KEGG   Theropithecus gelada (gelada): 112618874
Entry
112618874         CDS       T08041                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
tge  Theropithecus gelada (gelada)
Pathway
tge00562  Inositol phosphate metabolism
tge01100  Metabolic pathways
tge01521  EGFR tyrosine kinase inhibitor resistance
tge01522  Endocrine resistance
tge01524  Platinum drug resistance
tge04012  ErbB signaling pathway
tge04014  Ras signaling pathway
tge04015  Rap1 signaling pathway
tge04024  cAMP signaling pathway
tge04062  Chemokine signaling pathway
tge04066  HIF-1 signaling pathway
tge04068  FoxO signaling pathway
tge04070  Phosphatidylinositol signaling system
tge04071  Sphingolipid signaling pathway
tge04072  Phospholipase D signaling pathway
tge04081  Hormone signaling
tge04140  Autophagy - animal
tge04150  mTOR signaling pathway
tge04151  PI3K-Akt signaling pathway
tge04152  AMPK signaling pathway
tge04210  Apoptosis
tge04211  Longevity regulating pathway
tge04213  Longevity regulating pathway - multiple species
tge04218  Cellular senescence
tge04360  Axon guidance
tge04370  VEGF signaling pathway
tge04380  Osteoclast differentiation
tge04510  Focal adhesion
tge04550  Signaling pathways regulating pluripotency of stem cells
tge04611  Platelet activation
tge04613  Neutrophil extracellular trap formation
tge04620  Toll-like receptor signaling pathway
tge04625  C-type lectin receptor signaling pathway
tge04630  JAK-STAT signaling pathway
tge04650  Natural killer cell mediated cytotoxicity
tge04660  T cell receptor signaling pathway
tge04662  B cell receptor signaling pathway
tge04664  Fc epsilon RI signaling pathway
tge04666  Fc gamma R-mediated phagocytosis
tge04668  TNF signaling pathway
tge04670  Leukocyte transendothelial migration
tge04722  Neurotrophin signaling pathway
tge04725  Cholinergic synapse
tge04750  Inflammatory mediator regulation of TRP channels
tge04810  Regulation of actin cytoskeleton
tge04910  Insulin signaling pathway
tge04914  Progesterone-mediated oocyte maturation
tge04915  Estrogen signaling pathway
tge04917  Prolactin signaling pathway
tge04919  Thyroid hormone signaling pathway
tge04923  Regulation of lipolysis in adipocytes
tge04926  Relaxin signaling pathway
tge04929  GnRH secretion
tge04930  Type II diabetes mellitus
tge04931  Insulin resistance
tge04932  Non-alcoholic fatty liver disease
tge04933  AGE-RAGE signaling pathway in diabetic complications
tge04935  Growth hormone synthesis, secretion and action
tge04960  Aldosterone-regulated sodium reabsorption
tge04973  Carbohydrate digestion and absorption
tge05010  Alzheimer disease
tge05017  Spinocerebellar ataxia
tge05020  Prion disease
tge05100  Bacterial invasion of epithelial cells
tge05132  Salmonella infection
tge05135  Yersinia infection
tge05142  Chagas disease
tge05146  Amoebiasis
tge05160  Hepatitis C
tge05161  Hepatitis B
tge05162  Measles
tge05163  Human cytomegalovirus infection
tge05164  Influenza A
tge05165  Human papillomavirus infection
tge05166  Human T-cell leukemia virus 1 infection
tge05167  Kaposi sarcoma-associated herpesvirus infection
tge05168  Herpes simplex virus 1 infection
tge05169  Epstein-Barr virus infection
tge05170  Human immunodeficiency virus 1 infection
tge05171  Coronavirus disease - COVID-19
tge05200  Pathways in cancer
tge05203  Viral carcinogenesis
tge05205  Proteoglycans in cancer
tge05206  MicroRNAs in cancer
tge05207  Chemical carcinogenesis - receptor activation
tge05208  Chemical carcinogenesis - reactive oxygen species
tge05210  Colorectal cancer
tge05211  Renal cell carcinoma
tge05212  Pancreatic cancer
tge05213  Endometrial cancer
tge05214  Glioma
tge05215  Prostate cancer
tge05218  Melanoma
tge05220  Chronic myeloid leukemia
tge05221  Acute myeloid leukemia
tge05222  Small cell lung cancer
tge05223  Non-small cell lung cancer
tge05224  Breast cancer
tge05225  Hepatocellular carcinoma
tge05226  Gastric cancer
tge05230  Central carbon metabolism in cancer
tge05231  Choline metabolism in cancer
tge05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
tge05415  Diabetic cardiomyopathy
tge05417  Lipid and atherosclerosis
tge05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:tge00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    112618874 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    112618874 (PIK3CA)
   04014 Ras signaling pathway
    112618874 (PIK3CA)
   04015 Rap1 signaling pathway
    112618874 (PIK3CA)
   04370 VEGF signaling pathway
    112618874 (PIK3CA)
   04630 JAK-STAT signaling pathway
    112618874 (PIK3CA)
   04668 TNF signaling pathway
    112618874 (PIK3CA)
   04066 HIF-1 signaling pathway
    112618874 (PIK3CA)
   04068 FoxO signaling pathway
    112618874 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    112618874 (PIK3CA)
   04072 Phospholipase D signaling pathway
    112618874 (PIK3CA)
   04071 Sphingolipid signaling pathway
    112618874 (PIK3CA)
   04024 cAMP signaling pathway
    112618874 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    112618874 (PIK3CA)
   04152 AMPK signaling pathway
    112618874 (PIK3CA)
   04150 mTOR signaling pathway
    112618874 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    112618874 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    112618874 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    112618874 (PIK3CA)
   04218 Cellular senescence
    112618874 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112618874 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    112618874 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    112618874 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    112618874 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    112618874 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    112618874 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    112618874 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    112618874 (PIK3CA)
   04660 T cell receptor signaling pathway
    112618874 (PIK3CA)
   04662 B cell receptor signaling pathway
    112618874 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    112618874 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    112618874 (PIK3CA)
   04670 Leukocyte transendothelial migration
    112618874 (PIK3CA)
   04062 Chemokine signaling pathway
    112618874 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112618874 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    112618874 (PIK3CA)
   04929 GnRH secretion
    112618874 (PIK3CA)
   04915 Estrogen signaling pathway
    112618874 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    112618874 (PIK3CA)
   04917 Prolactin signaling pathway
    112618874 (PIK3CA)
   04926 Relaxin signaling pathway
    112618874 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    112618874 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    112618874 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    112618874 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    112618874 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    112618874 (PIK3CA)
   04722 Neurotrophin signaling pathway
    112618874 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    112618874 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    112618874 (PIK3CA)
   04380 Osteoclast differentiation
    112618874 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    112618874 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    112618874 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112618874 (PIK3CA)
   05206 MicroRNAs in cancer
    112618874 (PIK3CA)
   05205 Proteoglycans in cancer
    112618874 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    112618874 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    112618874 (PIK3CA)
   05203 Viral carcinogenesis
    112618874 (PIK3CA)
   05230 Central carbon metabolism in cancer
    112618874 (PIK3CA)
   05231 Choline metabolism in cancer
    112618874 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112618874 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112618874 (PIK3CA)
   05212 Pancreatic cancer
    112618874 (PIK3CA)
   05225 Hepatocellular carcinoma
    112618874 (PIK3CA)
   05226 Gastric cancer
    112618874 (PIK3CA)
   05214 Glioma
    112618874 (PIK3CA)
   05221 Acute myeloid leukemia
    112618874 (PIK3CA)
   05220 Chronic myeloid leukemia
    112618874 (PIK3CA)
   05218 Melanoma
    112618874 (PIK3CA)
   05211 Renal cell carcinoma
    112618874 (PIK3CA)
   05215 Prostate cancer
    112618874 (PIK3CA)
   05213 Endometrial cancer
    112618874 (PIK3CA)
   05224 Breast cancer
    112618874 (PIK3CA)
   05222 Small cell lung cancer
    112618874 (PIK3CA)
   05223 Non-small cell lung cancer
    112618874 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112618874 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    112618874 (PIK3CA)
   05161 Hepatitis B
    112618874 (PIK3CA)
   05160 Hepatitis C
    112618874 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    112618874 (PIK3CA)
   05164 Influenza A
    112618874 (PIK3CA)
   05162 Measles
    112618874 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    112618874 (PIK3CA)
   05163 Human cytomegalovirus infection
    112618874 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112618874 (PIK3CA)
   05169 Epstein-Barr virus infection
    112618874 (PIK3CA)
   05165 Human papillomavirus infection
    112618874 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    112618874 (PIK3CA)
   05135 Yersinia infection
    112618874 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    112618874 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    112618874 (PIK3CA)
   05142 Chagas disease
    112618874 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112618874 (PIK3CA)
   05017 Spinocerebellar ataxia
    112618874 (PIK3CA)
   05020 Prion disease
    112618874 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    112618874 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    112618874 (PIK3CA)
   05415 Diabetic cardiomyopathy
    112618874 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    112618874 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    112618874 (PIK3CA)
   04931 Insulin resistance
    112618874 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    112618874 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112618874 (PIK3CA)
   01524 Platinum drug resistance
    112618874 (PIK3CA)
   01522 Endocrine resistance
    112618874 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:tge04131]
    112618874 (PIK3CA)
Enzymes [BR:tge01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     112618874 (PIK3CA)
Membrane trafficking [BR:tge04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    112618874 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 112618874
NCBI-ProteinID: XP_025232274
Ensembl: ENSTGEG00000026176
UniProt: A0A8D2G9T0
LinkDB
Position
2:complement(111479767..111571748)
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataaccataaagcatgaactatttaaagaagcaagaaaataccccctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagggatctcaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcgccagaattgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtataccctgaaaatcaaccatgactgtgtaccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcctctgaacagctaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgttgatggctaaagaaagcctttattctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatttccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctacgtgaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgaccttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcatggggaaatataaacttgtttgattacacagacactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaattggtctgtg
tcccgagaagcaggatttagctattcccacgcaggactgagtaacaggctagctagagac
aatgaattaagggaaaatgacaaagaacagctcaaagcaatttctacacgagatcctctc
tctgaaatcactgagcaggagaaagattttctgtggagccacagacactattgtgtaact
atccccgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaagta
gcccagatgtattgcttggtaaaagactggcctccaatcaaacctgaacaggctatggaa
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatatttaacagatgacaaactgtctcagtatttaattcagctagtacaggtcctaaaa
tatgaacaatatttggataacttgcttgtgagatttttactgaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agccagaggtttggcctgcttttggagtcctattgtcgtgcatgtgggatgtatttgaag
cacctgaataggcaagtcgaggcaatggaaaagctcattaacttaactgacattctcaaa
caggagaaaaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgagg
cgaccagatttcatggatgctctacagggctttctatctcctctaaaccctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcaaattattcgtattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgcgaaattctcacactattatgcaaatt
cagtgcaaaggcggcttgaaaggtgcactgcagttcaacagccacactctacatcagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgtttacacgttca
tgtgctggatattgtgtcgctaccttcattctgggaattggagatcgtcacaatagtaac
atcatggtgaaagacgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagaacgtgtgccatttgttttgacacaggatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcgacagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgacattgca
tacattcgaaagaccctagccttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaaacagcatgcattgaactga

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