KEGG   Theropithecus gelada (gelada): 112627624
Entry
112627624         CDS       T08041                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
tge  Theropithecus gelada (gelada)
Pathway
tge01521  EGFR tyrosine kinase inhibitor resistance
tge01522  Endocrine resistance
tge04010  MAPK signaling pathway
tge04012  ErbB signaling pathway
tge04014  Ras signaling pathway
tge04015  Rap1 signaling pathway
tge04022  cGMP-PKG signaling pathway
tge04024  cAMP signaling pathway
tge04062  Chemokine signaling pathway
tge04066  HIF-1 signaling pathway
tge04068  FoxO signaling pathway
tge04071  Sphingolipid signaling pathway
tge04072  Phospholipase D signaling pathway
tge04114  Oocyte meiosis
tge04140  Autophagy - animal
tge04148  Efferocytosis
tge04150  mTOR signaling pathway
tge04151  PI3K-Akt signaling pathway
tge04210  Apoptosis
tge04218  Cellular senescence
tge04270  Vascular smooth muscle contraction
tge04370  VEGF signaling pathway
tge04371  Apelin signaling pathway
tge04380  Osteoclast differentiation
tge04510  Focal adhesion
tge04540  Gap junction
tge04550  Signaling pathways regulating pluripotency of stem cells
tge04613  Neutrophil extracellular trap formation
tge04620  Toll-like receptor signaling pathway
tge04650  Natural killer cell mediated cytotoxicity
tge04660  T cell receptor signaling pathway
tge04662  B cell receptor signaling pathway
tge04664  Fc epsilon RI signaling pathway
tge04666  Fc gamma R-mediated phagocytosis
tge04668  TNF signaling pathway
tge04720  Long-term potentiation
tge04722  Neurotrophin signaling pathway
tge04725  Cholinergic synapse
tge04726  Serotonergic synapse
tge04730  Long-term depression
tge04810  Regulation of actin cytoskeleton
tge04910  Insulin signaling pathway
tge04912  GnRH signaling pathway
tge04914  Progesterone-mediated oocyte maturation
tge04915  Estrogen signaling pathway
tge04916  Melanogenesis
tge04917  Prolactin signaling pathway
tge04919  Thyroid hormone signaling pathway
tge04921  Oxytocin signaling pathway
tge04926  Relaxin signaling pathway
tge04928  Parathyroid hormone synthesis, secretion and action
tge04929  GnRH secretion
tge04934  Cushing syndrome
tge04935  Growth hormone synthesis, secretion and action
tge05010  Alzheimer disease
tge05022  Pathways of neurodegeneration - multiple diseases
tge05034  Alcoholism
tge05132  Salmonella infection
tge05135  Yersinia infection
tge05160  Hepatitis C
tge05161  Hepatitis B
tge05163  Human cytomegalovirus infection
tge05164  Influenza A
tge05165  Human papillomavirus infection
tge05166  Human T-cell leukemia virus 1 infection
tge05167  Kaposi sarcoma-associated herpesvirus infection
tge05170  Human immunodeficiency virus 1 infection
tge05200  Pathways in cancer
tge05205  Proteoglycans in cancer
tge05206  MicroRNAs in cancer
tge05207  Chemical carcinogenesis - receptor activation
tge05208  Chemical carcinogenesis - reactive oxygen species
tge05210  Colorectal cancer
tge05211  Renal cell carcinoma
tge05212  Pancreatic cancer
tge05213  Endometrial cancer
tge05214  Glioma
tge05215  Prostate cancer
tge05216  Thyroid cancer
tge05218  Melanoma
tge05219  Bladder cancer
tge05220  Chronic myeloid leukemia
tge05221  Acute myeloid leukemia
tge05223  Non-small cell lung cancer
tge05224  Breast cancer
tge05225  Hepatocellular carcinoma
tge05226  Gastric cancer
tge05230  Central carbon metabolism in cancer
tge05231  Choline metabolism in cancer
tge05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:tge00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112627624 (MAP2K1)
   04012 ErbB signaling pathway
    112627624 (MAP2K1)
   04014 Ras signaling pathway
    112627624 (MAP2K1)
   04015 Rap1 signaling pathway
    112627624 (MAP2K1)
   04370 VEGF signaling pathway
    112627624 (MAP2K1)
   04371 Apelin signaling pathway
    112627624 (MAP2K1)
   04668 TNF signaling pathway
    112627624 (MAP2K1)
   04066 HIF-1 signaling pathway
    112627624 (MAP2K1)
   04068 FoxO signaling pathway
    112627624 (MAP2K1)
   04072 Phospholipase D signaling pathway
    112627624 (MAP2K1)
   04071 Sphingolipid signaling pathway
    112627624 (MAP2K1)
   04024 cAMP signaling pathway
    112627624 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    112627624 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    112627624 (MAP2K1)
   04150 mTOR signaling pathway
    112627624 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    112627624 (MAP2K1)
   04148 Efferocytosis
    112627624 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    112627624 (MAP2K1)
   04210 Apoptosis
    112627624 (MAP2K1)
   04218 Cellular senescence
    112627624 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112627624 (MAP2K1)
   04540 Gap junction
    112627624 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    112627624 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    112627624 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    112627624 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    112627624 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    112627624 (MAP2K1)
   04660 T cell receptor signaling pathway
    112627624 (MAP2K1)
   04662 B cell receptor signaling pathway
    112627624 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    112627624 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    112627624 (MAP2K1)
   04062 Chemokine signaling pathway
    112627624 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112627624 (MAP2K1)
   04929 GnRH secretion
    112627624 (MAP2K1)
   04912 GnRH signaling pathway
    112627624 (MAP2K1)
   04915 Estrogen signaling pathway
    112627624 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    112627624 (MAP2K1)
   04917 Prolactin signaling pathway
    112627624 (MAP2K1)
   04921 Oxytocin signaling pathway
    112627624 (MAP2K1)
   04926 Relaxin signaling pathway
    112627624 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    112627624 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    112627624 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    112627624 (MAP2K1)
   04916 Melanogenesis
    112627624 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    112627624 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    112627624 (MAP2K1)
   04726 Serotonergic synapse
    112627624 (MAP2K1)
   04720 Long-term potentiation
    112627624 (MAP2K1)
   04730 Long-term depression
    112627624 (MAP2K1)
   04722 Neurotrophin signaling pathway
    112627624 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    112627624 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112627624 (MAP2K1)
   05206 MicroRNAs in cancer
    112627624 (MAP2K1)
   05205 Proteoglycans in cancer
    112627624 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    112627624 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    112627624 (MAP2K1)
   05230 Central carbon metabolism in cancer
    112627624 (MAP2K1)
   05231 Choline metabolism in cancer
    112627624 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112627624 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112627624 (MAP2K1)
   05212 Pancreatic cancer
    112627624 (MAP2K1)
   05225 Hepatocellular carcinoma
    112627624 (MAP2K1)
   05226 Gastric cancer
    112627624 (MAP2K1)
   05214 Glioma
    112627624 (MAP2K1)
   05216 Thyroid cancer
    112627624 (MAP2K1)
   05221 Acute myeloid leukemia
    112627624 (MAP2K1)
   05220 Chronic myeloid leukemia
    112627624 (MAP2K1)
   05218 Melanoma
    112627624 (MAP2K1)
   05211 Renal cell carcinoma
    112627624 (MAP2K1)
   05219 Bladder cancer
    112627624 (MAP2K1)
   05215 Prostate cancer
    112627624 (MAP2K1)
   05213 Endometrial cancer
    112627624 (MAP2K1)
   05224 Breast cancer
    112627624 (MAP2K1)
   05223 Non-small cell lung cancer
    112627624 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112627624 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    112627624 (MAP2K1)
   05161 Hepatitis B
    112627624 (MAP2K1)
   05160 Hepatitis C
    112627624 (MAP2K1)
   05164 Influenza A
    112627624 (MAP2K1)
   05163 Human cytomegalovirus infection
    112627624 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112627624 (MAP2K1)
   05165 Human papillomavirus infection
    112627624 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    112627624 (MAP2K1)
   05135 Yersinia infection
    112627624 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112627624 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    112627624 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    112627624 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    112627624 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112627624 (MAP2K1)
   01522 Endocrine resistance
    112627624 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tge01001]
    112627624 (MAP2K1)
Enzymes [BR:tge01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     112627624 (MAP2K1)
Protein kinases [BR:tge01001]
 Serine/threonine kinases: STE group
  STE7 family
   112627624 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 112627624
NCBI-ProteinID: XP_025245880
Ensembl: ENSTGEG00000024763
LinkDB
Position
7a:41899970..42011013
AA seq 412 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVSPF
IPDSYSTCLFICCSVSHLCSTSRAHSFPAHCGPAEPGAAEYQTPVSSALPSV
NT seq 1239 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctcggccgagaccaacttggaggccttgcagaagaagctggaggagcta
gagcttgatgagcagcagcgaaagcgccttgaggcctttctcacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggggccggcaatggcggt
gtggtgttcaaggtctcccacaagccttctggcctggtcatggccagaaagctaattcat
ctggagatcaaacccgcaatccggaaccagatcataagggaactgcaggttctgcatgag
tgcaactctccatacatcgtgggcttctatggtgcattctacagtgatggcgagatcagt
atctgcatggagcacatggatggaggttctctggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaagcacaagatcatgcacagagatgtcaagccctccaacatcctagtcaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tctgtgcagtcagacatctggagcatgggactctctctggtagagatggcggttgggagg
tatcccatccctcctccagatgccaaggagctggaactgatgtttgggtgccaggtggag
ggagatgcagctgagaccccacctaggccaaggacccccgggaggccccttagctcatat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccaaaattgcccagtggagttttcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggtgagtccattt
attccagattcttacagtacctgtttattcatttgttgttctgtcagtcacctgtgcagt
acttccagagcccattcattccctgcccactgtggtccagctgagcctggggctgcagaa
taccaaacaccagtctcctctgccctcccatcagtttaa

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