ctcatctgcgatcacctgctcccaaaacgagacctgttactccagacacggcttgtcaat gatgtccaaagcatgagacctaacatctttctgggagtgagggaaggttcagctcagtac aagaagtggtactttgagctgatgatagaccaggtagagcactttgtaaccagcgaacct tctcacctgcgagtcgggtgggcttcctccaaaggctatgccccctacccagggggtgga gagggctgggggggtaacggagttggagatgacctctattcttatggctttgatggactt cacttgtggtcaggtcgaatcccacggagagtagcttcagtaaaccagcacatacttacc tcagatgacgtagtcagctgctgtttggatcttggggctccaagcatctcctttagaatc aacgggcagcctgtacaaggcatgtttgagagcttcaacacagacggtctcttcttccct gttgtcagcttctccgctggggtcaaggtgcgcttccttttaggtggtcgccatggtgaa ttcaagttccttcctccatcaggctatgctccctgctatgaggcactgcttcctaaagaa aggatgcgagtagaaccagtgaaggagtacaaaagggatgcggatggagttagagacttg ctgggcaccacacaatttctgtcccaggcttcttttatacccacaccagtggacaccact cagattgtcatgccgcctcacctggaaaaagtacgtgacaggctggctgagaacatccat gaactatgggccattaacaagattgaactgggctggacttatggcaagataagggatgat aataaaaggcagcacccctgcctggtggatttctcaaagctgcctgaaacagagaggaat tacaacctgcagatgtcaacagagacgttaaagactcttttggctcttggctgccatgtg gttcagttcaatgtcaacgctgaggaggagctgaaaaaagtgaaactcccaaagaactac atgatgtctaatggctacaagcccatgccactggagctttcagaagtgaaactgagccct gcacaagagctgcttgttgacaagttggctgagaatgcacacaacgtttgggccaaagat cgggttaaacagggctggacctatggcatacagcaggatttgaaaagtaagcgcaatccc cgtcttgtgccatatgcattgcttgatgagcgcaccaagaagtcgaaccgtgacagcctg cgtgaagccatccgtacactaattggctacggctataacatcgagcctcctgaccaggag gggggttgtgtggtggagagactaagcatcgataagattcgttttttccgtttggagagg acatatgcagtgaaaacagggaagtggtattttgagtttgagatagtgaccggaggagat atgagggtcggttgggctcggccaggcgtgcggcctgatgtggaactgggaacagatgat caggccttcgtcttcgatggatataagggtcatcgtgttcaccagggcagccgattgttt gggcgttgttggcatgctggggatgtggtgggctgcatgattaacatggaggacaagtcc atgatcttcacacttaatggagaaatcctcattacaaacaagggatcagaactttgcttt gctgactttgagacagaggatggctttattccagtctgtagtctgggcctttcccaagtt ggacgtatgaacctgggcaaagatgccagcaccttcaaatattatacaatgtgtggcctg caagaaggatttcagccctttgctgtcaacatgaaccgggaagtcactatgtggtttagc aagcgcctccctacatttgtcaatgttcccaaagatcatagtcatattgcggtcataagg attgatggcactattgacagccccccatgtctgaaagtgactcacaagacatttgggaca cagaacagcaatgcggacatggtgttcttccgtctgagcatgcctgtcgagttccactcc acctacaagaatttccctgtgactgaaatgaacggagtccatgaagaagagccactcaaa ctcaaatataggtatcctgtaaaatctatgaaacacgtagatgaagggaggagaactgac tatagtaacataacaacctactcccattcagtacgagtgtttgctggccaagatccctcg tgtgtgtgggtcggctgggtcacacctgacttccattactacagcaactactttaatctc agcaaaatccgaacggtgacggtaacattaggggacgaacgaggtcgggtccatgaaagt gttaaaaggagtaactgctacattgtatggggaggtgatgtcattagctccagccactcg tccagcagaagtaatgtggatttggagattggttgcctcattgatttggctactggctta gtgacctttactgtcaatggcagagaacttcctacctcatatcaggtggagccaaataca aagcttttccctgctgtgtttgtacgtcccaccagttcaaatctgttccagtttgaattg acaaagatcaagaatgctatgcccctttcatcagcaatttttaagagtgaacacaagaac ccaatccctcaatgtcctccccgtctggatatccagaccattaaatcggttctgtggagc cggatgcccaacacctttctgaaggtggacacagctcgagtgagtgaaagacatggatgg caggtccaatgtctggagccactgcagatgttggcagtacacattccagaggaaaaccgg tgtgtggacataatggaactctctgagcaggaagacctgcggacattccattatcacact ttaaaactttactgtgcactctgtgcccttggtaacacccgtgtagcacatgctctctgc agccaccttgaccagtcacagctcctttacattattgataaccaatacctgtctggcatg ctgcgccaaggcttctatgatgtcctcatcagtattcacctagagacggccaaagctgca caacttatgatgaacaatgagtttatcatcccaataacggcagagactcgcagcatacga ctctttctagattcttccaagagacaccagccacctggtgttggacttagtacatcacta aaacccagacttagctttgctccaccgtgcttcatcactccgaagcgtgatcagtatctc tacagcccagcaattccattagatgttctaagggagaaggcaattagcatgctaacagag gccgttcagggtggaggagaccacattcgagatcctgtaggtggtagtgtggagtatcag tttgtgccgattctccggctgattagcacaatgctaaccatgggtgtgctaacaagccag gatgttcataagatcttgctgctcattgaactgcatgtctttggggagcagaaagcagat gaaatgggtgaagctacggagaaagagggaatgacaggagcagaagagaaagcagtggag gctggagaagaagaagccaaagataagaagcagcaaatgaagggactgctggagaagaaa ttgccagaatcagtcaaacttcagatgtgcaaacttctgcagtacttctgtgactgtgaa ttaaggcaccgtattgaggccattgtttcattctctgatagttttgcatcaaagctgcag tttaaccagaagtttcgttacaatgagttaatgcttgctctcaatatgtctgctgctgtt actgccaagaagactaaagagttccgctcacccccacaagaacagatcaacatgctgtta aatttcagtatgggtgaggactgtccctgtcctgaggatattagggaggaactctatgaa ttccacagtgaactttgtctacactgcggtattccgatggaagaggaggaagaggatcag gacacatctttcaaaggccgtctgatggctctagtgaacaagatcaaggggcagcggcac aaagcagaagagaagccaaaagagaaagagcaagccattccttcaaatctcaaggagttg atctctcagaccatggttagctgggctcaggagagccacattcaagacccagagctggtc cgtgccatgttcagcctactgcggagacaatatgacagcattggcgagctgctgcgtgct atgcgcaaaagctacaccattagtgctgcatctgtgcacgacaccattcacctgctggcc tcactgggtcagatccgctcgttgctcagcgtccgtatgggcaaagaggaagagcagctc atgattgatggcctcagtgacataatgaacaataaggtgttctaccagcacccgaacctg atgagagtactaggcatgcatgagaccgtcatggaagttatggtgaatgtgctgggggga ggcaagtctcaggaaattgcttttcccaaaatggtggctagttgctgccgctttctgtgc tatttctgtcgaatcagccgacagaaccagaaggccatgtttgatcatttgagttacctg ctagagaacagcagtgtgggtttggcttctccatcaatgagaggatccactcctctagat gtagctgcttcttctgtaatggacaacaacagccttgcactcgctcttgaggaaccagac ctcaacaaggtggtaacatatctggctggctgtggactccagagttgtcccatgctcctt gccaaaggctatccagatattgggtggaacccaatcgagggagagcgctacctctccttt ctccgctttgctgtctttgtcaacggtgagagtgtagaagagaattccagcgttgtggta aagttgctgattcgtcgacctgagtgctttggccctgcgttgcgtggagaaggcggtaat ggactgctgtgcgccatgaaggaagccattaaaatatcagaaacgccagcacttgacctg cccagcaccacccagggccggatctctgacacgtctacagaggatgaggaggaggaagaa gtggttcacatgggcaacgccatcatgtccttctactcagctctcattgatctgctggga cgctgtgcacctgaaatgcatctcatcaataagggcaaaggagaggctctgagaatccgt gccatcctgcgctccttggtgcccactgaagaccttgttggcatcatcagcatcccactc agaatgcctgtagtcaataaagatggtagcgtgacagagccggacatgtcagcttgtttt tgcccggaccacaaggcacccatggttctgtttctggaccgagtctatggcatagaagac caaagcttccttctgcatcttctggaagttggtttcctgcctgacctaagagaggctgca tctctggacacagaagcattaaggaccacagaaacagcactggccatgaaccggtatatc ggatctgcaatgctgcccttgttgactcgctgtgccccgcattttgccggcacagagcac cacgtctcactaattgactccacgcttcacaccatctaccagctgagcaagggctcctca ctcactaaagcccagagagatgctatcgaggagtgcctgctggccgtatgcaagtactta aggccatctatgcttcaacagctgctgcgtcgcttggtgtttgacgtgcctctgctgtct gaatattgtaagatgcctcttaagctgttgaccaaccattatgagcagaactggaagtat tactgcctgccttctggttggggcagctatggcatggcctctgaggaggaattactacta accaagaagattttttggggcatctttgactcgctttctcaaaaaaagtatgagcaggag ctgtttaagatggctatgccatgtctgagtgctatagctggagctttgcctccggattat gttgactcttctctcagcaccacactggagaagccggtctttgtggatgcccagggcaac tttgaccccagacccatcaacacagcaatcatctccctcccagagaagctggaatacatc actcacaaatacgctgagcattcccatgataaatggtctgctgagaaggttgttttgggc tggaagtatggagataacgttgatgagaaagcaaaaacacaccccatgctgagatcctac aaatcactcacagagaaggaaaaggacatttatcgctttccggtgaaggagtctttgaag agtatgctagccatgggctggagcattgaccggaccaaagagggagaggccatgtttcag caaagagagaacgagaagatacgcaaaatatcccaagcatctcagggtagtggctttcac ccaagtccagtagacatgagcaacgtattgctctctcgtgaactgcaggctatggtagag ttgttggctgaaaactaccacaacatttgggcaaaaaagaagaagagtgacttagcagta aaaggtggaacacattctttgttggtgccatatgatacacttacggccaaagagaaggcc agagatcgtgagaaagcacaggacctgttccgcttcctgcagatcaatggctatgccatt accaggggatttaaagacatggagcaggactcctcctcgatggagaaaaggtttgcctat aaattcctgaaaaagctgctgaaatatgtggactgtgcacaagagtacattgctcatctg gaggctatggctagcagtggaaagaatgaccggtcacctcatgagcgggaaatcaagttt tttgccaaggtgcttctaccactgatagatcagtacttcaagaaccattctctctacttc ctctcctcccccagtaagaacctcagcagcagtgggtatgcttcaaacaaagagaaagag atggttaccagtcttttctgtaagctggcagctcttgttagacacaggatctctcttttt ggaagtgattccgccaccatggtcagctgtcttcatatcctggcccacacacttgacact agaacggtgatgaagtctggttctgagttggtgaaagctgccttgaggacattctttgag aatgcagcagatgacctggagaaaacactagagaacttgaagctagggaagttcacacac tcacgcagccagatgaagggtgtgtcacagaacatcaactacaccacagttgccctgttg cccatccttactgccttgtttgagcacatcactgagcatcagtttggagctgaccttcta ttggacgacgtccaggtctcatgctatcggatcctgagcagtctctactctttggggact gggaagaacatctatgttgaaagacagcttccagctcttggtgagtgtttggccaccctg gcaggagcgatgcctgtggcatttttggagcctcacctcaacacacacaaccctttctct gtcttcaacacaaaaacagcacgggaacgggccattttaggcatgcccgaaacagtgcaa cagatgtgcccagaagtgccgcatctcgactgcctgatgaaagacatcaatgacatgtct gagtcaggagctcgctacactgaaatgcctcatgtcatcgaggtagtgctgcctatgctg tgtaactacttatcctactggtgggagagaggcacagagaaccaggccaagggcataaca actgcatgtagcaccacagtcacctctgagcacctgagcatcatcctgggcaacatcctc aagattttgaatagcaatctgggcattgatgaggcctcctggatgaagaggattgcagtg tacgctcagcctatcatcagcaaagcgagggcagatcttttaaagacgcacttcctgcca acactggagaaattaaagaagaagacagtgaaggtagtggcagaggaggagcttctcaaa gctgacaacaaaggtgatacccaagaagcagagctactgatcctggatgagtttgcagtg ctgtgccgggatctgtatgctttctatcccatgctcattcgctatgtggacaacaacagg tcacgatggcagaaagaacctgatgctgactccaacgaacttttcaggatggtagcagaa attttcatcctttggtgcaagtcacacaattttaagcgagaggaacagaattttgttgtg cagaacgagatcaataatctctccttcctcactggggacagcaagacaaagatttcaaag ttgtttctgccaaaggcgggaggtcaggatcaggagagaaagcacaagaagagacgtggt gaggtttactctatccagacctcgttgatcgtggcagctctgaaaaaaatgctacccatt ggcctgaacatgtgcacacctggagaccaggagctcatctcattggctaagactcgctat 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aacgtgagggagcggggttccaaagttctacaaaatgatgagttcactaaagatctgttt aggttcctgcagctcctctgtgagggtcacaacaatgacttccagaactttctgaggact cagactggcaatacaactactgttaatataataataagcacagtggactatcttcttaga ttacaggagtccatcagcgatttttactggtattattctggcaaagatgtaatggatgag gctggtcagcgtaatttctctaaagctttaaatgtggccaagcagatctttaactccctt actgaatatatacagggtccgtgtataggaaaccaacagagtttggcccacagcaggtta tgggatgcagttgttggctttttgcatgtttttgccaacatgcaaatgaagctctcacag gactccagccagattaagttgctaaaagaactcatggatctgcagaaggatatgatagtc atgatgctgtcccttctagaaggaaatgttgtaaatggcaccattggcaaacagatggtt gacaccttggtggagtcctccaacaacgtagagatgatcctcaagttttttgatatgttc ctcaagcttaaggacctcaccacatctgacagtttcaaagagcatgactgtgatggcaaa ggagtcatttccaaaagagagtttcagaaatccatggaaaatcagaaacagtactctcag tctgaaattgaattcctgctttcttgcgtagaggcagacgaaaatgacatgttcaattat gtggaatttgtaaaacgcttccatgaacccgccaaggacattggttttaatgtcgcagta ctgcttacaaatctgtcagaacacatgcctcatgactcccgtctggctaccttcctgaac ctggcagagagtgtccttaattacttcgaggcgttcctgggccgtattgagatcatgggc ggtgccaagagaatagaaagggtctactttgaaatcagcgagtctagtagaacacagtgg gagaaaccacaagttaaggaatctaagagacagtttatttttgatgtagtcaacgaagga ggagaatcggagaagatggagttgtttgtcaatttctgtgaggataccatttttgagatg cagctagcttctctgatctcagagcctgatactgtggaaagaggagaagaagatgaggat gagatgcataatgtaattaaggatctggaggttgaagaggaggagaatacattggaatcc tcctcagctttcaccatggcatgtgtctcaatgaaaaagaacctctgtagccttggaaga ctgctcacactaaaaagcctgaggaaacattacaagaagttcagaaaaatgagtctgaga gagatgatttctgggttcttctcctttttctggatgatcttcactggccttctacgattc ttctacaacctggtgtggtgctttttccatattctctggtcaactctgtttggtggtggc ctggtggaaggtgccaagaatataaaggtgaccgacatccttggcaacatgccagacccc acacagtttggcatccatggtgatgtgatggagactgaaaaaatggaggttagtgaggct tctttggttgctgatgtagatcagatggcacaaggagacaaaacagaaatggatctcatg tcagagctcctaagtatacagcccaagaaggagggaggaaagcatggagctgagcctggt ctgggagatgtatctgaagtggttggagtcgattctccatctttagttactgcagtgcag cagaaaaaagctcaggaagctgcgagtaagcagtcagatgagaatgaattgaatgcagaa tcagaaaaagcagataaagtctatgtgtttgtccgcttcaatagtacagaggaaggggag aagaatgaccaagtcaagtctaaggagttgctcatggaaccgtcgtcagaggaagaaagg aagccgtccaagaggaggtgcgggaggaagaaagaacagccagaagtcattatggccagc ttttttgctggtctggaaatctaccaaaccaagattctaaattacctggctcgaaacttc tacaacctgcgattcctggctctgtttgtggcatttgccatcaacttcatccttctattc tataaggtaactggtgaggagtcggaggaggtggactcgtggacagggagaaatgaagac gaggatgaaagtgccattgagtattttatcctgcaggagaacactggttacatggcacct acactccgctttctagctgtactacacactatcatctcctttctctgtgtggtggggtat tactatctgaaggtgcctttggttgtttttaagcgagagaaggaaattgccaggaaactt gaatttgatggtctttatatcactgaacaaccttctgatgatgatattaaagggcaatgg gacagacttgttattaacacaccatcttttcctaataattactgggataagtttgtcaaa cggaaggtaataaataaatatggggacttgtatggagcagagcggattgctgagttgctc ggtctcgacaaaagcgctctggacttcaaccctactgaggaaactattgctaaagaagct tcactggtgttctggttaaacttcattgatacaaaatatcacatctggaaaatgggtgta gtgtttacagacaattcttttctgtacctggtgtggtataccacgatgtccatcctaggc cattacaacaatttcttttttgctgctcacctgctagacattgctatgggtttcaagact ttgaggactatcctttcttctgtcacccacaacggcaaacagctggtgctgactgtgggt ctgctggctgtagttgtgtatctatacactgttgtggcctttaacttcttccgtaaattc tacaacaagagcgagaacgaagacgaaccagacatgaagtgtgatgatatgatgacttgc tatttgttccacatgtacgtgggtgtgcgtgctggtgggggaataggagatgaaattgag gatccagcaggtgacccctatgagctttaccgcatcctctttgatatcacctttttcttc tttgtcattgtcatccttctggccattattcaaggtttgattatcgatgccttcggagaa ctgcgagaccagcaggagcaagtcaaagaggacatggagactaaatgcttcatctgtggc attgggaatgaatactttgacacgactccacatggctttgagacacacacattacaagag cacaacttggcaaactacctgtttttcctaatgtaccttgtcaacaaggatgaaacagag catactgggcaggagtcgtatgtgtggaagatgtatcaggagcgatgctgggatttcttt ccagctggagactgtttcaggaaacagtatgaggaccagctgggctaa

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