KEGG   Theropithecus gelada (gelada): 112628758
Entry
112628758         CDS       T08041                                 
Symbol
SOS2
Name
(RefSeq) LOW QUALITY PROTEIN: son of sevenless homolog 2
  KO
K03099  son of sevenless
Organism
tge  Theropithecus gelada (gelada)
Pathway
tge01521  EGFR tyrosine kinase inhibitor resistance
tge01522  Endocrine resistance
tge04010  MAPK signaling pathway
tge04012  ErbB signaling pathway
tge04014  Ras signaling pathway
tge04062  Chemokine signaling pathway
tge04068  FoxO signaling pathway
tge04072  Phospholipase D signaling pathway
tge04150  mTOR signaling pathway
tge04151  PI3K-Akt signaling pathway
tge04510  Focal adhesion
tge04540  Gap junction
tge04630  JAK-STAT signaling pathway
tge04650  Natural killer cell mediated cytotoxicity
tge04660  T cell receptor signaling pathway
tge04662  B cell receptor signaling pathway
tge04664  Fc epsilon RI signaling pathway
tge04714  Thermogenesis
tge04722  Neurotrophin signaling pathway
tge04810  Regulation of actin cytoskeleton
tge04910  Insulin signaling pathway
tge04912  GnRH signaling pathway
tge04915  Estrogen signaling pathway
tge04917  Prolactin signaling pathway
tge04926  Relaxin signaling pathway
tge04935  Growth hormone synthesis, secretion and action
tge05034  Alcoholism
tge05160  Hepatitis C
tge05161  Hepatitis B
tge05163  Human cytomegalovirus infection
tge05165  Human papillomavirus infection
tge05200  Pathways in cancer
tge05205  Proteoglycans in cancer
tge05206  MicroRNAs in cancer
tge05207  Chemical carcinogenesis - receptor activation
tge05208  Chemical carcinogenesis - reactive oxygen species
tge05210  Colorectal cancer
tge05211  Renal cell carcinoma
tge05213  Endometrial cancer
tge05214  Glioma
tge05215  Prostate cancer
tge05220  Chronic myeloid leukemia
tge05221  Acute myeloid leukemia
tge05223  Non-small cell lung cancer
tge05224  Breast cancer
tge05225  Hepatocellular carcinoma
tge05226  Gastric cancer
tge05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:tge00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112628758 (SOS2)
   04012 ErbB signaling pathway
    112628758 (SOS2)
   04014 Ras signaling pathway
    112628758 (SOS2)
   04630 JAK-STAT signaling pathway
    112628758 (SOS2)
   04068 FoxO signaling pathway
    112628758 (SOS2)
   04072 Phospholipase D signaling pathway
    112628758 (SOS2)
   04151 PI3K-Akt signaling pathway
    112628758 (SOS2)
   04150 mTOR signaling pathway
    112628758 (SOS2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112628758 (SOS2)
   04540 Gap junction
    112628758 (SOS2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    112628758 (SOS2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    112628758 (SOS2)
   04660 T cell receptor signaling pathway
    112628758 (SOS2)
   04662 B cell receptor signaling pathway
    112628758 (SOS2)
   04664 Fc epsilon RI signaling pathway
    112628758 (SOS2)
   04062 Chemokine signaling pathway
    112628758 (SOS2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112628758 (SOS2)
   04912 GnRH signaling pathway
    112628758 (SOS2)
   04915 Estrogen signaling pathway
    112628758 (SOS2)
   04917 Prolactin signaling pathway
    112628758 (SOS2)
   04926 Relaxin signaling pathway
    112628758 (SOS2)
   04935 Growth hormone synthesis, secretion and action
    112628758 (SOS2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    112628758 (SOS2)
  09159 Environmental adaptation
   04714 Thermogenesis
    112628758 (SOS2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112628758 (SOS2)
   05206 MicroRNAs in cancer
    112628758 (SOS2)
   05205 Proteoglycans in cancer
    112628758 (SOS2)
   05207 Chemical carcinogenesis - receptor activation
    112628758 (SOS2)
   05208 Chemical carcinogenesis - reactive oxygen species
    112628758 (SOS2)
   05231 Choline metabolism in cancer
    112628758 (SOS2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112628758 (SOS2)
   05225 Hepatocellular carcinoma
    112628758 (SOS2)
   05226 Gastric cancer
    112628758 (SOS2)
   05214 Glioma
    112628758 (SOS2)
   05221 Acute myeloid leukemia
    112628758 (SOS2)
   05220 Chronic myeloid leukemia
    112628758 (SOS2)
   05211 Renal cell carcinoma
    112628758 (SOS2)
   05215 Prostate cancer
    112628758 (SOS2)
   05213 Endometrial cancer
    112628758 (SOS2)
   05224 Breast cancer
    112628758 (SOS2)
   05223 Non-small cell lung cancer
    112628758 (SOS2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    112628758 (SOS2)
   05160 Hepatitis C
    112628758 (SOS2)
   05163 Human cytomegalovirus infection
    112628758 (SOS2)
   05165 Human papillomavirus infection
    112628758 (SOS2)
  09165 Substance dependence
   05034 Alcoholism
    112628758 (SOS2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112628758 (SOS2)
   01522 Endocrine resistance
    112628758 (SOS2)
SSDB
Motif
Pfam: RasGEF RasGEF_N RhoGEF SOS1_NGEF_PH PH RHG20_PH IQ_SEC7_PH
Other DBs
NCBI-GeneID: 112628758
NCBI-ProteinID: XP_025247755
Ensembl: ENSTGEG00000007730
LinkDB
Position
7b:complement(51458740..51575655)
AA seq 1227 aa
MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLC
MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY
KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD
IGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDI
EKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI
LSPEFNEHFNKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKA
CSEEQEDRECLNQAITALMNLQGSMDRIYKQHSPRRRPGDPVCPFYSHQLRSKHLAIKKM
NEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPG
YSSAEYRLKEKFVMRKIQICDKEDTCECKHAFELVSKDENSVVFAAKSAEEKNNWMAALI
SLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIK
GGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLA
IEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVR
GKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPAIEWHISKPGQFETFDLMTLHPI
EIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEA
ENFEERVAVLSRVIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILD
EAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR
KVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGNASEKEFTDYLFNKSLEIEPRNCK
QPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTV
SAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLS
EEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFMGLC
IVHLHHHQEILFLIPLHRFPFGLQNTL
NT seq 3684 nt   +upstreamnt  +downstreamnt
atgcagcaggcgccgcagccttacgagttcttcagtgaggagaatagtccgaaatggcgg
ggactgttggtctcggccctgcggaaggttcaggaacaagtgcatcccactctctcagct
aatgaagagtctctctattatattgaagagctgatttttcagctgcttaataaattatgc
atggcccagccaaggactgttcaagatgtagaggagcgagttcagaagacctttcctcac
ccaattgataaatgggccattgctgatgcacaatctgctatagaaaaacgaaaaagaaga
aatcctcttttactgcctgtggacaaaatccatccttcgttgaaggaagtgttagggtac
aaagtggactaccatgtgtccctatatattgtggctgtactagaatatatctcagctgat
attttaaaattggctggtaattatgtttttaatatccggcattatgaaatatctcagcag
gacattaaagtgtcaatgtgtgcggataaggttttgatggacatgtttgatcaggatgat
ataggcttggtttctctctgtgaagatgaacctagttcttccggtgaattaaactactat
gatcttgtcagaactgaaattgcagaagaaagacagtatctacgggaattaaatatgatc
ataaaagtgtttcgagaagcctttctttctgatagaaagctgtttaaaccttctgatatt
gaaaagatttttagtaacatttcagatatacatgaattgactgtgaaacttttaggtttg
attgaagacacagttgaaatgactgatgaaagcagtcctcatcccttagctggcagctgt
tttgaagatttggcagaagagcaagcatttgatccttatgaaacattatcacaggacatt
ctttcaccagagtttaatgaacatttcaataaattgatggccagacctgcagttgctcta
cactttcagtctattgctgatggctttaaagaggcagttcgttatgtccttccacgtctt
atgctggtgccagtgtatcactgttggcactattttgagttactaaagcaattgaaagca
tgtagtgaagaacaagaagacagagaatgtttgaaccaagctattactgctctcatgaat
ctccaaggtagcatggaccgaatttacaagcagcattcacctagacgccgacctggagat
cctgtttgccctttttatagtcaccaattaagaagcaaacacctggctatcaaaaaaatg
aatgaaattcagaaaaatatcgatggatgggaaggcaaagatattggacagtgttgtaat
gaattcattatggagggaccattgacaagaatcggtgccaaacatgaacggcatattttt
ctgtttgatggcttaatgatcagttgtaaacctaatcatggccagactcggcttccaggt
tacagtagtgcagaatacaggttaaaagaaaaatttgtcatgaggaaaatacaaatttgt
gataaagaagatacttgtgagtgcaagcatgcttttgaattagtatccaaagatgagaac
agcgtagtatttgctgctaagtctgctgaagaaaaaaacaactggatggcagcccttatt
tctcttcattatcgtagtactctagatcgaatgttagattcagtattactgaaagaagaa
aatgagcaaccactgagattaccaagtcctgaagtatatcgttttgtagtaaaagactct
gaggaaaacattgtttttgaagacaacttgcaaagtagaagtggcatccccattattaaa
ggaggaactgtagtgaagttaattgaaaggttaacatatcatatgtatgcagatcccaat
tttgttcgtacttttcttaccacatatcgttcattttgtaaaccacaggaattgctgagc
ttactgattgaacggtttgaaatcccagagccagaacctactgacgcagacaaattggca
atagagaaaggcgagcagccaatcagtgcagaccttaaaagatttcgcaaggaatatgtc
caaccagtacaacttaggatcttaaatgtatttcggcattgggttgaacatcatttttat
gactttgaaagagatttggaattgcttgaaagactagaatccttcatttcaagtgtaaga
gggaaagctatgaagaaatgggtagagtcaatcgctaagatcatcaagaggaagaagcaa
gctcaggcaaacggaataagccataatattacctttgaaagtccacctccagcaattgaa
tggcatatcagcaaaccaggacagtttgaaacatttgatctcatgacacttcatccaata
gaaattgcacgtcagctgacacttttggagtctgatctctacaggaaagttcaaccatct
gaacttgtaggaagtgtgtggaccaaagaagataaagaaataaattctccaaatttatta
aaaatgattcgccataccacaaatctcaccctctggtttgaaaaatgcattgtggaagca
gaaaattttgaagaacgggttgcagtactaagtagagttatagaaattctgcaagttttt
caagatttgaataatttcaatggcgtattggagatagtcagtgcagtaaattcagtgtca
gtatacagactagaccatacctttgaggcactgcaggaaagaaaaaggaaaattttggat
gaagctgtggaattaagtcaagatcactttaaaaaatacctagtaaaacttaagtcaatc
aatccaccttgtgtgcctttttttggaatatatttaacaaatattctgaagactgaagaa
gggaataatgattttttaaaaaagaaagggaaagatttaatcaatttcagtaagaggagg
aaagtagctgaaattactggagaaattcagcagtatcagaatcagccttactgtttacgg
atagaaccagatatgaggagattctttgaaaaccttaaccccatgggaaatgcgtctgaa
aaagagtttacagattatttgttcaacaagtcactagaaattgaacctcgaaactgcaaa
cagccacctcgatttcctagaaaatcaactttctccttgaaatctcctggaataaggcct
aacacaggccgacatggctctacctcaggtactttacgaggtcacccaacaccattagaa
agagaaccatgtaaaataagctttagtcggattgctgaaactgagctggaatcaacagtg
tcagcaccaacttctccaaatacaccatctactccaccagtatctgcttcttcagacctt
agtgtatttttagatgtggatctcaacagctcctgtggcagcaatagcatctttgctcca
gtgcttttgccacattcaaagtctttctttagttcatgtggtagtttacataaactaagt
gaagagcccctgattcctcctcctcttcctcctcgaaaaaagtttgatcatgatgcttca
aattctaagggaaatatgaaatctgatgatgatcctcctgctattccaccgagacagcct
cctcctcccaaggtaaaacccagagttcctgttcctactggtgcatttatgggcctctgc
atagtccacctccaccaccaccaagagatcctcttcctgatacccctccaccggttcccc
ttcggcctccagaacactttataa

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