KEGG   Theropithecus gelada (gelada): 112612288
Entry
112612288         CDS       T08041                                 
Symbol
AKT2
Name
(RefSeq) RAC-beta serine/threonine-protein kinase isoform X1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
tge  Theropithecus gelada (gelada)
Pathway
tge01521  EGFR tyrosine kinase inhibitor resistance
tge01522  Endocrine resistance
tge01524  Platinum drug resistance
tge04010  MAPK signaling pathway
tge04012  ErbB signaling pathway
tge04014  Ras signaling pathway
tge04015  Rap1 signaling pathway
tge04022  cGMP-PKG signaling pathway
tge04024  cAMP signaling pathway
tge04062  Chemokine signaling pathway
tge04066  HIF-1 signaling pathway
tge04068  FoxO signaling pathway
tge04071  Sphingolipid signaling pathway
tge04072  Phospholipase D signaling pathway
tge04140  Autophagy - animal
tge04150  mTOR signaling pathway
tge04151  PI3K-Akt signaling pathway
tge04152  AMPK signaling pathway
tge04210  Apoptosis
tge04211  Longevity regulating pathway
tge04213  Longevity regulating pathway - multiple species
tge04218  Cellular senescence
tge04261  Adrenergic signaling in cardiomyocytes
tge04370  VEGF signaling pathway
tge04371  Apelin signaling pathway
tge04380  Osteoclast differentiation
tge04510  Focal adhesion
tge04517  IgSF CAM signaling
tge04518  Integrin signaling
tge04550  Signaling pathways regulating pluripotency of stem cells
tge04611  Platelet activation
tge04613  Neutrophil extracellular trap formation
tge04620  Toll-like receptor signaling pathway
tge04625  C-type lectin receptor signaling pathway
tge04630  JAK-STAT signaling pathway
tge04660  T cell receptor signaling pathway
tge04662  B cell receptor signaling pathway
tge04664  Fc epsilon RI signaling pathway
tge04666  Fc gamma R-mediated phagocytosis
tge04668  TNF signaling pathway
tge04722  Neurotrophin signaling pathway
tge04725  Cholinergic synapse
tge04728  Dopaminergic synapse
tge04810  Regulation of actin cytoskeleton
tge04910  Insulin signaling pathway
tge04914  Progesterone-mediated oocyte maturation
tge04915  Estrogen signaling pathway
tge04917  Prolactin signaling pathway
tge04919  Thyroid hormone signaling pathway
tge04920  Adipocytokine signaling pathway
tge04922  Glucagon signaling pathway
tge04923  Regulation of lipolysis in adipocytes
tge04926  Relaxin signaling pathway
tge04929  GnRH secretion
tge04931  Insulin resistance
tge04932  Non-alcoholic fatty liver disease
tge04933  AGE-RAGE signaling pathway in diabetic complications
tge04935  Growth hormone synthesis, secretion and action
tge04936  Alcoholic liver disease
tge04973  Carbohydrate digestion and absorption
tge05010  Alzheimer disease
tge05017  Spinocerebellar ataxia
tge05132  Salmonella infection
tge05135  Yersinia infection
tge05142  Chagas disease
tge05145  Toxoplasmosis
tge05152  Tuberculosis
tge05160  Hepatitis C
tge05161  Hepatitis B
tge05162  Measles
tge05163  Human cytomegalovirus infection
tge05164  Influenza A
tge05165  Human papillomavirus infection
tge05166  Human T-cell leukemia virus 1 infection
tge05167  Kaposi sarcoma-associated herpesvirus infection
tge05168  Herpes simplex virus 1 infection
tge05169  Epstein-Barr virus infection
tge05170  Human immunodeficiency virus 1 infection
tge05200  Pathways in cancer
tge05205  Proteoglycans in cancer
tge05207  Chemical carcinogenesis - receptor activation
tge05208  Chemical carcinogenesis - reactive oxygen species
tge05210  Colorectal cancer
tge05211  Renal cell carcinoma
tge05212  Pancreatic cancer
tge05213  Endometrial cancer
tge05214  Glioma
tge05215  Prostate cancer
tge05218  Melanoma
tge05220  Chronic myeloid leukemia
tge05221  Acute myeloid leukemia
tge05222  Small cell lung cancer
tge05223  Non-small cell lung cancer
tge05224  Breast cancer
tge05225  Hepatocellular carcinoma
tge05226  Gastric cancer
tge05230  Central carbon metabolism in cancer
tge05231  Choline metabolism in cancer
tge05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
tge05415  Diabetic cardiomyopathy
tge05417  Lipid and atherosclerosis
tge05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:tge00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112612288 (AKT2)
   04012 ErbB signaling pathway
    112612288 (AKT2)
   04014 Ras signaling pathway
    112612288 (AKT2)
   04015 Rap1 signaling pathway
    112612288 (AKT2)
   04370 VEGF signaling pathway
    112612288 (AKT2)
   04371 Apelin signaling pathway
    112612288 (AKT2)
   04630 JAK-STAT signaling pathway
    112612288 (AKT2)
   04668 TNF signaling pathway
    112612288 (AKT2)
   04066 HIF-1 signaling pathway
    112612288 (AKT2)
   04068 FoxO signaling pathway
    112612288 (AKT2)
   04072 Phospholipase D signaling pathway
    112612288 (AKT2)
   04071 Sphingolipid signaling pathway
    112612288 (AKT2)
   04024 cAMP signaling pathway
    112612288 (AKT2)
   04022 cGMP-PKG signaling pathway
    112612288 (AKT2)
   04151 PI3K-Akt signaling pathway
    112612288 (AKT2)
   04152 AMPK signaling pathway
    112612288 (AKT2)
   04150 mTOR signaling pathway
    112612288 (AKT2)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    112612288 (AKT2)
   04518 Integrin signaling
    112612288 (AKT2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    112612288 (AKT2)
  09143 Cell growth and death
   04210 Apoptosis
    112612288 (AKT2)
   04218 Cellular senescence
    112612288 (AKT2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112612288 (AKT2)
   04550 Signaling pathways regulating pluripotency of stem cells
    112612288 (AKT2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    112612288 (AKT2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    112612288 (AKT2)
   04613 Neutrophil extracellular trap formation
    112612288 (AKT2)
   04620 Toll-like receptor signaling pathway
    112612288 (AKT2)
   04625 C-type lectin receptor signaling pathway
    112612288 (AKT2)
   04660 T cell receptor signaling pathway
    112612288 (AKT2)
   04662 B cell receptor signaling pathway
    112612288 (AKT2)
   04664 Fc epsilon RI signaling pathway
    112612288 (AKT2)
   04666 Fc gamma R-mediated phagocytosis
    112612288 (AKT2)
   04062 Chemokine signaling pathway
    112612288 (AKT2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112612288 (AKT2)
   04922 Glucagon signaling pathway
    112612288 (AKT2)
   04923 Regulation of lipolysis in adipocytes
    112612288 (AKT2)
   04920 Adipocytokine signaling pathway
    112612288 (AKT2)
   04929 GnRH secretion
    112612288 (AKT2)
   04915 Estrogen signaling pathway
    112612288 (AKT2)
   04914 Progesterone-mediated oocyte maturation
    112612288 (AKT2)
   04917 Prolactin signaling pathway
    112612288 (AKT2)
   04926 Relaxin signaling pathway
    112612288 (AKT2)
   04935 Growth hormone synthesis, secretion and action
    112612288 (AKT2)
   04919 Thyroid hormone signaling pathway
    112612288 (AKT2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    112612288 (AKT2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    112612288 (AKT2)
  09156 Nervous system
   04725 Cholinergic synapse
    112612288 (AKT2)
   04728 Dopaminergic synapse
    112612288 (AKT2)
   04722 Neurotrophin signaling pathway
    112612288 (AKT2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    112612288 (AKT2)
  09149 Aging
   04211 Longevity regulating pathway
    112612288 (AKT2)
   04213 Longevity regulating pathway - multiple species
    112612288 (AKT2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112612288 (AKT2)
   05205 Proteoglycans in cancer
    112612288 (AKT2)
   05207 Chemical carcinogenesis - receptor activation
    112612288 (AKT2)
   05208 Chemical carcinogenesis - reactive oxygen species
    112612288 (AKT2)
   05230 Central carbon metabolism in cancer
    112612288 (AKT2)
   05231 Choline metabolism in cancer
    112612288 (AKT2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112612288 (AKT2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112612288 (AKT2)
   05212 Pancreatic cancer
    112612288 (AKT2)
   05225 Hepatocellular carcinoma
    112612288 (AKT2)
   05226 Gastric cancer
    112612288 (AKT2)
   05214 Glioma
    112612288 (AKT2)
   05221 Acute myeloid leukemia
    112612288 (AKT2)
   05220 Chronic myeloid leukemia
    112612288 (AKT2)
   05218 Melanoma
    112612288 (AKT2)
   05211 Renal cell carcinoma
    112612288 (AKT2)
   05215 Prostate cancer
    112612288 (AKT2)
   05213 Endometrial cancer
    112612288 (AKT2)
   05224 Breast cancer
    112612288 (AKT2)
   05222 Small cell lung cancer
    112612288 (AKT2)
   05223 Non-small cell lung cancer
    112612288 (AKT2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112612288 (AKT2)
   05170 Human immunodeficiency virus 1 infection
    112612288 (AKT2)
   05161 Hepatitis B
    112612288 (AKT2)
   05160 Hepatitis C
    112612288 (AKT2)
   05164 Influenza A
    112612288 (AKT2)
   05162 Measles
    112612288 (AKT2)
   05168 Herpes simplex virus 1 infection
    112612288 (AKT2)
   05163 Human cytomegalovirus infection
    112612288 (AKT2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112612288 (AKT2)
   05169 Epstein-Barr virus infection
    112612288 (AKT2)
   05165 Human papillomavirus infection
    112612288 (AKT2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    112612288 (AKT2)
   05135 Yersinia infection
    112612288 (AKT2)
   05152 Tuberculosis
    112612288 (AKT2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    112612288 (AKT2)
   05142 Chagas disease
    112612288 (AKT2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112612288 (AKT2)
   05017 Spinocerebellar ataxia
    112612288 (AKT2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    112612288 (AKT2)
   05418 Fluid shear stress and atherosclerosis
    112612288 (AKT2)
   05415 Diabetic cardiomyopathy
    112612288 (AKT2)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    112612288 (AKT2)
   04932 Non-alcoholic fatty liver disease
    112612288 (AKT2)
   04931 Insulin resistance
    112612288 (AKT2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    112612288 (AKT2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112612288 (AKT2)
   01524 Platinum drug resistance
    112612288 (AKT2)
   01522 Endocrine resistance
    112612288 (AKT2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tge01001]
    112612288 (AKT2)
Enzymes [BR:tge01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     112612288 (AKT2)
Protein kinases [BR:tge01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   112612288 (AKT2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 Seadorna_VP7
Other DBs
NCBI-GeneID: 112612288
NCBI-ProteinID: XP_025222428
Ensembl: ENSTGEG00000024584
UniProt: A0A8D2G524
LinkDB
Position
19:39747911..39800403
AA seq 481 aa
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM
DYKCGSPSDSSAAEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
E
NT seq 1446 nt   +upstreamnt  +downstreamnt
atgaacgaggtgtctgtcatcaaagaaggctggctccacaagcgcggtgaatacatcaag
acctggaggccacggtacttcctgctgaagagcgacggctccttcattgggtacaaggag
aggcccgaggcccctgatcagacccttccccccttaaacaacttctctgtagcagaatgc
cagctgatgaagaccgagaggccgcggcccaacaccttcgtcatacgctgcctgcagtgg
accacagtcatcgagaggaccttccacgtggattctccagacgagagggaggaatggatg
cgggccatccagatggttgccaacagcctcaagcagcgggccccaggtgaggaccccatg
gactacaagtgtggctcccccagtgactcctccgcggccgaggagatggaagtggcggtc
agcaaggcacgggctaaagtgaccatgaatgatttcgactatctcaaactccttggcaag
ggaacctttggcaaagtcatcctggtgcgggagaaggccactggccgctactacgccatg
aagatcctgcggaaggaagtcatcattgccaaggatgaagtcgctcacacagtcaccgag
agccgggtcctccagaacaccaggcacccgttcctcactgcgctgaagtacgccttccag
acccacgaccgcctgtgcttcgtgatggagtacgccaacggtggcgagctgttcttccac
ctgtcccgggagcgtgtcttcacagaggagcgggcccggttttatggtgcagagatcgtc
tcggctcttgagtacttgcactcgcgggacgtggtgtaccgcgacatcaagctggaaaac
ctcatgctggacaaagacggccacatcaagatcactgactttggcctctgcaaagaaggc
atcagtgacggggctaccatgaaaaccttctgtgggaccccggagtacctggcgcctgag
gtgctggaggacaatgactatggccgggccgtggactggtgggggctgggtgtggtcatg
tacgagatgatgtgcggccgcctgcctttctacaaccaggaccacgagcgcctcttcgag
ctcatcctcatggaagagatccgcttcccgcgcacgctcagccccgaggccaagtccctg
cttgccgggctgcttaagaaggaccccaagcagaggcttggtggggggcccagcgatgcc
aaggaggtcatggagcacaggttcttcctcagcatcaactggcaggacgtggtccagaag
aagctcctgccacccttcaaacctcaggtcacgtccgaggtcgacacaaggtactttgat
gatgaattcaccgcccagtccatcacaatcacaccccccgaccgctatgacagcctgggc
ttactggagctggaccagcggacccacttcccccagttctcctactcggcgagcatccgc
gagtga

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