KEGG   Theropithecus gelada (gelada): 112616121
Entry
112616121         CDS       T08041                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
tge  Theropithecus gelada (gelada)
Pathway
tge01521  EGFR tyrosine kinase inhibitor resistance
tge01522  Endocrine resistance
tge04010  MAPK signaling pathway
tge04012  ErbB signaling pathway
tge04068  FoxO signaling pathway
tge04270  Vascular smooth muscle contraction
tge04650  Natural killer cell mediated cytotoxicity
tge04720  Long-term potentiation
tge04726  Serotonergic synapse
tge04730  Long-term depression
tge04810  Regulation of actin cytoskeleton
tge04910  Insulin signaling pathway
tge04914  Progesterone-mediated oocyte maturation
tge04928  Parathyroid hormone synthesis, secretion and action
tge05010  Alzheimer disease
tge05022  Pathways of neurodegeneration - multiple diseases
tge05034  Alcoholism
tge05160  Hepatitis C
tge05161  Hepatitis B
tge05200  Pathways in cancer
tge05205  Proteoglycans in cancer
tge05208  Chemical carcinogenesis - reactive oxygen species
tge05210  Colorectal cancer
tge05211  Renal cell carcinoma
tge05212  Pancreatic cancer
tge05213  Endometrial cancer
tge05214  Glioma
tge05215  Prostate cancer
tge05218  Melanoma
tge05219  Bladder cancer
tge05220  Chronic myeloid leukemia
tge05221  Acute myeloid leukemia
tge05223  Non-small cell lung cancer
tge05224  Breast cancer
tge05225  Hepatocellular carcinoma
tge05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:tge00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112616121 (ARAF)
   04012 ErbB signaling pathway
    112616121 (ARAF)
   04068 FoxO signaling pathway
    112616121 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    112616121 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    112616121 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112616121 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    112616121 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    112616121 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    112616121 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    112616121 (ARAF)
   04720 Long-term potentiation
    112616121 (ARAF)
   04730 Long-term depression
    112616121 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112616121 (ARAF)
   05205 Proteoglycans in cancer
    112616121 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    112616121 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112616121 (ARAF)
   05212 Pancreatic cancer
    112616121 (ARAF)
   05225 Hepatocellular carcinoma
    112616121 (ARAF)
   05226 Gastric cancer
    112616121 (ARAF)
   05214 Glioma
    112616121 (ARAF)
   05221 Acute myeloid leukemia
    112616121 (ARAF)
   05220 Chronic myeloid leukemia
    112616121 (ARAF)
   05218 Melanoma
    112616121 (ARAF)
   05211 Renal cell carcinoma
    112616121 (ARAF)
   05219 Bladder cancer
    112616121 (ARAF)
   05215 Prostate cancer
    112616121 (ARAF)
   05213 Endometrial cancer
    112616121 (ARAF)
   05224 Breast cancer
    112616121 (ARAF)
   05223 Non-small cell lung cancer
    112616121 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    112616121 (ARAF)
   05160 Hepatitis C
    112616121 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112616121 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    112616121 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    112616121 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112616121 (ARAF)
   01522 Endocrine resistance
    112616121 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tge01001]
    112616121 (ARAF)
Enzymes [BR:tge01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     112616121 (ARAF)
Protein kinases [BR:tge01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   112616121 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like TUG-UBL1
Other DBs
NCBI-GeneID: 112616121
NCBI-ProteinID: XP_025228886
Ensembl: ENSTGEG00000005326
LinkDB
Position
X:complement(11571961..11582848)
AA seq 606 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPRPHTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAASSRGGGDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNSIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaatggggccgagccgtcccgggcagtgggcacc
gtcaaagtgtacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctgaaggtgcggggtctaaatcaggactgctgtgtg
gtctaccgactcatcaagggacgaaagacagtcactgcctgggacacagccattgctccc
ctggatggcgaggagctcattgtcgaggtccttgaagatgtcccgctgaccatgcacaat
tttgtacggaagaccttcttcagcctggcattctgtgacttctgccttaagtttctgttc
catggcttccgttgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccaacagttctaccacagtgtccaggat
ttgtccggaggctccagacaacatgaggctccctcgaaccgccccctgaatgagttgcta
accccccagggtcccaggccccacactcagcactgtgacccggagcacttccccttccct
gccccggccaacgcccccctgcagcgcatccgctccacatccactcccaacgtccatatg
gtcagcaccacggcccccatggactccaacctcatccagctcactggccagagtttcagc
actgatgctgccagtagtagaggaggtggtgatggaaccccccgggggagccccagccca
gccagcgtgtcctcggggaggaagtccccacattccaagtcaccagcagagcagcgtgag
cggaagtccttggccgatgacaagaagaaagtgaagaacctggggtaccgggactcaggc
tattactgggaagtaccacccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgagggcggtggcatggcgatgtggctgtgaaggtgctcaaggtg
tcccagcccacagctgagcaggcccaagctttcaagaatgagatgcaggtgctcaggaag
acgcgacatgtcaacatcttgctgtttatgggcttcatgacccggccgggattcgccatc
atcacacagtggtgtgaaggctccagcctctaccatcacctgcatgtggccgacacgcgc
ttcgacatggtccagctcattgatgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacagtatcttcctacatgagggg
ctcacggtgaagattggtgactttggcttggccacagtgaagactcgatggagcggggcc
cagcccttggagcagccctcaggctctgtgctgtggatggcagctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcagatgtctatgcctacggggttgtgctctac
gagctcatgactggctcactgccttacagccacattggctgccgtgaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctctagcaactgccccaag
gccatgcggcgcctgctgtctgactgcctcaagttccagcgggaggaacggcccctcttc
ccccagatcctggccacaattgagctgctgcaacggtcactccccaagattgagcggagt
gcctcggagccctccttgcaccgcacccaggctgatgagttgcctgcctgcctactcagc
gcagcccgccttgtgccttag

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