Theropithecus gelada (gelada): 112627661 Help Entry 112627661         CDS       T08041                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism tge  Theropithecus gelada (gelada) Pathway tge04020   Calcium signaling pathway tge04371   Apelin signaling pathway tge04713   Circadian entrainment tge04921   Oxytocin signaling pathway tge04970   Salivary secretion tge05010   Alzheimer disease tge05012   Parkinson disease tge05020   Prion disease tge05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:tge00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     112627661 (RYR3)    04020 Calcium signaling pathway     112627661 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     112627661 (RYR3)   09154 Digestive system    04970 Salivary secretion     112627661 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     112627661 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     112627661 (RYR3)    05012 Parkinson disease     112627661 (RYR3)    05020 Prion disease     112627661 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     112627661 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:tge04040]     112627661 (RYR3) Ion channels [BR:tge04040]  Voltage-gated cation channels   Ryanodine receptor    112627661 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  112627661 NCBI-ProteinID:  XP_025246000 Ensembl:  ENSTGEG00000025258 UniProt:  A0A8D2G5F2 LinkDB All DBs Position 7a:8548147..9132298 Genome browser AA seq 4870 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRAKADTKSTAFSFRASKELKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHKVLDI LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRTVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGVRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADSAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICCLGLSQIGR MNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVMRID GTMDSPPCLKVTHKTFGTQHSNADMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEI LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVASSQRSNRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPNSFLKVESERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMRFHYH TLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRAGFYDLLISIHLANAKE RKLMMKNEYIIPITSTTRNICLFPDESKRHGLPGVGLRTCLKPGFRFSTPCFVATGEEHQ KQSPEIPLESLRTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLIDPSVFGEHSADTEEGTEKEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTKEFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPLEEEEEEEED TSWTGKLRALVYKIKGPPKPEKEQPTEEEERCPTTLKELISQTMICWAQEDQIQDAELVR MMFNLLRRQYDSIGELLQALRKTYTISHASVSDTINLLAALGQIRSLLSVRMGKEEELLM INGLGEIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLSTEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVSTEADEEEEEIVH MGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLP SLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLD TVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTDHCTSLIDSTLQTIYRLSKGRSLTK AQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCL PSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDT RITATLEKQISVDADGNFDPKPINTVNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKY GISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRE NEKLRSVSQANQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGG GSHPLLVPYDTLTAKEKFKDREKAQDLFKFLQVNGVIVSRGMKDMELDASSMEKRFAYKF LKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFANHRLYFLS SPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRT VMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPI LTSIFEHVAQHQFGMDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECVASLAA AIPVAFLEPTLNRYNPLSVFNTKTPRERSILGIPDTVEDMCPDIPQLEGLMKEINDLAES GARYTEMPHVIEVILPMLCNYLSYWWERGPENLPPSTGQCCTKVTSEHLSLILGNILKII NNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLRADG KGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFI LWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLY SIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYGHRDTDEEVREHLRNNLHLQEKS DDPAVKWQLNLYKDVLKSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLS KQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEE EEEEETEKQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEDEDK EKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGN AGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRE RGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQES ISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAV VGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLV ESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKREFQKAMEGQKQYTQSEID FLLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAES VLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQE KMELFVNFCEDTIFEMQLASQISESDSADRPEEEEEDEDSSYVLEIAGEEEEDGSFEPAS AFAMACASVKRNVADFLKRATLKNLRKQYRNVKKMTAKELVKVLCSFFWMLFLGLFQMLF TVLGGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTMEAERAEVMEPGI TTELVHFIKGEKGDTDIMSDLFGLHPKKEGSLKHGPEVGLGDLSEIIGKDEPPTLESTVQ KKRKAQAAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEHLWTEVTKKKKRRCGQK TEKPEAFTANFFKGLDIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEE ETEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCLKV PLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVIN KYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDN SFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVV VYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD PYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDY FDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDC FRKQYEDQLG NT seq 14613 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagtttctgaggactgaggatgaa gtggtactccagtgcatcgccaccattcacaaggagcagaggaagttctgcctggcagcc gagggacttgggaatcgcctgtgcttcttggaacccacttcagaagccaagtacattcct ccagatctctgcgtctgcaattttgtgctggaacagtccctatctgtcagagccctgcag gaaatgcttgccaacacaggtgaaaatggcggcgaaggggcagcacaaggaggtggccac aggaccctgttatatggccatgcaattctcctgaggcactctttcagcggaatgtatcta acatgcttgactacatcaagatcccagacagacaaacttgcctttgatgtaggtctacgg gaacatgccacaggagaagcctgttggtggactatacatcctgcttccaaacagaggtcc gaaggagagaaagttagaattggcgatgacctcatcctcgtcagcgtgtcctctgaaaga taccttcatctctcagtatcaaatggtaacatacaagtggatgcctcctttatgcagacc ctctggaatgtacatcctacgtgctcaggaagtagcatcgaagaaggatacctacttggt gggcacgtagtgcgtcttttccatggtcatgatgagtgtctgacgataccatctacagac cagaatgattcccagcacaggaggatattctacgaagctgggggagctgggactcgagcc aggtctctgtggagagtggaaccacttcggataagttggagtggcagtaacatcagatgg ggccaggcttttcgactccggcatctcaccacaggccactacctggccttgacagaagac caaggccttatactacaagaccgggcaaaggcagacaccaagtccacagctttctctttc cgggcatcaaaggaactcaaggagaaattagattccagtcacaagcgagacatagaaggc atgggagttccagaaatcaagtatggagattctgtctgctttgtacagcatatagccagt ggtctgtgggtgacctacaaagcacaagatgccaaaacttcccgcctgggacctctgaaa agaaaggtcatactccatcaggaaggccacatggatgatggattaacactgcagagatgc cagcgtgaggagtcccaggctgctcggatcatccggaacactacagccttattcagccag tttgtcagcggaaacaatcgcacagctgcccccatcaccctgcctatagaagaagtcctg cagaccctacaggacttgatcgcctacttccagcccccggaggaggagatgcgacatgaa gacaagcagaacaagctccgctcactcaaaaacagacaaaatcttttcaaggaagaggga atgttggctcttgtcttaaattgcattgaccgcttaaatatctacaatagcgtagcacac tttgcagggattgcaagggaagagagtggcatggcctggaaagaaattctgaacctcctc tacaaattgctggctgctctcattcgtggaaacagaaacaattgcgctcaattctccaat aaccttgattggctcatcagtaaattggacagactagaatcttcctcaggtatcttggaa gttttgcactgcatcttaactgaaagtccggaagccttaaatctgatagcagagggccac atcaagtccatcatctccctgttggataagcacgggcggaatcacaaggttctggatatc ctgtgctccctctgtctctgcaatggggttgcagtgagagccaaccagaatctgatctgt gacaacctgctgccccggagaaacctgctcttgcagacacgactgattaacgatgtaacc agtatccggccaaacatcttcctgggagtcgcggagggctcagcccagtacaagaagtgg tacttcgagctgattatcgaccaggtggaccccttcctaacagcagagcccacacatctg cgggtgggctgggcctcttcctcaggctatgctccatacccaggcggtggagaaggatgg ggaggcaatggtgttggcgatgacctgtactcctatggctttgatggacttcacctttgg tcaggccggatacccagaactgtggcttccatcaaccagcacctcctgagatcagatgat gtggtaagctgctgcctggacctcggggtgcccagcatttcattccgcatcaatggacaa cctgtgcaggggatgtttgagaacttcaacacagacgggctcttcttccctgtgatgagc ttttcagcaggtgttaaagtacgtttcctgatgggtggacgtcatggagagtttaagttc ctgccaccctctggctatgccccttgctatgaagccttacttccaaaagagaagatgaga ttggaacctgtcaaagaatataaacgtgatgctgatggcgttagagatctcttgggtacc acccagttcctatcccaagcctctttcatcccatgccccatagacaccagtcaggttgtt ttgccacctcacctcgaaaagatccgagacagactagctgaaaacatccacgagctttgg ggaatgaataaaatagagcttggctggactttcggcaagatacgagatgacaataaaaga caacacccttgccttgtggagttttcaaagctccccgaaactgagaagaattataacctg caaatgtcgactgaaaccttgaaaaccctcctggccctggggtgccacattgctcatgtt aacccagctgctgaggaggatctcaagaaggtcaaactgcccaaaaactatatgatgtcc aatggctataagccagcccctttggatttgtctgatgtgaagctgttacctcctcaagaa attttagtggataagcttgcagaaaatgcacacaatgtttgggcaaaagacagaataaaa caaggatggacctatggcatccaacaggatttgaagaacaaaagaaatccccgtctggtg ccatatgcattactggacgagcgtaccaagaagtcaaacagggacagcctgcgggaagct gtgcgcacttttgttggttacggatataacattgagccatcagaccaagaactagctgac tcggctgtggagaaagtcagcatagacaagatccgatttttccgggtagagcgatcttac gcagtgagatctggaaagtggtattttgagtttgaggtggtgactggaggagacatgcga gttggctgggccaggccaggctgtcggcctgatgtggaactgggggccgatgaccaagcc tttgtgtttgaaggcagcaggggccagcgttggcatcaaggaagtgggtattttgggcgt acgtggcagccaggagatgtggtcggatgtatgattaacctggatgatgcttcaatgatc ttcacgctgaatggggaactgctgatcaccaacaaaggctctgaacttgccttcgctgac tacgagattgagaatggctttgtgcccatctgctgtctggggctgtctcagattggccgc atgaatctcgggacagatgccagtaccttcaagttttataccatgtgcggtctccaagag ggctttgagccttttgctgtcaacatgaacagagatgttgctatgtggttcagcaagcgc ctcccgacgtttgtcaacgtgccaaaggaccatccacacatagaggtcatgaggattgat ggcaccatggacagccctccgtgtctcaaggtgacccataagacatttggcacacagcat agcaatgccgacatgatctactgccgcttgagcatgcctgtcgagtgccactcttccttc agccacagcccctgtctggacagtgaagctttccagaaaaggaaacagatgcaagaaata ctctctcatacaacaacacagtgctactatgccatccgcatctttgctggacaggatcca tcctgcgtctgggtcggatgggtgactccagactatcacttgtacagtgaaaagtttgac ctgaataaaaactgcacagtgactgtcaccctaggggatgaaagaggccgggtacacgaa agtgtgaaacgcagcaactgctacatggtctggggcggggacatagtggccagttcccag agatcaaatcggagcaacgtggacctggagatcggctgtcttgtggatctggcaatgggc atgttgtccttctcagccaacggaaaagaactgggcacctgctaccaggtggagcccaac accaaagtgtttccagcagtcttcctgcagcctacaagtacttccttgtttcagttcgaa cttggaaagctgaagaacgcaatgcccctgtcggcggccatattcaagagtgaagagaag aacccagtcccacagtgtccacctcggctggacgtccaaaccatccagcccgtgctctgg agccgcatgcccaacagcttcctgaaggtggagagcgagcgtgtgagcgagcgccacggc tgggtggtgcagtgcctggagcccctgcagatgatggcgctccacatccccgaggagaac aggtgtgtggatatcctggagctctgtgagcaggaggacctgatgcggttccattaccac acgctgaggctctacagcgcggtgtgcgccctgggaaacagccgcgtggcctacgccctg tgcagccacgtggacctctcccagctcttctatgccattgacaacaagtacctccccggc ctccttcgagctggcttctatgacctgctcatcagcatccacctggccaacgccaaggag aggaagctgatgatgaagaacgagtacatcatccccattaccagcaccaccaggaatatc tgcctcttcccggacgagtccaagaggcatggactgcctggggtgggcctgagaacatgt ctcaagcccgggttcaggttctccaccccttgctttgtcgcgactggtgaggagcaccaa aaacagagccctgagattcccttggagagtctcaggacgaaggctctgagtatgctgaca gaggcggtgcagtgcagcggggcccacatccgagaccccgtaggggggtctgtggagttc cagtttgtgcctgtgctgaaactcattggaaccctgctggtcatgggcgtgtttgatgat gacgatgttcggcagatcctcctcctgattgatccctctgtgtttggggagcatagcgca gacacagaggagggaacagaaaaggaggaagtgacccaggtggaggagaaggctgtggag gctggggagaaggccggcaaggaggctcctgtcaaaggcttgttgcagactcgattaccc gagtccgtcaagctgcagatgtgtgagctcctcagctatctctgcgactgtgagctgcag caccgagtggaggccattgtggcatttggtgacatttatgtctccaagctgcaggcaaat cagaagttccgctacaatgagctcatgcaggccctgaacatgtctgcggccttgactgcc cggaagaccaaggagttccgctcacccccacaggagcagatcaacatgcttcttaacttt caactgggagagaactgcccctgcccagaggagattcgggaggagctgtatgatttccat gaggaccttctccttcactgtggggttcctttggaagaagaggaagaggaggaggaggac acctcctggacgggaaaactccgtgccttggtttacaaaatcaaaggcccacccaagcca gagaaggaacagccaacggaggaggaggagagatgccccacaacattgaaggagctcatc tcacagacgatgatctgctgggcccaggaggaccagatccaggatgcagagctggtccga atgatgttcaaccttctccggaggcagtatgacagcatcggggagctgctgcaggcgctg cggaagacctacaccatcagccatgcctctgtaagcgacaccatcaacctgctggctgcc ctgggccagatccgctccctcctcagtgtcaggatgggcaaggaagaggagttgctcatg atcaacgggctgggagaaataatgaacaacaaggtgttttaccagcatcccaacctcatg agagtcctgggcatgcacgagacggtgatggaggtgatggtgaacgtgttgagtacagag aaatctcagattgcatttccaaagatggttgctagctgctgccgtttcctttgctatttc tgtcgaattagccggcaaaatcagaaggccatgtttgagcatctgagttaccttctggag aatagcagcgttggcctggcctccccgtcgatgaggggatccaccccgctggatgtggca gcgtcctctgtgatggacaacaacgagttagcgctgggcttggaggaaccagacctggag aaggtggtgacctacttggcaggctgtggcctacagagctgccccatgcttctggccaaa ggataccctgacgtcggctggaaccccatcgaaggggaacgctacctgtccttcctgagg tttgccgtcttcgtgaacagtgagagtgtggaagaaaatgccagcgttgtggtcaagctg ctcatcagacgcccagagtgcttcggcccggccctgcggggcgaggggggaaacggactg ttggcggccatgcagggtgccattaagatctctgagaaccccgcgcttgacctcccctct caaggatacaaaagagaagtcagcacggaggccgatgaagaggaagaagaaatcgtgcat atgggcaatgcaattatgtcattttattctgcccttatagatctactgggccgctgtgct cctgaaatgcacctcatccagacgggaaagggggaggccatccgcatcaggtccatactg cgctccctggtccccacagaagacctggttgggatcatcagcatccccttgaaactgccc tcccttaacaaagatgggtcggtcagtgagccggatatggcggccaacttctgccctgac cacaaggcacccatggtgctgttcttggaccgcgtctatggcattaaggatcaaactttt ctgctccacttgctggaggttggatttttacctgacctgagagcttctgcctccctagat acagtttccctgagcaccacagaggctgcgcttgcactaaataggtatatatgttctgct gtgctcccgctcctcacaagatgtgcccctctctttgccggaacagaccactgcacctct ctgattgattccacactgcagacgatatacaggctttccaagggacgttccctcaccaaa gcacaaagggacactatagaagaatgtctgcttgccatttgcaatcacttgaggccttcc atgttacagcagctcctgcgacgcctcgtttttgatgtgccccaactcaatgaatactgc aaaatgcctctcaagcttctgacgaatcactatgaacagtgctggaaatattactgcctg ccttcaggatgggggagctatgggctagctgtggaagaagagctgcacctaacggagaag cttttctgggggatttttgactctctctcccataagaaatatgacccagatcttttccga atggccctgccttgtctcagtgctatagctggggccttgccaccggattatttagatacc agaatcacagccacattggagaaacagatctcagtggatgcagatggcaactttgatccc aaacctatcaacactgtgaatttttccttgcctgaaaaattggaatacatcgtcaccaag tatgctgagcattcacatgataaatgggcctgtgacaagagtcagagtggatggaaatat gggatttccctggatgaaaatgtgaagactcacccactgataaggcctttcaagacatta acggagaaggagaaggaaatttatcgctggcctgcccgagagtccctgaaaaccatgcta gctgtgggctggactgtggagaggaccaaagagggagaagccttggttcaacagcgggaa aatgagaagcttcgaagcgtgtcccaggccaaccagggcaacagctacagccctgctccc ctcgacctctcaaacgttgtactctccagagagctccagggaatggtggaggtcgtggct gagaactatcacaatatctgggccaagaagaagaagctggagctggagagcaaaggtggt ggcagtcaccctcttctggtaccatatgacaccttgactgccaaagaaaagttcaaggac cgggagaaggcacaggacctgtttaagttcctccaagtgaatggtgtcatagtttccagg ggtatgaaggatatggagctggatgcctcctccatggaaaagaggtttgcctataagttc ttgaagaagatcctgaaatacgttgattcggcacaagaatttattgcccatttagaagcc attgtcagcagtgggaaaactgaaaagtctcctcatgaccaggagatcaaattctttgcc aaagttctcctcccgctggttgaccagtacttcgccaatcatcgcctctacttcttgtca tcccctctgaagccccttagcagcagcggatacgcctctcataaggagaaagaaatggtg gccagcctgttctgcaaacttgctgcccttgttagacacagaatttccctctttggtagt gattctactacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggact gtcatgaagtcaggctcggagctggtgaaggctgggttacgagcattctttgaaaatgct gcagaagacttggagaagacgtcagaaaacctgaaacttgggaagttcacccactcccga acgcagattaaaggcgtttctcagaatattaactatactacagtggccctgctccccatc ctgacgtccatctttgagcacgtcgctcagcatcagtttggaatggatctcctcttgggt gatgtgcagatttcctgctaccacatactgtgcagcctctactcccttgggacaggaaag aacatttatgttgaaaggcaacgccctgcccttggagaatgtgtggcctcgctggcagct gccataccagtggcattcctggagcccaccctcaatcgctacaatcctctctcggtcttc aacaccaaaacccccagggagaggtctattctggggataccagacacggtggaagacatg tgtcctgacatcccccagctggaaggcctgatgaaggaaatcaacgacctggccgagtca ggggcacggtacacagagatgccgcatgtcatcgaggtgatcttacccatgctctgcaac tacctgtcctactggtgggagcgggggcctgagaacctgccccccagcacagggcagtgc tgcaccaaggtcacctctgaacacctcagtctcatcctgggcaacattctgaaaatcatc aacaacaacctgggcatcgatgaagcctcctggatgaagcgcatcgcagtgtatgcacag cccatcatcagcaaagccaggcccgacctgctgagaagccacttcatcccaactctggag aagctgaagaaaaaggctgtcaagaccgtgcaggaggaggagcagttgagagccgatggc aaaggggacacccaggaggcggagctcctcatcctggatgaattcgcggtcctctgccga gatctctatgccttctaccccatgctgatccgctacgtggacaacaacagatctaactgg ctgaaaagccctgatgctgattctgaccagctcttccgcatggtggcagaagtcttcatc ctgtggtgtaaatctcacaacttcaagagggaagagcaaaattttgtgattcagaatgaa attaataatttggcatttttaactggagacagcaaaagcaagatgtcaaaagccatgcaa gtaaagtctggaggacaagaccaggagcggaagaagacaaagcggcggggagacttgtat tccatccagacctccctcatcgtggctgcactcaagaaaatgctgcccattggtttgaat atgtgtactccaggcgaccaggagctgatctccctcgcaaaatcgcgatacggccatagg gacacagatgaagaggtcagagaacatctgcggaacaacttgcacttgcaggaaaagtct gatgacccagctgtaaaatggcagctgaacctctacaaagatgttctgaagagtgaagaa cctttcaatccagaaaagacagtggagcgtgtgcagagaatttcagcagctgtcttccac ctggaacaggtggaacagcctttgaggtccaagaaggccgtctggcacaaactgctatca aagcaacggaaacgggcagtggtggcctgcttcaggatggcccctctctacaacctgccc aggcaccgctctattaacctcttcctccatggctatcagagattttggatagaaacagag gagtattcctttgaagagaaactagtacaggatttggctaaatctccaaaggtggaagag gaggaggaggaagagaccgaaaaacaacctgacccactgcatcagatcattctctatttt agccgcaacgctctcacggagaggagcaaattggaagacgaccctttgtacacctcctat tccagcatgatggctaagagttgtcaaagtggtgaggacgaagaagaagatgaagacaag gaaaaaacattcgaagagaaggagatggagaagcagaaaaccctgtatcagcaagctcgg ctgcatgagcgtggtgccgcggagatggtccttcagatgataagcgctagcaaaggtgag atgagccccatggtggttgagactctgaagctggggatcgccattctgaacggaggcaat gctggtgtgcaacagaaaatgctagattacctaaaggagaaaaaggatgctggattcttt caaagcctttctggtcttatgcagtcttgcagtgtccttgatttgaatgcatttgagagg cagaataaagctgaaggcctggggatggtgactgaagaaggaacactcattgttcgtgaa cgtggtgaaaaagtactccagaatgacgagttcacgcgtgatctctttagattcctacag ttactttgtgaggggcataacagtgactttcagaacttcctgcggactcagatgggtaac accaccaccgtgaatgtcatcatcagcactgtggactaccttctgcgtctgcaggaatca atcagtgatttctactggtattattcagggaaggacatcattgatgaatccggacagcac aatttctccaaagctctggcagtcaccaagcagattttcaattctcttacagaatacatc cagggcccttgcattggtaatcagcagagcctggctcacagcaggctgtgggacgccgtg gttggcttcctccatgtctttgctaatatgcagatgaaactgtctcaggattccagtcag atcgagctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtcc ctcctggaagggaatgtggtaaatggcaccattggcaagcagatggttgacacactggta gaatcatctaccaatgtagaaatgatcttgaaattctttgacatgttcttgaaacttaaa gacttaaccagctcagacaccttcaaagaatacgacccagatggtaaaggaattatctcc aaaagagaattccagaaggccatggaagggcaaaaacagtacacgcagtcagagattgac tttctcctttcgtgtgcagaagctgatgagaatgacatgtttaattacattgattttgta gaccggttccatgagccggccaaggacatagggtttaatgtggctgtgttattgacaaat ctttctgaacacatgccaaacgattcccggctgaagtgtctgttggacccagcagaaagt gtgctaaattacttcgaaccctacctaggacgcatcgagatcatgggtggggccaagaaa attgagcgtgtttattttgaaatcagtgagtccagtcgcactcagtgggagaagccccag gtgaaggaatctaagcgacagttcatttttgatgttgtcaacgaaggtggggagcaggaa aagatggagctgtttgtgaacttctgtgaggacaccatctttgaaatgcagttagcatct cagatctctgaatccgattcagcggacaggccagaagaggaggaagaagatgaagattct tcttacgtgttagaaattgcgggtgaagaggaggaagacgggtctttcgagccggcctct gcatttgcaatggcctgtgcctctgtgaagaggaacgtcgccgactttctgaagagggca accctgaagaacctcaggaagcagtacaggaacgtcaaaaagatgactgcgaaggagctg gtgaaggtgctctgctcctttttctggatgctgttcctggggctgttccagatgctcttc accgtcctgggaggaatctttcagatcctctggagcacagtgtttggagggggcctggta gaaggggcaaagaacatcagagtgaccaagatcctgggtgacatgcctgacccaacccaa tttggtatccatgatgacactatggaggctgagagggcagaggtgatggagccaggtatc accactgaactagtacacttcataaagggggagaagggagatacagatatcatgtcagac ctctttggactccacccaaagaaagagggcagcttaaagcatgggcctgaagtgggtttg ggtgacctctcagaaattattggcaaggatgaaccccctacgttagagagtactgtacag aagaagaggaaagctcaggcagcagagatgaaagcagcaaatgaagcagaaggcaaagta gaatccgagaaggcagacatggaagatggagagaaggaagacaaagacaaagaagaggag caagccgagcacctgtggacagaagtgacaaaaaagaagaagcggcggtgtggtcagaag actgagaagccggaagctttcacagccaatttctttaaagggctggacatctatcagacc aagttactgcattacctggccaggaatttctacaacctgaggttccttgctctgtttgta gccttcgctatcaacttcatcctgcttttttataaggtcactgaagaacctttagaagaa gagacagaggatgttgcaaacctatggaattcatttaatgacgaggaagaggaagaagcg atggtgttctttgtccttcaggagagcactgggtatatggcaccaacgctgcgggccctg gccatcatccacaccatcatctctctagtctgtgtggtgggctactactgcctgaaggtg cctttggtggtattcaaaagggaaaaagaaatcgccaggaagctggagtttgatggccta tatatcaccgaacagccatctgaagatgacatcaaggggcaatgggaccgcttggtgatc aacacaccatcttttcctaataactactgggacaagtttgtaaagaggaaggtgatcaac aagtatggagatctctacggagcagagcgcattgctgaacttctgggtttggacaaaaat gctcttgacttcagcccagtagaagagaccaaagcagaggcggcttctctggtgtcatgg ctaagttccatagacatgaagtaccatatctggaagcttggagttgtgtttactgacaac tcctttctgtaccttgcctggtatacaaccatgtcagtcctgggccactacaataacttc ttctttgctgctcacctgctggatatcgcaatgggcttcaagacactgaggaccattctg tcatctgtaactcacaatggcaaacagttggttctgacggttggtctcctggccgtggtg gtgtatctctatactgtggtggctttcaacttcttccgcaagttctacaacaaaagtgaa gacgatgacgagcctgatatgaagtgtgacgacatgatgacgtgttaccttttccacatg tacgtgggagtgagagcaggaggtggcattggtgacgagattgaagaccctgctggtgat ccttatgaaatgtatcgcattgtctttgacattacctttttcttctttgtcattgtcatc ttgctggccatcattcaaggtcttattattgatgctttcggagagctgagagaccagcag gaacaagtgcgagaagatatggagaccaaatgtttcatctgtgggattggcaatgactac tttgacacgacccctcatggttttgaaacacatacattacaagagcacaacttagccaac tacttgttctttctgatgtatttgattaataaagatgaaacagagcacacgggtcaggaa tcttatgtctggaagatgtaccaagaaaggtgctgggatttcttcccagccggtgactgc tttcgtaaacagtatgaagatcagcttggataa

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