KEGG   Theropithecus gelada (gelada): 112627584
Entry
112627584         CDS       T08041                                 
Symbol
PLCB2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
tge  Theropithecus gelada (gelada)
Pathway
tge00562  Inositol phosphate metabolism
tge01100  Metabolic pathways
tge04015  Rap1 signaling pathway
tge04020  Calcium signaling pathway
tge04022  cGMP-PKG signaling pathway
tge04062  Chemokine signaling pathway
tge04070  Phosphatidylinositol signaling system
tge04071  Sphingolipid signaling pathway
tge04072  Phospholipase D signaling pathway
tge04081  Hormone signaling
tge04082  Neuroactive ligand signaling
tge04261  Adrenergic signaling in cardiomyocytes
tge04270  Vascular smooth muscle contraction
tge04310  Wnt signaling pathway
tge04371  Apelin signaling pathway
tge04540  Gap junction
tge04611  Platelet activation
tge04613  Neutrophil extracellular trap formation
tge04621  NOD-like receptor signaling pathway
tge04713  Circadian entrainment
tge04720  Long-term potentiation
tge04723  Retrograde endocannabinoid signaling
tge04724  Glutamatergic synapse
tge04725  Cholinergic synapse
tge04726  Serotonergic synapse
tge04728  Dopaminergic synapse
tge04730  Long-term depression
tge04742  Taste transduction
tge04750  Inflammatory mediator regulation of TRP channels
tge04911  Insulin secretion
tge04912  GnRH signaling pathway
tge04915  Estrogen signaling pathway
tge04916  Melanogenesis
tge04918  Thyroid hormone synthesis
tge04919  Thyroid hormone signaling pathway
tge04921  Oxytocin signaling pathway
tge04922  Glucagon signaling pathway
tge04924  Renin secretion
tge04925  Aldosterone synthesis and secretion
tge04926  Relaxin signaling pathway
tge04927  Cortisol synthesis and secretion
tge04928  Parathyroid hormone synthesis, secretion and action
tge04929  GnRH secretion
tge04933  AGE-RAGE signaling pathway in diabetic complications
tge04934  Cushing syndrome
tge04935  Growth hormone synthesis, secretion and action
tge04961  Endocrine and other factor-regulated calcium reabsorption
tge04970  Salivary secretion
tge04971  Gastric acid secretion
tge04972  Pancreatic secretion
tge04973  Carbohydrate digestion and absorption
tge05010  Alzheimer disease
tge05016  Huntington disease
tge05017  Spinocerebellar ataxia
tge05022  Pathways of neurodegeneration - multiple diseases
tge05142  Chagas disease
tge05143  African trypanosomiasis
tge05146  Amoebiasis
tge05163  Human cytomegalovirus infection
tge05200  Pathways in cancer
tge05415  Diabetic cardiomyopathy
tge05417  Lipid and atherosclerosis
Module
tge_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:tge00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    112627584 (PLCB2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    112627584 (PLCB2)
   04310 Wnt signaling pathway
    112627584 (PLCB2)
   04371 Apelin signaling pathway
    112627584 (PLCB2)
   04020 Calcium signaling pathway
    112627584 (PLCB2)
   04070 Phosphatidylinositol signaling system
    112627584 (PLCB2)
   04072 Phospholipase D signaling pathway
    112627584 (PLCB2)
   04071 Sphingolipid signaling pathway
    112627584 (PLCB2)
   04022 cGMP-PKG signaling pathway
    112627584 (PLCB2)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    112627584 (PLCB2)
   04081 Hormone signaling
    112627584 (PLCB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    112627584 (PLCB2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    112627584 (PLCB2)
   04613 Neutrophil extracellular trap formation
    112627584 (PLCB2)
   04621 NOD-like receptor signaling pathway
    112627584 (PLCB2)
   04062 Chemokine signaling pathway
    112627584 (PLCB2)
  09152 Endocrine system
   04911 Insulin secretion
    112627584 (PLCB2)
   04922 Glucagon signaling pathway
    112627584 (PLCB2)
   04929 GnRH secretion
    112627584 (PLCB2)
   04912 GnRH signaling pathway
    112627584 (PLCB2)
   04915 Estrogen signaling pathway
    112627584 (PLCB2)
   04921 Oxytocin signaling pathway
    112627584 (PLCB2)
   04926 Relaxin signaling pathway
    112627584 (PLCB2)
   04935 Growth hormone synthesis, secretion and action
    112627584 (PLCB2)
   04918 Thyroid hormone synthesis
    112627584 (PLCB2)
   04919 Thyroid hormone signaling pathway
    112627584 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    112627584 (PLCB2)
   04916 Melanogenesis
    112627584 (PLCB2)
   04924 Renin secretion
    112627584 (PLCB2)
   04925 Aldosterone synthesis and secretion
    112627584 (PLCB2)
   04927 Cortisol synthesis and secretion
    112627584 (PLCB2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    112627584 (PLCB2)
   04270 Vascular smooth muscle contraction
    112627584 (PLCB2)
  09154 Digestive system
   04970 Salivary secretion
    112627584 (PLCB2)
   04971 Gastric acid secretion
    112627584 (PLCB2)
   04972 Pancreatic secretion
    112627584 (PLCB2)
   04973 Carbohydrate digestion and absorption
    112627584 (PLCB2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    112627584 (PLCB2)
  09156 Nervous system
   04724 Glutamatergic synapse
    112627584 (PLCB2)
   04725 Cholinergic synapse
    112627584 (PLCB2)
   04728 Dopaminergic synapse
    112627584 (PLCB2)
   04726 Serotonergic synapse
    112627584 (PLCB2)
   04720 Long-term potentiation
    112627584 (PLCB2)
   04730 Long-term depression
    112627584 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    112627584 (PLCB2)
  09157 Sensory system
   04742 Taste transduction
    112627584 (PLCB2)
   04750 Inflammatory mediator regulation of TRP channels
    112627584 (PLCB2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    112627584 (PLCB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112627584 (PLCB2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    112627584 (PLCB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    112627584 (PLCB2)
   05142 Chagas disease
    112627584 (PLCB2)
   05143 African trypanosomiasis
    112627584 (PLCB2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112627584 (PLCB2)
   05016 Huntington disease
    112627584 (PLCB2)
   05017 Spinocerebellar ataxia
    112627584 (PLCB2)
   05022 Pathways of neurodegeneration - multiple diseases
    112627584 (PLCB2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    112627584 (PLCB2)
   05415 Diabetic cardiomyopathy
    112627584 (PLCB2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    112627584 (PLCB2)
   04934 Cushing syndrome
    112627584 (PLCB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:tge04131]
    112627584 (PLCB2)
Enzymes [BR:tge01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     112627584 (PLCB2)
Membrane trafficking [BR:tge04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    112627584 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    112627584 (PLCB2)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 IATP
Other DBs
NCBI-GeneID: 112627584
NCBI-ProteinID: XP_025245761
Ensembl: ENSTGEG00000000692
UniProt: A0A8D2E475
LinkDB
Position
7a:complement(15612069..15632176)
AA seq 1185 aa
MSLLNPVLLPPRVKAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQSKEMEFLD
ITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKVWAEDILALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC
WKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKM
AEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSSPTSSSKDPGGE
AEGSSPRSAPAGEGTVWAGEEGTELEDEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEV
TAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQM
SRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEF
MRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRT
KLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHL
CLHSESNMPLTMPALFVFLEMKDYVPGAWADLTVALANPIKFFNAHDKRSVKLKEVMGGL
PEKPFPLASPVASQVNGALAPKSNGSPAAKAWAREEAMKEVAEPRTASLEELRELKGVVK
LQRRHEKELRELERRGARRWEELLQRGAAQLAELGPRGAGGGGAGKLGPGKGSRKKRSLP
CEESAGTAPGESPEGMDARVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMEL
AREKQAAELKALKETAEIDTKEMKKKLETKRLERIQGMTKVTADKMAQERLKREINNSHI
QEVVQVIKQMTENLEKHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKE
SVRACFRTCFPSETKDKPERDCECPPELCEQDPVVAKTDVQESHL
NT seq 3558 nt   +upstreamnt  +downstreamnt
atgtctctgctcaaccctgtgctgctgccccccagggtgaaggcctatctgagccaaggg
gagcgcttcatcaaatgggatgatgaaactacaattgcctctccagttatcctccgtgtg
gatcctaagggctactacttatactggacatatcaaagcaaggagatggagtttctggat
atcaccagcatccgggacactcgctttgggaagtttgccaagatgcccaagagccagaag
ctccgggacgtcttcaacatggactttcctgacaacagcttcctgctgaagacgctcacc
gtggtgtctggcccggacatggtggacctcaccttccacaacttcgtctcctacaaggag
aacgtgggcaaggtctgggctgaggacatactggccctagtcaagcatccgctgacggcc
aacgcctcccgcagcaccttcctggacaagatcctcgtgaagctcaagatgcagctcaac
tctgaagggaagattccagtgaagaactttttccagatgtttcctgctgaccgcaagcgg
gtggaagctgctctcagtgcctgccacctccctaaaggcaagaatgacgccatcaatcct
gaggacttcccagaacctgtctacaagagtttcctcatgagcctctgtcctcggccagaa
atagatgagatcttcacttcttaccatgctaaggccaaaccctacatgacgaaggagcac
ctgaccaaattcatcaaccagaaacagcgggactcccggcttaactccctgctgttcccg
ccagcacggcctgaccaggtgcagggcctcatcgacaagtatgagcccagtggcatcaat
gtgcagaggggccagttgtcacctgagggcatggtctggtttctctgtgggccggagaac
agtgtgctggcccaggacaagctgctgctccaccacgacatgacacagccactcaatcat
tacttcatcaactcgtcccacaacacctacctgacagcgggccagttctcaggcctctcc
tcggctgagatgtaccgccaggtgctgctgtccggctgccgttgcgtggagctagattgc
tggaaggggaaaccccctgacgaagagcccattatcacccacggcttcaccatgaccaca
gacatcttcttcaaagaagcaattgaggctattgcagaaagcgcctttaagacctccccg
tatcctatcatcctgtcatttgagaaccatgtggactcaccccgccagcaggctaagatg
gctgagtattgccggacgatctttggggatatgctgctcacagagcccctggaaaagttc
ccactgaaaccaggtgtccccctgcccagccctgaggatctcaggggcaagatcctcatc
aagaacaagaagaaccagttttccagccccacctcctccagtaaggatcctgggggggag
gctgagggcagcagcccacgcagtgcccctgcaggtgagggcacagtgtgggctggcgag
gaagggactgagctggaggacgaggaggtggaagaggaagaggaggaggagtcaggaaac
ctggacgaagaagagattaagaagatgcagtcggatgagggcacagcgggcctggaagtg
acggcttatgaggagatgtccagcctagtcaattacattcagcccaccaagttcatctcc
tttgagttctctgctcaaaagaaccgaagttatgtcatctcgtccttcacagaactcaag
gcatatgacctgctctccaaggcctcggtgcagtttgtggactacaacaagcgccagatg
agccgcatttaccccaagggaacccgcatggactcctccaactacatgccccagatgttc
tggaatgctggatgccagatggttgccctcaacttccagacgatggacttgcccatgcag
cagaacatggcagtgtttgagttcaatgggcagagcggctacctcctcaagcacgagttc
atgcgccggccggacaagcagttcaaccccttctcagtggaccgcatcgacgtggtggtg
gccaccaccctttctatcacggtgatctctgggcagttcctgtcagaacgcagcgtgcgc
acctatgtggaagtggagctgtttggccttcctggggaccccaagaggcgctaccgaact
aagctgtcacccagtaccaattccatcaatcctgtctggaaggaggagccctttgtcttt
gagaagatcttgatgcctgagctggcctctctcagggtggctgtgatggaggaaggcaac
aagtttcttggacaccgcatcatccccatcaatgccctaaattctgggtaccaccacctg
tgcctacacagtgagagcaacatgcccctcaccatgcctgcgctcttcgtcttcctggag
atgaaggactacgtacctggtgcctgggcagatctcactgtggccctcgccaaccccatc
aagttcttcaatgcccatgacaagaggtctgtgaagctcaaggaggtcatgggagggctg
cctgagaagcccttcccactggcgagtccagttgccagccaggtcaatggtgcgttggcc
ccaaagagcaatgggtcaccagcagccaaggcctgggccagggaagaggctatgaaagaa
gttgcggagccacggaccgccagcctggaggagctccgggagctaaagggcgtcgtgaag
ctgcagcggcggcacgagaaggaactgcgggagttggagcggcgcggagcgcggcgctgg
gaggagctgctgcagcggggcgcggcgcagctggccgagctcgggccacggggcgctggg
ggtggcggggccggcaagctcggcccgggcaaaggctctcgcaagaagaggagcctgcct
tgcgaggagagcgccggaaccgcgccgggcgagagccctgagggcatggacgcgcgcgtg
cgggagctgaaggacaggctggagctggagctgctgcggcagggcgaggagcagtacgag
tgcgttctgaagcgcaaggagcagcacgtggccgagcaaatctccaaaatgatggagctg
gccagagagaaacaggcggcagagctgaaggccctgaaggagaccgcggagatcgacacc
aaagagatgaagaaaaagctggagaccaagagactggagcggatccagggcatgaccaaa
gtcaccgcagataagatggcccaggagaggttgaagagagagattaacaactcccacatc
caggaagtagtgcaggtgatcaagcagatgacagagaacttggagaagcaccaggagaag
ctggaagagaagcaggctgcttgcctggaacagatacgggagatggaaaagcagttccag
aaggaggcgctggcagagtatgaggccaggatgaagggtctggaggcagaggtgaaggag
tcggtgagggcctgcttcaggacctgctttccctctgagaccaaggacaagcctgagagg
gactgcgagtgccccccggagctgtgtgagcaggacccagtcgtagcaaagacagatgtc
caggagagccacctttga

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